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Protein

Nurim

Gene

NRM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Nurim
Alternative name(s):
Nuclear envelope membrane protein
Nuclear rim protein
Gene namesi
Name:NRM
Synonyms:NRM29
ORF Names:UNQ555/PRO1112
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8003. NRM.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4NuclearSequence analysis4
Transmembranei5 – 28HelicalSequence analysisAdd BLAST24
Topological domaini29 – 58Perinuclear spaceSequence analysisAdd BLAST30
Transmembranei59 – 80HelicalSequence analysisAdd BLAST22
Topological domaini81 – 97NuclearSequence analysisAdd BLAST17
Transmembranei98 – 114HelicalSequence analysisAdd BLAST17
Topological domaini115 – 133Perinuclear spaceSequence analysisAdd BLAST19
Transmembranei134 – 164HelicalSequence analysisAdd BLAST31
Topological domaini165 – 191NuclearSequence analysisAdd BLAST27
Transmembranei192 – 210HelicalSequence analysisAdd BLAST19
Topological domaini211 – 216Perinuclear spaceSequence analysis6
Transmembranei217 – 234HelicalSequence analysisAdd BLAST18
Topological domaini235 – 262NuclearSequence analysisAdd BLAST28

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • nuclear inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11270.
OpenTargetsiENSG00000137404.
ENSG00000206484.
ENSG00000228854.
ENSG00000228867.
ENSG00000234809.
ENSG00000235773.
ENSG00000236843.
PharmGKBiPA31782.

Polymorphism and mutation databases

DMDMi74750736.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993951 – 262NurimAdd BLAST262

Proteomic databases

EPDiQ8IXM6.
MaxQBiQ8IXM6.
PaxDbiQ8IXM6.
PeptideAtlasiQ8IXM6.
PRIDEiQ8IXM6.

PTM databases

iPTMnetiQ8IXM6.
PhosphoSitePlusiQ8IXM6.
SwissPalmiQ8IXM6.

Expressioni

Gene expression databases

BgeeiENSG00000137404.
CleanExiHS_NRM.
ExpressionAtlasiQ8IXM6. baseline and differential.
GenevisibleiQ8IXM6. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA83EBI-10262547,EBI-6942903
SUN2Q9UH993EBI-10262547,EBI-1044964
TRIM59Q8IWR15EBI-10262547,EBI-10262539

Protein-protein interaction databases

BioGridi116427. 8 interactors.
IntActiQ8IXM6. 5 interactors.
STRINGi9606.ENSP00000259953.

Structurei

3D structure databases

ProteinModelPortaliQ8IXM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 72Poly-Leu6
Compositional biasi139 – 253Leu-richAdd BLAST115

Sequence similaritiesi

Belongs to the nurim family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVGT. Eukaryota.
ENOG4111VYI. LUCA.
GeneTreeiENSGT00390000008146.
HOVERGENiHBG102998.
InParanoidiQ8IXM6.
OMAiFIIAFWA.
OrthoDBiEOG091G0MZT.
PhylomeDBiQ8IXM6.
TreeFamiTF324853.

Family and domain databases

InterProiIPR033580. Nurim-like.
[Graphical view]
PANTHERiPTHR31040. PTHR31040. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXM6-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPALLLIPA ALASFILAFG TGVEFVRFTS LRPLLGGIPE SGGPDARQGW
60 70 80 90 100
LAALQDRSIL APLAWDLGLL LLFVGQHSLM AAERVKAWTS RYFGVLQRSL
110 120 130 140 150
YVACTALALQ LVMRYWEPIP KGPVLWEARA EPWATWVPLL CFVLHVISWL
160 170 180 190 200
LIFSILLVFD YAELMGLKQV YYHVLGLGEP LALKSPRALR LFSHLRHPVC
210 220 230 240 250
VELLTVLWVV PTLGTDRLLL AFLLTLYLGL AHGLDQQDLR YLRAQLQRKL
260
HLLSRPQDGE AE
Length:262
Mass (Da):29,379
Last modified:March 1, 2003 - v1
Checksum:i47ED52384BE6C299
GO
Isoform 2 (identifier: Q8IXM6-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     110-168: Missing.

Show »
Length:203
Mass (Da):22,397
Checksum:i1BCA26472F9A84BA
GO
Isoform 3 (identifier: Q8IXM6-6) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     45-109: DARQGWLAAL...LYVACTALAL → GILPCAGAGR...YPLPGPGSRA
     110-262: Missing.

Show »
Length:109
Mass (Da):10,526
Checksum:iAF1B4FB1FDB23157
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05431145 – 109DARQG…TALAL → GILPCAGAGRASGPEVSPGS QTLLPPAPPSVCGAADSAVG GAYPGHGPSPPCFPPYPLPG PGSRA in isoform 3. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_054312110 – 262Missing in isoform 3. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_027627110 – 168Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ798186 mRNA. Translation: AFL55648.1.
JQ798187 mRNA. Translation: AFL55649.1.
AY358411 mRNA. Translation: AAQ88777.1.
AK315190 mRNA. Translation: BAG37630.1.
AB110935 Genomic DNA. Translation: BAD13701.1.
AB110936 Genomic DNA. Translation: BAD13702.1.
AB202096 Genomic DNA. Translation: BAE78616.1.
AL732442 Genomic DNA. Translation: CAI17763.1.
AL662797 Genomic DNA. Translation: CAI18193.1.
AL845353 Genomic DNA. Translation: CAI41884.1.
AL845353 Genomic DNA. Translation: CAI41885.1.
AL732442 Genomic DNA. Translation: CAM25010.1.
AL662797 Genomic DNA. Translation: CAM25511.1.
CR936878 Genomic DNA. Translation: CAQ06810.1.
CR936878 Genomic DNA. Translation: CAQ06811.1.
BX908728 Genomic DNA. Translation: CAQ07428.1.
BX908728 Genomic DNA. Translation: CAQ07429.1.
CR788240 Genomic DNA. Translation: CAQ07568.1.
CR788240 Genomic DNA. Translation: CAQ07569.1.
CR759873 Genomic DNA. Translation: CAQ08687.1.
CR759873 Genomic DNA. Translation: CAQ08688.1.
CH471081 Genomic DNA. Translation: EAX03320.1.
BC004509 mRNA. Translation: AAH04509.2.
BC021260 mRNA. Translation: AAH21260.1.
BC039865 mRNA. Translation: AAH39865.1.
AF143676 mRNA. Translation: AAD45885.1.
CCDSiCCDS4686.1. [Q8IXM6-1]
CCDS59498.1. [Q8IXM6-2]
RefSeqiNP_001257636.1. NM_001270707.1.
NP_001257637.1. NM_001270708.1.
NP_001257638.1. NM_001270709.1. [Q8IXM6-2]
NP_001257639.1. NM_001270710.1. [Q8IXM6-6]
NP_009174.1. NM_007243.2. [Q8IXM6-1]
UniGeneiHs.519993.

Genome annotation databases

EnsembliENST00000259953; ENSP00000259953; ENSG00000137404. [Q8IXM6-1]
ENST00000376420; ENSP00000365602; ENSG00000137404. [Q8IXM6-2]
ENST00000376421; ENSP00000365603; ENSG00000137404. [Q8IXM6-1]
ENST00000383570; ENSP00000373064; ENSG00000206484. [Q8IXM6-2]
ENST00000383571; ENSP00000373065; ENSG00000206484. [Q8IXM6-1]
ENST00000422181; ENSP00000409285; ENSG00000234809. [Q8IXM6-1]
ENST00000422664; ENSP00000394788; ENSG00000228854. [Q8IXM6-2]
ENST00000422747; ENSP00000414927; ENSG00000236843. [Q8IXM6-1]
ENST00000427944; ENSP00000405789; ENSG00000228854. [Q8IXM6-1]
ENST00000431322; ENSP00000398752; ENSG00000228867. [Q8IXM6-1]
ENST00000438502; ENSP00000397755; ENSG00000235773. [Q8IXM6-1]
ENST00000445058; ENSP00000389958; ENSG00000236843. [Q8IXM6-2]
ENST00000449041; ENSP00000399560; ENSG00000228867. [Q8IXM6-2]
ENST00000450138; ENSP00000407111; ENSG00000234809. [Q8IXM6-2]
ENST00000456720; ENSP00000392502; ENSG00000235773. [Q8IXM6-2]
ENST00000610775; ENSP00000481407; ENSG00000228867. [Q8IXM6-1]
ENST00000612190; ENSP00000482593; ENSG00000234809. [Q8IXM6-1]
ENST00000613827; ENSP00000481406; ENSG00000228854. [Q8IXM6-1]
ENST00000617159; ENSP00000478812; ENSG00000236843. [Q8IXM6-1]
ENST00000617220; ENSP00000483875; ENSG00000206484. [Q8IXM6-1]
ENST00000620249; ENSP00000482740; ENSG00000235773. [Q8IXM6-1]
GeneIDi11270.
KEGGihsa:11270.
UCSCiuc003nrc.4. human. [Q8IXM6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ798186 mRNA. Translation: AFL55648.1.
JQ798187 mRNA. Translation: AFL55649.1.
AY358411 mRNA. Translation: AAQ88777.1.
AK315190 mRNA. Translation: BAG37630.1.
AB110935 Genomic DNA. Translation: BAD13701.1.
AB110936 Genomic DNA. Translation: BAD13702.1.
AB202096 Genomic DNA. Translation: BAE78616.1.
AL732442 Genomic DNA. Translation: CAI17763.1.
AL662797 Genomic DNA. Translation: CAI18193.1.
AL845353 Genomic DNA. Translation: CAI41884.1.
AL845353 Genomic DNA. Translation: CAI41885.1.
AL732442 Genomic DNA. Translation: CAM25010.1.
AL662797 Genomic DNA. Translation: CAM25511.1.
CR936878 Genomic DNA. Translation: CAQ06810.1.
CR936878 Genomic DNA. Translation: CAQ06811.1.
BX908728 Genomic DNA. Translation: CAQ07428.1.
BX908728 Genomic DNA. Translation: CAQ07429.1.
CR788240 Genomic DNA. Translation: CAQ07568.1.
CR788240 Genomic DNA. Translation: CAQ07569.1.
CR759873 Genomic DNA. Translation: CAQ08687.1.
CR759873 Genomic DNA. Translation: CAQ08688.1.
CH471081 Genomic DNA. Translation: EAX03320.1.
BC004509 mRNA. Translation: AAH04509.2.
BC021260 mRNA. Translation: AAH21260.1.
BC039865 mRNA. Translation: AAH39865.1.
AF143676 mRNA. Translation: AAD45885.1.
CCDSiCCDS4686.1. [Q8IXM6-1]
CCDS59498.1. [Q8IXM6-2]
RefSeqiNP_001257636.1. NM_001270707.1.
NP_001257637.1. NM_001270708.1.
NP_001257638.1. NM_001270709.1. [Q8IXM6-2]
NP_001257639.1. NM_001270710.1. [Q8IXM6-6]
NP_009174.1. NM_007243.2. [Q8IXM6-1]
UniGeneiHs.519993.

3D structure databases

ProteinModelPortaliQ8IXM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116427. 8 interactors.
IntActiQ8IXM6. 5 interactors.
STRINGi9606.ENSP00000259953.

PTM databases

iPTMnetiQ8IXM6.
PhosphoSitePlusiQ8IXM6.
SwissPalmiQ8IXM6.

Polymorphism and mutation databases

DMDMi74750736.

Proteomic databases

EPDiQ8IXM6.
MaxQBiQ8IXM6.
PaxDbiQ8IXM6.
PeptideAtlasiQ8IXM6.
PRIDEiQ8IXM6.

Protocols and materials databases

DNASUi11270.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259953; ENSP00000259953; ENSG00000137404. [Q8IXM6-1]
ENST00000376420; ENSP00000365602; ENSG00000137404. [Q8IXM6-2]
ENST00000376421; ENSP00000365603; ENSG00000137404. [Q8IXM6-1]
ENST00000383570; ENSP00000373064; ENSG00000206484. [Q8IXM6-2]
ENST00000383571; ENSP00000373065; ENSG00000206484. [Q8IXM6-1]
ENST00000422181; ENSP00000409285; ENSG00000234809. [Q8IXM6-1]
ENST00000422664; ENSP00000394788; ENSG00000228854. [Q8IXM6-2]
ENST00000422747; ENSP00000414927; ENSG00000236843. [Q8IXM6-1]
ENST00000427944; ENSP00000405789; ENSG00000228854. [Q8IXM6-1]
ENST00000431322; ENSP00000398752; ENSG00000228867. [Q8IXM6-1]
ENST00000438502; ENSP00000397755; ENSG00000235773. [Q8IXM6-1]
ENST00000445058; ENSP00000389958; ENSG00000236843. [Q8IXM6-2]
ENST00000449041; ENSP00000399560; ENSG00000228867. [Q8IXM6-2]
ENST00000450138; ENSP00000407111; ENSG00000234809. [Q8IXM6-2]
ENST00000456720; ENSP00000392502; ENSG00000235773. [Q8IXM6-2]
ENST00000610775; ENSP00000481407; ENSG00000228867. [Q8IXM6-1]
ENST00000612190; ENSP00000482593; ENSG00000234809. [Q8IXM6-1]
ENST00000613827; ENSP00000481406; ENSG00000228854. [Q8IXM6-1]
ENST00000617159; ENSP00000478812; ENSG00000236843. [Q8IXM6-1]
ENST00000617220; ENSP00000483875; ENSG00000206484. [Q8IXM6-1]
ENST00000620249; ENSP00000482740; ENSG00000235773. [Q8IXM6-1]
GeneIDi11270.
KEGGihsa:11270.
UCSCiuc003nrc.4. human. [Q8IXM6-1]

Organism-specific databases

CTDi11270.
DisGeNETi11270.
GeneCardsiNRM.
HGNCiHGNC:8003. NRM.
neXtProtiNX_Q8IXM6.
OpenTargetsiENSG00000137404.
ENSG00000206484.
ENSG00000228854.
ENSG00000228867.
ENSG00000234809.
ENSG00000235773.
ENSG00000236843.
PharmGKBiPA31782.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVGT. Eukaryota.
ENOG4111VYI. LUCA.
GeneTreeiENSGT00390000008146.
HOVERGENiHBG102998.
InParanoidiQ8IXM6.
OMAiFIIAFWA.
OrthoDBiEOG091G0MZT.
PhylomeDBiQ8IXM6.
TreeFamiTF324853.

Miscellaneous databases

GenomeRNAii11270.
PROiQ8IXM6.

Gene expression databases

BgeeiENSG00000137404.
CleanExiHS_NRM.
ExpressionAtlasiQ8IXM6. baseline and differential.
GenevisibleiQ8IXM6. HS.

Family and domain databases

InterProiIPR033580. Nurim-like.
[Graphical view]
PANTHERiPTHR31040. PTHR31040. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNRM_HUMAN
AccessioniPrimary (citable) accession number: Q8IXM6
Secondary accession number(s): B0S7R0
, B0S7R1, I3XIE2, I3XIE3, Q5JP57, Q5JP58, Q5JP59, Q5JP60, Q8WU45, Q9BSX3, Q9UN92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.