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Protein

IQ domain-containing protein F2

Gene

IQCF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31790-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein F2
Gene namesi
Name:IQCF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31815. IQCF2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184345.
PharmGKBiPA134900355.

Polymorphism and mutation databases

BioMutaiIQCF2.
DMDMi74728210.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825591 – 164IQ domain-containing protein F2Add BLAST164

Proteomic databases

PaxDbiQ8IXL9.
PRIDEiQ8IXL9.

PTM databases

iPTMnetiQ8IXL9.
PhosphoSitePlusiQ8IXL9.

Expressioni

Gene expression databases

BgeeiENSG00000184345.
CleanExiHS_IQCF2.
GenevisibleiQ8IXL9. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LONRF1Q17RB83EBI-10238842,EBI-2341787

GO - Molecular functioni

Protein-protein interaction databases

BioGridi132986. 1 interactor.
IntActiQ8IXL9. 1 interactor.
STRINGi9606.ENSP00000329904.

Structurei

3D structure databases

ProteinModelPortaliQ8IXL9.
SMRiQ8IXL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 72IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini99 – 128IQ 2PROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXIB. Eukaryota.
ENOG4111BID. LUCA.
GeneTreeiENSGT00390000004641.
HOGENOMiHOG000060238.
HOVERGENiHBG071368.
InParanoidiQ8IXL9.
OMAiQGHWQCH.
OrthoDBiEOG091G0QGG.
PhylomeDBiQ8IXL9.
TreeFamiTF337908.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00612. IQ. 3 hits.
[Graphical view]
SMARTiSM00015. IQ. 3 hits.
[Graphical view]
PROSITEiPS50096. IQ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IXL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVRFCTKGN LILVIIEDVE ESIEWKTLQK KKQQKIKEKL RIRTKAAVKI
60 70 80 90 100
QAWWRGTLVR RTLLHAALRA WIIQCWWRMT LSRVLEKKRQ AALIAYATRE
110 120 130 140 150
RAVIKLQSLV RMWRVRWRYC QVLNAIYIIQ GHWQCHNCQT CALLQGHCVV
160
TATHLQFHIE IINS
Length:164
Mass (Da):19,627
Last modified:March 1, 2003 - v1
Checksum:i45931CDAF11D9F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040047 mRNA. Translation: AAH40047.1.
CCDSiCCDS2835.1.
RefSeqiNP_982248.1. NM_203424.1.
UniGeneiHs.412294.

Genome annotation databases

EnsembliENST00000333127; ENSP00000329904; ENSG00000184345.
GeneIDi389123.
KEGGihsa:389123.
UCSCiuc003dbt.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040047 mRNA. Translation: AAH40047.1.
CCDSiCCDS2835.1.
RefSeqiNP_982248.1. NM_203424.1.
UniGeneiHs.412294.

3D structure databases

ProteinModelPortaliQ8IXL9.
SMRiQ8IXL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132986. 1 interactor.
IntActiQ8IXL9. 1 interactor.
STRINGi9606.ENSP00000329904.

PTM databases

iPTMnetiQ8IXL9.
PhosphoSitePlusiQ8IXL9.

Polymorphism and mutation databases

BioMutaiIQCF2.
DMDMi74728210.

Proteomic databases

PaxDbiQ8IXL9.
PRIDEiQ8IXL9.

Protocols and materials databases

DNASUi389123.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333127; ENSP00000329904; ENSG00000184345.
GeneIDi389123.
KEGGihsa:389123.
UCSCiuc003dbt.2. human.

Organism-specific databases

CTDi389123.
GeneCardsiIQCF2.
HGNCiHGNC:31815. IQCF2.
neXtProtiNX_Q8IXL9.
OpenTargetsiENSG00000184345.
PharmGKBiPA134900355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXIB. Eukaryota.
ENOG4111BID. LUCA.
GeneTreeiENSGT00390000004641.
HOGENOMiHOG000060238.
HOVERGENiHBG071368.
InParanoidiQ8IXL9.
OMAiQGHWQCH.
OrthoDBiEOG091G0QGG.
PhylomeDBiQ8IXL9.
TreeFamiTF337908.

Enzyme and pathway databases

BioCyciZFISH:G66-31790-MONOMER.

Miscellaneous databases

GenomeRNAii389123.
PROiQ8IXL9.

Gene expression databases

BgeeiENSG00000184345.
CleanExiHS_IQCF2.
GenevisibleiQ8IXL9. HS.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00612. IQ. 3 hits.
[Graphical view]
SMARTiSM00015. IQ. 3 hits.
[Graphical view]
PROSITEiPS50096. IQ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIQCF2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.