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Protein

GPALPP motifs-containing protein 1

Gene

GPALPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GPALPP motifs-containing protein 1
Alternative name(s):
Lipopolysaccharide-specific response protein 7
Gene namesi
Name:GPALPP1
Synonyms:KIAA1704, LSR7
ORF Names:AD029
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20298. GPALPP1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133114.
PharmGKBiPA134943194.

Polymorphism and mutation databases

BioMutaiGPALPP1.
DMDMi74728222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002937142 – 340GPALPP motifs-containing protein 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei138PhosphothreonineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IXQ4.
MaxQBiQ8IXQ4.
PaxDbiQ8IXQ4.
PeptideAtlasiQ8IXQ4.
PRIDEiQ8IXQ4.

PTM databases

iPTMnetiQ8IXQ4.
PhosphoSitePlusiQ8IXQ4.

Expressioni

Gene expression databases

BgeeiENSG00000133114.
CleanExiHS_KIAA1704.
ExpressionAtlasiQ8IXQ4. baseline and differential.
GenevisibleiQ8IXQ4. HS.

Organism-specific databases

HPAiHPA038966.
HPA058739.

Interactioni

Protein-protein interaction databases

BioGridi120665. 24 interactors.
IntActiQ8IXQ4. 9 interactors.
STRINGi9606.ENSP00000355211.

Structurei

3D structure databases

ProteinModelPortaliQ8IXQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 12GPALPP motif 16
Motifi32 – 37GPALPP motif 26
Motifi92 – 97GPALPP motif 36
Motifi112 – 117GPALPP motif 46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 49Poly-Ser9
Compositional biasi81 – 88Poly-Asp8

Phylogenomic databases

eggNOGiKOG4188. Eukaryota.
ENOG4111F1D. LUCA.
GeneTreeiENSGT00390000008389.
HOVERGENiHBG057200.
InParanoidiQ8IXQ4.
OMAiPIVRESW.
OrthoDBiEOG091G0INW.
PhylomeDBiQ8IXQ4.
TreeFamiTF314389.

Family and domain databases

InterProiIPR022226. DUF3752.
[Graphical view]
PfamiPF12572. DUF3752. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARDLIGPAL PPGFKARGTA EDEERDPSPV AGPALPPNYK SSSSDSSDSD
60 70 80 90 100
EDSSSLYEEG NQESEEDDSG PTARKQRKNQ DDDDDDDDGF FGPALPPGFK
110 120 130 140 150
KQDDSPPRPI IGPALPPGFI KSTQKSDKGR DDPGQQETDS SEDEDIIGPM
160 170 180 190 200
PAKGPVNYNV TTEFEKRAQR MKEKLTKGDD DSSKPIVRES WMTELPPEMK
210 220 230 240 250
DFGLGPRTFK RRADDTSGDR SIWTDTPADR ERKAKETQEA RKSSSKKDEE
260 270 280 290 300
HILSGRDKRL AEQVSSYNES KRSESLMDIH HKKLKSKAAE DKNKPQERIP
310 320 330 340
FDRDKDLKVN RFDEAQKKAL IKKSRELNTR FSHGKGNMFL
Length:340
Mass (Da):38,142
Last modified:March 1, 2003 - v1
Checksum:iF752A6A2917132E6
GO
Isoform 2 (identifier: Q8IXQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):22,226
Checksum:iF398D2648B8C9B52
GO
Isoform 3 (identifier: Q8IXQ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):19,807
Checksum:iB181167EB8421D96
GO
Isoform 4 (identifier: Q8IXQ4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-175: ETDSSEDEDI...KRAQRMKEKL → VSSSHFNSKV...CSYYNHWTQL
     176-340: Missing.

Note: No experimental confirmation available.
Show »
Length:175
Mass (Da):19,237
Checksum:i0606892D4AFD3B66
GO

Sequence cautioni

The sequence AAH17776 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB21795 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126S → I in AAH32333 (PubMed:15489334).Curated1
Sequence conflicti194E → K in AAF70548 (Ref. 1) Curated1
Sequence conflicti212R → G in AAF70548 (Ref. 1) Curated1
Sequence conflicti242K → E in AAF70548 (Ref. 1) Curated1
Sequence conflicti280H → Q in AAH17776 (PubMed:15489334).Curated1
Sequence conflicti295P → L in AAH39586 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0265671 – 170Missing in isoform 3. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_0265681 – 149Missing in isoform 2. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_026569137 – 175ETDSS…MKEKL → VSSSHFNSKVWKVFIERIRC IVTNSKLYACSYYNHWTQL in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_026570176 – 340Missing in isoform 4. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145122 mRNA. Translation: AAF70548.1.
AB051491 mRNA. Translation: BAB21795.1. Different initiation.
AF245045 mRNA. Translation: AAG44482.1.
AK292493 mRNA. Translation: BAF85182.1.
AL359706 Genomic DNA. Translation: CAI12866.2.
AL359706 Genomic DNA. Translation: CAI12868.2.
CH471075 Genomic DNA. Translation: EAX08720.1.
BC017776 mRNA. Translation: AAH17776.1. Sequence problems.
BC032333 mRNA. Translation: AAH32333.1.
BC039586 mRNA. Translation: AAH39586.1.
CCDSiCCDS9394.1. [Q8IXQ4-1]
RefSeqiNP_001303880.1. NM_001316951.1. [Q8IXQ4-1]
NP_001303881.1. NM_001316952.1.
NP_061029.2. NM_018559.3. [Q8IXQ4-1]
XP_005266501.1. XM_005266444.3. [Q8IXQ4-1]
UniGeneiHs.731811.
Hs.744143.

Genome annotation databases

EnsembliENST00000357537; ENSP00000350145; ENSG00000133114. [Q8IXQ4-3]
ENST00000379151; ENSP00000368447; ENSG00000133114. [Q8IXQ4-1]
ENST00000497558; ENSP00000432500; ENSG00000133114. [Q8IXQ4-1]
GeneIDi55425.
KEGGihsa:55425.
UCSCiuc001uzq.4. human. [Q8IXQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145122 mRNA. Translation: AAF70548.1.
AB051491 mRNA. Translation: BAB21795.1. Different initiation.
AF245045 mRNA. Translation: AAG44482.1.
AK292493 mRNA. Translation: BAF85182.1.
AL359706 Genomic DNA. Translation: CAI12866.2.
AL359706 Genomic DNA. Translation: CAI12868.2.
CH471075 Genomic DNA. Translation: EAX08720.1.
BC017776 mRNA. Translation: AAH17776.1. Sequence problems.
BC032333 mRNA. Translation: AAH32333.1.
BC039586 mRNA. Translation: AAH39586.1.
CCDSiCCDS9394.1. [Q8IXQ4-1]
RefSeqiNP_001303880.1. NM_001316951.1. [Q8IXQ4-1]
NP_001303881.1. NM_001316952.1.
NP_061029.2. NM_018559.3. [Q8IXQ4-1]
XP_005266501.1. XM_005266444.3. [Q8IXQ4-1]
UniGeneiHs.731811.
Hs.744143.

3D structure databases

ProteinModelPortaliQ8IXQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120665. 24 interactors.
IntActiQ8IXQ4. 9 interactors.
STRINGi9606.ENSP00000355211.

PTM databases

iPTMnetiQ8IXQ4.
PhosphoSitePlusiQ8IXQ4.

Polymorphism and mutation databases

BioMutaiGPALPP1.
DMDMi74728222.

Proteomic databases

EPDiQ8IXQ4.
MaxQBiQ8IXQ4.
PaxDbiQ8IXQ4.
PeptideAtlasiQ8IXQ4.
PRIDEiQ8IXQ4.

Protocols and materials databases

DNASUi55425.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357537; ENSP00000350145; ENSG00000133114. [Q8IXQ4-3]
ENST00000379151; ENSP00000368447; ENSG00000133114. [Q8IXQ4-1]
ENST00000497558; ENSP00000432500; ENSG00000133114. [Q8IXQ4-1]
GeneIDi55425.
KEGGihsa:55425.
UCSCiuc001uzq.4. human. [Q8IXQ4-1]

Organism-specific databases

CTDi55425.
GeneCardsiGPALPP1.
HGNCiHGNC:20298. GPALPP1.
HPAiHPA038966.
HPA058739.
neXtProtiNX_Q8IXQ4.
OpenTargetsiENSG00000133114.
PharmGKBiPA134943194.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4188. Eukaryota.
ENOG4111F1D. LUCA.
GeneTreeiENSGT00390000008389.
HOVERGENiHBG057200.
InParanoidiQ8IXQ4.
OMAiPIVRESW.
OrthoDBiEOG091G0INW.
PhylomeDBiQ8IXQ4.
TreeFamiTF314389.

Miscellaneous databases

ChiTaRSiGPALPP1. human.
GeneWikiiKIAA1704.
GenomeRNAii55425.
PROiQ8IXQ4.

Gene expression databases

BgeeiENSG00000133114.
CleanExiHS_KIAA1704.
ExpressionAtlasiQ8IXQ4. baseline and differential.
GenevisibleiQ8IXQ4. HS.

Family and domain databases

InterProiIPR022226. DUF3752.
[Graphical view]
PfamiPF12572. DUF3752. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPAM1_HUMAN
AccessioniPrimary (citable) accession number: Q8IXQ4
Secondary accession number(s): A8K8X8
, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q9C0F9, Q9H2R0, Q9P0W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.