Q8IXP2 (Q8IXP2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase RuleBase RU003492
EC=2.7.10.2 RuleBase RU003492

Gene names

Name:

JAK2 EMBL AAH39695.1

Organism

Homo sapiens (Human) EMBL AAH39695.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1129 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. RuleBase RU003492 SAAS SAAS020635
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. RuleBase RU003492 Contains 1 SH2 domain. RuleBase RU003492 Contains 1 protein kinase domain. SAAS SAAS020635

Ontologies

Keywords
Domain	SH2 domain RuleBase RU003492
Ligand	ATP-binding SAAS SAAS020635 RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS020635
PTM	Phosphoprotein RuleBase RU003493
Gene Ontology (GO)
Cellular component	cytoskeleton Inferred from electronic annotation. Source: InterPro membrane Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW histone binding Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IXP2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: E9C4C59F8118DDF6	FASTA	1,129	130,286
	10 20 30 40 50 60 MGMACLTMTE MEGTSTSSIY QNGDISGNAN SIDPVLQVYL YHSLGKSEAD YLTFPSGEYV 70 80 90 100 110 120 AEEICIAASK ACGITPVYHN MFALMSETER IWYPPNHVFH IDESTRHNVL YRIRFYFPRW 130 140 150 160 170 180 YCSGSNRAYR HGISRGAEAP LLDDFVMSYL FAQWRHDFVH GWIKVPVTHE TQEECLGMAV 190 200 210 220 230 240 LDMMRIAKEN DQTPLAIYNS ISYKTFLPKC IRAKIQDYHI LTRKRIRYRF RRFIQQFSQC 250 260 270 280 290 300 KATARNLKLK YLINLETLQS AFYTEKFEVK EPGSGPSGEE IFATIIITGN GGIQWSRGKH 310 320 330 340 350 360 KESETLTEQD LQLYCDFPNI IDVSIKQANQ EGSNESRVVT IHKQDGKNLE IELSSLREAL 370 380 390 400 410 420 SFVSLIDGYY RLTADAHHYL CKEVAPPAVL ENIQSNCHGP ISMDFAISKL KKAGNQTGLY 430 440 450 460 470 480 VLRCSPKDFN KYFLTFAVER ENVIEYKHCL ITKNENEEYN LSGTKKNFSS LKDLLNCYQM 490 500 510 520 530 540 ETVRSDNIIF QFTKCCPPKP KDKSNLLVFR TNGVSDVPTS PTLQRPTHMN QMVFHKIRNE 550 560 570 580 590 600 DLIFNESLGQ GTFTKIFKGV RREVGDYGQL HETEVLLKVL DKAHRNYSES FFEAASMMSK 610 620 630 640 650 660 LSHKHLVLNY GVCVCGDENI LVQEFVKFGS LDTYLKKNKN CINILWKLEV AKQLAWAMHF 670 680 690 700 710 720 LEENTLIHGN VCAKNILLIR EEDRKTGNPP FIKLSDPGIS ITVLPKDILQ ERIPWVPPEC 730 740 750 760 770 780 IENPKNLNLA TDKWSFGTTL WEICSGGDKP LSALDSQRKL QFYEDRHQLP APKWAELANL 790 800 810 820 830 840 INNCMDYEPD FRPSFRAIIR DLNSLFTPDY ELLTENDMLP NMRIGALGFS GAFEDRDPTQ 850 860 870 880 890 900 FEERHLKFLQ QLGKGNFGSV EMCRYDPLQD NTGEVVAVKK LQHSTEEHLR DFEREIEILK 910 920 930 940 950 960 SLQHDNIVKY KGVCYSAGRR NLKLIMEYLP YGSLRDYLQK HKERIDHIKL LQYTSQICKG 970 980 990 1000 1010 1020 MEYLGTKRYI HRDLATRNIL VENENRVKIG DFGLTKVLPQ DKEYYKVKEP GESPIFWYAP 1030 1040 1050 1060 1070 1080 ESLTESKFSV ASDVWSFGVV LYELFTYIEK SKSPPAEFMR MIGNDKQGQM IVFHLIELLK 1090 1100 1110 1120 NNGRLPRPDG CPDEIYMIMT ECWNNNVNQR PSFRDLALRV DQIRDNMAG

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus EMBL AAH39695.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC039695 mRNA. Translation: AAH39695.1.
IPI	IPI00031016.
UniGene	Hs.656213.
3D structure databases
HSSP	HSSP built from PDB template 1R1W based on UniProtKB P08581.
ProteinModelPortal	Q8IXP2.
SMR	Q8IXP2. Positions 837-1129.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IXP2.
Proteomic databases
PRIDE	Q8IXP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084141.
HOVERGEN	HBG006195.
Gene expression databases
ArrayExpress	Q8IXP2.
Bgee	Q8IXP2.
Family and domain databases
InterPro	IPR019749. Band_41_domain. IPR019748. FERM_central. IPR000299. FERM_domain. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2. IPR020693. Tyr_kinase_non-rcpt_Jak2. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF07714. Pkinase_Tyr. 2 hits. PF00017. SH2. 1 hit. [Graphical view]
PIRSF	PIRSF000636. TyrPK_Jak. 1 hit.
PRINTS	PR01823. JANUSKINASE. PR01825. JANUSKINASE2. PR00109. TYRKINASE.
SMART	SM00295. B41. 1 hit. SM00252. SH2. 1 hit. SM00219. TyrKc. 2 hits. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit. SSF56112. Kinase_like. 2 hits.
PROSITE	PS50057. FERM_3. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8IXP2_HUMAN

Accession

Primary (citable) accession number: Q8IXP2

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.