Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor protein p53-inducible nuclear protein 2

Gene

TP53INP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processAutophagy, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ8IXH6

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p53-inducible nuclear protein 2
Alternative name(s):
Diabetes and obesity-regulated gene
p53-inducible protein U
Short name:
PIG-U
Gene namesi
Name:TP53INP2
Synonyms:C20orf110, DOR, PINH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000078804.12
HGNCiHGNC:16104 TP53INP2
MIMi617549 gene
neXtProtiNX_Q8IXH6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi58476
OpenTargetsiENSG00000078804
PharmGKBiPA25650

Polymorphism and mutation databases

BioMutaiTP53INP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724091 – 220Tumor protein p53-inducible nuclear protein 2Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IXH6
PaxDbiQ8IXH6
PeptideAtlasiQ8IXH6
PRIDEiQ8IXH6

PTM databases

iPTMnetiQ8IXH6
PhosphoSitePlusiQ8IXH6

Expressioni

Gene expression databases

BgeeiENSG00000078804
CleanExiHS_TP53INP2
ExpressionAtlasiQ8IXH6 baseline and differential
GenevisibleiQ8IXH6 HS

Interactioni

Subunit structurei

Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121809, 2 interactors
IntActiQ8IXH6, 2 interactors
MINTiQ8IXH6
STRINGi9606.ENSP00000363942

Structurei

3D structure databases

ProteinModelPortaliQ8IXH6
SMRiQ8IXH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi26 – 41LIRAdd BLAST16

Domaini

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.

Phylogenomic databases

eggNOGiENOG410IXBP Eukaryota
ENOG4111S9D LUCA
GeneTreeiENSGT00530000063829
HOGENOMiHOG000010288
HOVERGENiHBG055647
InParanoidiQ8IXH6
KOiK21247
OMAiEDPECPR
OrthoDBiEOG091G0FZC
PhylomeDBiQ8IXH6
TreeFamiTF333017

Family and domain databases

InterProiView protein in InterPro
IPR029431 TP53INP
IPR029558 TP53INP2
PANTHERiPTHR31671 PTHR31671, 1 hit
PTHR31671:SF2 PTHR31671:SF2, 1 hit
PfamiView protein in Pfam
PF14839 DOR, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IXH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQRLSSLFF STPSPPEDPD CPRAFVSEED EVDGWLIIDL PDSYAAPPSP
60 70 80 90 100
GAAPAPAGRP PPAPSLMDES WFVTPPACFT AEGPGLGPAR LQSSPLEDLL
110 120 130 140 150
IEHPSMSVYV TGSTIVLEPG SPSPLPDAAL PDGDLSEGEL TPARREPRAA
160 170 180 190 200
RHAAPLPARA ALLEKAGQVR RLQRARQRAE RHALSAKAVQ RQNRARESRP
210 220
RRSKNQSSFI YQPCQRQFNY
Length:220
Mass (Da):23,980
Last modified:July 11, 2003 - v2
Checksum:iD64E010B2F68A705
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136S → N in CAC82592 (PubMed:18030323).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297792 mRNA Translation: CAC82592.1
AY422170 mRNA Translation: AAR23799.1
AK292443 mRNA Translation: BAF85132.1
AL109824 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76256.1
CH471077 Genomic DNA Translation: EAW76257.1
BC035639 mRNA Translation: AAH35639.1
CCDSiCCDS13240.1
RefSeqiNP_001316358.1, NM_001329429.1
NP_001316359.1, NM_001329430.1
NP_001316360.1, NM_001329431.1
NP_067025.1, NM_021202.2
UniGeneiHs.516994

Genome annotation databases

EnsembliENST00000374809; ENSP00000363942; ENSG00000078804
ENST00000374810; ENSP00000363943; ENSG00000078804
GeneIDi58476
KEGGihsa:58476
UCSCiuc002xau.2 human

Similar proteinsi

Entry informationi

Entry nameiT53I2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXH6
Secondary accession number(s): A8K8S8
, E1P5P6, Q5JX64, Q8IYL5, Q9NU00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: February 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health