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Protein

Tumor suppressor candidate 5

Gene

TUSC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in fat metabolism.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 5
Alternative name(s):
Dispanin subfamily B member 1
Short name:
DSPB1
Interferon-induced transmembrane domain-containing protein D3
Protein located at seventeen-p-thirteen point three 1
Gene namesi
Name:TUSC5
Synonyms:IFITMD3, LOST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29592. TUSC5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 105105ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 15327CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Topological domaini175 – 1773ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868023.

Polymorphism and mutation databases

BioMutaiTUSC5.
DMDMi229462764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Tumor suppressor candidate 5PRO_0000263639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei87 – 871PhosphoserineBy similarity
Modified residuei88 – 881PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IXB3.
PeptideAtlasiQ8IXB3.
PRIDEiQ8IXB3.

PTM databases

iPTMnetiQ8IXB3.
PhosphoSiteiQ8IXB3.

Expressioni

Tissue specificityi

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.1 Publication

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiQ8IXB3.
CleanExiHS_TUSC5.
GenevisibleiQ8IXB3. HS.

Organism-specific databases

HPAiHPA050825.

Interactioni

Protein-protein interaction databases

BioGridi130417. 8 interactions.
STRINGi9606.ENSP00000329548.

Structurei

3D structure databases

ProteinModelPortaliQ8IXB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYHE. Eukaryota.
ENOG4111PC3. LUCA.
GeneTreeiENSGT00530000063980.
HOGENOMiHOG000261613.
HOVERGENiHBG094099.
InParanoidiQ8IXB3.
OMAiMSRSSMQ.
OrthoDBiEOG7QK0FC.
PhylomeDBiQ8IXB3.
TreeFamiTF333012.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IXB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPVQSEFP SAQEPGSAAF LDLPEMEILL TKAENKDDKT LNLSKTLSGP
60 70 80 90 100
LDLEQNSQGL PFKAISEGHL EAPLPRSPSR ASSRRASSIA TTSYAQDQEA
110 120 130 140 150
PRDYLILAVV ACFCPVWPLN LIPLIISIMS RSSMQQGNVD GARRLGRLAR
160 170
LLSITLIIMG IVIIMVAVTV NFTVQKK
Length:177
Mass (Da):19,254
Last modified:May 5, 2009 - v2
Checksum:iFCF701E12EDA70A5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31H → Y.1 Publication
Corresponds to variant rs75616699 [ dbSNP | Ensembl ].
VAR_029589
Natural varianti15 – 151P → S.1 Publication
Corresponds to variant rs111587833 [ dbSNP | Ensembl ].
VAR_029590
Natural varianti18 – 181A → T.1 Publication
Corresponds to variant rs111701043 [ dbSNP | Ensembl ].
VAR_029591
Natural varianti20 – 201F → S.1 Publication
Corresponds to variant rs6502774 [ dbSNP | Ensembl ].
VAR_029592
Natural varianti34 – 341E → D.1 Publication
Corresponds to variant rs75025906 [ dbSNP | Ensembl ].
VAR_029593
Natural varianti57 – 571S → G.1 Publication
Corresponds to variant rs6502776 [ dbSNP | Ensembl ].
VAR_029594

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090231 mRNA. Translation: BAC43751.1.
AC032044 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90630.1.
CCDSiCCDS42225.1.
RefSeqiNP_758955.2. NM_172367.2.
UniGeneiHs.146059.

Genome annotation databases

EnsembliENST00000333813; ENSP00000329548; ENSG00000184811.
GeneIDi286753.
KEGGihsa:286753.
UCSCiuc002fsi.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090231 mRNA. Translation: BAC43751.1.
AC032044 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90630.1.
CCDSiCCDS42225.1.
RefSeqiNP_758955.2. NM_172367.2.
UniGeneiHs.146059.

3D structure databases

ProteinModelPortaliQ8IXB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130417. 8 interactions.
STRINGi9606.ENSP00000329548.

PTM databases

iPTMnetiQ8IXB3.
PhosphoSiteiQ8IXB3.

Polymorphism and mutation databases

BioMutaiTUSC5.
DMDMi229462764.

Proteomic databases

PaxDbiQ8IXB3.
PeptideAtlasiQ8IXB3.
PRIDEiQ8IXB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333813; ENSP00000329548; ENSG00000184811.
GeneIDi286753.
KEGGihsa:286753.
UCSCiuc002fsi.1. human.

Organism-specific databases

CTDi286753.
GeneCardsiTUSC5.
H-InvDBHIX0013398.
HGNCiHGNC:29592. TUSC5.
HPAiHPA050825.
MIMi612211. gene.
neXtProtiNX_Q8IXB3.
PharmGKBiPA134868023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYHE. Eukaryota.
ENOG4111PC3. LUCA.
GeneTreeiENSGT00530000063980.
HOGENOMiHOG000261613.
HOVERGENiHBG094099.
InParanoidiQ8IXB3.
OMAiMSRSSMQ.
OrthoDBiEOG7QK0FC.
PhylomeDBiQ8IXB3.
TreeFamiTF333012.

Miscellaneous databases

ChiTaRSiTUSC5. human.
GenomeRNAii286753.
PROiQ8IXB3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IXB3.
CleanExiHS_TUSC5.
GenevisibleiQ8IXB3. HS.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer."
    Konishi H., Sugiyama M., Mizuno K., Saito H., Yatabe Y., Takahashi T., Osada H., Takahashi T.
    Oncogene 22:1892-1905(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS TYR-3; SER-15; THR-18; SER-20; ASP-34 AND GLY-57.
    Tissue: Lung.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
    Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
    PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiTUSC5_HUMAN
AccessioniPrimary (citable) accession number: Q8IXB3
Secondary accession number(s): A6NMK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 5, 2009
Last modified: July 6, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.