Q8IX12 (CCAR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division cycle and apoptosis regulator protein 1

Alternative name(s):
Cell cycle and apoptosis regulatory protein 1
Short name=CARP-1
Death inducer with SAP domain

Gene names

Name:	CCAR1
Synonyms:	CARP1, DIS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1150 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation By similarity. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. Ref.1
Subunit structure	Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53 By similarity. Ref.8
Subcellular location	Cytoplasm › perinuclear region Ref.1.
Tissue specificity	Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. Ref.1
Sequence similarities	Contains 1 SAP domain.
Sequence caution	The sequence AAH26036.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAI08683.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA91354.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis Cell cycle Transcription Transcription regulation
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW mRNA splicing, via spliceosome Traceable author statement. Source: Reactome regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ligand-dependent nuclear receptor transcription coactivator activity Inferred from genetic interaction Ref.8. Source: MGI nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
WWTR1	Q9GZV5	2	EBI-356265,EBI-747743
Wwtr1	Q9EPK5	5	EBI-356265,EBI-1211920	From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IX12-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IX12-2)

The sequence of this isoform differs from the canonical sequence as follows:
     83-97: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1150	1150	Cell division cycle and apoptosis regulator protein 1		PRO_0000233148
Regions
	Domain	636 – 670	35	SAP
	Coiled coil	594 – 618	25	Potential
	Coiled coil	1033 – 1114	82	Potential
	Compositional bias	73 – 79	7	Poly-Ala
	Compositional bias	293 – 361	69	Arg-rich
	Compositional bias	673 – 889	217	Glu-rich
Amino acid modifications
	Modified residue	685	1	Phosphoserine Ref.10
	Modified residue	697	1	Phosphoserine Ref.10
	Modified residue	861	1	Phosphothreonine Ref.10 Ref.12
	Cross-link	637		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.9
Natural variations
	Alternative sequence	83 – 97	15	Missing in isoform 2.		VSP_037736
	Natural variant	588	1	T → I. Corresponds to variant rs1782338 [ dbSNP | Ensembl ].		VAR_058330
	Natural variant	607	1	E → K in a colorectal cancer sample; somatic mutation. Ref.13		VAR_035497
	Natural variant	681	1	E → G. Corresponds to variant rs1060145 [ dbSNP | Ensembl ].		VAR_058331
	Natural variant	747	1	M → V. Corresponds to variant rs11542602 [ dbSNP | Ensembl ].		VAR_058332
Experimental info
	Sequence conflict	296	1	D → Y in BAA91354. Ref.3
	Sequence conflict	305	1	N → S in BAG60310. Ref.3
	Sequence conflict	492	1	K → E in BAA91847. Ref.3
	Sequence conflict	618	1	D → Y in AAH15475. Ref.6
	Sequence conflict	650	1	S → G in AAO17319. Ref.2
	Sequence conflict	650	1	S → G in BAA91700. Ref.3
	Sequence conflict	723	1	L → S in BAF85338. Ref.3
	Sequence conflict	801 – 803	3	EKD → KKK in AAH89420. Ref.6
	Sequence conflict	816 – 818	3	EER → KKK in AAH15475. Ref.6
	Sequence conflict	853	1	D → G Ref.1
	Sequence conflict	853	1	D → G Ref.2
	Sequence conflict	853	1	D → G in BAA91700. Ref.3
	Sequence conflict	1104	1	N → S Ref.1
	Sequence conflict	1104	1	N → S Ref.2
	Sequence conflict	1104	1	N → S in BAA91700. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 30618DCC8097F552	FASTA	1,150	132,821
	10 20 30 40 50 60 MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA AGLTTQTPAN 70 80 90 100 110 120 YQLTQTAALQ QQAAAAAAAL QQQYSQPQQA LYSVQQQLQQ PQQTLLTQPA VALPTSLSLS 130 140 150 160 170 180 TPQPTAQITV SYPTPRSSQQ QTQPQKQRVF TGVVTKLHDT FGFVDEDVFF QLSAVKGKTP 190 200 210 220 230 240 QVGDRVLVEA TYNPNMPFKW NAQRIQTLPN QNQSQTQPLL KTPPAVLQPI APQTTFGVQT 250 260 270 280 290 300 QPQPQSLLQA QISAASITPL LQTQPQPLLQ QPQQKAGLLQ PPVRIVSQPQ PARRLDPPSR 310 320 330 340 350 360 FSGRNDRGDQ VPNRKDDRSR ERERERRRSR ERSPQRKRSR ERSPRRERER SPRRVRRVVP 370 380 390 400 410 420 RYTVQFSKFS LDCPSCDMME LRRRYQNLYI PSDFFDAQFT WVDAFPLSRP FQLGNYCNFY 430 440 450 460 470 480 VMHREVESLE KNMAILDPPD ADHLYSAKVM LMASPSMEDL YHKSCALAED PQELRDGFQH 490 500 510 520 530 540 PARLVKFLVG MKGKDEAMAI GGHWSPSLDG PDPEKDPSVL IKTAIRCCKA LTGIDLSVCT 550 560 570 580 590 600 QWYRFAEIRY HRPEETHKGR TVPAHVETVV LFFPDVWHCL PTRSEWETLS RGYKQQLVEK 610 620 630 640 650 660 LQGERKEADG EQDEEEKDDG EAKEISTPTH WSKLDPKTMK VNDLRKELES RALSSKGLKS 670 680 690 700 710 720 QLIARLTKQL KVEEQKEEQK ELEKSEKEED EDDDRKSEDD KEEEERKRQE EIERQRRERR 730 740 750 760 770 780 YILPDEPAII VHPNWAAKSG KFDCSIMSLS VLLDYRLEDN KEHSFEVSLF AELFNEMLQR 790 800 810 820 830 840 DFGVRIYKSL LSLPEKEDKK EKDKKSKKDE RKDKKEERDD ETDEPKPKRR KSGDDKDKKE 850 860 870 880 890 900 DRDERKKEDK RKDDSKDDDE TEEDNNQDEY DPMEAEEAED EEDDRDEEEM TKRDDKRDIN 910 920 930 940 950 960 RYCKERPSKD KEKEKTQMIT INRDLLMAFV YFDQSHCGYL LEKDLEEILY TLGLHLSRAQ 970 980 990 1000 1010 1020 VKKLLNKVVL RESCFYRKLT DTSKDEENHE ESESLQEDML GNRLLLPTPT VKQESKDVEE 1030 1040 1050 1060 1070 1080 NVGLIVYNGA MVDVGSLLQK LEKSEKVRAE VEQKLQLLEE KTDEDEKTIL NLENSNKSLS 1090 1100 1110 1120 1130 1140 GELREVKKDL SQLQENLKIS ENMNLQFENQ MNKTIRNLST VMDEIHTVLK KDNVKNEDKD 1150 QKSKENGASV
	Isoform 2 [UniParc]. Checksum: 1F36D655EC82941E	FASTA	1,135	131,043
	10 20 30 40 50 60 MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA AGLTTQTPAN 70 80 90 100 110 120 YQLTQTAALQ QQAAAAAAAL QQLQQPQQTL LTQPAVALPT SLSLSTPQPT AQITVSYPTP 130 140 150 160 170 180 RSSQQQTQPQ KQRVFTGVVT KLHDTFGFVD EDVFFQLSAV KGKTPQVGDR VLVEATYNPN 190 200 210 220 230 240 MPFKWNAQRI QTLPNQNQSQ TQPLLKTPPA VLQPIAPQTT FGVQTQPQPQ SLLQAQISAA 250 260 270 280 290 300 SITPLLQTQP QPLLQQPQQK AGLLQPPVRI VSQPQPARRL DPPSRFSGRN DRGDQVPNRK 310 320 330 340 350 360 DDRSRERERE RRRSRERSPQ RKRSRERSPR RERERSPRRV RRVVPRYTVQ FSKFSLDCPS 370 380 390 400 410 420 CDMMELRRRY QNLYIPSDFF DAQFTWVDAF PLSRPFQLGN YCNFYVMHRE VESLEKNMAI 430 440 450 460 470 480 LDPPDADHLY SAKVMLMASP SMEDLYHKSC ALAEDPQELR DGFQHPARLV KFLVGMKGKD 490 500 510 520 530 540 EAMAIGGHWS PSLDGPDPEK DPSVLIKTAI RCCKALTGID LSVCTQWYRF AEIRYHRPEE 550 560 570 580 590 600 THKGRTVPAH VETVVLFFPD VWHCLPTRSE WETLSRGYKQ QLVEKLQGER KEADGEQDEE 610 620 630 640 650 660 EKDDGEAKEI STPTHWSKLD PKTMKVNDLR KELESRALSS KGLKSQLIAR LTKQLKVEEQ 670 680 690 700 710 720 KEEQKELEKS EKEEDEDDDR KSEDDKEEEE RKRQEEIERQ RRERRYILPD EPAIIVHPNW 730 740 750 760 770 780 AAKSGKFDCS IMSLSVLLDY RLEDNKEHSF EVSLFAELFN EMLQRDFGVR IYKSLLSLPE 790 800 810 820 830 840 KEDKKEKDKK SKKDERKDKK EERDDETDEP KPKRRKSGDD KDKKEDRDER KKEDKRKDDS 850 860 870 880 890 900 KDDDETEEDN NQDEYDPMEA EEAEDEEDDR DEEEMTKRDD KRDINRYCKE RPSKDKEKEK 910 920 930 940 950 960 TQMITINRDL LMAFVYFDQS HCGYLLEKDL EEILYTLGLH LSRAQVKKLL NKVVLRESCF 970 980 990 1000 1010 1020 YRKLTDTSKD EENHEESESL QEDMLGNRLL LPTPTVKQES KDVEENVGLI VYNGAMVDVG 1030 1040 1050 1060 1070 1080 SLLQKLEKSE KVRAEVEQKL QLLEEKTDED EKTILNLENS NKSLSGELRE VKKDLSQLQE 1090 1100 1110 1120 1130 NLKISENMNL QFENQMNKTI RNLSTVMDEI HTVLKKDNVK NEDKDQKSKE NGASV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437." Rishi A.K., Zhang L., Boyanapalli M., Wali A., Mohammad R.M., Yu Y., Fontana J.A., Hatfield J.S., Dawson M.I., Majumdar A.P.N., Reichert U. J. Biol. Chem. 278:33422-33435(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]	"TAZ binding partners identified by mass spectrometry." Tian Y., Li D., Benjamin T. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1058 (ISOFORM 2). Tissue: Hepatoma, Lung, Placenta, Teratocarcinoma and Thymus.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-818 (ISOFORM 1). Tissue: Cerebellum, Lung, Lymph, Muscle and Skin.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[8]	"CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes." Kim J.H., Yang C.K., Heo K., Roeder R.G., An W., Stallcup M.R. Mol. Cell 31:510-519(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CALCOCO1.
[9]	"Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells." Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X. Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-637, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-685; SER-697 AND THR-861, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-861, MASS SPECTROMETRY.
[13]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-607.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY249140 mRNA. Translation: AAP82002.1. AF465616 mRNA. Translation: AAO17319.1. AK000741 mRNA. Translation: BAA91354.1. Different initiation. AK001452 mRNA. Translation: BAA91700.1. AK001701 mRNA. Translation: BAA91847.1. AK023438 mRNA. Translation: BAB14574.1. AK298004 mRNA. Translation: BAG60310.1. AK299307 mRNA. Translation: BAG61320.1. AK292649 mRNA. Translation: BAF85338.1. AL513534, AL391539 Genomic DNA. Translation: CAH70221.1. AL391539, AL513534 Genomic DNA. Translation: CAH73835.1. CH471083 Genomic DNA. Translation: EAW54302.1. BC015475 mRNA. Translation: AAH15475.1. BC026036 mRNA. Translation: AAH26036.1. Sequence problems. BC089420 mRNA. Translation: AAH89420.1. BC130626 mRNA. Translation: AAI30627.1. BC132725 mRNA. Translation: AAI32726.1. BC108682 mRNA. Translation: AAI08683.1. Sequence problems.
IPI	IPI00217357. IPI00939119.
RefSeq	NP_060707.2. NM_018237.2.
UniGene	Hs.49853.
3D structure databases
ProteinModelPortal	Q8IX12.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27607N.
IntAct	Q8IX12. 12 interactions.
MINT	MINT-1139760.
PTM databases
PhosphoSite	Q8IX12.
Polymorphism databases
DMDM	94707499.
Proteomic databases
PaxDb	Q8IX12.
PeptideAtlas	Q8IX12.
PRIDE	Q8IX12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265872; ENSP00000265872; ENSG00000060339. ENST00000535016; ENSP00000441820; ENSG00000060339. ENST00000539539; ENSP00000439252; ENSG00000060339. ENST00000543719; ENSP00000445254; ENSG00000060339.
GeneID	55749.
KEGG	hsa:55749.
UCSC	uc001jom.1. human. uc010qiz.1. human.
Organism-specific databases
CTD	55749.
GeneCards	GC10P070480.
HGNC	HGNC:24236. CCAR1.
HPA	HPA007856.
MIM	612569. gene.
neXtProt	NX_Q8IX12.
PharmGKB	PA134920227.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313311.
HOVERGEN	HBG079908.
InParanoid	Q8IX12.
OMA	MITVNRD.
OrthoDB	EOG4CC410.
PhylomeDB	Q8IX12.
Enzyme and pathway databases
Reactome	REACT_1675. mRNA Processing. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q8IX12.
Bgee	Q8IX12.
CleanEx	HS_CCAR1.
Genevestigator	Q8IX12.
GermOnline	ENSG00000060339. Homo sapiens.
Family and domain databases
Gene3D	1.10.720.30. 1 hit. 2.40.50.140. 1 hit.
InterPro	IPR025224. DBC1/CARP1. IPR025954. DBC1/CARP1_inactive_NUDIX_dom. IPR012340. NA-bd_OB-fold. IPR025223. S1-like_RNA-bd_dom. IPR003034. SAP_dom. [Graphical view]
PANTHER	PTHR14304. PTHR14304. 1 hit.
Pfam	PF14443. DBC1. 1 hit. PF14444. S1-like. 1 hit. PF02037. SAP. 1 hit. [Graphical view]
SMART	SM00513. SAP. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
PROSITE	PS50800. SAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CCAR1. human.
GenomeRNAi	55749.
NextBio	60733.
SOURCE	Search...

Entry information

Entry name

CCAR1_HUMAN

Accession

Primary (citable) accession number: Q8IX12
Secondary accession number(s): A0JLT7 , A1L4P7, A8K9D4, B4DNP8, B4DRK8, Q32NE3, Q5EBM3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	April 3, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.