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Q8IXF9

- AQ12A_HUMAN

UniProt

Q8IXF9 - AQ12A_HUMAN

Protein

Aquaporin-12A

Gene

AQP12A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi1.A.8.17.2. the major intrinsic protein (mip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin-12A
    Short name:
    AQP-12
    Gene namesi
    Name:AQP12A
    Synonyms:AQP12, AQPX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:19941. AQP12A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977417.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Aquaporin-12APRO_0000063971Add
    BLAST

    Proteomic databases

    PaxDbiQ8IXF9.
    PRIDEiQ8IXF9.

    Expressioni

    Tissue specificityi

    Restricted to the pancreas.1 Publication

    Gene expression databases

    BgeeiQ8IXF9.
    CleanExiHS_AQP12A.
    GenevestigatoriQ8IXF9.

    Organism-specific databases

    HPAiHPA042216.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000337144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IXF9.
    SMRiQ8IXF9. Positions 57-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12627Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi81 – 833NPA 1
    Motifi200 – 2023NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46671.
    HOGENOMiHOG000034023.
    HOVERGENiHBG050557.
    InParanoidiQ8IXF9.
    KOiK09871.
    OrthoDBiEOG7327QH.
    PhylomeDBiQ8IXF9.
    TreeFamiTF320251.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR016697. Aquaporin_11/12.
    IPR023265. Aquaporin_12.
    IPR000425. MIP.
    [Graphical view]
    PANTHERiPTHR21191:SF8. PTHR21191:SF8. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
    PRINTSiPR02025. AQUAPORIN12.
    PR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8IXF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AMRTLVELGP    50
    WAGDFGPDLL LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEQSLPGTL 100
    LKLAAQGLGM QAACTLMRLC WAWELSDLHL LQSLMAQSCS SALRTSVPHG 150
    ALVEAACAFC FHLTLLHLRH SPPAYSGPAV ALLVTVTAYT AGPFTSAFFN 200
    PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG RLPHLFQRNL 250
    FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS 295
    Length:295
    Mass (Da):31,475
    Last modified:March 1, 2003 - v1
    Checksum:i67F1AF50DB977CDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040748 mRNA. Translation: BAC45006.1.
    RefSeqiNP_945349.1. NM_198998.2.
    UniGeneiHs.534650.

    Genome annotation databases

    EnsembliENST00000337801; ENSP00000337144; ENSG00000184945.
    GeneIDi375318.
    KEGGihsa:375318.
    UCSCiuc002vzu.3. human.

    Polymorphism databases

    DMDMi47115836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040748 mRNA. Translation: BAC45006.1 .
    RefSeqi NP_945349.1. NM_198998.2.
    UniGenei Hs.534650.

    3D structure databases

    ProteinModelPortali Q8IXF9.
    SMRi Q8IXF9. Positions 57-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000337144.

    Protein family/group databases

    TCDBi 1.A.8.17.2. the major intrinsic protein (mip) family.

    Polymorphism databases

    DMDMi 47115836.

    Proteomic databases

    PaxDbi Q8IXF9.
    PRIDEi Q8IXF9.

    Protocols and materials databases

    DNASUi 375318.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337801 ; ENSP00000337144 ; ENSG00000184945 .
    GeneIDi 375318.
    KEGGi hsa:375318.
    UCSCi uc002vzu.3. human.

    Organism-specific databases

    CTDi 375318.
    GeneCardsi GC02P241632.
    H-InvDB HIX0024040.
    HGNCi HGNC:19941. AQP12A.
    HPAi HPA042216.
    MIMi 609789. gene.
    neXtProti NX_Q8IXF9.
    PharmGKBi PA134977417.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46671.
    HOGENOMi HOG000034023.
    HOVERGENi HBG050557.
    InParanoidi Q8IXF9.
    KOi K09871.
    OrthoDBi EOG7327QH.
    PhylomeDBi Q8IXF9.
    TreeFami TF320251.

    Miscellaneous databases

    GenomeRNAii 375318.
    NextBioi 100478.
    PROi Q8IXF9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IXF9.
    CleanExi HS_AQP12A.
    Genevestigatori Q8IXF9.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR016697. Aquaporin_11/12.
    IPR023265. Aquaporin_12.
    IPR000425. MIP.
    [Graphical view ]
    PANTHERi PTHR21191:SF8. PTHR21191:SF8. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017529. Aquaporin_11/12. 1 hit.
    PRINTSi PR02025. AQUAPORIN12.
    PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells."
      Itoh T., Rai T., Kuwahara M., Ko S.B., Uchida S., Sasaki S., Ishibashi K.
      Biochem. Biophys. Res. Commun. 330:832-838(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    2. "Molecular cloning of a new aquaporin superfamily in mammals: AQPX1 and AQPX2."
      Ishibashi K., Kuwahara M., Kageyama Y., Sasaki S., Suzuki M., Imai M.
      (In) Hohmann S., Nielsen S. (eds.); Molecular biology and physiology of water and solute transport, pp.123-126, Kluwer Academic/Plenum Publishers, New York. (2000)
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAQ12A_HUMAN
    AccessioniPrimary (citable) accession number: Q8IXF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3