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Protein

Chromatin complexes subunit BAP18

Gene

BAP18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of chromatin complexes such as the MLL1/MLL and NURF complexes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin complexes subunit BAP18
Alternative name(s):
BPTF-associated protein of 18 kDa
Gene namesi
Name:BAP18
Synonyms:C17orf49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28737. C17orf49.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • MLL1 complex Source: UniProtKB
  • nucleoplasm Source: HPA
  • NURF complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672232.

Polymorphism and mutation databases

BioMutaiBAP18.
DMDMi74759674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Chromatin complexes subunit BAP18PRO_0000264251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IXM2.
MaxQBiQ8IXM2.
PaxDbiQ8IXM2.
PeptideAtlasiQ8IXM2.
PRIDEiQ8IXM2.

PTM databases

iPTMnetiQ8IXM2.
PhosphoSiteiQ8IXM2.

Expressioni

Gene expression databases

BgeeiENSG00000258315.
CleanExiHS_C17orf49.
ExpressionAtlasiQ8IXM2. baseline and differential.
GenevisibleiQ8IXM2. HS.

Organism-specific databases

HPAiHPA022961.
HPA024457.

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the nucleosome-remodeling factor (NURF) complex.2 Publications

Protein-protein interaction databases

BioGridi125903. 29 interactions.
DIPiDIP-60552N.
IntActiQ8IXM2. 6 interactions.
STRINGi9606.ENSP00000448598.

Structurei

3D structure databases

ProteinModelPortaliQ8IXM2.
SMRiQ8IXM2. Positions 35-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 8649SANTAdd
BLAST

Sequence similaritiesi

Contains 1 SANT domain.Curated

Phylogenomic databases

eggNOGiKOG4834. Eukaryota.
ENOG4111K4E. LUCA.
GeneTreeiENSGT00390000014721.
HOGENOMiHOG000234357.
HOVERGENiHBG056647.
InParanoidiQ8IXM2.
OrthoDBiEOG091G0ZKS.
PhylomeDBiQ8IXM2.
TreeFamiTF324877.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVADSSPAGA KWTETEIEML
60 70 80 90 100
RAAVKRFGDD LNHISCVIKE RTVAQIKATV KRKVYEDSGI PLPAESPKKG
110 120 130 140 150
PKKVASGVLS PPPAAPPPSS SSVPEAGGPP IKKQKADVTL SALNDSDANS
160 170
DVVDIEGLGE TPPAKKLNFD QA
Length:172
Mass (Da):17,900
Last modified:March 1, 2003 - v1
Checksum:iEED33FA9BD649F19
GO
Isoform 2 (identifier: Q8IXM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-73: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):13,958
Checksum:i30D3C4ECF6F6D97A
GO
Isoform 3 (identifier: Q8IXM2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-172: A → DSLTLDSGLLMTSADPPLLSC

Note: Gene prediction based on EST data.
Show »
Length:192
Mass (Da):19,961
Checksum:i764AC185E4B868A4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei40 – 7334Missing in isoform 2. 1 PublicationVSP_043754Add
BLAST
Alternative sequencei172 – 1721A → DSLTLDSGLLMTSADPPLLS C in isoform 3. CuratedVSP_047095

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CN280697 mRNA. No translation available.
AK295795 mRNA. Translation: BAG58615.1.
AC040977 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90278.1.
BC040036 mRNA. Translation: AAH40036.1.
BC040148 mRNA. Translation: AAH40148.1.
CCDSiCCDS32542.1. [Q8IXM2-1]
CCDS45595.1. [Q8IXM2-3]
CCDS45596.1. [Q8IXM2-2]
RefSeqiNP_001136270.1. NM_001142798.2. [Q8IXM2-3]
NP_001136271.1. NM_001142799.2. [Q8IXM2-2]
NP_777553.1. NM_174893.3. [Q8IXM2-1]
UniGeneiHs.511801.

Genome annotation databases

EnsembliENST00000439424; ENSP00000411851; ENSG00000258315. [Q8IXM2-1]
ENST00000546495; ENSP00000448598; ENSG00000258315. [Q8IXM2-3]
ENST00000552402; ENSP00000448746; ENSG00000258315. [Q8IXM2-2]
GeneIDi124944.
KEGGihsa:124944.
UCSCiuc002ged.4. human. [Q8IXM2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CN280697 mRNA. No translation available.
AK295795 mRNA. Translation: BAG58615.1.
AC040977 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90278.1.
BC040036 mRNA. Translation: AAH40036.1.
BC040148 mRNA. Translation: AAH40148.1.
CCDSiCCDS32542.1. [Q8IXM2-1]
CCDS45595.1. [Q8IXM2-3]
CCDS45596.1. [Q8IXM2-2]
RefSeqiNP_001136270.1. NM_001142798.2. [Q8IXM2-3]
NP_001136271.1. NM_001142799.2. [Q8IXM2-2]
NP_777553.1. NM_174893.3. [Q8IXM2-1]
UniGeneiHs.511801.

3D structure databases

ProteinModelPortaliQ8IXM2.
SMRiQ8IXM2. Positions 35-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125903. 29 interactions.
DIPiDIP-60552N.
IntActiQ8IXM2. 6 interactions.
STRINGi9606.ENSP00000448598.

PTM databases

iPTMnetiQ8IXM2.
PhosphoSiteiQ8IXM2.

Polymorphism and mutation databases

BioMutaiBAP18.
DMDMi74759674.

Proteomic databases

EPDiQ8IXM2.
MaxQBiQ8IXM2.
PaxDbiQ8IXM2.
PeptideAtlasiQ8IXM2.
PRIDEiQ8IXM2.

Protocols and materials databases

DNASUi124944.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439424; ENSP00000411851; ENSG00000258315. [Q8IXM2-1]
ENST00000546495; ENSP00000448598; ENSG00000258315. [Q8IXM2-3]
ENST00000552402; ENSP00000448746; ENSG00000258315. [Q8IXM2-2]
GeneIDi124944.
KEGGihsa:124944.
UCSCiuc002ged.4. human. [Q8IXM2-1]

Organism-specific databases

CTDi124944.
GeneCardsiC17orf49.
H-InvDBHIX0157195.
HGNCiHGNC:28737. C17orf49.
HPAiHPA022961.
HPA024457.
neXtProtiNX_Q8IXM2.
PharmGKBiPA142672232.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4834. Eukaryota.
ENOG4111K4E. LUCA.
GeneTreeiENSGT00390000014721.
HOGENOMiHOG000234357.
HOVERGENiHBG056647.
InParanoidiQ8IXM2.
OrthoDBiEOG091G0ZKS.
PhylomeDBiQ8IXM2.
TreeFamiTF324877.

Miscellaneous databases

ChiTaRSiC17orf49. human.
GenomeRNAii124944.
PROiQ8IXM2.

Gene expression databases

BgeeiENSG00000258315.
CleanExiHS_C17orf49.
ExpressionAtlasiQ8IXM2. baseline and differential.
GenevisibleiQ8IXM2. HS.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBAP18_HUMAN
AccessioniPrimary (citable) accession number: Q8IXM2
Secondary accession number(s): B4DIV3, C9J4G0, E9PB29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.