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Q8IXF9 (AQ12A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aquaporin-12A

Short name=AQP-12
Gene names
Name:AQP12A
Synonyms:AQP12, AQPX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Restricted to the pancreas. Ref.2

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Aquaporin-12A
PRO_0000063971

Regions

Transmembrane1 – 2121Helical; Name=1; Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Transmembrane100 – 12627Helical; Name=3; Potential
Transmembrane146 – 16621Helical; Name=4; Potential
Transmembrane179 – 19921Helical; Name=5; Potential
Transmembrane216 – 23621Helical; Name=6; Potential
Motif81 – 833NPA 1
Motif200 – 2023NPA 2

Sequences

Sequence LengthMass (Da)Tools
Q8IXF9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 67F1AF50DB977CDE

FASTA29531,475
        10         20         30         40         50         60 
MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL 

        70         80         90        100        110        120 
LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEQSLPGTL LKLAAQGLGM QAACTLMRLC 

       130        140        150        160        170        180 
WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV 

       190        200        210        220        230        240 
ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG 

       250        260        270        280        290 
RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS 

« Hide

References

[1]"Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells."
Itoh T., Rai T., Kuwahara M., Ko S.B., Uchida S., Sasaki S., Ishibashi K.
Biochem. Biophys. Res. Commun. 330:832-838(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
[2]"Molecular cloning of a new aquaporin superfamily in mammals: AQPX1 and AQPX2."
Ishibashi K., Kuwahara M., Kageyama Y., Sasaki S., Suzuki M., Imai M.
(In) Hohmann S., Nielsen S. (eds.); Molecular biology and physiology of water and solute transport, pp.123-126, Kluwer Academic/Plenum Publishers, New York. (2000)
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB040748 mRNA. Translation: BAC45006.1.
RefSeqNP_945349.1. NM_198998.2.
UniGeneHs.534650.

3D structure databases

ProteinModelPortalQ8IXF9.
SMRQ8IXF9. Positions 57-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000337144.

Protein family/group databases

TCDB1.A.8.17.2. the major intrinsic protein (mip) family.

Polymorphism databases

DMDM47115836.

Proteomic databases

PaxDbQ8IXF9.
PRIDEQ8IXF9.

Protocols and materials databases

DNASU375318.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000337801; ENSP00000337144; ENSG00000184945.
GeneID375318.
KEGGhsa:375318.
UCSCuc002vzu.3. human.

Organism-specific databases

CTD375318.
GeneCardsGC02P241632.
H-InvDBHIX0024040.
HGNCHGNC:19941. AQP12A.
HPAHPA042216.
MIM609789. gene.
neXtProtNX_Q8IXF9.
PharmGKBPA134977417.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46671.
HOGENOMHOG000034023.
HOVERGENHBG050557.
InParanoidQ8IXF9.
KOK09871.
OrthoDBEOG7327QH.
PhylomeDBQ8IXF9.
TreeFamTF320251.

Gene expression databases

BgeeQ8IXF9.
CleanExHS_AQP12A.
GenevestigatorQ8IXF9.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
InterProIPR023271. Aquaporin-like.
IPR016697. Aquaporin_11/12.
IPR023265. Aquaporin_12.
IPR000425. MIP.
[Graphical view]
PANTHERPTHR21191:SF8. PTHR21191:SF8. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PIRSFPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSPR02025. AQUAPORIN12.
PR00783. MINTRINSICP.
SUPFAMSSF81338. SSF81338. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi375318.
NextBio100478.
PROQ8IXF9.
SOURCESearch...

Entry information

Entry nameAQ12A_HUMAN
AccessionPrimary (citable) accession number: Q8IXF9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM