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Protein

Aquaporin-12A

Gene

AQP12A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi1.A.8.17.2. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-12A
Short name:
AQP-12
Gene namesi
Name:AQP12A
Synonyms:AQP12, AQPX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19941. AQP12A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12627Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977417.

Polymorphism and mutation databases

BioMutaiAQP12A.
DMDMi47115836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Aquaporin-12APRO_0000063971Add
BLAST

Proteomic databases

PaxDbiQ8IXF9.
PRIDEiQ8IXF9.

Expressioni

Tissue specificityi

Restricted to the pancreas.1 Publication

Gene expression databases

BgeeiQ8IXF9.
CleanExiHS_AQP12A.
ExpressionAtlasiQ8IXF9. baseline.
GenevisibleiQ8IXF9. HS.

Organism-specific databases

HPAiHPA042216.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000337144.

Structurei

3D structure databases

ProteinModelPortaliQ8IXF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 833NPA 1
Motifi200 – 2023NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46671.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034023.
HOVERGENiHBG050557.
InParanoidiQ8IXF9.
KOiK09871.
OrthoDBiEOG7327QH.
PhylomeDBiQ8IXF9.
TreeFamiTF320251.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR016697. Aquaporin_11/12.
IPR023265. Aquaporin_12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF8. PTHR21191:SF8. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02025. AQUAPORIN12.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IXF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AMRTLVELGP
60 70 80 90 100
WAGDFGPDLL LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEQSLPGTL
110 120 130 140 150
LKLAAQGLGM QAACTLMRLC WAWELSDLHL LQSLMAQSCS SALRTSVPHG
160 170 180 190 200
ALVEAACAFC FHLTLLHLRH SPPAYSGPAV ALLVTVTAYT AGPFTSAFFN
210 220 230 240 250
PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG RLPHLFQRNL
260 270 280 290
FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS
Length:295
Mass (Da):31,475
Last modified:March 1, 2003 - v1
Checksum:i67F1AF50DB977CDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040748 mRNA. Translation: BAC45006.1.
RefSeqiNP_945349.1. NM_198998.2.
UniGeneiHs.534650.

Genome annotation databases

EnsembliENST00000337801; ENSP00000337144; ENSG00000184945.
GeneIDi375318.
KEGGihsa:375318.
UCSCiuc002vzu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040748 mRNA. Translation: BAC45006.1.
RefSeqiNP_945349.1. NM_198998.2.
UniGeneiHs.534650.

3D structure databases

ProteinModelPortaliQ8IXF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000337144.

Protein family/group databases

TCDBi1.A.8.17.2. the major intrinsic protein (mip) family.

Polymorphism and mutation databases

BioMutaiAQP12A.
DMDMi47115836.

Proteomic databases

PaxDbiQ8IXF9.
PRIDEiQ8IXF9.

Protocols and materials databases

DNASUi375318.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337801; ENSP00000337144; ENSG00000184945.
GeneIDi375318.
KEGGihsa:375318.
UCSCiuc002vzu.3. human.

Organism-specific databases

CTDi375318.
GeneCardsiGC02P241632.
H-InvDBHIX0024040.
HGNCiHGNC:19941. AQP12A.
HPAiHPA042216.
MIMi609789. gene.
neXtProtiNX_Q8IXF9.
PharmGKBiPA134977417.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46671.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034023.
HOVERGENiHBG050557.
InParanoidiQ8IXF9.
KOiK09871.
OrthoDBiEOG7327QH.
PhylomeDBiQ8IXF9.
TreeFamiTF320251.

Miscellaneous databases

GenomeRNAii375318.
NextBioi100478.
PROiQ8IXF9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IXF9.
CleanExiHS_AQP12A.
ExpressionAtlasiQ8IXF9. baseline.
GenevisibleiQ8IXF9. HS.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR016697. Aquaporin_11/12.
IPR023265. Aquaporin_12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF8. PTHR21191:SF8. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02025. AQUAPORIN12.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells."
    Itoh T., Rai T., Kuwahara M., Ko S.B., Uchida S., Sasaki S., Ishibashi K.
    Biochem. Biophys. Res. Commun. 330:832-838(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "Molecular cloning of a new aquaporin superfamily in mammals: AQPX1 and AQPX2."
    Ishibashi K., Kuwahara M., Kageyama Y., Sasaki S., Suzuki M., Imai M.
    (In) Hohmann S., Nielsen S. (eds.); Molecular biology and physiology of water and solute transport, pp.123-126, Kluwer Academic/Plenum Publishers, New York. (2000)
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiAQ12A_HUMAN
AccessioniPrimary (citable) accession number: Q8IXF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.