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Protein

N-acetylaspartylglutamate synthase A

Gene

RIMKLA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate.By similarity

Miscellaneous

N-acetyl-L-aspartyl-L-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous system (CNS).By similarity

Catalytic activityi

ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate.By similarity
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei154ATPBy similarity1
Binding sitei215ATPBy similarity1
Metal bindingi260Magnesium or manganese 1PROSITE-ProRule annotation1
Metal bindingi273Magnesium or manganese 1PROSITE-ProRule annotation1
Metal bindingi273Magnesium or manganese 2PROSITE-ProRule annotation1
Metal bindingi275Magnesium or manganese 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi189 – 199ATPPROSITE-ProRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylaspartylglutamate synthase A (EC:6.3.2.41By similarity)
Short name:
NAAG synthetase A
Short name:
NAAGS
Alternative name(s):
N-acetylaspartylglutamylglutamate synthase A (EC:6.3.2.42By similarity)
Ribosomal protein S6 modification-like protein A
Gene namesi
Name:RIMKLA
Synonyms:FAM80A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177181.14
HGNCiHGNC:28725 RIMKLA
neXtProtiNX_Q8IXN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177181
PharmGKBiPA164725339

Polymorphism and mutation databases

BioMutaiRIMKLA
DMDMi143458650

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825681 – 391N-acetylaspartylglutamate synthase AAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IXN7
PeptideAtlasiQ8IXN7
PRIDEiQ8IXN7

PTM databases

iPTMnetiQ8IXN7
PhosphoSitePlusiQ8IXN7

Expressioni

Gene expression databases

BgeeiENSG00000177181
CleanExiHS_RIMKLA
ExpressionAtlasiQ8IXN7 baseline and differential
GenevisibleiQ8IXN7 HS

Organism-specific databases

HPAiHPA027826

Interactioni

Protein-protein interaction databases

BioGridi1299403 interactors.
STRINGi9606.ENSP00000414330

Structurei

3D structure databases

ProteinModelPortaliQ8IXN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 300ATP-graspPROSITE-ProRule annotationAdd BLAST186

Sequence similaritiesi

Belongs to the RimK family.Curated

Phylogenomic databases

eggNOGiENOG410IGDC Eukaryota
COG0189 LUCA
GeneTreeiENSGT00390000014577
HOGENOMiHOG000043112
HOVERGENiHBG108408
InParanoidiQ8IXN7
KOiK18311
OMAiCHLVRHD
OrthoDBiEOG091G09CF
PhylomeDBiQ8IXN7
TreeFamiTF332035

Family and domain databases

Gene3Di3.30.1490.201 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013651 ATP-grasp_RimK-type
IPR013815 ATP_grasp_subdomain_1
IPR004666 RpS6_RimK/Lys_biosynth_LsyX
PfamiView protein in Pfam
PF08443 RimK, 1 hit
TIGRFAMsiTIGR00768 rimK_fam, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IXN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSQLWFLTD RRIREDYPQV QILRALRQRC SEQDVRFRAV LMDQIAVTIV
60 70 80 90 100
GGHLGLQLNQ KALTTFPDVV LVRVPTPSVQ SDSDITVLRH LEKLGCRLVN
110 120 130 140 150
RPQSILNCIN KFWTFQELAG HGVPMPDTFS YGGHEDFSKM IDEAEPLGYP
160 170 180 190 200
VVVKSTRGHR GKAVFLARDK HHLSDICHLI RHDVPYLFQK YVKESHGKDI
210 220 230 240 250
RVVVVGGQVI GSMLRCSTDG RMQSNCSLGG VGVKCPLTEQ GKQLAIQVSN
260 270 280 290 300
ILGMDFCGID LLIMDDGSFV VCEANANVGF LAFDQACNLD VGGIIADYTM
310 320 330 340 350
SLLPNRQTGK MAVLPGLSSP REKNEPDGCA SAQGVAESVY TINSGSTSSE
360 370 380 390
SEPELGEIRD SSASTMGAPP SMLPEPGYNI NNRIASELKL K
Length:391
Mass (Da):42,864
Last modified:April 3, 2007 - v2
Checksum:i8E78DFA4C0C89592
GO

Sequence cautioni

The sequence AAH39737 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH70661 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513331 Genomic DNA Translation: CAH70659.2
AL513331 Genomic DNA Translation: CAH70661.1 Sequence problems.
BC039737 mRNA Translation: AAH39737.1 Different initiation.
CCDSiCCDS466.2
RefSeqiNP_775913.2, NM_173642.3
UniGeneiHs.420244

Genome annotation databases

EnsembliENST00000431473; ENSP00000414330; ENSG00000177181
GeneIDi284716
KEGGihsa:284716
UCSCiuc001chi.3 human

Similar proteinsi

Entry informationi

Entry nameiRIMKA_HUMAN
AccessioniPrimary (citable) accession number: Q8IXN7
Secondary accession number(s): Q5VUS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: February 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome