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Protein

Tyrosine-protein kinase

Gene

JAK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei879ATPUniRule annotation1
Active sitei973Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi852 – 860ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IXP2

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:JAK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiQ8IXP2

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8IXP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 377FERMInterPro annotationAdd BLAST344
Domaini398 – 479SH2InterPro annotationAdd BLAST82
Domaini542 – 806Protein kinaseInterPro annotationAdd BLAST265
Domaini846 – 1123Protein kinaseInterPro annotationAdd BLAST278

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
HOVERGENiHBG006195

Family and domain databases

CDDicd13333 FERM_C_JAK2, 1 hit
cd05078 PTK_Jak2_rpt1, 1 hit
cd14205 PTKc_Jak2_rpt2, 1 hit
cd10379 SH2_Jak2, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR000299 FERM_domain
IPR037838 JAK2_FERM_C-lobe
IPR035860 JAK2_SH2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR035588 PTK_Jak2_rpt1
IPR035589 PTKc_Jak2_rpt2
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR020693 Tyr_kinase_non-rcpt_Jak2
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PF00017 SH2, 1 hit
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR01825 JANUSKINASE2
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IXP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMACLTMTE MEGTSTSSIY QNGDISGNAN SIDPVLQVYL YHSLGKSEAD
60 70 80 90 100
YLTFPSGEYV AEEICIAASK ACGITPVYHN MFALMSETER IWYPPNHVFH
110 120 130 140 150
IDESTRHNVL YRIRFYFPRW YCSGSNRAYR HGISRGAEAP LLDDFVMSYL
160 170 180 190 200
FAQWRHDFVH GWIKVPVTHE TQEECLGMAV LDMMRIAKEN DQTPLAIYNS
210 220 230 240 250
ISYKTFLPKC IRAKIQDYHI LTRKRIRYRF RRFIQQFSQC KATARNLKLK
260 270 280 290 300
YLINLETLQS AFYTEKFEVK EPGSGPSGEE IFATIIITGN GGIQWSRGKH
310 320 330 340 350
KESETLTEQD LQLYCDFPNI IDVSIKQANQ EGSNESRVVT IHKQDGKNLE
360 370 380 390 400
IELSSLREAL SFVSLIDGYY RLTADAHHYL CKEVAPPAVL ENIQSNCHGP
410 420 430 440 450
ISMDFAISKL KKAGNQTGLY VLRCSPKDFN KYFLTFAVER ENVIEYKHCL
460 470 480 490 500
ITKNENEEYN LSGTKKNFSS LKDLLNCYQM ETVRSDNIIF QFTKCCPPKP
510 520 530 540 550
KDKSNLLVFR TNGVSDVPTS PTLQRPTHMN QMVFHKIRNE DLIFNESLGQ
560 570 580 590 600
GTFTKIFKGV RREVGDYGQL HETEVLLKVL DKAHRNYSES FFEAASMMSK
610 620 630 640 650
LSHKHLVLNY GVCVCGDENI LVQEFVKFGS LDTYLKKNKN CINILWKLEV
660 670 680 690 700
AKQLAWAMHF LEENTLIHGN VCAKNILLIR EEDRKTGNPP FIKLSDPGIS
710 720 730 740 750
ITVLPKDILQ ERIPWVPPEC IENPKNLNLA TDKWSFGTTL WEICSGGDKP
760 770 780 790 800
LSALDSQRKL QFYEDRHQLP APKWAELANL INNCMDYEPD FRPSFRAIIR
810 820 830 840 850
DLNSLFTPDY ELLTENDMLP NMRIGALGFS GAFEDRDPTQ FEERHLKFLQ
860 870 880 890 900
QLGKGNFGSV EMCRYDPLQD NTGEVVAVKK LQHSTEEHLR DFEREIEILK
910 920 930 940 950
SLQHDNIVKY KGVCYSAGRR NLKLIMEYLP YGSLRDYLQK HKERIDHIKL
960 970 980 990 1000
LQYTSQICKG MEYLGTKRYI HRDLATRNIL VENENRVKIG DFGLTKVLPQ
1010 1020 1030 1040 1050
DKEYYKVKEP GESPIFWYAP ESLTESKFSV ASDVWSFGVV LYELFTYIEK
1060 1070 1080 1090 1100
SKSPPAEFMR MIGNDKQGQM IVFHLIELLK NNGRLPRPDG CPDEIYMIMT
1110 1120
ECWNNNVNQR PSFRDLALRV DQIRDNMAG
Length:1,129
Mass (Da):130,286
Last modified:March 1, 2003 - v1
Checksum:iE9C4C59F8118DDF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039695 mRNA Translation: AAH39695.1
UniGeneiHs.656213

Similar proteinsi

Entry informationi

Entry nameiQ8IXP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXP2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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