SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IXK0

- PHC2_HUMAN

UniProt

Q8IXK0 - PHC2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Polyhomeotic-like protein 2

Gene
PHC2, EDR2, PH2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri633 – 66735FCS-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_169436. Oxidative Stress Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyhomeotic-like protein 2
Short name:
hPH2
Alternative name(s):
Early development regulatory protein 2
Gene namesi
Name:PHC2
Synonyms:EDR2, PH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3183. PHC2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: UniProtKB
  3. PcG protein complex Source: UniProtKB
  4. PRC1 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Polyhomeotic-like protein 2PRO_0000076286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei621 – 6211Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IXK0.
PaxDbiQ8IXK0.
PRIDEiQ8IXK0.

PTM databases

PhosphoSiteiQ8IXK0.

Expressioni

Gene expression databases

ArrayExpressiQ8IXK0.
BgeeiQ8IXK0.
GenevestigatoriQ8IXK0.

Organism-specific databases

HPAiHPA047403.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP By similarity. Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Bmi1P259162EBI-713786,EBI-927401From a different organism.
MCRS1Q96EZ82EBI-713786,EBI-348259
PLK1P533502EBI-713786,EBI-476768
SP1P080472EBI-713786,EBI-298336

Protein-protein interaction databases

BioGridi108234. 43 interactions.
DIPiDIP-34464N.
IntActiQ8IXK0. 40 interactions.
MINTiMINT-1369031.

Structurei

3D structure databases

ProteinModelPortaliQ8IXK0.
SMRiQ8IXK0. Positions 640-670, 792-852.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini794 – 85865SAMAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi558 – 58730HD1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 3727Ser-richAdd
BLAST
Compositional biasi55 – 11157Gln-richAdd
BLAST
Compositional biasi329 – 37749Gln-richAdd
BLAST

Domaini

HD1 motif interacts with SAM domain of PHC1.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri633 – 66735FCS-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG145736.
HOVERGENiHBG039325.
InParanoidiQ8IXK0.
KOiK11457.
OMAiHTSSSAC.
OrthoDBiEOG789C9Q.
PhylomeDBiQ8IXK0.
TreeFamiTF331299.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR012313. Znf_FCS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS51024. ZF_FCS. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IXK0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MENELPVPHT SSSACATSST SGASSSSGCN NSSSGGSGRP TGPQISVYSG    50
IPDRQTVQVI QQALHRQPST AAQYLQQMYA AQQQHLMLQT AALQQQHLSS 100
AQLQSLAAVQ QASLVSNRQG STSGSNVSAQ APAQSSSINL AASPAAAQLL 150
NRAQSVNSAA ASGIAQQAVL LGNTSSPALT ASQAQMYLRA QMLIFTPTAT 200
VATVQPELGT GSPARPPTPA QVQNLTLRTQ QTPAAAASGP TPTQPVLPSL 250
ALKPTPGGSQ PLPTPAQSRN TAQASPAGAK PGIADSVMEP HKKGDGNSSV 300
PGSMEGRAGL SRTVPAVAAH PLIAPAYAQL QPHQLLPQPS SKHLQPQFVI 350
QQQPQPQQQQ PPPQQSRPVL QAEPHPQLAS VSPSVALQPS SEAHAMPLGP 400
VTPALPLQCP TANLHKPGGS QQCHPPTPDT GPQNGHPEGV PHTPQRRFQH 450
TSAVILQLQP ASPPQQCVPD DWKEVAPGEK SVPETRSGPS PHQQAIVTAM 500
PGGLPVPTSP NIQPSPAHET GQGIVHALTD LSSPGMTSGN GNSASSIAGT 550
APQNGENKPP QAIVKPQILT HVIEGFVIQE GAEPFPVGRS SLLVGNLKKK 600
YAQGFLPEKL PQQDHTTTTD SEMEEPYLQE SKEEGAPLKL KCELCGRVDF 650
AYKFKRSKRF CSMACAKRYN VGCTKRVGLF HSDRSKLQKA GAATHNRRRA 700
SKASLPPLTK DTKKQPTGTV PLSVTAALQL THSQEDSSRC SDNSSYEEPL 750
SPISASSSTS RRRQGQRDLE LPDMHMRDLV GMGHHFLPSE PTKWNVEDVY 800
EFIRSLPGCQ EIAEEFRAQE IDGQALLLLK EDHLMSAMNI KLGPALKIYA 850
RISMLKDS 858
Length:858
Mass (Da):90,713
Last modified:March 1, 2003 - v1
Checksum:i2E3FD3898CFD702B
GO
Isoform 2 (identifier: Q8IXK0-2) [UniParc]FASTAAdd to Basket

Also known as: isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     1-535: Missing.

Show »
Length:323
Mass (Da):35,760
Checksum:i3D469465CA2C39AD
GO
Isoform 3 (identifier: Q8IXK0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-585: Missing.
     586-586: P → M
     809-852: CQEIAEEFRA...GPALKIYARI → LPSSFPKGHE...WPVLRPRPHL
     853-858: Missing.

Show »
Length:267
Mass (Da):30,053
Checksum:i2E784C87AA459AD0
GO
Isoform 4 (identifier: Q8IXK0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-221: Missing.

Note: No experimental confirmation available.

Show »
Length:829
Mass (Da):87,812
Checksum:iFFAF6D7224ADBD72
GO
Isoform 5 (identifier: Q8IXK0-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     463-463: P → PV

Note: No experimental confirmation available.

Show »
Length:859
Mass (Da):90,812
Checksum:i7F6C839B758194DC
GO

Sequence cautioni

The sequence AAH68573.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAH92492.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAI13956.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti254 – 2541P → S.
Corresponds to variant rs10914692 [ dbSNP | Ensembl ].
VAR_051276
Natural varianti475 – 4751V → M.1 Publication
Corresponds to variant rs12026290 [ dbSNP | Ensembl ].
VAR_051277

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 585585Missing in isoform 3. VSP_016914Add
BLAST
Alternative sequencei1 – 535535Missing in isoform 2. VSP_016915Add
BLAST
Alternative sequencei193 – 22129Missing in isoform 4. VSP_027217Add
BLAST
Alternative sequencei463 – 4631P → PV in isoform 5. VSP_039755
Alternative sequencei586 – 5861P → M in isoform 3. VSP_016916
Alternative sequencei809 – 85244CQEIA…IYARI → LPSSFPKGHETSIYSLSKHL RHSRFPQSPSGSCLWPVLRP RPHL in isoform 3. VSP_016917Add
BLAST
Alternative sequencei853 – 8586Missing in isoform 3. VSP_016918

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti745 – 7451S → N in BAC87622. 1 Publication
Sequence conflicti778 – 7781D → E in BAC87622. 1 Publication
Sequence conflicti813 – 8131A → E in AAH28396. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ419231 mRNA. Translation: CAD11673.1.
AK128821 mRNA. Translation: BAC87622.1.
AK292905 mRNA. Translation: BAF85594.1.
AL513327 Genomic DNA. Translation: CAI13955.1.
AL513327 Genomic DNA. Translation: CAI13956.1. Sequence problems.
AL513327 Genomic DNA. Translation: CAI13957.1.
CH471059 Genomic DNA. Translation: EAX07457.1.
CH471059 Genomic DNA. Translation: EAX07458.1.
CH471059 Genomic DNA. Translation: EAX07459.1.
BC015450 mRNA. Translation: AAH15450.1.
BC028396 mRNA. Translation: AAH28396.3.
BC029269 mRNA. Translation: AAH29269.1.
BC068573 mRNA. Translation: AAH68573.1. Different initiation.
BC092492 mRNA. Translation: AAH92492.1. Different initiation.
BC110863 mRNA. Translation: AAI10864.2.
BC130630 mRNA. Translation: AAI30631.1.
AJ242730 mRNA. Translation: CAB44779.1.
CCDSiCCDS378.1. [Q8IXK0-1]
CCDS379.1. [Q8IXK0-2]
RefSeqiNP_004418.2. NM_004427.3. [Q8IXK0-2]
NP_932157.1. NM_198040.2. [Q8IXK0-1]
XP_005270627.1. XM_005270570.1. [Q8IXK0-2]
XP_005270628.1. XM_005270571.1. [Q8IXK0-2]
UniGeneiHs.524271.

Genome annotation databases

EnsembliENST00000257118; ENSP00000257118; ENSG00000134686. [Q8IXK0-1]
ENST00000373418; ENSP00000362517; ENSG00000134686. [Q8IXK0-2]
ENST00000419414; ENSP00000391440; ENSG00000134686. [Q8IXK0-5]
ENST00000431992; ENSP00000389436; ENSG00000134686. [Q8IXK0-4]
GeneIDi1912.
KEGGihsa:1912.
UCSCiuc001bxe.1. human. [Q8IXK0-2]
uc001bxf.1. human. [Q8IXK0-3]
uc001bxg.1. human. [Q8IXK0-1]
uc009vuh.1. human.

Polymorphism databases

DMDMi74750731.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ419231 mRNA. Translation: CAD11673.1 .
AK128821 mRNA. Translation: BAC87622.1 .
AK292905 mRNA. Translation: BAF85594.1 .
AL513327 Genomic DNA. Translation: CAI13955.1 .
AL513327 Genomic DNA. Translation: CAI13956.1 . Sequence problems.
AL513327 Genomic DNA. Translation: CAI13957.1 .
CH471059 Genomic DNA. Translation: EAX07457.1 .
CH471059 Genomic DNA. Translation: EAX07458.1 .
CH471059 Genomic DNA. Translation: EAX07459.1 .
BC015450 mRNA. Translation: AAH15450.1 .
BC028396 mRNA. Translation: AAH28396.3 .
BC029269 mRNA. Translation: AAH29269.1 .
BC068573 mRNA. Translation: AAH68573.1 . Different initiation.
BC092492 mRNA. Translation: AAH92492.1 . Different initiation.
BC110863 mRNA. Translation: AAI10864.2 .
BC130630 mRNA. Translation: AAI30631.1 .
AJ242730 mRNA. Translation: CAB44779.1 .
CCDSi CCDS378.1. [Q8IXK0-1 ]
CCDS379.1. [Q8IXK0-2 ]
RefSeqi NP_004418.2. NM_004427.3. [Q8IXK0-2 ]
NP_932157.1. NM_198040.2. [Q8IXK0-1 ]
XP_005270627.1. XM_005270570.1. [Q8IXK0-2 ]
XP_005270628.1. XM_005270571.1. [Q8IXK0-2 ]
UniGenei Hs.524271.

3D structure databases

ProteinModelPortali Q8IXK0.
SMRi Q8IXK0. Positions 640-670, 792-852.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108234. 43 interactions.
DIPi DIP-34464N.
IntActi Q8IXK0. 40 interactions.
MINTi MINT-1369031.

PTM databases

PhosphoSitei Q8IXK0.

Polymorphism databases

DMDMi 74750731.

Proteomic databases

MaxQBi Q8IXK0.
PaxDbi Q8IXK0.
PRIDEi Q8IXK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257118 ; ENSP00000257118 ; ENSG00000134686 . [Q8IXK0-1 ]
ENST00000373418 ; ENSP00000362517 ; ENSG00000134686 . [Q8IXK0-2 ]
ENST00000419414 ; ENSP00000391440 ; ENSG00000134686 . [Q8IXK0-5 ]
ENST00000431992 ; ENSP00000389436 ; ENSG00000134686 . [Q8IXK0-4 ]
GeneIDi 1912.
KEGGi hsa:1912.
UCSCi uc001bxe.1. human. [Q8IXK0-2 ]
uc001bxf.1. human. [Q8IXK0-3 ]
uc001bxg.1. human. [Q8IXK0-1 ]
uc009vuh.1. human.

Organism-specific databases

CTDi 1912.
GeneCardsi GC01M033789.
HGNCi HGNC:3183. PHC2.
HPAi HPA047403.
MIMi 602979. gene.
neXtProti NX_Q8IXK0.
PharmGKBi PA27620.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145736.
HOVERGENi HBG039325.
InParanoidi Q8IXK0.
KOi K11457.
OMAi HTSSSAC.
OrthoDBi EOG789C9Q.
PhylomeDBi Q8IXK0.
TreeFami TF331299.

Enzyme and pathway databases

Reactomei REACT_169436. Oxidative Stress Induced Senescence.

Miscellaneous databases

ChiTaRSi PHC2. human.
GeneWikii PHC2.
GenomeRNAii 1912.
NextBioi 35464715.
PROi Q8IXK0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IXK0.
Bgeei Q8IXK0.
Genevestigatori Q8IXK0.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
InterProi IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR012313. Znf_FCS.
[Graphical view ]
Pfami PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS50105. SAM_DOMAIN. 1 hit.
PS51024. ZF_FCS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family."
    Tonkin E., Hagan D.-M., Li W., Strachan T.
    Hum. Genet. 111:435-442(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
    Tissue: Testis and Trachea.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5), VARIANT MET-475.
    Tissue: Cerebellum, Hypothalamus, Placenta, Prostate and Retina.
  6. "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."
    Gunther M., Laithier M., Brison O.
    Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-266 (ISOFORM 1), INTERACTION WITH SP1.
    Tissue: Colon carcinoma.
  7. "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic."
    Gunster M.J., Satijn D.P.E., Hamer K.M., den Blaauwen J.L., de Bruijn D., Alkema M.J., van Lohuizen M., van Driel R., Otte A.P.
    Mol. Cell. Biol. 17:2326-2335(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BMI1 AND PHC1.
  8. "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor."
    Satijn D.P.E., Gunster M.J., van der Vlag J., Hamer K.M., Schul W., Alkema M.J., Saurin A.J., Freemont P.S., van Driel R., Otte A.P.
    Mol. Cell. Biol. 17:4105-4113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RING1; PHC1 AND BMI1.
  9. "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."
    Levine S.S., Weiss A., Erdjument-Bromage H., Shao Z., Tempst P., Kingston R.E.
    Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A PRC1-LIKE HPRC-H COMPLEX WITH BMI1; CBX2; CBX4; CBX8; PHC1; PHC3; RING1 AND RNF2.
  10. "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity."
    Yannoni Y.M., Gaestel M., Lin L.L.
    FEBS Lett. 564:205-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAPKAPK2.
  11. "Role of histone H2A ubiquitination in Polycomb silencing."
    Wang H., Wang L., Erdjument-Bromage H., Vidal M., Tempst P., Jones R.S., Zhang Y.
    Nature 431:873-878(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."
    Maertens G.N., El Messaoudi-Aubert S., Racek T., Stock J.K., Nicholls J., Rodriguez-Niedenfuhr M., Gil J., Peters G.
    PLoS ONE 4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX.
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-621, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."
    Vandamme J., Volkel P., Rosnoblet C., Le Faou P., Angrand P.O.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX, INTERACTION WITH CBX4, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPHC2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXK0
Secondary accession number(s): A1L4Q1
, A8KA40, D3DPR2, Q2TAL3, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The hPRC-H complex purification reported by 1 Publication probably presents a mixture of different PRC1-like complexes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi