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Unreviewed, UniProtKB/TrEMBL Q8IX89 (Q8IX89_HUMAN)

Last modified February 9, 2010. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Programmed cell death 1 EMBL AAN64003.1
Submitted name:
    cDNA, FLJ94476, highly similar to Homo sapiens programmed cell death 1 (PDCD1), mRNA EMBL BAG36577.1
Gene names
Name: PDCD1 EMBL AAN64003.1
ORF Names: hCG_1776289 EMBL EAW71298.1
OrganismHomo sapiens (Human) EMBL AAN64003.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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Ontologies

Gene Ontology (GO)
   Cellular componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Compara

   Molecular functionprotein binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q8IX89-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A5210FD40C304FB7

FASTA28831,647
        10         20         30         40         50         60 
MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS 

        70         80         90        100        110        120 
ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT 

       130        140        150        160        170        180 
YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFQTLV VGVVGGLLGS 

       190        200        210        220        230        240 
LVLLVWVLAV ICSRAARGTI GARRTGQPLK EDPSAVPVFS VDYGELDFQW REKTPEPPVP 

       250        260        270        280 
CVPEQTEYAT IVFPSGMGTS SPARRGSADG PRSAQPLRPE DGHCSWPL

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References

« Hide 'large scale' references
[1]"A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans."
Prokunina L., Castillejo-Lopez C., Oberg F., Gunnarsson I., Berg L., Magnusson V., Brookes A.J., Tentler D., Kristjansdottir H., Grondal G., Bolstad A.I., Svenungsson E., Lundberg I., Sturfelt G., Jonssen A., Truedsson L., Lima G., Alcocer-Varela J. expand/collapse author list , Jonsson R., Gyllensten U.B., Harley J.B., Alarcon-Segovia D., Steinsson K., Alarcon-Riquelme M.E.
Nat. Genet. 32:666-669(2002) [PubMed: 12402038] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]"NEDO functional analysis of protein and research application project."
Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pooled tissue EMBL AAH74740.1.
[6]"Cloning of PD-1 cDNA from activated peripheral leukocytes."
He X., Xu L., Liu Y., Zeng Y.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC074740 mRNA. Translation: AAH74740.1.
AF363458 Genomic DNA. Translation: AAN64003.1.
AY238517 mRNA. Translation: AAO63583.1.
EF064716 Genomic DNA. Translation: ABK41899.1.
AK313848 mRNA. Translation: BAG36577.1.
CH471063 Genomic DNA. Translation: EAW71298.1.
IPIIPI00014830.
RefSeqNP_005009.2.
UniGeneHs.158297

3D structure databases

HSSPHSSP built from PDB template 1REI based on UniProtKB P01607.
SMRQ8IX89. Positions 31-147, 38-186.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8IX89.

Proteomic databases

PRIDEQ8IX89.

Genome annotation databases

EnsemblENST00000334409; ENSP00000335062; ENSG00000188389; Homo sapiens. [Genome view]
GeneID5133.
KEGGhsa:5133.
NMPDRfig|9606.3.peg.22013.

Organism-specific databases

CTD5133.
HGNCHGNC:8760. PDCD1.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ8IX89.
OMAEHFVLNW.
PhylomeDBQ8IX89.

Gene expression databases

ArrayExpressQ8IX89.
BgeeQ8IX89.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_sub.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio19792.

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Entry information

Entry nameQ8IX89_HUMAN
AccessionPrimary (citable) accession number: Q8IX89
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 9, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information