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Q8IX12

- CCAR1_HUMAN

UniProt

Q8IX12 - CCAR1_HUMAN

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Protein

Cell division cycle and apoptosis regulator protein 1

Gene

CCAR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.By similarity1 Publication

GO - Molecular functioni

  1. ligand-dependent nuclear receptor transcription coactivator activity Source: MGI
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell cycle Source: UniProtKB-KW
  3. gene expression Source: Reactome
  4. mRNA splicing, via spliceosome Source: Reactome
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. RNA splicing Source: Reactome
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_467. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle and apoptosis regulator protein 1
Alternative name(s):
Cell cycle and apoptosis regulatory protein 1
Short name:
CARP-1
Death inducer with SAP domain
Gene namesi
Name:CCAR1
Synonyms:CARP1, DIS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:24236. CCAR1.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11501150Cell division cycle and apoptosis regulator protein 1PRO_0000233148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki637 – 637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei685 – 6851Phosphoserine1 Publication
Modified residuei697 – 6971Phosphoserine1 Publication
Modified residuei861 – 8611Phosphothreonine2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8IX12.
PaxDbiQ8IX12.
PeptideAtlasiQ8IX12.
PRIDEiQ8IX12.

PTM databases

PhosphoSiteiQ8IX12.

Expressioni

Tissue specificityi

Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.1 Publication

Gene expression databases

BgeeiQ8IX12.
CleanExiHS_CCAR1.
ExpressionAtlasiQ8IX12. baseline and differential.
GenevestigatoriQ8IX12.

Organism-specific databases

HPAiHPA007856.
HPA048513.

Interactioni

Subunit structurei

Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM63Q969Q12EBI-356265,EBI-5661333
WWTR1Q9GZV52EBI-356265,EBI-747743
Wwtr1Q9EPK55EBI-356265,EBI-1211920From a different organism.

Protein-protein interaction databases

BioGridi120867. 22 interactions.
DIPiDIP-27607N.
IntActiQ8IX12. 22 interactions.
MINTiMINT-1139760.

Structurei

3D structure databases

ProteinModelPortaliQ8IX12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini636 – 67035SAPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili594 – 61825Sequence AnalysisAdd
BLAST
Coiled coili1033 – 111482Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi73 – 797Poly-Ala
Compositional biasi293 – 36169Arg-richAdd
BLAST
Compositional biasi673 – 889217Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 SAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG313311.
GeneTreeiENSGT00530000063672.
HOVERGENiHBG079908.
InParanoidiQ8IX12.
OMAiELYHKSC.
OrthoDBiEOG7CK365.
PhylomeDBiQ8IX12.
TreeFamiTF316387.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR025224. CCAR1/CCAR2.
IPR025954. DBC1/CARP1_inactive_NUDIX_dom.
IPR012340. NA-bd_OB-fold.
IPR025223. S1-like_RNA-bd_dom.
IPR003034. SAP_dom.
[Graphical view]
PANTHERiPTHR14304. PTHR14304. 1 hit.
PfamiPF14443. DBC1. 1 hit.
PF14444. S1-like. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IX12-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA
60 70 80 90 100
AGLTTQTPAN YQLTQTAALQ QQAAAAAAAL QQQYSQPQQA LYSVQQQLQQ
110 120 130 140 150
PQQTLLTQPA VALPTSLSLS TPQPTAQITV SYPTPRSSQQ QTQPQKQRVF
160 170 180 190 200
TGVVTKLHDT FGFVDEDVFF QLSAVKGKTP QVGDRVLVEA TYNPNMPFKW
210 220 230 240 250
NAQRIQTLPN QNQSQTQPLL KTPPAVLQPI APQTTFGVQT QPQPQSLLQA
260 270 280 290 300
QISAASITPL LQTQPQPLLQ QPQQKAGLLQ PPVRIVSQPQ PARRLDPPSR
310 320 330 340 350
FSGRNDRGDQ VPNRKDDRSR ERERERRRSR ERSPQRKRSR ERSPRRERER
360 370 380 390 400
SPRRVRRVVP RYTVQFSKFS LDCPSCDMME LRRRYQNLYI PSDFFDAQFT
410 420 430 440 450
WVDAFPLSRP FQLGNYCNFY VMHREVESLE KNMAILDPPD ADHLYSAKVM
460 470 480 490 500
LMASPSMEDL YHKSCALAED PQELRDGFQH PARLVKFLVG MKGKDEAMAI
510 520 530 540 550
GGHWSPSLDG PDPEKDPSVL IKTAIRCCKA LTGIDLSVCT QWYRFAEIRY
560 570 580 590 600
HRPEETHKGR TVPAHVETVV LFFPDVWHCL PTRSEWETLS RGYKQQLVEK
610 620 630 640 650
LQGERKEADG EQDEEEKDDG EAKEISTPTH WSKLDPKTMK VNDLRKELES
660 670 680 690 700
RALSSKGLKS QLIARLTKQL KVEEQKEEQK ELEKSEKEED EDDDRKSEDD
710 720 730 740 750
KEEEERKRQE EIERQRRERR YILPDEPAII VHPNWAAKSG KFDCSIMSLS
760 770 780 790 800
VLLDYRLEDN KEHSFEVSLF AELFNEMLQR DFGVRIYKSL LSLPEKEDKK
810 820 830 840 850
EKDKKSKKDE RKDKKEERDD ETDEPKPKRR KSGDDKDKKE DRDERKKEDK
860 870 880 890 900
RKDDSKDDDE TEEDNNQDEY DPMEAEEAED EEDDRDEEEM TKRDDKRDIN
910 920 930 940 950
RYCKERPSKD KEKEKTQMIT INRDLLMAFV YFDQSHCGYL LEKDLEEILY
960 970 980 990 1000
TLGLHLSRAQ VKKLLNKVVL RESCFYRKLT DTSKDEENHE ESESLQEDML
1010 1020 1030 1040 1050
GNRLLLPTPT VKQESKDVEE NVGLIVYNGA MVDVGSLLQK LEKSEKVRAE
1060 1070 1080 1090 1100
VEQKLQLLEE KTDEDEKTIL NLENSNKSLS GELREVKKDL SQLQENLKIS
1110 1120 1130 1140 1150
ENMNLQFENQ MNKTIRNLST VMDEIHTVLK KDNVKNEDKD QKSKENGASV
Length:1,150
Mass (Da):132,821
Last modified:May 2, 2006 - v2
Checksum:i30618DCC8097F552
GO
Isoform 2 (identifier: Q8IX12-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-97: Missing.

Note: No experimental confirmation available.

Show »
Length:1,135
Mass (Da):131,043
Checksum:i1F36D655EC82941E
GO

Sequence cautioni

The sequence AAH26036.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAI08683.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAA91354.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961D → Y in BAA91354. (PubMed:14702039)Curated
Sequence conflicti305 – 3051N → S in BAG60310. (PubMed:14702039)Curated
Sequence conflicti492 – 4921K → E in BAA91847. (PubMed:14702039)Curated
Sequence conflicti618 – 6181D → Y in AAH15475. (PubMed:15489334)Curated
Sequence conflicti650 – 6501S → G in AAO17319. 1 PublicationCurated
Sequence conflicti650 – 6501S → G in BAA91700. (PubMed:14702039)Curated
Sequence conflicti723 – 7231L → S in BAF85338. (PubMed:14702039)Curated
Sequence conflicti801 – 8033EKD → KKK in AAH89420. (PubMed:15489334)Curated
Sequence conflicti816 – 8183EER → KKK in AAH15475. (PubMed:15489334)Curated
Sequence conflicti853 – 8531D → G(PubMed:12816952)Curated
Sequence conflicti853 – 8531D → G1 PublicationCurated
Sequence conflicti853 – 8531D → G in BAA91700. (PubMed:14702039)Curated
Sequence conflicti1104 – 11041N → S(PubMed:12816952)Curated
Sequence conflicti1104 – 11041N → S1 PublicationCurated
Sequence conflicti1104 – 11041N → S in BAA91700. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti588 – 5881T → I.
Corresponds to variant rs1782338 [ dbSNP | Ensembl ].
VAR_058330
Natural varianti607 – 6071E → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035497
Natural varianti681 – 6811E → G.
Corresponds to variant rs1060145 [ dbSNP | Ensembl ].
VAR_058331
Natural varianti747 – 7471M → V.
Corresponds to variant rs11542602 [ dbSNP | Ensembl ].
VAR_058332

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei83 – 9715Missing in isoform 2. 1 PublicationVSP_037736Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY249140 mRNA. Translation: AAP82002.1.
AF465616 mRNA. Translation: AAO17319.1.
AK000741 mRNA. Translation: BAA91354.1. Different initiation.
AK001452 mRNA. Translation: BAA91700.1.
AK001701 mRNA. Translation: BAA91847.1.
AK023438 mRNA. Translation: BAB14574.1.
AK298004 mRNA. Translation: BAG60310.1.
AK299307 mRNA. Translation: BAG61320.1.
AK292649 mRNA. Translation: BAF85338.1.
AL513534, AL391539 Genomic DNA. Translation: CAH70221.1.
AL391539, AL513534 Genomic DNA. Translation: CAH73835.1.
CH471083 Genomic DNA. Translation: EAW54302.1.
BC015475 mRNA. Translation: AAH15475.1.
BC026036 mRNA. Translation: AAH26036.1. Sequence problems.
BC089420 mRNA. Translation: AAH89420.1.
BC130626 mRNA. Translation: AAI30627.1.
BC132725 mRNA. Translation: AAI32726.1.
BC108682 mRNA. Translation: AAI08683.1. Sequence problems.
CCDSiCCDS60547.1. [Q8IX12-2]
CCDS7282.1. [Q8IX12-1]
RefSeqiNP_001269888.1. NM_001282959.1. [Q8IX12-2]
NP_001269889.1. NM_001282960.1. [Q8IX12-2]
NP_060707.2. NM_018237.3. [Q8IX12-1]
UniGeneiHs.49853.

Genome annotation databases

EnsembliENST00000265872; ENSP00000265872; ENSG00000060339. [Q8IX12-1]
ENST00000539539; ENSP00000439252; ENSG00000060339.
ENST00000543719; ENSP00000445254; ENSG00000060339. [Q8IX12-2]
GeneIDi55749.
KEGGihsa:55749.
UCSCiuc001jom.1. human. [Q8IX12-1]
uc010qiz.1. human. [Q8IX12-2]

Polymorphism databases

DMDMi94707499.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY249140 mRNA. Translation: AAP82002.1 .
AF465616 mRNA. Translation: AAO17319.1 .
AK000741 mRNA. Translation: BAA91354.1 . Different initiation.
AK001452 mRNA. Translation: BAA91700.1 .
AK001701 mRNA. Translation: BAA91847.1 .
AK023438 mRNA. Translation: BAB14574.1 .
AK298004 mRNA. Translation: BAG60310.1 .
AK299307 mRNA. Translation: BAG61320.1 .
AK292649 mRNA. Translation: BAF85338.1 .
AL513534 , AL391539 Genomic DNA. Translation: CAH70221.1 .
AL391539 , AL513534 Genomic DNA. Translation: CAH73835.1 .
CH471083 Genomic DNA. Translation: EAW54302.1 .
BC015475 mRNA. Translation: AAH15475.1 .
BC026036 mRNA. Translation: AAH26036.1 . Sequence problems.
BC089420 mRNA. Translation: AAH89420.1 .
BC130626 mRNA. Translation: AAI30627.1 .
BC132725 mRNA. Translation: AAI32726.1 .
BC108682 mRNA. Translation: AAI08683.1 . Sequence problems.
CCDSi CCDS60547.1. [Q8IX12-2 ]
CCDS7282.1. [Q8IX12-1 ]
RefSeqi NP_001269888.1. NM_001282959.1. [Q8IX12-2 ]
NP_001269889.1. NM_001282960.1. [Q8IX12-2 ]
NP_060707.2. NM_018237.3. [Q8IX12-1 ]
UniGenei Hs.49853.

3D structure databases

ProteinModelPortali Q8IX12.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120867. 22 interactions.
DIPi DIP-27607N.
IntActi Q8IX12. 22 interactions.
MINTi MINT-1139760.

PTM databases

PhosphoSitei Q8IX12.

Polymorphism databases

DMDMi 94707499.

Proteomic databases

MaxQBi Q8IX12.
PaxDbi Q8IX12.
PeptideAtlasi Q8IX12.
PRIDEi Q8IX12.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265872 ; ENSP00000265872 ; ENSG00000060339 . [Q8IX12-1 ]
ENST00000539539 ; ENSP00000439252 ; ENSG00000060339 .
ENST00000543719 ; ENSP00000445254 ; ENSG00000060339 . [Q8IX12-2 ]
GeneIDi 55749.
KEGGi hsa:55749.
UCSCi uc001jom.1. human. [Q8IX12-1 ]
uc010qiz.1. human. [Q8IX12-2 ]

Organism-specific databases

CTDi 55749.
GeneCardsi GC10P070480.
HGNCi HGNC:24236. CCAR1.
HPAi HPA007856.
HPA048513.
MIMi 612569. gene.
neXtProti NX_Q8IX12.
PharmGKBi PA134920227.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313311.
GeneTreei ENSGT00530000063672.
HOVERGENi HBG079908.
InParanoidi Q8IX12.
OMAi ELYHKSC.
OrthoDBi EOG7CK365.
PhylomeDBi Q8IX12.
TreeFami TF316387.

Enzyme and pathway databases

Reactomei REACT_467. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSi CCAR1. human.
GeneWikii CCAR1.
GenomeRNAii 55749.
NextBioi 60733.
PROi Q8IX12.
SOURCEi Search...

Gene expression databases

Bgeei Q8IX12.
CleanExi HS_CCAR1.
ExpressionAtlasi Q8IX12. baseline and differential.
Genevestigatori Q8IX12.

Family and domain databases

Gene3Di 1.10.720.30. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR025224. CCAR1/CCAR2.
IPR025954. DBC1/CARP1_inactive_NUDIX_dom.
IPR012340. NA-bd_OB-fold.
IPR025223. S1-like_RNA-bd_dom.
IPR003034. SAP_dom.
[Graphical view ]
PANTHERi PTHR14304. PTHR14304. 1 hit.
Pfami PF14443. DBC1. 1 hit.
PF14444. S1-like. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view ]
SMARTi SM00513. SAP. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
PROSITEi PS50800. SAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437."
    Rishi A.K., Zhang L., Boyanapalli M., Wali A., Mohammad R.M., Yu Y., Fontana J.A., Hatfield J.S., Dawson M.I., Majumdar A.P.N., Reichert U.
    J. Biol. Chem. 278:33422-33435(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "TAZ binding partners identified by mass spectrometry."
    Tian Y., Li D., Benjamin T.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1058 (ISOFORM 2).
    Tissue: Hepatoma, Lung, Placenta, Teratocarcinoma and Thymus.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-818 (ISOFORM 1).
    Tissue: Cerebellum, Lung, Lymph, Muscle and Skin.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  8. "CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes."
    Kim J.H., Yang C.K., Heo K., Roeder R.G., An W., Stallcup M.R.
    Mol. Cell 31:510-519(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CALCOCO1.
  9. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
    Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
    Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-637.
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-685; SER-697 AND THR-861, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-861, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-607.

Entry informationi

Entry nameiCCAR1_HUMAN
AccessioniPrimary (citable) accession number: Q8IX12
Secondary accession number(s): A0JLT7
, A1L4P7, A8K9D4, B4DNP8, B4DRK8, Q32NE3, Q5EBM3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3