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Protein

Tumor protein p53-inducible nuclear protein 2

Gene

TP53INP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Autophagy, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ8IXH6.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p53-inducible nuclear protein 2
Alternative name(s):
Diabetes and obesity-regulated gene
p53-inducible protein U
Short name:
PIG-U
Gene namesi
Name:TP53INP2
Synonyms:C20orf110, DOR, PINH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16104. TP53INP2.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB-KW
  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
  • PML body Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25650.

Polymorphism and mutation databases

BioMutaiTP53INP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Tumor protein p53-inducible nuclear protein 2PRO_0000072409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineCombined sources
Modified residuei136 – 1361PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IXH6.
PaxDbiQ8IXH6.
PeptideAtlasiQ8IXH6.
PRIDEiQ8IXH6.

PTM databases

iPTMnetiQ8IXH6.
PhosphoSiteiQ8IXH6.

Expressioni

Gene expression databases

BgeeiQ8IXH6.
CleanExiHS_TP53INP2.
ExpressionAtlasiQ8IXH6. baseline and differential.
GenevisibleiQ8IXH6. HS.

Organism-specific databases

HPAiHPA052974.

Interactioni

Subunit structurei

Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA.3 Publications

Protein-protein interaction databases

BioGridi121809. 2 interactions.
IntActiQ8IXH6. 2 interactions.
MINTiMINT-7714266.
STRINGi9606.ENSP00000363942.

Structurei

3D structure databases

ProteinModelPortaliQ8IXH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi26 – 4116LIRAdd
BLAST

Domaini

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.

Phylogenomic databases

eggNOGiENOG410IXBP. Eukaryota.
ENOG4111S9D. LUCA.
GeneTreeiENSGT00530000063829.
HOGENOMiHOG000010288.
HOVERGENiHBG055647.
InParanoidiQ8IXH6.
OMAiSKNQGSF.
OrthoDBiEOG7MSMPN.
PhylomeDBiQ8IXH6.
TreeFamiTF333017.

Family and domain databases

InterProiIPR029431. TP53INP.
IPR029558. TP53INP2.
[Graphical view]
PANTHERiPTHR31671. PTHR31671. 1 hit.
PTHR31671:SF2. PTHR31671:SF2. 1 hit.
PfamiPF14839. DOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IXH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQRLSSLFF STPSPPEDPD CPRAFVSEED EVDGWLIIDL PDSYAAPPSP
60 70 80 90 100
GAAPAPAGRP PPAPSLMDES WFVTPPACFT AEGPGLGPAR LQSSPLEDLL
110 120 130 140 150
IEHPSMSVYV TGSTIVLEPG SPSPLPDAAL PDGDLSEGEL TPARREPRAA
160 170 180 190 200
RHAAPLPARA ALLEKAGQVR RLQRARQRAE RHALSAKAVQ RQNRARESRP
210 220
RRSKNQSSFI YQPCQRQFNY
Length:220
Mass (Da):23,980
Last modified:July 11, 2003 - v2
Checksum:iD64E010B2F68A705
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361S → N in CAC82592 (PubMed:18030323).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297792 mRNA. Translation: CAC82592.1.
AY422170 mRNA. Translation: AAR23799.1.
AK292443 mRNA. Translation: BAF85132.1.
AL109824 Genomic DNA. Translation: CAI19375.1.
CH471077 Genomic DNA. Translation: EAW76256.1.
CH471077 Genomic DNA. Translation: EAW76257.1.
BC035639 mRNA. Translation: AAH35639.1.
CCDSiCCDS13240.1.
RefSeqiNP_067025.1. NM_021202.1.
XP_005260533.1. XM_005260476.2.
XP_011527254.1. XM_011528952.1.
XP_011527255.1. XM_011528953.1.
UniGeneiHs.516994.

Genome annotation databases

EnsembliENST00000374809; ENSP00000363942; ENSG00000078804.
ENST00000374810; ENSP00000363943; ENSG00000078804.
GeneIDi58476.
KEGGihsa:58476.
UCSCiuc002xau.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297792 mRNA. Translation: CAC82592.1.
AY422170 mRNA. Translation: AAR23799.1.
AK292443 mRNA. Translation: BAF85132.1.
AL109824 Genomic DNA. Translation: CAI19375.1.
CH471077 Genomic DNA. Translation: EAW76256.1.
CH471077 Genomic DNA. Translation: EAW76257.1.
BC035639 mRNA. Translation: AAH35639.1.
CCDSiCCDS13240.1.
RefSeqiNP_067025.1. NM_021202.1.
XP_005260533.1. XM_005260476.2.
XP_011527254.1. XM_011528952.1.
XP_011527255.1. XM_011528953.1.
UniGeneiHs.516994.

3D structure databases

ProteinModelPortaliQ8IXH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121809. 2 interactions.
IntActiQ8IXH6. 2 interactions.
MINTiMINT-7714266.
STRINGi9606.ENSP00000363942.

PTM databases

iPTMnetiQ8IXH6.
PhosphoSiteiQ8IXH6.

Polymorphism and mutation databases

BioMutaiTP53INP2.

Proteomic databases

MaxQBiQ8IXH6.
PaxDbiQ8IXH6.
PeptideAtlasiQ8IXH6.
PRIDEiQ8IXH6.

Protocols and materials databases

DNASUi58476.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374809; ENSP00000363942; ENSG00000078804.
ENST00000374810; ENSP00000363943; ENSG00000078804.
GeneIDi58476.
KEGGihsa:58476.
UCSCiuc002xau.2. human.

Organism-specific databases

CTDi58476.
GeneCardsiTP53INP2.
HGNCiHGNC:16104. TP53INP2.
HPAiHPA052974.
neXtProtiNX_Q8IXH6.
PharmGKBiPA25650.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXBP. Eukaryota.
ENOG4111S9D. LUCA.
GeneTreeiENSGT00530000063829.
HOGENOMiHOG000010288.
HOVERGENiHBG055647.
InParanoidiQ8IXH6.
OMAiSKNQGSF.
OrthoDBiEOG7MSMPN.
PhylomeDBiQ8IXH6.
TreeFamiTF333017.

Enzyme and pathway databases

SIGNORiQ8IXH6.

Miscellaneous databases

ChiTaRSiTP53INP2. human.
GenomeRNAii58476.
PROiQ8IXH6.

Gene expression databases

BgeeiQ8IXH6.
CleanExiHS_TP53INP2.
ExpressionAtlasiQ8IXH6. baseline and differential.
GenevisibleiQ8IXH6. HS.

Family and domain databases

InterProiIPR029431. TP53INP.
IPR029558. TP53INP2.
[Graphical view]
PANTHERiPTHR31671. PTHR31671. 1 hit.
PTHR31671:SF2. PTHR31671:SF2. 1 hit.
PfamiPF14839. DOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH THRA.
    Tissue: Heart.
  2. "PIG-U is a novel oncogene in human bladder cancer."
    Guo Z., Wu G., Sidransky D., Trink B.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "TP53INP2 is the new guest at the table of self-eating."
    Nowak J., Iovanna J.L.
    Autophagy 5:383-384(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH VMP1; GABARAP; GABARAPL2 AND MAP1LC3A.
  10. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
    Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
    PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GABARAP; GABARAPL1; GABARAPL2; MAP1LC3A; MAP1LC3B AND MAP1LC3C.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiT53I2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXH6
Secondary accession number(s): A8K8S8
, E1P5P6, Q5JX64, Q8IYL5, Q9NU00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: July 6, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.