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Q8IXM3

- RM41_HUMAN

UniProt

Q8IXM3 - RM41_HUMAN

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Protein
39S ribosomal protein L41, mitochondrial
Gene
MRPL41, BMRP, MRPL27, RPML27, PIG3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.2 Publications

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell cycle Source: UniProtKB-KW
  3. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Apoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L41, mitochondrial
Short name:
L41mt
Short name:
MRP-L41
Alternative name(s):
39S ribosomal protein L27 homolog
Bcl-2-interacting mitochondrial ribosomal protein L41
Cell proliferation-inducing gene 3 protein
MRP-L27 homolog
Gene namesi
Name:MRPL41
Synonyms:BMRP, MRPL27, RPML27
ORF Names:PIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14492. MRPL41.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: UniProtKB
  2. mitochondrion Source: HPA
  3. ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313Mitochondrion By similarity
Add
BLAST
Chaini14 – 13712439S ribosomal protein L41, mitochondrial
PRO_0000273228Add
BLAST

Proteomic databases

MaxQBiQ8IXM3.
PaxDbiQ8IXM3.
PeptideAtlasiQ8IXM3.
PRIDEiQ8IXM3.

Expressioni

Tissue specificityi

Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).1 Publication

Gene expression databases

BgeeiQ8IXM3.
CleanExiHS_MRPL27.
HS_MRPL41.
GenevestigatoriQ8IXM3.

Organism-specific databases

HPAiHPA024550.
HPA027160.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM63Q969Q12EBI-912501,EBI-5661333

Protein-protein interaction databases

BioGridi122363. 27 interactions.
IntActiQ8IXM3. 5 interactions.
MINTiMINT-6492237.
STRINGi9606.ENSP00000360498.

Structurei

3D structure databases

ProteinModelPortaliQ8IXM3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG264900.
HOGENOMiHOG000231555.
HOVERGENiHBG080323.
InParanoidiQ8IXM3.
KOiK17422.
OMAiHNKGRGA.
OrthoDBiEOG708W17.
PhylomeDBiQ8IXM3.
TreeFamiTF325007.

Family and domain databases

InterProiIPR019189. Ribosomal_L27/L41_mit.
[Graphical view]
PfamiPF09809. MRP-L27. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IXM3-1 [UniParc]FASTAAdd to Basket

« Hide

MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF    50
VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI 100
EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR 137
Length:137
Mass (Da):15,383
Last modified:March 1, 2003 - v1
Checksum:i25A9F3105ABF1189
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY232291 mRNA. Translation: AAP69986.1.
AL365502 Genomic DNA. Translation: CAI14583.1.
BC040035 mRNA. Translation: AAH40035.1.
AB051625 Genomic DNA. Translation: BAB54952.1.
CCDSiCCDS7046.1.
RefSeqiNP_115866.1. NM_032477.2.
UniGeneiHs.44017.

Genome annotation databases

EnsembliENST00000371443; ENSP00000360498; ENSG00000182154.
GeneIDi64975.
KEGGihsa:64975.
UCSCiuc004cnh.4. human.

Polymorphism databases

DMDMi74750734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY232291 mRNA. Translation: AAP69986.1 .
AL365502 Genomic DNA. Translation: CAI14583.1 .
BC040035 mRNA. Translation: AAH40035.1 .
AB051625 Genomic DNA. Translation: BAB54952.1 .
CCDSi CCDS7046.1.
RefSeqi NP_115866.1. NM_032477.2.
UniGenei Hs.44017.

3D structure databases

ProteinModelPortali Q8IXM3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122363. 27 interactions.
IntActi Q8IXM3. 5 interactions.
MINTi MINT-6492237.
STRINGi 9606.ENSP00000360498.

Polymorphism databases

DMDMi 74750734.

Proteomic databases

MaxQBi Q8IXM3.
PaxDbi Q8IXM3.
PeptideAtlasi Q8IXM3.
PRIDEi Q8IXM3.

Protocols and materials databases

DNASUi 64975.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371443 ; ENSP00000360498 ; ENSG00000182154 .
GeneIDi 64975.
KEGGi hsa:64975.
UCSCi uc004cnh.4. human.

Organism-specific databases

CTDi 64975.
GeneCardsi GC09P140445.
HGNCi HGNC:14492. MRPL41.
HPAi HPA024550.
HPA027160.
MIMi 611846. gene.
neXtProti NX_Q8IXM3.
PharmGKBi PA30973.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG264900.
HOGENOMi HOG000231555.
HOVERGENi HBG080323.
InParanoidi Q8IXM3.
KOi K17422.
OMAi HNKGRGA.
OrthoDBi EOG708W17.
PhylomeDBi Q8IXM3.
TreeFami TF325007.

Miscellaneous databases

GeneWikii Mitochondrial_ribosomal_protein_L41.
GenomeRNAii 64975.
NextBioi 67156.
PROi Q8IXM3.
SOURCEi Search...

Gene expression databases

Bgeei Q8IXM3.
CleanExi HS_MRPL27.
HS_MRPL41.
Genevestigatori Q8IXM3.

Family and domain databases

InterProi IPR019189. Ribosomal_L27/L41_mit.
[Graphical view ]
Pfami PF09809. MRP-L27. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kim J.W.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-135.
  5. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: INTERACTION WITH BCL2, TISSUE SPECIFICITY.
  7. "Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1."
    Yoo Y.A., Kim M.J., Park J.K., Chung Y.M., Lee J.H., Chi S.-G., Kim J.S., Yoo Y.D.
    Mol. Cell. Biol. 25:6603-6616(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1)."
    Kim M.J., Yoo Y.A., Kim H.J., Kang S., Kim Y.G., Kim J.S., Yoo Y.D.
    Biochem. Biophys. Res. Commun. 338:1179-1184(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM41_HUMAN
AccessioniPrimary (citable) accession number: Q8IXM3
Secondary accession number(s): Q96Q49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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