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Protein

Tumor suppressor candidate 5

Gene

TUSC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in fat metabolism.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33928-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 5
Alternative name(s):
Dispanin subfamily B member 1
Short name:
DSPB1
Interferon-induced transmembrane domain-containing protein D3
Protein located at seventeen-p-thirteen point three 1
Gene namesi
Name:TUSC5
Synonyms:IFITMD3, LOST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29592. TUSC5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 105ExtracellularSequence analysisAdd BLAST105
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 153CytoplasmicSequence analysisAdd BLAST27
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 177ExtracellularSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi286753.
OpenTargetsiENSG00000184811.
PharmGKBiPA134868023.

Polymorphism and mutation databases

BioMutaiTUSC5.
DMDMi229462764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636391 – 177Tumor suppressor candidate 5Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IXB3.
PeptideAtlasiQ8IXB3.
PRIDEiQ8IXB3.

PTM databases

iPTMnetiQ8IXB3.
PhosphoSitePlusiQ8IXB3.

Expressioni

Tissue specificityi

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.1 Publication

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000184811.
CleanExiHS_TUSC5.
GenevisibleiQ8IXB3. HS.

Organism-specific databases

HPAiHPA050825.

Interactioni

Protein-protein interaction databases

BioGridi130417. 8 interactors.
STRINGi9606.ENSP00000329548.

Structurei

3D structure databases

ProteinModelPortaliQ8IXB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYHE. Eukaryota.
ENOG4111PC3. LUCA.
GeneTreeiENSGT00530000063980.
HOGENOMiHOG000261613.
HOVERGENiHBG094099.
InParanoidiQ8IXB3.
OMAiMSRSSMQ.
OrthoDBiEOG091G0JH3.
PhylomeDBiQ8IXB3.
TreeFamiTF333012.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IXB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPVQSEFP SAQEPGSAAF LDLPEMEILL TKAENKDDKT LNLSKTLSGP
60 70 80 90 100
LDLEQNSQGL PFKAISEGHL EAPLPRSPSR ASSRRASSIA TTSYAQDQEA
110 120 130 140 150
PRDYLILAVV ACFCPVWPLN LIPLIISIMS RSSMQQGNVD GARRLGRLAR
160 170
LLSITLIIMG IVIIMVAVTV NFTVQKK
Length:177
Mass (Da):19,254
Last modified:May 5, 2009 - v2
Checksum:iFCF701E12EDA70A5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0295893H → Y.1 PublicationCorresponds to variant rs75616699dbSNPEnsembl.1
Natural variantiVAR_02959015P → S.1 PublicationCorresponds to variant rs111587833dbSNPEnsembl.1
Natural variantiVAR_02959118A → T.1 PublicationCorresponds to variant rs111701043dbSNPEnsembl.1
Natural variantiVAR_02959220F → S.1 PublicationCorresponds to variant rs6502774dbSNPEnsembl.1
Natural variantiVAR_02959334E → D.1 PublicationCorresponds to variant rs75025906dbSNPEnsembl.1
Natural variantiVAR_02959457S → G.1 PublicationCorresponds to variant rs6502776dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090231 mRNA. Translation: BAC43751.1.
AC032044 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90630.1.
CCDSiCCDS42225.1.
RefSeqiNP_758955.2. NM_172367.2.
UniGeneiHs.146059.

Genome annotation databases

EnsembliENST00000333813; ENSP00000329548; ENSG00000184811.
GeneIDi286753.
KEGGihsa:286753.
UCSCiuc002fsi.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090231 mRNA. Translation: BAC43751.1.
AC032044 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90630.1.
CCDSiCCDS42225.1.
RefSeqiNP_758955.2. NM_172367.2.
UniGeneiHs.146059.

3D structure databases

ProteinModelPortaliQ8IXB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130417. 8 interactors.
STRINGi9606.ENSP00000329548.

PTM databases

iPTMnetiQ8IXB3.
PhosphoSitePlusiQ8IXB3.

Polymorphism and mutation databases

BioMutaiTUSC5.
DMDMi229462764.

Proteomic databases

PaxDbiQ8IXB3.
PeptideAtlasiQ8IXB3.
PRIDEiQ8IXB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333813; ENSP00000329548; ENSG00000184811.
GeneIDi286753.
KEGGihsa:286753.
UCSCiuc002fsi.1. human.

Organism-specific databases

CTDi286753.
DisGeNETi286753.
GeneCardsiTUSC5.
H-InvDBHIX0013398.
HGNCiHGNC:29592. TUSC5.
HPAiHPA050825.
MIMi612211. gene.
neXtProtiNX_Q8IXB3.
OpenTargetsiENSG00000184811.
PharmGKBiPA134868023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYHE. Eukaryota.
ENOG4111PC3. LUCA.
GeneTreeiENSGT00530000063980.
HOGENOMiHOG000261613.
HOVERGENiHBG094099.
InParanoidiQ8IXB3.
OMAiMSRSSMQ.
OrthoDBiEOG091G0JH3.
PhylomeDBiQ8IXB3.
TreeFamiTF333012.

Enzyme and pathway databases

BioCyciZFISH:G66-33928-MONOMER.

Miscellaneous databases

ChiTaRSiTUSC5. human.
GenomeRNAii286753.
PROiQ8IXB3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184811.
CleanExiHS_TUSC5.
GenevisibleiQ8IXB3. HS.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTUSC5_HUMAN
AccessioniPrimary (citable) accession number: Q8IXB3
Secondary accession number(s): A6NMK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.