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Q8IXI1

- MIRO2_HUMAN

UniProt

Q8IXI1 - MIRO2_HUMAN

Protein

Mitochondrial Rho GTPase 2

Gene

RHOT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188GTP 1Sequence Analysis
    Nucleotide bindingi57 – 615GTP 1Sequence Analysis
    Nucleotide bindingi118 – 1214GTP 1Sequence Analysis
    Calcium bindingi197 – 208121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi317 – 328122PROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi423 – 4308GTP 2Sequence Analysis
    Nucleotide bindingi459 – 4635GTP 2Sequence Analysis
    Nucleotide bindingi524 – 5274GTP 2Sequence Analysis

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. GTPase activity Source: InterPro
    3. GTP binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular homeostasis Source: UniProtKB
    2. mitochondrial outer membrane permeabilization Source: UniProtKB
    3. mitochondrion transport along microtubule Source: UniProtKB
    4. regulation of small GTPase mediated signal transduction Source: Reactome
    5. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calcium, GTP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial Rho GTPase 2 (EC:3.6.5.-)
    Short name:
    MIRO-2
    Short name:
    hMiro-2
    Alternative name(s):
    Ras homolog gene family member T2
    Gene namesi
    Name:RHOT2
    Synonyms:ARHT2, C16orf39
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:21169. RHOT2.

    Subcellular locationi

    Mitochondrion outer membrane 2 Publications; Single-pass type IV membrane protein 2 Publications
    Note: Colocalizes with MGARP and RHOT2 at the mitochondria.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of mitochondrial outer membrane Source: UniProtKB
    4. membrane Source: UniProtKB
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi13 – 131A → V: Causes constitutive activation inducing an aggregation of the mitochondrial network. 2 Publications
    Mutagenesisi18 – 181T → N: Induces an aggregation of the mitochondrial network. 1 Publication

    Organism-specific databases

    PharmGKBiPA134889674.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 618618Mitochondrial Rho GTPase 2PRO_0000239318Add
    BLAST

    Proteomic databases

    MaxQBiQ8IXI1.
    PaxDbiQ8IXI1.
    PRIDEiQ8IXI1.

    PTM databases

    PhosphoSiteiQ8IXI1.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.2 Publications

    Gene expression databases

    ArrayExpressiQ8IXI1.
    BgeeiQ8IXI1.
    CleanExiHS_RHOT2.
    GenevestigatoriQ8IXI1.

    Organism-specific databases

    HPAiHPA012624.
    HPA012895.

    Interactioni

    Subunit structurei

    Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules.By similarity

    Protein-protein interaction databases

    BioGridi124646. 27 interactions.
    IntActiQ8IXI1. 6 interactions.
    MINTiMINT-1191538.
    STRINGi9606.ENSP00000321971.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IXI1.
    SMRiQ8IXI1. Positions 5-167, 180-578.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 592592Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini616 – 6183CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei593 – 61523Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 142142Miro 1Add
    BLAST
    Domaini184 – 21936EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini304 – 33936EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini410 – 618209Miro 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the mitochondrial Rho GTPase family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 2 Miro domains.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1100.
    HOVERGENiHBG079778.
    InParanoidiQ8IXI1.
    KOiK07871.
    OMAiVLPQITI.
    OrthoDBiEOG7PK8Z0.
    PhylomeDBiQ8IXI1.
    TreeFamiTF300814.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    3.40.50.300. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR013566. EF_hand_assoc_1.
    IPR013567. EF_hand_assoc_2.
    IPR002048. EF_hand_dom.
    IPR020860. MIRO.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR029506. Rho_GTPase_2.
    IPR021181. Rho_GTPase_Mt.
    IPR001806. Small_GTPase.
    [Graphical view]
    PANTHERiPTHR24072:SF70. PTHR24072:SF70. 1 hit.
    PfamiPF08355. EF_assoc_1. 1 hit.
    PF08356. EF_assoc_2. 1 hit.
    PF08477. Miro. 1 hit.
    PF00071. Ras. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS51423. MIRO. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IXI1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRDVRILLL GEAQVGKTSL ILSLVGEEFP EEVPPRAEEI TIPADVTPEK    50
    VPTHIVDYSE AEQTDEELRE EIHKANVVCV VYDVSEEATI EKIRTKWIPL 100
    VNGGTTQGPR VPIILVGNKS DLRSGSSMEA VLPIMSQFPE IETCVECSAK 150
    NLRNISELFY YAQKAVLHPT APLYDPEAKQ LRPACAQALT RIFRLSDQDL 200
    DQALSDEELN AFQKSCFGHP LAPQALEDVK TVVCRNVAGG VREDRLTLDG 250
    FLFLNTLFIQ RGRHETTWTI LRRFGYSDAL ELTADYLSPL IHVPPGCSTE 300
    LNHLGYQFVQ RVFEKHDQDR DGALSPVELQ SLFSVFPAAP WGPELPRTVR 350
    TEAGRLPLHG YLCQWTLVTY LDVRSCLGHL GYLGYPTLCE QDQAHAITVT 400
    REKRLDQEKG QTQRSVLLCK VVGARGVGKS AFLQAFLGRG LGHQDTREQP 450
    PGYAIDTVQV NGQEKYLILC EVGTDGLLAT SLDATCDVAC LMFDGSDPKS 500
    FAHCASVYKH HYMDGQTPCL FVSSKADLPE GVAVSGPSPA EFCRKHRLPA 550
    PVPFSCAGPA EPSTTIFTQL ATMAAFPHLV HAELHPSSFW LRGLLGVVGA 600
    AVAAVLSFSL YRVLVKSQ 618
    Length:618
    Mass (Da):68,118
    Last modified:June 13, 2006 - v2
    Checksum:iC72ECBCA33D04B6B
    GO
    Isoform 2 (identifier: Q8IXI1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-127: Missing.
         251-340: FLFLNTLFIQ...SLFSVFPAAP → EAGCPPVPGE...PWLPVCAESV
         341-618: Missing.

    Show »
    Length:213
    Mass (Da):23,077
    Checksum:i76722819B54E29DE
    GO

    Sequence cautioni

    The sequence BAB15740.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC03407.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAK61240.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391P → S in CAD56957. (PubMed:12482879)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti245 – 2451R → Q.1 Publication
    Corresponds to variant rs1139897 [ dbSNP | Ensembl ].
    VAR_026637
    Natural varianti425 – 4251R → C.1 Publication
    Corresponds to variant rs3177338 [ dbSNP | Ensembl ].
    VAR_026638

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 127127Missing in isoform 2. 2 PublicationsVSP_019162Add
    BLAST
    Alternative sequencei251 – 34090FLFLN…FPAAP → EAGCPPVPGECGEGAVPGAP PALSRCRFPLPEHALHPARP ARDHLDHPAALRLQRCPGAD CGLSLPSDPRAPRLQHGAQP PWLPVCAESV in isoform 2. 2 PublicationsVSP_019163Add
    BLAST
    Alternative sequencei341 – 618278Missing in isoform 2. 2 PublicationsVSP_019164Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ517413 mRNA. Translation: CAD56957.1.
    AY207375 mRNA. Translation: AAP46090.1.
    AK024450 mRNA. Translation: BAB15740.1. Different initiation.
    AK090426 mRNA. Translation: BAC03407.1. Different initiation.
    AE006464 Genomic DNA. Translation: AAK61240.1. Sequence problems.
    Z92544 Genomic DNA. Translation: CAM26351.1.
    CH471112 Genomic DNA. Translation: EAW85763.1.
    BC004327 mRNA. Translation: AAH04327.1.
    BC014942 mRNA. Translation: AAH14942.1.
    CCDSiCCDS10417.1. [Q8IXI1-1]
    RefSeqiNP_620124.1. NM_138769.2. [Q8IXI1-1]
    UniGeneiHs.513242.

    Genome annotation databases

    EnsembliENST00000315082; ENSP00000321971; ENSG00000140983. [Q8IXI1-1]
    GeneIDi89941.
    KEGGihsa:89941.
    UCSCiuc002cip.3. human. [Q8IXI1-1]

    Polymorphism databases

    DMDMi108860798.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ517413 mRNA. Translation: CAD56957.1 .
    AY207375 mRNA. Translation: AAP46090.1 .
    AK024450 mRNA. Translation: BAB15740.1 . Different initiation.
    AK090426 mRNA. Translation: BAC03407.1 . Different initiation.
    AE006464 Genomic DNA. Translation: AAK61240.1 . Sequence problems.
    Z92544 Genomic DNA. Translation: CAM26351.1 .
    CH471112 Genomic DNA. Translation: EAW85763.1 .
    BC004327 mRNA. Translation: AAH04327.1 .
    BC014942 mRNA. Translation: AAH14942.1 .
    CCDSi CCDS10417.1. [Q8IXI1-1 ]
    RefSeqi NP_620124.1. NM_138769.2. [Q8IXI1-1 ]
    UniGenei Hs.513242.

    3D structure databases

    ProteinModelPortali Q8IXI1.
    SMRi Q8IXI1. Positions 5-167, 180-578.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124646. 27 interactions.
    IntActi Q8IXI1. 6 interactions.
    MINTi MINT-1191538.
    STRINGi 9606.ENSP00000321971.

    PTM databases

    PhosphoSitei Q8IXI1.

    Polymorphism databases

    DMDMi 108860798.

    Proteomic databases

    MaxQBi Q8IXI1.
    PaxDbi Q8IXI1.
    PRIDEi Q8IXI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315082 ; ENSP00000321971 ; ENSG00000140983 . [Q8IXI1-1 ]
    GeneIDi 89941.
    KEGGi hsa:89941.
    UCSCi uc002cip.3. human. [Q8IXI1-1 ]

    Organism-specific databases

    CTDi 89941.
    GeneCardsi GC16P000826.
    HGNCi HGNC:21169. RHOT2.
    HPAi HPA012624.
    HPA012895.
    MIMi 613889. gene.
    neXtProti NX_Q8IXI1.
    PharmGKBi PA134889674.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOVERGENi HBG079778.
    InParanoidi Q8IXI1.
    KOi K07871.
    OMAi VLPQITI.
    OrthoDBi EOG7PK8Z0.
    PhylomeDBi Q8IXI1.
    TreeFami TF300814.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    GeneWikii RHOT2.
    GenomeRNAii 89941.
    NextBioi 76445.
    PROi Q8IXI1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IXI1.
    Bgeei Q8IXI1.
    CleanExi HS_RHOT2.
    Genevestigatori Q8IXI1.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    3.40.50.300. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR013566. EF_hand_assoc_1.
    IPR013567. EF_hand_assoc_2.
    IPR002048. EF_hand_dom.
    IPR020860. MIRO.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR029506. Rho_GTPase_2.
    IPR021181. Rho_GTPase_Mt.
    IPR001806. Small_GTPase.
    [Graphical view ]
    PANTHERi PTHR24072:SF70. PTHR24072:SF70. 1 hit.
    Pfami PF08355. EF_assoc_1. 1 hit.
    PF08356. EF_assoc_2. 1 hit.
    PF08477. Miro. 1 hit.
    PF00071. Ras. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037488. Mt_Rho_GTPase. 1 hit.
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS51423. MIRO. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis."
      Fransson A., Ruusala A., Aspenstroem P.
      J. Biol. Chem. 278:6495-6502(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS GLN-245 AND CYS-425.
    2. "Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase."
      Shan Y., Hexige S., Guo Z., Wan B., Chen K., Chen X., Ma L., Huang C., Zhao S., Yu L.
      Cytogenet. Genome Res. 106:91-97(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    4. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    5. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta and Skin.
    9. "Rho GTPases have diverse effects on the organization of the actin filament system."
      Aspenstroem P., Fransson A., Saras J.
      Biochem. J. 377:327-337(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ALA-13.
    10. "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking."
      Fransson S., Ruusala A., Aspenstroem P.
      Biochem. Biophys. Res. Commun. 344:500-510(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRAK1 AND TRAK2, MUTAGENESIS OF ALA-13 AND THR-18.
    11. "HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport."
      Li Y., Lim S., Hoffman D., Aspenstrom P., Federoff H.J., Rempe D.A.
      J. Cell Biol. 185:1065-1081(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMIRO2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IXI1
    Secondary accession number(s): A2IDC2
    , Q8NF53, Q96C13, Q96S17, Q9BT60, Q9H7M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3