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Protein

39S ribosomal protein L41, mitochondrial

Gene

MRPL41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.2 Publications

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell cycle Source: UniProtKB-KW
  3. mitochondrial translation Source: Reactome
  4. mitochondrial translational elongation Source: Reactome
  5. mitochondrial translational initiation Source: Reactome
  6. mitochondrial translational termination Source: Reactome
  7. organelle organization Source: Reactome
  8. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Apoptosis, Cell cycle

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L41, mitochondrial
Short name:
L41mt
Short name:
MRP-L41
Alternative name(s):
39S ribosomal protein L27 homolog
Bcl-2-interacting mitochondrial ribosomal protein L41
Cell proliferation-inducing gene 3 protein
MRP-L27 homolog
Gene namesi
Name:MRPL41
Synonyms:BMRP, MRPL27, RPML27
ORF Names:PIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:14492. MRPL41.

Subcellular locationi

  1. Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial large ribosomal subunit Source: UniProtKB
  3. mitochondrion Source: HPA
  4. ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30973.

Polymorphism and mutation databases

BioMutaiMRPL41.
DMDMi74750734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313MitochondrionBy similarityAdd
BLAST
Chaini14 – 13712439S ribosomal protein L41, mitochondrialPRO_0000273228Add
BLAST

Proteomic databases

MaxQBiQ8IXM3.
PaxDbiQ8IXM3.
PeptideAtlasiQ8IXM3.
PRIDEiQ8IXM3.

Expressioni

Tissue specificityi

Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).1 Publication

Gene expression databases

BgeeiQ8IXM3.
CleanExiHS_MRPL27.
HS_MRPL41.
GenevestigatoriQ8IXM3.

Organism-specific databases

HPAiHPA024550.
HPA027160.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM63Q969Q12EBI-912501,EBI-5661333

Protein-protein interaction databases

BioGridi122363. 34 interactions.
IntActiQ8IXM3. 5 interactions.
MINTiMINT-6492237.
STRINGi9606.ENSP00000360498.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4091-137[»]
ProteinModelPortaliQ8IXM3.
SMRiQ8IXM3. Positions 7-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L41 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG264900.
GeneTreeiENSGT00390000013158.
HOGENOMiHOG000231555.
HOVERGENiHBG080323.
InParanoidiQ8IXM3.
KOiK17422.
OMAiHNKGRGA.
OrthoDBiEOG708W17.
PhylomeDBiQ8IXM3.
TreeFamiTF325007.

Family and domain databases

InterProiIPR019189. Ribosomal_L27/L41_mit.
[Graphical view]
PfamiPF09809. MRP-L27. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IXM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF
60 70 80 90 100
VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI
110 120 130
EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR
Length:137
Mass (Da):15,383
Last modified:March 1, 2003 - v1
Checksum:i25A9F3105ABF1189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY232291 mRNA. Translation: AAP69986.1.
AL365502 Genomic DNA. Translation: CAI14583.1.
BC040035 mRNA. Translation: AAH40035.1.
AB051625 Genomic DNA. Translation: BAB54952.1.
CCDSiCCDS7046.1.
RefSeqiNP_115866.1. NM_032477.2.
UniGeneiHs.44017.

Genome annotation databases

EnsembliENST00000371443; ENSP00000360498; ENSG00000182154.
GeneIDi64975.
KEGGihsa:64975.
UCSCiuc004cnh.4. human.

Polymorphism and mutation databases

BioMutaiMRPL41.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY232291 mRNA. Translation: AAP69986.1.
AL365502 Genomic DNA. Translation: CAI14583.1.
BC040035 mRNA. Translation: AAH40035.1.
AB051625 Genomic DNA. Translation: BAB54952.1.
CCDSiCCDS7046.1.
RefSeqiNP_115866.1. NM_032477.2.
UniGeneiHs.44017.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4091-137[»]
ProteinModelPortaliQ8IXM3.
SMRiQ8IXM3. Positions 7-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122363. 34 interactions.
IntActiQ8IXM3. 5 interactions.
MINTiMINT-6492237.
STRINGi9606.ENSP00000360498.

Polymorphism and mutation databases

BioMutaiMRPL41.
DMDMi74750734.

Proteomic databases

MaxQBiQ8IXM3.
PaxDbiQ8IXM3.
PeptideAtlasiQ8IXM3.
PRIDEiQ8IXM3.

Protocols and materials databases

DNASUi64975.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371443; ENSP00000360498; ENSG00000182154.
GeneIDi64975.
KEGGihsa:64975.
UCSCiuc004cnh.4. human.

Organism-specific databases

CTDi64975.
GeneCardsiGC09P140445.
HGNCiHGNC:14492. MRPL41.
HPAiHPA024550.
HPA027160.
MIMi611846. gene.
neXtProtiNX_Q8IXM3.
PharmGKBiPA30973.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG264900.
GeneTreeiENSGT00390000013158.
HOGENOMiHOG000231555.
HOVERGENiHBG080323.
InParanoidiQ8IXM3.
KOiK17422.
OMAiHNKGRGA.
OrthoDBiEOG708W17.
PhylomeDBiQ8IXM3.
TreeFamiTF325007.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

GeneWikiiMitochondrial_ribosomal_protein_L41.
GenomeRNAii64975.
NextBioi67156.
PROiQ8IXM3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IXM3.
CleanExiHS_MRPL27.
HS_MRPL41.
GenevestigatoriQ8IXM3.

Family and domain databases

InterProiIPR019189. Ribosomal_L27/L41_mit.
[Graphical view]
PfamiPF09809. MRP-L27. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kim J.W.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-135.
  5. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: INTERACTION WITH BCL2, TISSUE SPECIFICITY.
  7. "Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1."
    Yoo Y.A., Kim M.J., Park J.K., Chung Y.M., Lee J.H., Chi S.-G., Kim J.S., Yoo Y.D.
    Mol. Cell. Biol. 25:6603-6616(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1)."
    Kim M.J., Yoo Y.A., Kim H.J., Kang S., Kim Y.G., Kim J.S., Yoo Y.D.
    Biochem. Biophys. Res. Commun. 338:1179-1184(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM41_HUMAN
AccessioniPrimary (citable) accession number: Q8IXM3
Secondary accession number(s): Q96Q49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.