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Protein

cTAGE family member 4

Gene

CTAGE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tumor-associated antigen.

Enzyme and pathway databases

BioCyciZFISH:G66-31654-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
cTAGE family member 4
Short name:
Protein cTAGE-4
Gene namesi
Name:CTAGE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:24772. CTAGE4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000225932.
PharmGKBiPA134946406.

Polymorphism and mutation databases

BioMutaiCTAGE4.
DMDMi229462987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895401 – 777cTAGE family member 4Add BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei299PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IX94.
MaxQBiQ8IX94.
PaxDbiQ8IX94.
PeptideAtlasiQ8IX94.
PRIDEiQ8IX94.

PTM databases

iPTMnetiQ8IX94.
PhosphoSitePlusiQ8IX94.

Expressioni

Tissue specificityi

Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach.1 Publication

Gene expression databases

CleanExiHS_CTAGE4.
GenevisibleiQ8IX94. HS.

Organism-specific databases

HPAiHPA000387.
HPA000922.

Interactioni

Protein-protein interaction databases

BioGridi936688. 1 interactor.
STRINGi9606.ENSP00000419539.

Structurei

3D structure databases

ProteinModelPortaliQ8IX94.
SMRiQ8IX94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 269Sequence analysisAdd BLAST152
Coiled coili339 – 494Sequence analysisAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi555 – 560Poly-Gly6
Compositional biasi691 – 775Pro-richAdd BLAST85

Sequence similaritiesi

Belongs to the cTAGE family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063635.
HOGENOMiHOG000112043.
HOVERGENiHBG051216.
InParanoidiQ8IX94.
OrthoDBiEOG091G0LUI.
PhylomeDBiQ8IX94.
TreeFamiTF333137.

Sequencei

Sequence statusi: Complete.

Q8IX94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI
60 70 80 90 100
GFFVVLLFLW RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ
110 120 130 140 150
KEYEGYEVES SLEDASFEKA AAEEARSLEA TCEKLNRSNS ELEDEILCLE
160 170 180 190 200
KDLKEEKSKH SQQDELMADI SKSIQSLEDE SKSLKSQIAE AKIICKTFKM
210 220 230 240 250
SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGEVSE LNKQKITFED
260 270 280 290 300
SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
310 320 330 340 350
WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE
360 370 380 390 400
ELTEHIKNLQ TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR
410 420 430 440 450
KLTVEENYRI EEEEKLSRVE EKISRATEGL ETYRKLAKDL EEELERTVHF
460 470 480 490 500
YQKQVISYEK RGHDNWLAAR TAERNLSDLR KENAHNKQKL TETELKFELL
510 520 530 540 550
EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ TLLEDPLRLS
560 570 580 590 600
PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP
610 620 630 640 650
VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL
660 670 680 690 700
DKMDRSMPSE MESSRNDAKD DLGNLNVPDS SLPAENEATG PGLIPPPLAP
710 720 730 740 750
ISGPLFPVDT RGPFMRRGPP FPPPPPGTMF GASRGYFPPR DFPGPPHAPF
760 770
AMRNIYPPRG LPPYLHPRPG FYPNPTF
Length:777
Mass (Da):87,989
Last modified:May 5, 2009 - v3
Checksum:iAEB0C9DBAC58AC8A
GO

Sequence cautioni

The sequence AAN77609 differs from that shown. Reason: Frameshift at positions 643, 646 and 662.Curated
The sequence AAN77609 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155E → Q in BAF84925 (PubMed:14702039).Curated1
Sequence conflicti237E → Q in BAF84925 (PubMed:14702039).Curated1
Sequence conflicti568L → P in BAF84925 (PubMed:14702039).Curated1
Sequence conflicti655R → G in AAN77609 (PubMed:12839582).Curated1
Sequence conflicti662E → G in AAN77609 (PubMed:12839582).Curated1
Sequence conflicti701 – 702IS → VR in BAF84925 (PubMed:14702039).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292236 mRNA. Translation: BAF84925.1.
AC004889 Genomic DNA. No translation available.
AF338232 mRNA. Translation: AAN77609.1. Sequence problems.
CCDSiCCDS55176.1.
RefSeqiNP_001265436.1. NM_001278507.1.
NP_940897.2. NM_198495.2.
UniGeneiHs.645204.
Hs.661442.
Hs.720693.

Genome annotation databases

EnsembliENST00000486333; ENSP00000419539; ENSG00000225932.
GeneIDi100128553.
100142659.
KEGGihsa:100128553.
hsa:100142659.
UCSCiuc010lpc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292236 mRNA. Translation: BAF84925.1.
AC004889 Genomic DNA. No translation available.
AF338232 mRNA. Translation: AAN77609.1. Sequence problems.
CCDSiCCDS55176.1.
RefSeqiNP_001265436.1. NM_001278507.1.
NP_940897.2. NM_198495.2.
UniGeneiHs.645204.
Hs.661442.
Hs.720693.

3D structure databases

ProteinModelPortaliQ8IX94.
SMRiQ8IX94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi936688. 1 interactor.
STRINGi9606.ENSP00000419539.

PTM databases

iPTMnetiQ8IX94.
PhosphoSitePlusiQ8IX94.

Polymorphism and mutation databases

BioMutaiCTAGE4.
DMDMi229462987.

Proteomic databases

EPDiQ8IX94.
MaxQBiQ8IX94.
PaxDbiQ8IX94.
PeptideAtlasiQ8IX94.
PRIDEiQ8IX94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000486333; ENSP00000419539; ENSG00000225932.
GeneIDi100128553.
100142659.
KEGGihsa:100128553.
hsa:100142659.
UCSCiuc010lpc.5. human.

Organism-specific databases

CTDi100128553.
100142659.
GeneCardsiCTAGE4.
H-InvDBHIX0033556.
HIX0151950.
HIX0167845.
HIX0167846.
HGNCiHGNC:24772. CTAGE4.
HPAiHPA000387.
HPA000922.
MIMi608910. gene.
neXtProtiNX_Q8IX94.
OpenTargetsiENSG00000225932.
PharmGKBiPA134946406.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063635.
HOGENOMiHOG000112043.
HOVERGENiHBG051216.
InParanoidiQ8IX94.
OrthoDBiEOG091G0LUI.
PhylomeDBiQ8IX94.
TreeFamiTF333137.

Enzyme and pathway databases

BioCyciZFISH:G66-31654-MONOMER.

Miscellaneous databases

PROiQ8IX94.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CTAGE4.
GenevisibleiQ8IX94. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCTGE4_HUMAN
AccessioniPrimary (citable) accession number: Q8IX94
Secondary accession number(s): A8K871, O95046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.