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Q8IXM3

- RM41_HUMAN

UniProt

Q8IXM3 - RM41_HUMAN

Protein

39S ribosomal protein L41, mitochondrial

Gene

MRPL41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.2 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell cycle Source: UniProtKB-KW
    3. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    Apoptosis, Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L41, mitochondrial
    Short name:
    L41mt
    Short name:
    MRP-L41
    Alternative name(s):
    39S ribosomal protein L27 homolog
    Bcl-2-interacting mitochondrial ribosomal protein L41
    Cell proliferation-inducing gene 3 protein
    MRP-L27 homolog
    Gene namesi
    Name:MRPL41
    Synonyms:BMRP, MRPL27, RPML27
    ORF Names:PIG3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:14492. MRPL41.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: UniProtKB
    2. mitochondrion Source: HPA
    3. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30973.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1313MitochondrionBy similarityAdd
    BLAST
    Chaini14 – 13712439S ribosomal protein L41, mitochondrialPRO_0000273228Add
    BLAST

    Proteomic databases

    MaxQBiQ8IXM3.
    PaxDbiQ8IXM3.
    PeptideAtlasiQ8IXM3.
    PRIDEiQ8IXM3.

    Expressioni

    Tissue specificityi

    Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).1 Publication

    Gene expression databases

    BgeeiQ8IXM3.
    CleanExiHS_MRPL27.
    HS_MRPL41.
    GenevestigatoriQ8IXM3.

    Organism-specific databases

    HPAiHPA024550.
    HPA027160.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRIM63Q969Q12EBI-912501,EBI-5661333

    Protein-protein interaction databases

    BioGridi122363. 27 interactions.
    IntActiQ8IXM3. 5 interactions.
    MINTiMINT-6492237.
    STRINGi9606.ENSP00000360498.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IXM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L41 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG264900.
    HOGENOMiHOG000231555.
    HOVERGENiHBG080323.
    InParanoidiQ8IXM3.
    KOiK17422.
    OMAiHNKGRGA.
    OrthoDBiEOG708W17.
    PhylomeDBiQ8IXM3.
    TreeFamiTF325007.

    Family and domain databases

    InterProiIPR019189. Ribosomal_L27/L41_mit.
    [Graphical view]
    PfamiPF09809. MRP-L27. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8IXM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF    50
    VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI 100
    EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR 137
    Length:137
    Mass (Da):15,383
    Last modified:March 1, 2003 - v1
    Checksum:i25A9F3105ABF1189
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY232291 mRNA. Translation: AAP69986.1.
    AL365502 Genomic DNA. Translation: CAI14583.1.
    BC040035 mRNA. Translation: AAH40035.1.
    AB051625 Genomic DNA. Translation: BAB54952.1.
    CCDSiCCDS7046.1.
    RefSeqiNP_115866.1. NM_032477.2.
    UniGeneiHs.44017.

    Genome annotation databases

    EnsembliENST00000371443; ENSP00000360498; ENSG00000182154.
    GeneIDi64975.
    KEGGihsa:64975.
    UCSCiuc004cnh.4. human.

    Polymorphism databases

    DMDMi74750734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY232291 mRNA. Translation: AAP69986.1 .
    AL365502 Genomic DNA. Translation: CAI14583.1 .
    BC040035 mRNA. Translation: AAH40035.1 .
    AB051625 Genomic DNA. Translation: BAB54952.1 .
    CCDSi CCDS7046.1.
    RefSeqi NP_115866.1. NM_032477.2.
    UniGenei Hs.44017.

    3D structure databases

    ProteinModelPortali Q8IXM3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122363. 27 interactions.
    IntActi Q8IXM3. 5 interactions.
    MINTi MINT-6492237.
    STRINGi 9606.ENSP00000360498.

    Polymorphism databases

    DMDMi 74750734.

    Proteomic databases

    MaxQBi Q8IXM3.
    PaxDbi Q8IXM3.
    PeptideAtlasi Q8IXM3.
    PRIDEi Q8IXM3.

    Protocols and materials databases

    DNASUi 64975.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371443 ; ENSP00000360498 ; ENSG00000182154 .
    GeneIDi 64975.
    KEGGi hsa:64975.
    UCSCi uc004cnh.4. human.

    Organism-specific databases

    CTDi 64975.
    GeneCardsi GC09P140445.
    HGNCi HGNC:14492. MRPL41.
    HPAi HPA024550.
    HPA027160.
    MIMi 611846. gene.
    neXtProti NX_Q8IXM3.
    PharmGKBi PA30973.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264900.
    HOGENOMi HOG000231555.
    HOVERGENi HBG080323.
    InParanoidi Q8IXM3.
    KOi K17422.
    OMAi HNKGRGA.
    OrthoDBi EOG708W17.
    PhylomeDBi Q8IXM3.
    TreeFami TF325007.

    Miscellaneous databases

    GeneWikii Mitochondrial_ribosomal_protein_L41.
    GenomeRNAii 64975.
    NextBioi 67156.
    PROi Q8IXM3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IXM3.
    CleanExi HS_MRPL27.
    HS_MRPL41.
    Genevestigatori Q8IXM3.

    Family and domain databases

    InterProi IPR019189. Ribosomal_L27/L41_mit.
    [Graphical view ]
    Pfami PF09809. MRP-L27. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kim J.W.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    4. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-135.
    5. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. Cited for: INTERACTION WITH BCL2, TISSUE SPECIFICITY.
    7. "Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1."
      Yoo Y.A., Kim M.J., Park J.K., Chung Y.M., Lee J.H., Chi S.-G., Kim J.S., Yoo Y.D.
      Mol. Cell. Biol. 25:6603-6616(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1)."
      Kim M.J., Yoo Y.A., Kim H.J., Kang S., Kim Y.G., Kim J.S., Yoo Y.D.
      Biochem. Biophys. Res. Commun. 338:1179-1184(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM41_HUMAN
    AccessioniPrimary (citable) accession number: Q8IXM3
    Secondary accession number(s): Q96Q49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3