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Protein

39S ribosomal protein L41, mitochondrial

Gene

MRPL41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).4 Publications

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processApoptosis, Cell cycle

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L41, mitochondrial
Short name:
L41mt
Short name:
MRP-L41
Alternative name(s):
39S ribosomal protein L27 homolog
Bcl-2-interacting mitochondrial ribosomal protein L41
Cell proliferation-inducing gene 3 protein
MRP-L27 homolog
Mitochondrial large ribosomal subunit protein mL411 Publication
Gene namesi
Name:MRPL41
Synonyms:BMRP, MRPL27, RPML27
ORF Names:PIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000182154.7
HGNCiHGNC:14492 MRPL41
MIMi611846 gene
neXtProtiNX_Q8IXM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi64975
OpenTargetsiENSG00000182154
PharmGKBiPA30973

Polymorphism and mutation databases

BioMutaiMRPL41
DMDMi74750734

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13MitochondrionBy similarityAdd BLAST13
ChainiPRO_000027322814 – 13739S ribosomal protein L41, mitochondrialAdd BLAST124

Proteomic databases

EPDiQ8IXM3
MaxQBiQ8IXM3
PaxDbiQ8IXM3
PeptideAtlasiQ8IXM3
PRIDEiQ8IXM3
TopDownProteomicsiQ8IXM3

PTM databases

PhosphoSitePlusiQ8IXM3

Expressioni

Tissue specificityi

Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000182154
CleanExiHS_MRPL27
HS_MRPL41
GenevisibleiQ8IXM3 HS

Organism-specific databases

HPAiHPA024550
HPA027160

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379). Interacts with BCL2 (PubMed:15547950).1 Publication3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM63Q969Q12EBI-912501,EBI-5661333

Protein-protein interaction databases

BioGridi122363, 75 interactors
CORUMiQ8IXM3
IntActiQ8IXM3, 15 interactors
MINTiQ8IXM3
STRINGi9606.ENSP00000360498

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 19Combined sources3
Turni23 – 25Combined sources3
Helixi28 – 33Combined sources6
Beta strandi42 – 45Combined sources4
Turni46 – 48Combined sources3
Beta strandi49 – 52Combined sources4
Turni54 – 56Combined sources3
Beta strandi72 – 74Combined sources3
Helixi88 – 104Combined sources17
Helixi114 – 116Combined sources3
Turni130 – 133Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4091-137[»]
3J9Melectron microscopy3.5091-137[»]
5OOLelectron microscopy3.0691-137[»]
5OOMelectron microscopy3.0391-137[»]
ProteinModelPortaliQ8IXM3
SMRiQ8IXM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4756 Eukaryota
ENOG4111ND6 LUCA
GeneTreeiENSGT00390000013158
HOGENOMiHOG000231555
HOVERGENiHBG080323
InParanoidiQ8IXM3
KOiK17422
OMAiHNKGRGA
OrthoDBiEOG091G0UQ0
PhylomeDBiQ8IXM3
TreeFamiTF325007

Family and domain databases

InterProiView protein in InterPro
IPR019189 Ribosomal_L27/L41_mit
PANTHERiPTHR21338 PTHR21338, 1 hit
PfamiView protein in Pfam
PF09809 MRP-L27, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IXM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF
60 70 80 90 100
VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI
110 120 130
EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR
Length:137
Mass (Da):15,383
Last modified:March 1, 2003 - v1
Checksum:i25A9F3105ABF1189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY232291 mRNA Translation: AAP69986.1
AL365502 Genomic DNA No translation available.
BC040035 mRNA Translation: AAH40035.1
AB051625 Genomic DNA Translation: BAB54952.1
CCDSiCCDS7046.1
RefSeqiNP_115866.1, NM_032477.2
UniGeneiHs.44017

Genome annotation databases

EnsembliENST00000371443; ENSP00000360498; ENSG00000182154
GeneIDi64975
KEGGihsa:64975
UCSCiuc004cnh.5 human

Similar proteinsi

Entry informationi

Entry nameiRM41_HUMAN
AccessioniPrimary (citable) accession number: Q8IXM3
Secondary accession number(s): Q96Q49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health