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Q8IXK0

- PHC2_HUMAN

UniProt

Q8IXK0 - PHC2_HUMAN

Protein

Polyhomeotic-like protein 2

Gene

PHC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri633 – 66735FCS-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_169436. Oxidative Stress Induced Senescence.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyhomeotic-like protein 2
    Short name:
    hPH2
    Alternative name(s):
    Early development regulatory protein 2
    Gene namesi
    Name:PHC2
    Synonyms:EDR2, PH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3183. PHC2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: UniProtKB
    3. PcG protein complex Source: UniProtKB
    4. PRC1 complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27620.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858Polyhomeotic-like protein 2PRO_0000076286Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei621 – 6211Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IXK0.
    PaxDbiQ8IXK0.
    PRIDEiQ8IXK0.

    PTM databases

    PhosphoSiteiQ8IXK0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IXK0.
    BgeeiQ8IXK0.
    GenevestigatoriQ8IXK0.

    Organism-specific databases

    HPAiHPA047403.

    Interactioni

    Subunit structurei

    Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP By similarity. Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2.By similarity8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Bmi1P259162EBI-713786,EBI-927401From a different organism.
    MCRS1Q96EZ82EBI-713786,EBI-348259
    PLK1P533502EBI-713786,EBI-476768
    SP1P080472EBI-713786,EBI-298336

    Protein-protein interaction databases

    BioGridi108234. 43 interactions.
    DIPiDIP-34464N.
    IntActiQ8IXK0. 40 interactions.
    MINTiMINT-1369031.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IXK0.
    SMRiQ8IXK0. Positions 640-670, 792-852.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini794 – 85865SAMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi558 – 58730HD1Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi11 – 3727Ser-richAdd
    BLAST
    Compositional biasi55 – 11157Gln-richAdd
    BLAST
    Compositional biasi329 – 37749Gln-richAdd
    BLAST

    Domaini

    HD1 motif interacts with SAM domain of PHC1.

    Sequence similaritiesi

    Contains 1 FCS-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri633 – 66735FCS-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG145736.
    HOVERGENiHBG039325.
    InParanoidiQ8IXK0.
    KOiK11457.
    OMAiHTSSSAC.
    OrthoDBiEOG789C9Q.
    PhylomeDBiQ8IXK0.
    TreeFamiTF331299.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    InterProiIPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR012313. Znf_FCS.
    [Graphical view]
    PfamiPF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS50105. SAM_DOMAIN. 1 hit.
    PS51024. ZF_FCS. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IXK0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENELPVPHT SSSACATSST SGASSSSGCN NSSSGGSGRP TGPQISVYSG    50
    IPDRQTVQVI QQALHRQPST AAQYLQQMYA AQQQHLMLQT AALQQQHLSS 100
    AQLQSLAAVQ QASLVSNRQG STSGSNVSAQ APAQSSSINL AASPAAAQLL 150
    NRAQSVNSAA ASGIAQQAVL LGNTSSPALT ASQAQMYLRA QMLIFTPTAT 200
    VATVQPELGT GSPARPPTPA QVQNLTLRTQ QTPAAAASGP TPTQPVLPSL 250
    ALKPTPGGSQ PLPTPAQSRN TAQASPAGAK PGIADSVMEP HKKGDGNSSV 300
    PGSMEGRAGL SRTVPAVAAH PLIAPAYAQL QPHQLLPQPS SKHLQPQFVI 350
    QQQPQPQQQQ PPPQQSRPVL QAEPHPQLAS VSPSVALQPS SEAHAMPLGP 400
    VTPALPLQCP TANLHKPGGS QQCHPPTPDT GPQNGHPEGV PHTPQRRFQH 450
    TSAVILQLQP ASPPQQCVPD DWKEVAPGEK SVPETRSGPS PHQQAIVTAM 500
    PGGLPVPTSP NIQPSPAHET GQGIVHALTD LSSPGMTSGN GNSASSIAGT 550
    APQNGENKPP QAIVKPQILT HVIEGFVIQE GAEPFPVGRS SLLVGNLKKK 600
    YAQGFLPEKL PQQDHTTTTD SEMEEPYLQE SKEEGAPLKL KCELCGRVDF 650
    AYKFKRSKRF CSMACAKRYN VGCTKRVGLF HSDRSKLQKA GAATHNRRRA 700
    SKASLPPLTK DTKKQPTGTV PLSVTAALQL THSQEDSSRC SDNSSYEEPL 750
    SPISASSSTS RRRQGQRDLE LPDMHMRDLV GMGHHFLPSE PTKWNVEDVY 800
    EFIRSLPGCQ EIAEEFRAQE IDGQALLLLK EDHLMSAMNI KLGPALKIYA 850
    RISMLKDS 858
    Length:858
    Mass (Da):90,713
    Last modified:March 1, 2003 - v1
    Checksum:i2E3FD3898CFD702B
    GO
    Isoform 2 (identifier: Q8IXK0-2) [UniParc]FASTAAdd to Basket

    Also known as: isoform b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-535: Missing.

    Show »
    Length:323
    Mass (Da):35,760
    Checksum:i3D469465CA2C39AD
    GO
    Isoform 3 (identifier: Q8IXK0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-585: Missing.
         586-586: P → M
         809-852: CQEIAEEFRA...GPALKIYARI → LPSSFPKGHE...WPVLRPRPHL
         853-858: Missing.

    Show »
    Length:267
    Mass (Da):30,053
    Checksum:i2E784C87AA459AD0
    GO
    Isoform 4 (identifier: Q8IXK0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         193-221: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:829
    Mass (Da):87,812
    Checksum:iFFAF6D7224ADBD72
    GO
    Isoform 5 (identifier: Q8IXK0-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         463-463: P → PV

    Note: No experimental confirmation available.

    Show »
    Length:859
    Mass (Da):90,812
    Checksum:i7F6C839B758194DC
    GO

    Sequence cautioni

    The sequence AAH68573.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAH92492.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAI13956.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti745 – 7451S → N in BAC87622. (PubMed:14702039)Curated
    Sequence conflicti778 – 7781D → E in BAC87622. (PubMed:14702039)Curated
    Sequence conflicti813 – 8131A → E in AAH28396. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti254 – 2541P → S.
    Corresponds to variant rs10914692 [ dbSNP | Ensembl ].
    VAR_051276
    Natural varianti475 – 4751V → M.1 Publication
    Corresponds to variant rs12026290 [ dbSNP | Ensembl ].
    VAR_051277

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 585585Missing in isoform 3. 1 PublicationVSP_016914Add
    BLAST
    Alternative sequencei1 – 535535Missing in isoform 2. 1 PublicationVSP_016915Add
    BLAST
    Alternative sequencei193 – 22129Missing in isoform 4. 1 PublicationVSP_027217Add
    BLAST
    Alternative sequencei463 – 4631P → PV in isoform 5. 2 PublicationsVSP_039755
    Alternative sequencei586 – 5861P → M in isoform 3. 1 PublicationVSP_016916
    Alternative sequencei809 – 85244CQEIA…IYARI → LPSSFPKGHETSIYSLSKHL RHSRFPQSPSGSCLWPVLRP RPHL in isoform 3. 1 PublicationVSP_016917Add
    BLAST
    Alternative sequencei853 – 8586Missing in isoform 3. 1 PublicationVSP_016918

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ419231 mRNA. Translation: CAD11673.1.
    AK128821 mRNA. Translation: BAC87622.1.
    AK292905 mRNA. Translation: BAF85594.1.
    AL513327 Genomic DNA. Translation: CAI13955.1.
    AL513327 Genomic DNA. Translation: CAI13956.1. Sequence problems.
    AL513327 Genomic DNA. Translation: CAI13957.1.
    CH471059 Genomic DNA. Translation: EAX07457.1.
    CH471059 Genomic DNA. Translation: EAX07458.1.
    CH471059 Genomic DNA. Translation: EAX07459.1.
    BC015450 mRNA. Translation: AAH15450.1.
    BC028396 mRNA. Translation: AAH28396.3.
    BC029269 mRNA. Translation: AAH29269.1.
    BC068573 mRNA. Translation: AAH68573.1. Different initiation.
    BC092492 mRNA. Translation: AAH92492.1. Different initiation.
    BC110863 mRNA. Translation: AAI10864.2.
    BC130630 mRNA. Translation: AAI30631.1.
    AJ242730 mRNA. Translation: CAB44779.1.
    CCDSiCCDS378.1. [Q8IXK0-1]
    CCDS379.1. [Q8IXK0-2]
    RefSeqiNP_004418.2. NM_004427.3. [Q8IXK0-2]
    NP_932157.1. NM_198040.2. [Q8IXK0-1]
    XP_005270627.1. XM_005270570.1. [Q8IXK0-2]
    XP_005270628.1. XM_005270571.1. [Q8IXK0-2]
    UniGeneiHs.524271.

    Genome annotation databases

    EnsembliENST00000257118; ENSP00000257118; ENSG00000134686. [Q8IXK0-1]
    ENST00000373418; ENSP00000362517; ENSG00000134686. [Q8IXK0-2]
    ENST00000431992; ENSP00000389436; ENSG00000134686. [Q8IXK0-4]
    GeneIDi1912.
    KEGGihsa:1912.
    UCSCiuc001bxe.1. human. [Q8IXK0-2]
    uc001bxf.1. human. [Q8IXK0-3]
    uc001bxg.1. human. [Q8IXK0-1]
    uc009vuh.1. human.

    Polymorphism databases

    DMDMi74750731.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ419231 mRNA. Translation: CAD11673.1 .
    AK128821 mRNA. Translation: BAC87622.1 .
    AK292905 mRNA. Translation: BAF85594.1 .
    AL513327 Genomic DNA. Translation: CAI13955.1 .
    AL513327 Genomic DNA. Translation: CAI13956.1 . Sequence problems.
    AL513327 Genomic DNA. Translation: CAI13957.1 .
    CH471059 Genomic DNA. Translation: EAX07457.1 .
    CH471059 Genomic DNA. Translation: EAX07458.1 .
    CH471059 Genomic DNA. Translation: EAX07459.1 .
    BC015450 mRNA. Translation: AAH15450.1 .
    BC028396 mRNA. Translation: AAH28396.3 .
    BC029269 mRNA. Translation: AAH29269.1 .
    BC068573 mRNA. Translation: AAH68573.1 . Different initiation.
    BC092492 mRNA. Translation: AAH92492.1 . Different initiation.
    BC110863 mRNA. Translation: AAI10864.2 .
    BC130630 mRNA. Translation: AAI30631.1 .
    AJ242730 mRNA. Translation: CAB44779.1 .
    CCDSi CCDS378.1. [Q8IXK0-1 ]
    CCDS379.1. [Q8IXK0-2 ]
    RefSeqi NP_004418.2. NM_004427.3. [Q8IXK0-2 ]
    NP_932157.1. NM_198040.2. [Q8IXK0-1 ]
    XP_005270627.1. XM_005270570.1. [Q8IXK0-2 ]
    XP_005270628.1. XM_005270571.1. [Q8IXK0-2 ]
    UniGenei Hs.524271.

    3D structure databases

    ProteinModelPortali Q8IXK0.
    SMRi Q8IXK0. Positions 640-670, 792-852.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108234. 43 interactions.
    DIPi DIP-34464N.
    IntActi Q8IXK0. 40 interactions.
    MINTi MINT-1369031.

    PTM databases

    PhosphoSitei Q8IXK0.

    Polymorphism databases

    DMDMi 74750731.

    Proteomic databases

    MaxQBi Q8IXK0.
    PaxDbi Q8IXK0.
    PRIDEi Q8IXK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257118 ; ENSP00000257118 ; ENSG00000134686 . [Q8IXK0-1 ]
    ENST00000373418 ; ENSP00000362517 ; ENSG00000134686 . [Q8IXK0-2 ]
    ENST00000431992 ; ENSP00000389436 ; ENSG00000134686 . [Q8IXK0-4 ]
    GeneIDi 1912.
    KEGGi hsa:1912.
    UCSCi uc001bxe.1. human. [Q8IXK0-2 ]
    uc001bxf.1. human. [Q8IXK0-3 ]
    uc001bxg.1. human. [Q8IXK0-1 ]
    uc009vuh.1. human.

    Organism-specific databases

    CTDi 1912.
    GeneCardsi GC01M033789.
    HGNCi HGNC:3183. PHC2.
    HPAi HPA047403.
    MIMi 602979. gene.
    neXtProti NX_Q8IXK0.
    PharmGKBi PA27620.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145736.
    HOVERGENi HBG039325.
    InParanoidi Q8IXK0.
    KOi K11457.
    OMAi HTSSSAC.
    OrthoDBi EOG789C9Q.
    PhylomeDBi Q8IXK0.
    TreeFami TF331299.

    Enzyme and pathway databases

    Reactomei REACT_169436. Oxidative Stress Induced Senescence.

    Miscellaneous databases

    ChiTaRSi PHC2. human.
    GeneWikii PHC2.
    GenomeRNAii 1912.
    NextBioi 35464715.
    PROi Q8IXK0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IXK0.
    Bgeei Q8IXK0.
    Genevestigatori Q8IXK0.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    InterProi IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR012313. Znf_FCS.
    [Graphical view ]
    Pfami PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS50105. SAM_DOMAIN. 1 hit.
    PS51024. ZF_FCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family."
      Tonkin E., Hagan D.-M., Li W., Strachan T.
      Hum. Genet. 111:435-442(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
      Tissue: Testis and Trachea.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5), VARIANT MET-475.
      Tissue: Cerebellum, Hypothalamus, Placenta, Prostate and Retina.
    6. "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."
      Gunther M., Laithier M., Brison O.
      Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-266 (ISOFORM 1), INTERACTION WITH SP1.
      Tissue: Colon carcinoma.
    7. "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic."
      Gunster M.J., Satijn D.P.E., Hamer K.M., den Blaauwen J.L., de Bruijn D., Alkema M.J., van Lohuizen M., van Driel R., Otte A.P.
      Mol. Cell. Biol. 17:2326-2335(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BMI1 AND PHC1.
    8. "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor."
      Satijn D.P.E., Gunster M.J., van der Vlag J., Hamer K.M., Schul W., Alkema M.J., Saurin A.J., Freemont P.S., van Driel R., Otte A.P.
      Mol. Cell. Biol. 17:4105-4113(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RING1; PHC1 AND BMI1.
    9. "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."
      Levine S.S., Weiss A., Erdjument-Bromage H., Shao Z., Tempst P., Kingston R.E.
      Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A PRC1-LIKE HPRC-H COMPLEX WITH BMI1; CBX2; CBX4; CBX8; PHC1; PHC3; RING1 AND RNF2.
    10. "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity."
      Yannoni Y.M., Gaestel M., Lin L.L.
      FEBS Lett. 564:205-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAPKAPK2.
    11. "Role of histone H2A ubiquitination in Polycomb silencing."
      Wang H., Wang L., Erdjument-Bromage H., Vidal M., Tempst P., Jones R.S., Zhang Y.
      Nature 431:873-878(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."
      Maertens G.N., El Messaoudi-Aubert S., Racek T., Stock J.K., Nicholls J., Rodriguez-Niedenfuhr M., Gil J., Peters G.
      PLoS ONE 4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX.
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-621, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."
      Vandamme J., Volkel P., Rosnoblet C., Le Faou P., Angrand P.O.
      Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX, INTERACTION WITH CBX4, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPHC2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IXK0
    Secondary accession number(s): A1L4Q1
    , A8KA40, D3DPR2, Q2TAL3, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3