ID AQ12A_HUMAN Reviewed; 295 AA. AC Q8IXF9; DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 24-JAN-2024, entry version 133. DE RecName: Full=Aquaporin-12A; DE Short=AQP-12; GN Name=AQP12A; Synonyms=AQP12, AQPX2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pancreas; RX PubMed=15809071; DOI=10.1016/j.bbrc.2005.03.046; RA Itoh T., Rai T., Kuwahara M., Ko S.B., Uchida S., Sasaki S., Ishibashi K.; RT "Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar RT cells."; RL Biochem. Biophys. Res. Commun. 330:832-838(2005). RN [2] RP TISSUE SPECIFICITY. RA Ishibashi K., Kuwahara M., Kageyama Y., Sasaki S., Suzuki M., Imai M.; RT "Molecular cloning of a new aquaporin superfamily in mammals: AQPX1 and RT AQPX2."; RL (In) Hohmann S., Nielsen S. (eds.); RL Molecular biology and physiology of water and solute transport, pp.123-126, RL Kluwer Academic/Plenum Publishers, New York. (2000). CC -!- FUNCTION: Aquaporins facilitate the transport of water and small CC neutral solutes across cell membranes. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Restricted to the pancreas. {ECO:0000269|Ref.2}. CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three CC membrane-spanning domains and a pore-forming loop with the signature CC motif Asn-Pro-Ala (NPA). CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB040748; BAC45006.1; -; mRNA. DR RefSeq; NP_945349.1; NM_198998.2. DR AlphaFoldDB; Q8IXF9; -. DR SMR; Q8IXF9; -. DR STRING; 9606.ENSP00000405899; -. DR TCDB; 1.A.8.4.2; the major intrinsic protein (mip) family. DR PhosphoSitePlus; Q8IXF9; -. DR BioMuta; AQP12A; -. DR DMDM; 47115836; -. DR MassIVE; Q8IXF9; -. DR PaxDb; 9606-ENSP00000405899; -. DR PeptideAtlas; Q8IXF9; -. DR Antibodypedia; 54747; 82 antibodies from 19 providers. DR DNASU; 375318; -. DR Ensembl; ENST00000337801.9; ENSP00000337144.4; ENSG00000184945.15. DR GeneID; 375318; -. DR KEGG; hsa:375318; -. DR MANE-Select; ENST00000337801.9; ENSP00000337144.4; NM_198998.3; NP_945349.1. DR UCSC; uc002vzu.3; human. DR AGR; HGNC:19941; -. DR CTD; 375318; -. DR DisGeNET; 375318; -. DR GeneCards; AQP12A; -. DR HGNC; HGNC:19941; AQP12A. DR HPA; ENSG00000184945; Tissue enriched (pancreas). DR MIM; 609789; gene. DR neXtProt; NX_Q8IXF9; -. DR OpenTargets; ENSG00000184945; -. DR PharmGKB; PA134977417; -. DR VEuPathDB; HostDB:ENSG00000184945; -. DR eggNOG; ENOG502RYFD; Eukaryota. DR GeneTree; ENSGT00530000063816; -. DR HOGENOM; CLU_074449_3_0_1; -. DR InParanoid; Q8IXF9; -. DR OrthoDB; 5386092at2759; -. DR PhylomeDB; Q8IXF9; -. DR TreeFam; TF320251; -. DR PathwayCommons; Q8IXF9; -. DR Reactome; R-HSA-432047; Passive transport by Aquaporins. DR SignaLink; Q8IXF9; -. DR BioGRID-ORCS; 375318; 5 hits in 207 CRISPR screens. DR GenomeRNAi; 375318; -. DR Pharos; Q8IXF9; Tbio. DR PRO; PR:Q8IXF9; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q8IXF9; Protein. DR Bgee; ENSG00000184945; Expressed in body of pancreas and 65 other cell types or tissues. DR ExpressionAtlas; Q8IXF9; baseline. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015267; F:channel activity; IBA:GO_Central. DR GO; GO:0015250; F:water channel activity; IEA:UniProt. DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1. DR InterPro; IPR023271; Aquaporin-like. DR InterPro; IPR016697; Aquaporin_11/12. DR InterPro; IPR023265; Aquaporin_12. DR InterPro; IPR000425; MIP. DR PANTHER; PTHR21191; AQUAPORIN; 1. DR PANTHER; PTHR21191:SF8; AQUAPORIN-12A-RELATED; 1. DR Pfam; PF00230; MIP; 1. DR PIRSF; PIRSF017529; Aquaporin_11/12; 1. DR PRINTS; PR02025; AQUAPORIN12. DR PRINTS; PR00783; MINTRINSICP. DR SUPFAM; SSF81338; Aquaporin-like; 1. DR Genevisible; Q8IXF9; HS. PE 2: Evidence at transcript level; KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; KW Transport. FT CHAIN 1..295 FT /note="Aquaporin-12A" FT /id="PRO_0000063971" FT TRANSMEM 1..21 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TRANSMEM 55..75 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TRANSMEM 100..126 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TRANSMEM 146..166 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TRANSMEM 179..199 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TRANSMEM 216..236 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT REGION 257..295 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 81..83 FT /note="NPA 1" FT MOTIF 200..202 FT /note="NPA 2" SQ SEQUENCE 295 AA; 31475 MW; 67F1AF50DB977CDE CRC64; MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEQSLPGTL LKLAAQGLGM QAACTLMRLC WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS //