Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box only protein 16

Gene

FBXO16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 16
Gene namesi
Name:FBXO16
Synonyms:FBX16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:13618. FBXO16.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901223.

Polymorphism and mutation databases

BioMutaiFBXO16.
DMDMi30580423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292F-box only protein 16PRO_0000119896Add
BLAST

Proteomic databases

MaxQBiQ8IX29.
PaxDbiQ8IX29.
PRIDEiQ8IX29.

PTM databases

iPTMnetiQ8IX29.
PhosphoSiteiQ8IX29.

Expressioni

Tissue specificityi

Expressed in heart, spleen and colon.1 Publication

Gene expression databases

BgeeiENSG00000214050.
CleanExiHS_FBXO16.
ExpressionAtlasiQ8IX29. baseline and differential.
GenevisibleiQ8IX29. HS.

Organism-specific databases

HPAiHPA053955.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

BioGridi127606. 1 interaction.
STRINGi9606.ENSP00000369604.

Structurei

3D structure databases

ProteinModelPortaliQ8IX29.
SMRiQ8IX29. Positions 82-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 13247F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQD0. Eukaryota.
ENOG41102EU. LUCA.
GeneTreeiENSGT00530000063689.
HOGENOMiHOG000110666.
HOVERGENiHBG051567.
InParanoidiQ8IX29.
KOiK10299.
PhylomeDBiQ8IX29.
TreeFamiTF328656.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IX29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAFAPPKNT DGPKMQTKMS TWTPLNHQLL NDRVFEERRA LLGKWFDKWT
60 70 80 90 100
DSQRRRILTG LLERCSLSQQ KFCCRKLQEK IPAEALDFTT KLPRVLSLYI
110 120 130 140 150
FSFLDPRSLC RCAQVCWHWK NLAELDQLWM LKCLRFNWYI NFSPTPFEQG
160 170 180 190 200
IWKKHYIQMV KELHITKPKT PPKDGFVIAD VQLVTSNSPE EKQSPLSAFR
210 220 230 240 250
SSSSLRKKNN SGEKALPPWR SSDKHPTDII RFNYLDNRDP METVQQGRRK
260 270 280 290
RNQMTPDFSR QSHDKKNKLQ DRTRLRKAQS MMSRRNPFPL CP
Length:292
Mass (Da):34,588
Last modified:March 1, 2003 - v1
Checksum:i0A7030EFE682EDFD
GO
Isoform 2 (identifier: Q8IX29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-45: Missing.

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):33,102
Checksum:iBD071C08CBFA7C0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2552MT → IN in AAI02028 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751R → Q.
Corresponds to variant rs3735726 [ dbSNP | Ensembl ].
VAR_020409
Natural varianti254 – 2541M → I.
Corresponds to variant rs1390963 [ dbSNP | Ensembl ].
VAR_024442
Natural varianti255 – 2551T → N.
Corresponds to variant rs7016831 [ dbSNP | Ensembl ].
VAR_049041

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 4512Missing in isoform 2. 1 PublicationVSP_045600Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453435 mRNA. Translation: AAN76812.1.
AC025871 Genomic DNA. No translation available.
BC074986 mRNA. Translation: AAH74986.1.
BC102026 mRNA. Translation: AAI02027.1.
BC102027 mRNA. Translation: AAI02028.1.
BC102028 mRNA. Translation: AAI02029.1.
CCDSiCCDS59099.1. [Q8IX29-2]
CCDS6068.1. [Q8IX29-1]
RefSeqiNP_001245140.1. NM_001258211.1. [Q8IX29-2]
NP_758954.1. NM_172366.3. [Q8IX29-1]
UniGeneiHs.741522.

Genome annotation databases

EnsembliENST00000380254; ENSP00000369604; ENSG00000214050. [Q8IX29-1]
ENST00000518734; ENSP00000429687; ENSG00000214050. [Q8IX29-2]
GeneIDi157574.
KEGGihsa:157574.
UCSCiuc003xgu.5. human. [Q8IX29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453435 mRNA. Translation: AAN76812.1.
AC025871 Genomic DNA. No translation available.
BC074986 mRNA. Translation: AAH74986.1.
BC102026 mRNA. Translation: AAI02027.1.
BC102027 mRNA. Translation: AAI02028.1.
BC102028 mRNA. Translation: AAI02029.1.
CCDSiCCDS59099.1. [Q8IX29-2]
CCDS6068.1. [Q8IX29-1]
RefSeqiNP_001245140.1. NM_001258211.1. [Q8IX29-2]
NP_758954.1. NM_172366.3. [Q8IX29-1]
UniGeneiHs.741522.

3D structure databases

ProteinModelPortaliQ8IX29.
SMRiQ8IX29. Positions 82-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127606. 1 interaction.
STRINGi9606.ENSP00000369604.

PTM databases

iPTMnetiQ8IX29.
PhosphoSiteiQ8IX29.

Polymorphism and mutation databases

BioMutaiFBXO16.
DMDMi30580423.

Proteomic databases

MaxQBiQ8IX29.
PaxDbiQ8IX29.
PRIDEiQ8IX29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380254; ENSP00000369604; ENSG00000214050. [Q8IX29-1]
ENST00000518734; ENSP00000429687; ENSG00000214050. [Q8IX29-2]
GeneIDi157574.
KEGGihsa:157574.
UCSCiuc003xgu.5. human. [Q8IX29-1]

Organism-specific databases

CTDi157574.
GeneCardsiFBXO16.
H-InvDBHIX0079005.
HGNCiHGNC:13618. FBXO16.
HPAiHPA053955.
MIMi608519. gene.
neXtProtiNX_Q8IX29.
PharmGKBiPA134901223.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQD0. Eukaryota.
ENOG41102EU. LUCA.
GeneTreeiENSGT00530000063689.
HOGENOMiHOG000110666.
HOVERGENiHBG051567.
InParanoidiQ8IX29.
KOiK10299.
PhylomeDBiQ8IX29.
TreeFamiTF328656.

Miscellaneous databases

GenomeRNAii157574.
PROiQ8IX29.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214050.
CleanExiHS_FBXO16.
ExpressionAtlasiQ8IX29. baseline and differential.
GenevisibleiQ8IX29. HS.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX16_HUMAN
AccessioniPrimary (citable) accession number: Q8IX29
Secondary accession number(s): Q3T1B2, Q3T1B3, Q3T1B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.