Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 4N5

Gene

OR4N5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31165-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4N5
Alternative name(s):
Olfactory receptor OR14-33
Gene namesi
Name:OR4N5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15358. OR4N5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 308CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184394.
PharmGKBiPA32333.

Polymorphism and mutation databases

BioMutaiOR4N5.
DMDMi37081339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505651 – 308Olfactory receptor 4N5Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IXE1.
PRIDEiQ8IXE1.

PTM databases

iPTMnetiQ8IXE1.
PhosphoSitePlusiQ8IXE1.

Expressioni

Gene expression databases

CleanExiHS_OR4N5.
ExpressionAtlasiQ8IXE1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332110.

Structurei

3D structure databases

ProteinModelPortaliQ8IXE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKKT. Eukaryota.
ENOG41117FS. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8IXE1.
KOiK04257.
OMAiILCRIRE.
OrthoDBiEOG091G0FBN.
PhylomeDBiQ8IXE1.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IXE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQNLTVVT EFILLGLTQS QDAQLLVFVL VLIFYLIILP GNFLIIFTIK
60 70 80 90 100
SDPGLTAPLY FFLGNLALLD ASYSFIVVPR MLVDFLSEKK VISYRSCITQ
110 120 130 140 150
LFFLHFLGAG EMFLLVVMAF DRYIAICRPL HYSTIMNPRA CYALSLVLWL
160 170 180 190 200
GGFIHSIVQV ALILHLPFCG PNQLDNFFCD VPQVIKLACT NTFVVELLMV
210 220 230 240 250
SNSGLLSLLC FLGLLASYAV ILCRIREHSS EGKSKAISTC TTHIIIIFLM
260 270 280 290 300
FGPAIFIYTC PFQAFPADKV VSLFHTVIFP LMNPVIYTLR NQEVKASMRK

LLSQHMFC
Length:308
Mass (Da):34,696
Last modified:March 1, 2003 - v1
Checksum:i4A123FBB723822BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024095191N → D.Corresponds to variant rs10131326dbSNPEnsembl.1
Natural variantiVAR_034208234S → T.Corresponds to variant rs10140908dbSNPEnsembl.1
Natural variantiVAR_034209260C → R.Corresponds to variant rs10134472dbSNPEnsembl.1
Natural variantiVAR_053175290R → H.Corresponds to variant rs10141025dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065890 Genomic DNA. Translation: BAC45262.1.
BK004451 Genomic DNA. Translation: DAA04849.1.
CCDSiCCDS32031.1.
RefSeqiNP_001004724.1. NM_001004724.1.
UniGeneiHs.553766.

Genome annotation databases

EnsembliENST00000333629; ENSP00000332110; ENSG00000184394.
GeneIDi390437.
KEGGihsa:390437.
UCSCiuc010tla.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065890 Genomic DNA. Translation: BAC45262.1.
BK004451 Genomic DNA. Translation: DAA04849.1.
CCDSiCCDS32031.1.
RefSeqiNP_001004724.1. NM_001004724.1.
UniGeneiHs.553766.

3D structure databases

ProteinModelPortaliQ8IXE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332110.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8IXE1.
PhosphoSitePlusiQ8IXE1.

Polymorphism and mutation databases

BioMutaiOR4N5.
DMDMi37081339.

Proteomic databases

PaxDbiQ8IXE1.
PRIDEiQ8IXE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333629; ENSP00000332110; ENSG00000184394.
GeneIDi390437.
KEGGihsa:390437.
UCSCiuc010tla.2. human.

Organism-specific databases

CTDi390437.
GeneCardsiOR4N5.
H-InvDBHIX0211293.
HGNCiHGNC:15358. OR4N5.
neXtProtiNX_Q8IXE1.
OpenTargetsiENSG00000184394.
PharmGKBiPA32333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKT. Eukaryota.
ENOG41117FS. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8IXE1.
KOiK04257.
OMAiILCRIRE.
OrthoDBiEOG091G0FBN.
PhylomeDBiQ8IXE1.
TreeFamiTF338273.

Enzyme and pathway databases

BioCyciZFISH:G66-31165-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4N5.
GenomeRNAii390437.
PROiQ8IXE1.

Gene expression databases

CleanExiHS_OR4N5.
ExpressionAtlasiQ8IXE1. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4N5_HUMAN
AccessioniPrimary (citable) accession number: Q8IXE1
Secondary accession number(s): Q6IF11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.