Unreviewed, UniProtKB/TrEMBL Q8IX89 (Q8IX89_HUMAN)

Names and origin

Protein names

Submitted name:
    Programmed cell death 1 EMBL AAN64003.1
Submitted name:
    cDNA, FLJ94476, highly similar to Homo sapiens programmed cell death 1 (PDCD1), mRNA EMBL BAG36577.1

Gene names

Name:	PDCD1 EMBL AAN64003.1
ORF Names:	hCG_1776289 EMBL EAW71298.1

Organism

Homo sapiens (Human) EMBL AAN64003.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Cellular component	external side of plasma membrane Inferred from electronic annotation. Source: Compara
Molecular function	protein binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IX89-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A5210FD40C304FB7	FASTA	288	31,647
	10 20 30 40 50 60 MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS 70 80 90 100 110 120 ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT 130 140 150 160 170 180 YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFQTLV VGVVGGLLGS 190 200 210 220 230 240 LVLLVWVLAV ICSRAARGTI GARRTGQPLK EDPSAVPVFS VDYGELDFQW REKTPEPPVP 250 260 270 280 CVPEQTEYAT IVFPSGMGTS SPARRGSADG PRSAQPLRPE DGHCSWPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans." Prokunina L., Castillejo-Lopez C., Oberg F., Gunnarsson I., Berg L., Magnusson V., Brookes A.J., Tentler D., Kristjansdottir H., Grondal G., Bolstad A.I., Svenungsson E., Lundberg I., Sturfelt G., Jonssen A., Truedsson L., Lima G., Alcocer-Varela J. , Jonsson R., Gyllensten U.B., Harley J.B., Alarcon-Segovia D., Steinsson K., Alarcon-Riquelme M.E. Nat. Genet. 32:666-669(2002) [PubMed: 12402038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pooled tissue EMBL AAH74740.1.
[6]	"Cloning of PD-1 cDNA from activated peripheral leukocytes." He X., Xu L., Liu Y., Zeng Y. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC074740 mRNA. Translation: AAH74740.1. AF363458 Genomic DNA. Translation: AAN64003.1. AY238517 mRNA. Translation: AAO63583.1. EF064716 Genomic DNA. Translation: ABK41899.1. AK313848 mRNA. Translation: BAG36577.1. CH471063 Genomic DNA. Translation: EAW71298.1.
IPI	IPI00014830.
RefSeq	NP_005009.2.
UniGene	Hs.158297
3D structure databases
HSSP	HSSP built from PDB template 1REI based on UniProtKB P01607.
SMR	Q8IX89. Positions 31-147, 38-186.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IX89.
Proteomic databases
PRIDE	Q8IX89.
Genome annotation databases
Ensembl	ENST00000334409; ENSP00000335062; ENSG00000188389; Homo sapiens. [Genome view]
GeneID	5133.
KEGG	hsa:5133.
NMPDR	fig|9606.3.peg.22013.
Organism-specific databases
CTD	5133.
HGNC	HGNC:8760. PDCD1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IX89.
OMA	EHFVLNW.
PhylomeDB	Q8IX89.
Gene expression databases
ArrayExpress	Q8IX89.
Bgee	Q8IX89.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	19792.

Entry information

Entry name

Q8IX89_HUMAN

Accession

Primary (citable) accession number: Q8IX89

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.