Reviewed, UniProtKB/Swiss-Prot Q8IXB3 (TUSC5_HUMAN)

Names and origin

Protein names

Recommended name:
    Tumor suppressor candidate 5
Alternative name(s):
    Protein located at seventeen-p-thirteen point three 1

Gene names

Name:	TUSC5
Synonyms:	LOST1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in fat metabolism By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus. Ref.1
Developmental stage	Expressed in fetal brain. Ref.1
Sequence similarities	Belongs to the CD225 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Gene Ontology (GO)
Biological process	response to biotic stimulus Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Tumor suppressor candidate 5		PRO_0000263639
Regions
	Transmembrane	106 – 126	21	Potential
	Transmembrane	154 – 174	21	Potential
Natural variations
	Natural variant	3	1	H → Y Ref.1		VAR_029589
	Natural variant	15	1	P → S Ref.1		VAR_029590
	Natural variant	18	1	A → T Ref.1		VAR_029591
	Natural variant	20	1	F → S: dbSNP rs6502774.		VAR_029592
	Natural variant	34	1	E → D Ref.1		VAR_029593
	Natural variant	57	1	S → G: dbSNP rs6502776.		VAR_029594

Sequences

	Sequence		Length	Mass (Da)
	Q8IXB3-1 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: FCF701E12EDA70A5	FASTA	177	19,254
	10 20 30 40 50 60 MAHPVQSEFP SAQEPGSAAF LDLPEMEILL TKAENKDDKT LNLSKTLSGP LDLEQNSQGL 70 80 90 100 110 120 PFKAISEGHL EAPLPRSPSR ASSRRASSIA TTSYAQDQEA PRDYLILAVV ACFCPVWPLN 130 140 150 160 170 LIPLIISIMS RSSMQQGNVD GARRLGRLAR LLSITLIIMG IVIIMVAVTV NFTVQKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer." Konishi H., Sugiyama M., Mizuno K., Saito H., Yatabe Y., Takahashi T., Osada H., Takahashi T. Oncogene 22:1892-1905(2003) [PubMed: 12660825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS TYR-3; SER-15; THR-18; SER-20; ASP-34 AND GLY-57. Tissue: Lung.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB090231 mRNA. Translation: BAC43751.1. AC032044 Genomic DNA. No translation available. CH471108 Genomic DNA. Translation: EAW90630.1.
IPI	IPI00217491.
RefSeq	NP_758955.2.
UniGene	Hs.146059
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000184811. Homo sapiens. [Contig view]
GeneID	286753.
Organism-specific databases
GeneCards	GC17P001129.
H-InvDB	HIX0013398.
HGNC	HGNC:29592. TUSC5.
PharmGKB	PA134868023.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IXB3.
Gene expression databases
ArrayExpress	Q8IXB3.
Bgee	Q8IXB3.
CleanEx	HS_TUSC5.
Family and domain databases
InterPro	IPR007593. Interferon-induced_TM_protein. [Graphical view]
Pfam	PF04505. CD225. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TUSC5_HUMAN

Accession

Primary (citable) accession number: Q8IXB3
Secondary accession number(s): A6NMK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 5, 2009
Last modified:	June 16, 2009
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)