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Q8IX12

- CCAR1_HUMAN

UniProt

Q8IX12 - CCAR1_HUMAN

Protein

Cell division cycle and apoptosis regulator protein 1

Gene

CCAR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation By similarity. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.By similarity1 Publication

    GO - Molecular functioni

    1. ligand-dependent nuclear receptor transcription coactivator activity Source: MGI
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell cycle Source: UniProtKB-KW
    3. gene expression Source: Reactome
    4. mRNA splicing, via spliceosome Source: Reactome
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. RNA splicing Source: Reactome
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Cell cycle, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_467. mRNA Splicing - Major Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division cycle and apoptosis regulator protein 1
    Alternative name(s):
    Cell cycle and apoptosis regulatory protein 1
    Short name:
    CARP-1
    Death inducer with SAP domain
    Gene namesi
    Name:CCAR1
    Synonyms:CARP1, DIS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:24236. CCAR1.

    Subcellular locationi

    Cytoplasmperinuclear region 1 Publication

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134920227.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11501150Cell division cycle and apoptosis regulator protein 1PRO_0000233148Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki637 – 637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei685 – 6851Phosphoserine1 Publication
    Modified residuei697 – 6971Phosphoserine1 Publication
    Modified residuei861 – 8611Phosphothreonine2 Publications

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8IX12.
    PaxDbiQ8IX12.
    PeptideAtlasiQ8IX12.
    PRIDEiQ8IX12.

    PTM databases

    PhosphoSiteiQ8IX12.

    Expressioni

    Tissue specificityi

    Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.1 Publication

    Gene expression databases

    ArrayExpressiQ8IX12.
    BgeeiQ8IX12.
    CleanExiHS_CCAR1.
    GenevestigatoriQ8IX12.

    Organism-specific databases

    HPAiHPA007856.
    HPA048513.

    Interactioni

    Subunit structurei

    Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRIM63Q969Q12EBI-356265,EBI-5661333
    WWTR1Q9GZV52EBI-356265,EBI-747743
    Wwtr1Q9EPK55EBI-356265,EBI-1211920From a different organism.

    Protein-protein interaction databases

    BioGridi120867. 17 interactions.
    DIPiDIP-27607N.
    IntActiQ8IX12. 22 interactions.
    MINTiMINT-1139760.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IX12.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini636 – 67035SAPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili594 – 61825Sequence AnalysisAdd
    BLAST
    Coiled coili1033 – 111482Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi73 – 797Poly-Ala
    Compositional biasi293 – 36169Arg-richAdd
    BLAST
    Compositional biasi673 – 889217Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG313311.
    HOVERGENiHBG079908.
    InParanoidiQ8IX12.
    OMAiELYHKSC.
    OrthoDBiEOG7CK365.
    PhylomeDBiQ8IX12.
    TreeFamiTF316387.

    Family and domain databases

    Gene3Di1.10.720.30. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR025224. DBC1/CARP1.
    IPR025954. DBC1/CARP1_inactive_NUDIX_dom.
    IPR012340. NA-bd_OB-fold.
    IPR025223. S1-like_RNA-bd_dom.
    IPR003034. SAP_dom.
    [Graphical view]
    PANTHERiPTHR14304. PTHR14304. 1 hit.
    PfamiPF14443. DBC1. 1 hit.
    PF14444. S1-like. 1 hit.
    PF02037. SAP. 1 hit.
    [Graphical view]
    SMARTiSM00513. SAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    PROSITEiPS50800. SAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IX12-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA     50
    AGLTTQTPAN YQLTQTAALQ QQAAAAAAAL QQQYSQPQQA LYSVQQQLQQ 100
    PQQTLLTQPA VALPTSLSLS TPQPTAQITV SYPTPRSSQQ QTQPQKQRVF 150
    TGVVTKLHDT FGFVDEDVFF QLSAVKGKTP QVGDRVLVEA TYNPNMPFKW 200
    NAQRIQTLPN QNQSQTQPLL KTPPAVLQPI APQTTFGVQT QPQPQSLLQA 250
    QISAASITPL LQTQPQPLLQ QPQQKAGLLQ PPVRIVSQPQ PARRLDPPSR 300
    FSGRNDRGDQ VPNRKDDRSR ERERERRRSR ERSPQRKRSR ERSPRRERER 350
    SPRRVRRVVP RYTVQFSKFS LDCPSCDMME LRRRYQNLYI PSDFFDAQFT 400
    WVDAFPLSRP FQLGNYCNFY VMHREVESLE KNMAILDPPD ADHLYSAKVM 450
    LMASPSMEDL YHKSCALAED PQELRDGFQH PARLVKFLVG MKGKDEAMAI 500
    GGHWSPSLDG PDPEKDPSVL IKTAIRCCKA LTGIDLSVCT QWYRFAEIRY 550
    HRPEETHKGR TVPAHVETVV LFFPDVWHCL PTRSEWETLS RGYKQQLVEK 600
    LQGERKEADG EQDEEEKDDG EAKEISTPTH WSKLDPKTMK VNDLRKELES 650
    RALSSKGLKS QLIARLTKQL KVEEQKEEQK ELEKSEKEED EDDDRKSEDD 700
    KEEEERKRQE EIERQRRERR YILPDEPAII VHPNWAAKSG KFDCSIMSLS 750
    VLLDYRLEDN KEHSFEVSLF AELFNEMLQR DFGVRIYKSL LSLPEKEDKK 800
    EKDKKSKKDE RKDKKEERDD ETDEPKPKRR KSGDDKDKKE DRDERKKEDK 850
    RKDDSKDDDE TEEDNNQDEY DPMEAEEAED EEDDRDEEEM TKRDDKRDIN 900
    RYCKERPSKD KEKEKTQMIT INRDLLMAFV YFDQSHCGYL LEKDLEEILY 950
    TLGLHLSRAQ VKKLLNKVVL RESCFYRKLT DTSKDEENHE ESESLQEDML 1000
    GNRLLLPTPT VKQESKDVEE NVGLIVYNGA MVDVGSLLQK LEKSEKVRAE 1050
    VEQKLQLLEE KTDEDEKTIL NLENSNKSLS GELREVKKDL SQLQENLKIS 1100
    ENMNLQFENQ MNKTIRNLST VMDEIHTVLK KDNVKNEDKD QKSKENGASV 1150
    Length:1,150
    Mass (Da):132,821
    Last modified:May 2, 2006 - v2
    Checksum:i30618DCC8097F552
    GO
    Isoform 2 (identifier: Q8IX12-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         83-97: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,135
    Mass (Da):131,043
    Checksum:i1F36D655EC82941E
    GO

    Sequence cautioni

    The sequence AAH26036.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAI08683.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAA91354.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti296 – 2961D → Y in BAA91354. (PubMed:14702039)Curated
    Sequence conflicti305 – 3051N → S in BAG60310. (PubMed:14702039)Curated
    Sequence conflicti492 – 4921K → E in BAA91847. (PubMed:14702039)Curated
    Sequence conflicti618 – 6181D → Y in AAH15475. (PubMed:15489334)Curated
    Sequence conflicti650 – 6501S → G in AAO17319. 1 PublicationCurated
    Sequence conflicti650 – 6501S → G in BAA91700. (PubMed:14702039)Curated
    Sequence conflicti723 – 7231L → S in BAF85338. (PubMed:14702039)Curated
    Sequence conflicti801 – 8033EKD → KKK in AAH89420. (PubMed:15489334)Curated
    Sequence conflicti816 – 8183EER → KKK in AAH15475. (PubMed:15489334)Curated
    Sequence conflicti853 – 8531D → G(PubMed:12816952)Curated
    Sequence conflicti853 – 8531D → G1 PublicationCurated
    Sequence conflicti853 – 8531D → G in BAA91700. (PubMed:14702039)Curated
    Sequence conflicti1104 – 11041N → S(PubMed:12816952)Curated
    Sequence conflicti1104 – 11041N → S1 PublicationCurated
    Sequence conflicti1104 – 11041N → S in BAA91700. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti588 – 5881T → I.
    Corresponds to variant rs1782338 [ dbSNP | Ensembl ].
    VAR_058330
    Natural varianti607 – 6071E → K in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035497
    Natural varianti681 – 6811E → G.
    Corresponds to variant rs1060145 [ dbSNP | Ensembl ].
    VAR_058331
    Natural varianti747 – 7471M → V.
    Corresponds to variant rs11542602 [ dbSNP | Ensembl ].
    VAR_058332

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei83 – 9715Missing in isoform 2. 1 PublicationVSP_037736Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY249140 mRNA. Translation: AAP82002.1.
    AF465616 mRNA. Translation: AAO17319.1.
    AK000741 mRNA. Translation: BAA91354.1. Different initiation.
    AK001452 mRNA. Translation: BAA91700.1.
    AK001701 mRNA. Translation: BAA91847.1.
    AK023438 mRNA. Translation: BAB14574.1.
    AK298004 mRNA. Translation: BAG60310.1.
    AK299307 mRNA. Translation: BAG61320.1.
    AK292649 mRNA. Translation: BAF85338.1.
    AL513534, AL391539 Genomic DNA. Translation: CAH70221.1.
    AL391539, AL513534 Genomic DNA. Translation: CAH73835.1.
    CH471083 Genomic DNA. Translation: EAW54302.1.
    BC015475 mRNA. Translation: AAH15475.1.
    BC026036 mRNA. Translation: AAH26036.1. Sequence problems.
    BC089420 mRNA. Translation: AAH89420.1.
    BC130626 mRNA. Translation: AAI30627.1.
    BC132725 mRNA. Translation: AAI32726.1.
    BC108682 mRNA. Translation: AAI08683.1. Sequence problems.
    CCDSiCCDS60547.1. [Q8IX12-2]
    CCDS7282.1. [Q8IX12-1]
    RefSeqiNP_001269888.1. NM_001282959.1. [Q8IX12-2]
    NP_001269889.1. NM_001282960.1. [Q8IX12-2]
    NP_060707.2. NM_018237.3. [Q8IX12-1]
    UniGeneiHs.49853.

    Genome annotation databases

    EnsembliENST00000265872; ENSP00000265872; ENSG00000060339. [Q8IX12-1]
    ENST00000539539; ENSP00000439252; ENSG00000060339.
    ENST00000543719; ENSP00000445254; ENSG00000060339. [Q8IX12-2]
    GeneIDi55749.
    KEGGihsa:55749.
    UCSCiuc001jom.1. human. [Q8IX12-1]
    uc010qiz.1. human. [Q8IX12-2]

    Polymorphism databases

    DMDMi94707499.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY249140 mRNA. Translation: AAP82002.1 .
    AF465616 mRNA. Translation: AAO17319.1 .
    AK000741 mRNA. Translation: BAA91354.1 . Different initiation.
    AK001452 mRNA. Translation: BAA91700.1 .
    AK001701 mRNA. Translation: BAA91847.1 .
    AK023438 mRNA. Translation: BAB14574.1 .
    AK298004 mRNA. Translation: BAG60310.1 .
    AK299307 mRNA. Translation: BAG61320.1 .
    AK292649 mRNA. Translation: BAF85338.1 .
    AL513534 , AL391539 Genomic DNA. Translation: CAH70221.1 .
    AL391539 , AL513534 Genomic DNA. Translation: CAH73835.1 .
    CH471083 Genomic DNA. Translation: EAW54302.1 .
    BC015475 mRNA. Translation: AAH15475.1 .
    BC026036 mRNA. Translation: AAH26036.1 . Sequence problems.
    BC089420 mRNA. Translation: AAH89420.1 .
    BC130626 mRNA. Translation: AAI30627.1 .
    BC132725 mRNA. Translation: AAI32726.1 .
    BC108682 mRNA. Translation: AAI08683.1 . Sequence problems.
    CCDSi CCDS60547.1. [Q8IX12-2 ]
    CCDS7282.1. [Q8IX12-1 ]
    RefSeqi NP_001269888.1. NM_001282959.1. [Q8IX12-2 ]
    NP_001269889.1. NM_001282960.1. [Q8IX12-2 ]
    NP_060707.2. NM_018237.3. [Q8IX12-1 ]
    UniGenei Hs.49853.

    3D structure databases

    ProteinModelPortali Q8IX12.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120867. 17 interactions.
    DIPi DIP-27607N.
    IntActi Q8IX12. 22 interactions.
    MINTi MINT-1139760.

    PTM databases

    PhosphoSitei Q8IX12.

    Polymorphism databases

    DMDMi 94707499.

    Proteomic databases

    MaxQBi Q8IX12.
    PaxDbi Q8IX12.
    PeptideAtlasi Q8IX12.
    PRIDEi Q8IX12.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265872 ; ENSP00000265872 ; ENSG00000060339 . [Q8IX12-1 ]
    ENST00000539539 ; ENSP00000439252 ; ENSG00000060339 .
    ENST00000543719 ; ENSP00000445254 ; ENSG00000060339 . [Q8IX12-2 ]
    GeneIDi 55749.
    KEGGi hsa:55749.
    UCSCi uc001jom.1. human. [Q8IX12-1 ]
    uc010qiz.1. human. [Q8IX12-2 ]

    Organism-specific databases

    CTDi 55749.
    GeneCardsi GC10P070480.
    HGNCi HGNC:24236. CCAR1.
    HPAi HPA007856.
    HPA048513.
    MIMi 612569. gene.
    neXtProti NX_Q8IX12.
    PharmGKBi PA134920227.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313311.
    HOVERGENi HBG079908.
    InParanoidi Q8IX12.
    OMAi ELYHKSC.
    OrthoDBi EOG7CK365.
    PhylomeDBi Q8IX12.
    TreeFami TF316387.

    Enzyme and pathway databases

    Reactomei REACT_467. mRNA Splicing - Major Pathway.

    Miscellaneous databases

    ChiTaRSi CCAR1. human.
    GeneWikii CCAR1.
    GenomeRNAii 55749.
    NextBioi 60733.
    PROi Q8IX12.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IX12.
    Bgeei Q8IX12.
    CleanExi HS_CCAR1.
    Genevestigatori Q8IX12.

    Family and domain databases

    Gene3Di 1.10.720.30. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR025224. DBC1/CARP1.
    IPR025954. DBC1/CARP1_inactive_NUDIX_dom.
    IPR012340. NA-bd_OB-fold.
    IPR025223. S1-like_RNA-bd_dom.
    IPR003034. SAP_dom.
    [Graphical view ]
    PANTHERi PTHR14304. PTHR14304. 1 hit.
    Pfami PF14443. DBC1. 1 hit.
    PF14444. S1-like. 1 hit.
    PF02037. SAP. 1 hit.
    [Graphical view ]
    SMARTi SM00513. SAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    PROSITEi PS50800. SAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437."
      Rishi A.K., Zhang L., Boyanapalli M., Wali A., Mohammad R.M., Yu Y., Fontana J.A., Hatfield J.S., Dawson M.I., Majumdar A.P.N., Reichert U.
      J. Biol. Chem. 278:33422-33435(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    2. "TAZ binding partners identified by mass spectrometry."
      Tian Y., Li D., Benjamin T.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1058 (ISOFORM 2).
      Tissue: Hepatoma, Lung, Placenta, Teratocarcinoma and Thymus.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-818 (ISOFORM 1).
      Tissue: Cerebellum, Lung, Lymph, Muscle and Skin.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    8. "CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes."
      Kim J.H., Yang C.K., Heo K., Roeder R.G., An W., Stallcup M.R.
      Mol. Cell 31:510-519(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CALCOCO1.
    9. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
      Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
      Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-637.
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-685; SER-697 AND THR-861, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-861, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-607.

    Entry informationi

    Entry nameiCCAR1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IX12
    Secondary accession number(s): A0JLT7
    , A1L4P7, A8K9D4, B4DNP8, B4DRK8, Q32NE3, Q5EBM3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3