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Protein

Homeobox and leucine zipper protein Homez

Gene

HOMEZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcriptional regulator.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi55 – 114Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi355 – 415Homeobox 2PROSITE-ProRule annotationAdd BLAST61
DNA bindingi451 – 510Homeobox 3PROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33453-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox and leucine zipper protein Homez
Alternative name(s):
Homeodomain leucine zipper-containing factor
Gene namesi
Name:HOMEZ
Synonyms:KIAA1443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20164. HOMEZ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57594.
OpenTargetsiENSG00000215271.
PharmGKBiPA162391555.

Polymorphism and mutation databases

BioMutaiHOMEZ.
DMDMi317373364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491351 – 550Homeobox and leucine zipper protein HomezAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei351PhosphoserineCombined sources1
Modified residuei451PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IX15.
MaxQBiQ8IX15.
PaxDbiQ8IX15.
PeptideAtlasiQ8IX15.
PRIDEiQ8IX15.

PTM databases

iPTMnetiQ8IX15.
PhosphoSitePlusiQ8IX15.

Expressioni

Tissue specificityi

Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000215271.
CleanExiHS_HOMEZ.
ExpressionAtlasiQ8IX15. baseline and differential.
GenevisibleiQ8IX15. HS.

Organism-specific databases

HPAiHPA036316.
HPA036317.

Interactioni

Subunit structurei

Homodimer or heterodimer (Potential). Interacts with HOXC8.Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AENQ8WTP83EBI-10172004,EBI-8637627
AESQ081173EBI-10172004,EBI-717810
APITD1Q8N2Z93EBI-10172004,EBI-5529649
DEF6Q9H4E73EBI-10172004,EBI-745369
DNTTIP1Q9H1473EBI-10172004,EBI-2795449
EBF1Q9UH733EBI-10172004,EBI-765426
EIF4E2O605733EBI-10172004,EBI-398610
GRB2P629933EBI-10172004,EBI-401755
KPNA2Q6NVW73EBI-10172004,EBI-9377406
LNX1Q8TBB13EBI-10172004,EBI-739832
LRRC7A1L1C63EBI-10172004,EBI-10171988
MAD2L1BPQ150133EBI-10172004,EBI-712181
MED18Q9BUE03EBI-10172004,EBI-394640
MRPL11Q9Y3B73EBI-10172004,EBI-5453723
NCK2O436393EBI-10172004,EBI-713635
PIN1Q135263EBI-10172004,EBI-714158
PRKAA1Q131313EBI-10172004,EBI-1181405
PRKAA2P546463EBI-10172004,EBI-1383852
RBM39Q14498-33EBI-10172004,EBI-6654703
RNF8O760643EBI-10172004,EBI-373337
RPL9P9P329693EBI-10172004,EBI-358122
SDCBPO005603EBI-10172004,EBI-727004
SH3RF2Q08AM83EBI-10172004,EBI-10225873
SMYD1Q8NB123EBI-10172004,EBI-8463848
SNRPB2P085793EBI-10172004,EBI-1053651
SUMO2P619563EBI-10172004,EBI-473220
TCEB3Q142413EBI-10172004,EBI-742350
TRAF4Q9BUZ43EBI-10172004,EBI-3650647
ZBTB7AO953653EBI-10172004,EBI-2795384

Protein-protein interaction databases

BioGridi121645. 34 interactors.
IntActiQ8IX15. 31 interactors.
STRINGi9606.ENSP00000350049.

Structurei

Secondary structure

1550
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi365 – 377Combined sources13
Helixi383 – 392Combined sources10
Helixi397 – 413Combined sources17
Helixi464 – 472Combined sources9
Helixi480 – 487Combined sources8
Helixi492 – 502Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECCNMR-A361-423[»]
2YS9NMR-A453-509[»]
ProteinModelPortaliQ8IX15.
SMRiQ8IX15.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX15.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi358 – 363Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 195Pro-richAdd BLAST36
Compositional biasi284 – 291Poly-Ser8
Compositional biasi425 – 465Pro-richAdd BLAST41
Compositional biasi515 – 536Glu-richAdd BLAST22
Compositional biasi537 – 544Poly-Asp8

Sequence similaritiesi

Contains 3 homeobox DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiENOG410IFGX. Eukaryota.
ENOG410YKZF. LUCA.
GeneTreeiENSGT00530000063149.
HOGENOMiHOG000136732.
HOVERGENiHBG051919.
InParanoidiQ8IX15.
OMAiKESLMTP.
OrthoDBiEOG091G02WT.
PhylomeDBiQ8IX15.
TreeFamiTF333363.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR024578. Homez_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF11569. Homez. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IX15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE
60 70 80 90 100
LQLVWTQAAQ TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK
110 120 130 140 150
TWFMAQRLRC GISWSSEEIE ETRARVVYRR DQLHFKSLLS FTHHAGRPPE
160 170 180 190 200
EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG LKVEPEEPSQ MPPLPQSHQK
210 220 230 240 250
LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS HGIGTASWNH
260 270 280 290 300
STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT
310 320 330 340 350
AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL
360 370 380 390 400
SPDMQRQRKT KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI
410 420 430 440 450
IQWFGDTRYA LKHGQLKWFR DNAVPGAPSF QDPAIPTPPP STRSLNERAE
460 470 480 490 500
TPPLPIPPPP PDIQPLERYW AAHQQLRETD IPQLSQASRL STQQVLDWFD
510 520 530 540 550
SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD DDDDDVIIQD
Length:550
Mass (Da):61,240
Last modified:January 11, 2011 - v2
Checksum:iA7DDF6DD56D8BDF0
GO
Isoform 2 (identifier: Q8IX15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MVRGWEPPPGLDC → MLKSRISMRSRHPRR

Note: No experimental confirmation available.
Show »
Length:552
Mass (Da):61,695
Checksum:i2079A7F5CE2B97D5
GO

Sequence cautioni

The sequence AAN76991 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302A → T in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti529Missing in AAN76991 (PubMed:12925734).Curated1
Sequence conflicti529Missing in BAA92681 (PubMed:10718198).Curated1
Sequence conflicti529Missing in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti538D → E in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti538Missing in BAG63992 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055956278A → T.Corresponds to variant rs10131813dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0543031 – 13MVRGW…PGLDC → MLKSRISMRSRHPRR in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF463523 mRNA. Translation: AAN76991.1. Different initiation.
AB037864 mRNA. Translation: BAA92681.1. Different initiation.
AK302788 mRNA. Translation: BAG63992.1.
AL049829 Genomic DNA. No translation available.
BC130392 mRNA. Translation: AAI30393.1.
CCDSiCCDS45085.1. [Q8IX15-1]
RefSeqiNP_065885.2. NM_020834.2. [Q8IX15-1]
UniGeneiHs.632332.

Genome annotation databases

EnsembliENST00000357460; ENSP00000350049; ENSG00000215271. [Q8IX15-1]
ENST00000561013; ENSP00000453979; ENSG00000215271. [Q8IX15-3]
GeneIDi57594.
KEGGihsa:57594.
UCSCiuc001wja.3. human. [Q8IX15-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF463523 mRNA. Translation: AAN76991.1. Different initiation.
AB037864 mRNA. Translation: BAA92681.1. Different initiation.
AK302788 mRNA. Translation: BAG63992.1.
AL049829 Genomic DNA. No translation available.
BC130392 mRNA. Translation: AAI30393.1.
CCDSiCCDS45085.1. [Q8IX15-1]
RefSeqiNP_065885.2. NM_020834.2. [Q8IX15-1]
UniGeneiHs.632332.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECCNMR-A361-423[»]
2YS9NMR-A453-509[»]
ProteinModelPortaliQ8IX15.
SMRiQ8IX15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121645. 34 interactors.
IntActiQ8IX15. 31 interactors.
STRINGi9606.ENSP00000350049.

PTM databases

iPTMnetiQ8IX15.
PhosphoSitePlusiQ8IX15.

Polymorphism and mutation databases

BioMutaiHOMEZ.
DMDMi317373364.

Proteomic databases

EPDiQ8IX15.
MaxQBiQ8IX15.
PaxDbiQ8IX15.
PeptideAtlasiQ8IX15.
PRIDEiQ8IX15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357460; ENSP00000350049; ENSG00000215271. [Q8IX15-1]
ENST00000561013; ENSP00000453979; ENSG00000215271. [Q8IX15-3]
GeneIDi57594.
KEGGihsa:57594.
UCSCiuc001wja.3. human. [Q8IX15-1]

Organism-specific databases

CTDi57594.
DisGeNETi57594.
GeneCardsiHOMEZ.
H-InvDBHIX0011535.
HGNCiHGNC:20164. HOMEZ.
HPAiHPA036316.
HPA036317.
MIMi608119. gene.
neXtProtiNX_Q8IX15.
OpenTargetsiENSG00000215271.
PharmGKBiPA162391555.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFGX. Eukaryota.
ENOG410YKZF. LUCA.
GeneTreeiENSGT00530000063149.
HOGENOMiHOG000136732.
HOVERGENiHBG051919.
InParanoidiQ8IX15.
OMAiKESLMTP.
OrthoDBiEOG091G02WT.
PhylomeDBiQ8IX15.
TreeFamiTF333363.

Enzyme and pathway databases

BioCyciZFISH:G66-33453-MONOMER.

Miscellaneous databases

ChiTaRSiHOMEZ. human.
EvolutionaryTraceiQ8IX15.
GenomeRNAii57594.
PROiQ8IX15.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215271.
CleanExiHS_HOMEZ.
ExpressionAtlasiQ8IX15. baseline and differential.
GenevisibleiQ8IX15. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR024578. Homez_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF11569. Homez. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOMEZ_HUMAN
AccessioniPrimary (citable) accession number: Q8IX15
Secondary accession number(s): A1L445
, B4DZ80, F8WCA3, Q6P049, Q86XB6, Q9P2A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.