Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IXF9

- AQ12A_HUMAN

UniProt

Q8IXF9 - AQ12A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Aquaporin-12A

Gene

AQP12A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi1.A.8.17.2. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-12A
Short name:
AQP-12
Gene namesi
Name:AQP12A
Synonyms:AQP12, AQPX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:19941. AQP12A.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Aquaporin-12APRO_0000063971Add
BLAST

Proteomic databases

PaxDbiQ8IXF9.
PRIDEiQ8IXF9.

Expressioni

Tissue specificityi

Restricted to the pancreas.1 Publication

Gene expression databases

BgeeiQ8IXF9.
CleanExiHS_AQP12A.
ExpressionAtlasiQ8IXF9. baseline.
GenevestigatoriQ8IXF9.

Organism-specific databases

HPAiHPA042216.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000337144.

Structurei

3D structure databases

ProteinModelPortaliQ8IXF9.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12627Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 833NPA 1
Motifi200 – 2023NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46671.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034023.
HOVERGENiHBG050557.
InParanoidiQ8IXF9.
KOiK09871.
OrthoDBiEOG7327QH.
PhylomeDBiQ8IXF9.
TreeFamiTF320251.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR016697. Aquaporin_11/12.
IPR023265. Aquaporin_12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF8. PTHR21191:SF8. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02025. AQUAPORIN12.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IXF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AMRTLVELGP
60 70 80 90 100
WAGDFGPDLL LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEQSLPGTL
110 120 130 140 150
LKLAAQGLGM QAACTLMRLC WAWELSDLHL LQSLMAQSCS SALRTSVPHG
160 170 180 190 200
ALVEAACAFC FHLTLLHLRH SPPAYSGPAV ALLVTVTAYT AGPFTSAFFN
210 220 230 240 250
PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG RLPHLFQRNL
260 270 280 290
FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS
Length:295
Mass (Da):31,475
Last modified:March 1, 2003 - v1
Checksum:i67F1AF50DB977CDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040748 mRNA. Translation: BAC45006.1.
RefSeqiNP_945349.1. NM_198998.2.
UniGeneiHs.534650.

Genome annotation databases

EnsembliENST00000337801; ENSP00000337144; ENSG00000184945.
GeneIDi375318.
KEGGihsa:375318.
UCSCiuc002vzu.3. human.

Polymorphism databases

DMDMi47115836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040748 mRNA. Translation: BAC45006.1 .
RefSeqi NP_945349.1. NM_198998.2.
UniGenei Hs.534650.

3D structure databases

ProteinModelPortali Q8IXF9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000337144.

Protein family/group databases

TCDBi 1.A.8.17.2. the major intrinsic protein (mip) family.

Polymorphism databases

DMDMi 47115836.

Proteomic databases

PaxDbi Q8IXF9.
PRIDEi Q8IXF9.

Protocols and materials databases

DNASUi 375318.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337801 ; ENSP00000337144 ; ENSG00000184945 .
GeneIDi 375318.
KEGGi hsa:375318.
UCSCi uc002vzu.3. human.

Organism-specific databases

CTDi 375318.
GeneCardsi GC02P241632.
H-InvDB HIX0024040.
HGNCi HGNC:19941. AQP12A.
HPAi HPA042216.
MIMi 609789. gene.
neXtProti NX_Q8IXF9.
PharmGKBi PA134977417.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46671.
GeneTreei ENSGT00530000063816.
HOGENOMi HOG000034023.
HOVERGENi HBG050557.
InParanoidi Q8IXF9.
KOi K09871.
OrthoDBi EOG7327QH.
PhylomeDBi Q8IXF9.
TreeFami TF320251.

Miscellaneous databases

GenomeRNAii 375318.
NextBioi 100478.
PROi Q8IXF9.
SOURCEi Search...

Gene expression databases

Bgeei Q8IXF9.
CleanExi HS_AQP12A.
ExpressionAtlasi Q8IXF9. baseline.
Genevestigatori Q8IXF9.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR016697. Aquaporin_11/12.
IPR023265. Aquaporin_12.
IPR000425. MIP.
[Graphical view ]
PANTHERi PTHR21191:SF8. PTHR21191:SF8. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PIRSFi PIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSi PR02025. AQUAPORIN12.
PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells."
    Itoh T., Rai T., Kuwahara M., Ko S.B., Uchida S., Sasaki S., Ishibashi K.
    Biochem. Biophys. Res. Commun. 330:832-838(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "Molecular cloning of a new aquaporin superfamily in mammals: AQPX1 and AQPX2."
    Ishibashi K., Kuwahara M., Kageyama Y., Sasaki S., Suzuki M., Imai M.
    (In) Hohmann S., Nielsen S. (eds.); Molecular biology and physiology of water and solute transport, pp.123-126, Kluwer Academic/Plenum Publishers, New York. (2000)
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiAQ12A_HUMAN
AccessioniPrimary (citable) accession number: Q8IXF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3