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Protein

Homeobox and leucine zipper protein Homez

Gene

HOMEZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcriptional regulator.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi55 – 11460Homeobox 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi355 – 41561Homeobox 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi451 – 51060Homeobox 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox and leucine zipper protein Homez
Alternative name(s):
Homeodomain leucine zipper-containing factor
Gene namesi
Name:HOMEZ
Synonyms:KIAA1443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20164. HOMEZ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391555.

Polymorphism and mutation databases

BioMutaiHOMEZ.
DMDMi317373364.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Homeobox and leucine zipper protein HomezPRO_0000049135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki182 – 182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei351 – 3511PhosphoserineCombined sources
Modified residuei451 – 4511PhosphothreonineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8IX15.
PaxDbiQ8IX15.
PRIDEiQ8IX15.

PTM databases

iPTMnetiQ8IX15.
PhosphoSiteiQ8IX15.

Expressioni

Tissue specificityi

Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.1 Publication

Gene expression databases

BgeeiQ8IX15.
CleanExiHS_HOMEZ.
ExpressionAtlasiQ8IX15. baseline and differential.
GenevisibleiQ8IX15. HS.

Organism-specific databases

HPAiHPA036316.
HPA036317.

Interactioni

Subunit structurei

Homodimer or heterodimer (Potential). Interacts with HOXC8.Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AENQ8WTP83EBI-10172004,EBI-8637627
AESQ081173EBI-10172004,EBI-717810
APITD1Q8N2Z93EBI-10172004,EBI-5529649
DEF6Q9H4E73EBI-10172004,EBI-745369
DNTTIP1Q9H1473EBI-10172004,EBI-2795449
EBF1Q9UH733EBI-10172004,EBI-765426
EIF4E2O605733EBI-10172004,EBI-398610
GRB2P629933EBI-10172004,EBI-401755
KPNA2Q6NVW73EBI-10172004,EBI-9377406
LNX1Q8TBB13EBI-10172004,EBI-739832
LRRC7A1L1C63EBI-10172004,EBI-10171988
MAD2L1BPQ150133EBI-10172004,EBI-712181
MED18Q9BUE03EBI-10172004,EBI-394640
MRPL11Q9Y3B73EBI-10172004,EBI-5453723
NCK2O436393EBI-10172004,EBI-713635
PIN1Q135263EBI-10172004,EBI-714158
PRKAA1Q131313EBI-10172004,EBI-1181405
PRKAA2P546463EBI-10172004,EBI-1383852
RBM39Q14498-33EBI-10172004,EBI-6654703
RNF8O760643EBI-10172004,EBI-373337
RPL9P9P329693EBI-10172004,EBI-358122
SDCBPO005603EBI-10172004,EBI-727004
SH3RF2Q08AM83EBI-10172004,EBI-10225873
SMYD1Q8NB123EBI-10172004,EBI-8463848
SNRPB2P085793EBI-10172004,EBI-1053651
SUMO2P619563EBI-10172004,EBI-473220
TCEB3Q142413EBI-10172004,EBI-742350
TRAF4Q9BUZ43EBI-10172004,EBI-3650647
ZBTB7AO953653EBI-10172004,EBI-2795384

Protein-protein interaction databases

BioGridi121645. 34 interactions.
IntActiQ8IX15. 31 interactions.
STRINGi9606.ENSP00000350049.

Structurei

Secondary structure

1
550
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi365 – 37713Combined sources
Helixi383 – 39210Combined sources
Helixi397 – 41317Combined sources
Helixi464 – 4729Combined sources
Helixi480 – 4878Combined sources
Helixi492 – 50211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ECCNMR-A361-423[»]
2YS9NMR-A453-509[»]
ProteinModelPortaliQ8IX15.
SMRiQ8IX15. Positions 361-423, 467-509.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX15.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi358 – 3636Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi160 – 19536Pro-richAdd
BLAST
Compositional biasi284 – 2918Poly-Ser
Compositional biasi425 – 46541Pro-richAdd
BLAST
Compositional biasi515 – 53622Glu-richAdd
BLAST
Compositional biasi537 – 5448Poly-Asp

Sequence similaritiesi

Contains 3 homeobox DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiENOG410IFGX. Eukaryota.
ENOG410YKZF. LUCA.
GeneTreeiENSGT00530000063149.
HOGENOMiHOG000136732.
HOVERGENiHBG051919.
InParanoidiQ8IX15.
OMAiKESLMTP.
OrthoDBiEOG776SPX.
PhylomeDBiQ8IX15.
TreeFamiTF333363.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR024578. Homez_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF11569. Homez. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IX15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE
60 70 80 90 100
LQLVWTQAAQ TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK
110 120 130 140 150
TWFMAQRLRC GISWSSEEIE ETRARVVYRR DQLHFKSLLS FTHHAGRPPE
160 170 180 190 200
EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG LKVEPEEPSQ MPPLPQSHQK
210 220 230 240 250
LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS HGIGTASWNH
260 270 280 290 300
STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT
310 320 330 340 350
AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL
360 370 380 390 400
SPDMQRQRKT KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI
410 420 430 440 450
IQWFGDTRYA LKHGQLKWFR DNAVPGAPSF QDPAIPTPPP STRSLNERAE
460 470 480 490 500
TPPLPIPPPP PDIQPLERYW AAHQQLRETD IPQLSQASRL STQQVLDWFD
510 520 530 540 550
SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD DDDDDVIIQD
Length:550
Mass (Da):61,240
Last modified:January 11, 2011 - v2
Checksum:iA7DDF6DD56D8BDF0
GO
Isoform 2 (identifier: Q8IX15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MVRGWEPPPGLDC → MLKSRISMRSRHPRR

Note: No experimental confirmation available.
Show »
Length:552
Mass (Da):61,695
Checksum:i2079A7F5CE2B97D5
GO

Sequence cautioni

The sequence AAN76991.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti302 – 3021A → T in AAI30393 (PubMed:15489334).Curated
Sequence conflicti529 – 5291Missing in AAN76991 (PubMed:12925734).Curated
Sequence conflicti529 – 5291Missing in BAA92681 (PubMed:10718198).Curated
Sequence conflicti529 – 5291Missing in AAI30393 (PubMed:15489334).Curated
Sequence conflicti538 – 5381D → E in AAI30393 (PubMed:15489334).Curated
Sequence conflicti538 – 5381Missing in BAG63992 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti278 – 2781A → T.
Corresponds to variant rs10131813 [ dbSNP | Ensembl ].
VAR_055956

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MVRGW…PGLDC → MLKSRISMRSRHPRR in isoform 2. 1 PublicationVSP_054303Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF463523 mRNA. Translation: AAN76991.1. Different initiation.
AB037864 mRNA. Translation: BAA92681.1. Different initiation.
AK302788 mRNA. Translation: BAG63992.1.
AL049829 Genomic DNA. No translation available.
BC130392 mRNA. Translation: AAI30393.1.
CCDSiCCDS45085.1. [Q8IX15-1]
RefSeqiNP_065885.2. NM_020834.2. [Q8IX15-1]
UniGeneiHs.632332.

Genome annotation databases

EnsembliENST00000357460; ENSP00000350049; ENSG00000215271. [Q8IX15-1]
ENST00000561013; ENSP00000453979; ENSG00000215271. [Q8IX15-3]
GeneIDi57594.
KEGGihsa:57594.
UCSCiuc001wja.3. human. [Q8IX15-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF463523 mRNA. Translation: AAN76991.1. Different initiation.
AB037864 mRNA. Translation: BAA92681.1. Different initiation.
AK302788 mRNA. Translation: BAG63992.1.
AL049829 Genomic DNA. No translation available.
BC130392 mRNA. Translation: AAI30393.1.
CCDSiCCDS45085.1. [Q8IX15-1]
RefSeqiNP_065885.2. NM_020834.2. [Q8IX15-1]
UniGeneiHs.632332.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ECCNMR-A361-423[»]
2YS9NMR-A453-509[»]
ProteinModelPortaliQ8IX15.
SMRiQ8IX15. Positions 361-423, 467-509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121645. 34 interactions.
IntActiQ8IX15. 31 interactions.
STRINGi9606.ENSP00000350049.

PTM databases

iPTMnetiQ8IX15.
PhosphoSiteiQ8IX15.

Polymorphism and mutation databases

BioMutaiHOMEZ.
DMDMi317373364.

Proteomic databases

MaxQBiQ8IX15.
PaxDbiQ8IX15.
PRIDEiQ8IX15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357460; ENSP00000350049; ENSG00000215271. [Q8IX15-1]
ENST00000561013; ENSP00000453979; ENSG00000215271. [Q8IX15-3]
GeneIDi57594.
KEGGihsa:57594.
UCSCiuc001wja.3. human. [Q8IX15-1]

Organism-specific databases

CTDi57594.
GeneCardsiHOMEZ.
H-InvDBHIX0011535.
HGNCiHGNC:20164. HOMEZ.
HPAiHPA036316.
HPA036317.
MIMi608119. gene.
neXtProtiNX_Q8IX15.
PharmGKBiPA162391555.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFGX. Eukaryota.
ENOG410YKZF. LUCA.
GeneTreeiENSGT00530000063149.
HOGENOMiHOG000136732.
HOVERGENiHBG051919.
InParanoidiQ8IX15.
OMAiKESLMTP.
OrthoDBiEOG776SPX.
PhylomeDBiQ8IX15.
TreeFamiTF333363.

Miscellaneous databases

ChiTaRSiHOMEZ. human.
EvolutionaryTraceiQ8IX15.
GenomeRNAii57594.
PROiQ8IX15.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IX15.
CleanExiHS_HOMEZ.
ExpressionAtlasiQ8IX15. baseline and differential.
GenevisibleiQ8IX15. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR024578. Homez_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF11569. Homez. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH HOXC8, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-550 (ISOFORM 1).
    Tissue: Testis.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-451, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."
    Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C.
    Cell Rep. 10:1778-1791(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the homeobox domains of human homeodomain leucine zipper-encoding gene (HOMEZ)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 361-423 AND 453-509.

Entry informationi

Entry nameiHOMEZ_HUMAN
AccessioniPrimary (citable) accession number: Q8IX15
Secondary accession number(s): A1L445
, B4DZ80, F8WCA3, Q6P049, Q86XB6, Q9P2A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 11, 2011
Last modified: June 8, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.