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Q8IX07

- FOG1_HUMAN

UniProt

Q8IX07 - FOG1_HUMAN

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Protein
Zinc finger protein ZFPM1
Gene
ZFPM1, FOG1, ZFN89A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri241 – 26424C2HC-type 1
Add
BLAST
Zinc fingeri290 – 31425C2H2-type 1
Add
BLAST
Zinc fingeri320 – 34223C2H2-type 2
Add
BLAST
Zinc fingeri348 – 37124C2H2-type 3
Add
BLAST
Zinc fingeri577 – 699123C2HC-type 2
Add
BLAST
Zinc fingeri683 – 70523C2HC-type 3
Add
BLAST
Zinc fingeri817 – 83923C2HC-type 4
Add
BLAST
Zinc fingeri854 – 87724C2H2-type 4
Add
BLAST
Zinc fingeri974 – 100027C2HC-type 5
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: BHF-UCL
  3. RNA polymerase II transcription factor binding Source: BHF-UCL
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: IntAct
  6. transcription factor binding Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. T-helper cell lineage commitment Source: BHF-UCL
  2. atrial septum morphogenesis Source: BHF-UCL
  3. atrioventricular valve morphogenesis Source: BHF-UCL
  4. blood coagulation Source: Reactome
  5. cardiac muscle tissue morphogenesis Source: BHF-UCL
  6. definitive erythrocyte differentiation Source: Ensembl
  7. embryonic hemopoiesis Source: BHF-UCL
  8. erythrocyte differentiation Source: BHF-UCL
  9. granulocyte differentiation Source: Ensembl
  10. megakaryocyte development Source: Ensembl
  11. megakaryocyte differentiation Source: BHF-UCL
  12. mitral valve formation Source: BHF-UCL
  13. negative regulation of fat cell differentiation Source: BHF-UCL
  14. negative regulation of interleukin-4 biosynthetic process Source: BHF-UCL
  15. negative regulation of mast cell differentiation Source: BHF-UCL
  16. negative regulation of protein binding Source: BHF-UCL
  17. negative regulation of transcription from RNA polymerase II promoter Source: GOC
  18. outflow tract morphogenesis Source: BHF-UCL
  19. platelet formation Source: BHF-UCL
  20. positive regulation of interferon-gamma biosynthetic process Source: BHF-UCL
  21. primitive erythrocyte differentiation Source: Ensembl
  22. regulation of chemokine production Source: Ensembl
  23. regulation of definitive erythrocyte differentiation Source: BHF-UCL
  24. transcriptional activation by promoter-enhancer looping Source: BHF-UCL
  25. tricuspid valve formation Source: BHF-UCL
  26. ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM1
Alternative name(s):
Friend of GATA protein 1
Short name:
FOG-1
Short name:
Friend of GATA 1
Zinc finger protein 89A
Zinc finger protein multitype 1
Gene namesi
Name:ZFPM1
Synonyms:FOG1, ZFN89A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:19762. ZFPM1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleoplasm Source: Reactome
  3. transcription factor complex Source: BHF-UCL
  4. transcriptional repressor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920282.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10061006Zinc finger protein ZFPM1
PRO_0000221041Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei786 – 7861Phosphoserine1 Publication
Modified residuei901 – 9011Phosphoserine1 Publication
Modified residuei909 – 9091Phosphoserine1 Publication
Modified residuei935 – 9351Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IX07.
PaxDbiQ8IX07.
PRIDEiQ8IX07.

PTM databases

PhosphoSiteiQ8IX07.

Expressioni

Tissue specificityi

Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.1 Publication

Gene expression databases

BgeeiQ8IX07.
CleanExiHS_ZFPM1.
GenevestigatoriQ8IX07.

Organism-specific databases

HPAiHPA046603.

Interactioni

Subunit structurei

Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity By similarity. Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GSK3BP498412EBI-3942619,EBI-373586
RBBP4Q090284EBI-3942619,EBI-620823

Protein-protein interaction databases

BioGridi127806. 8 interactions.
DIPiDIP-48415N.
IntActiQ8IX07. 3 interactions.
STRINGi9606.ENSP00000326630.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XU7X-ray1.90C/D1-15[»]
ProteinModelPortaliQ8IX07.
SMRiQ8IX07. Positions 234-370, 847-875, 964-1003.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni330 – 34112Interaction with TACC3 By similarity
Add
BLAST
Regioni794 – 8007Interaction with CTBP2 By similarity

Domaini

The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG146797.
HOGENOMiHOG000112626.
HOVERGENiHBG101018.
InParanoidiQ8IX07.
KOiK17441.
OMAiKLYELHA.
OrthoDBiEOG74TWXR.
PhylomeDBiQ8IX07.
TreeFamiTF331342.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IX07-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRKQSNPR QIKRSLGDME AREEVQLVGA SHMEQKATAP EAPSPPSADV     50
NSPPPLPPPT SPGGPKELEG QEPEPRPTEE EPGSPWSGPD ELEPVVQDGQ 100
RRIRARLSLA TGLSWGPFHG SVQTRASSPR QAEPSPALTL LLVDEACWLR 150
TLPQALTEAE ANTEIHRKDD ALWCRVTKPV PAGGLLSVLL TAEPHSTPGH 200
PVKKEPAEPT CPAPAHDLQL LPQQAGMASI LATAVINKDV FPCKDCGIWY 250
RSERNLQAHL LYYCASRQGT GSPAAAATDE KPKETYPNER VCPFPQCRKS 300
CPSASSLEIH MRSHSGERPF VCLICLSAFT TKANCERHLK VHTDTLSGVC 350
HSCGFISTTR DILYSHLVTN HMVCQPGSKG EIYSPGAGHP ATKLPPDSLG 400
SFQQQHTALQ GPLASADLGL APTPSPGLDR KALAEATNGE ARAEPLAQNG 450
GSSEPPAAPR SIKVEAVEEP EAAPILGPGE PGPQAPSRTP SPRSPAPARV 500
KAELSSPTPG SSPVPGELGL AGALFLPQYV FGPDAAPPAS EILAKMSELV 550
HSRLQQGAGA GAGGAQTGLF PGAPKGATCF ECEITFSNVN NYYVHKRLYC 600
SGRRAPEDAP AARRPKAPPG PARAPPGQPA EPDAPRSSPG PGAREEGAGG 650
AATPEDGAGG RGSEGSQSPG SSVDDAEDDP SRTLCEACNI RFSRHETYTV 700
HKRYYCASRH DPPPRRPAAP PGPPGPAAPP APSPAAPVRT RRRRKLYELH 750
AAGAPPPPPP GHAPAPESPR PGSGSGSGPG LAPARSPGPA ADGPIDLSKK 800
PRRPLPGAPA PALADYHECT ACRVSFHSLE AYLAHKKYSC PAAPPPGALG 850
LPAAACPYCP PNGPVRGDLL EHFRLAHGLL LGAPLAGPGV EARTPADRGP 900
SPAPAPAASP QPGSRGPRDG LGPEPQEPPP GPPPSPAAAP EAVPPPPAPP 950
SYSDKGVQTP SKGTPAPLPN GNHRYCRLCN IKFSSLSTFI AHKKYYCSSH 1000
AAEHVK 1006
Length:1,006
Mass (Da):104,888
Last modified:May 18, 2010 - v2
Checksum:iE9C2363503A64898
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701G → A.
Corresponds to variant rs34916016 [ dbSNP | Ensembl ].
VAR_057491

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221R → G in AAN45858. 1 Publication
Sequence conflicti444 – 4474EPLA → AP in AAN45858. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF488691 mRNA. Translation: AAN45858.1.
AC116552 Genomic DNA. No translation available.
AC135049 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66806.1.
CCDSiCCDS32502.1.
RefSeqiNP_722520.2. NM_153813.2.
UniGeneiHs.632218.

Genome annotation databases

EnsembliENST00000319555; ENSP00000326630; ENSG00000179588.
GeneIDi161882.
KEGGihsa:161882.
UCSCiuc002fkv.3. human.

Polymorphism databases

DMDMi296434508.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF488691 mRNA. Translation: AAN45858.1 .
AC116552 Genomic DNA. No translation available.
AC135049 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66806.1 .
CCDSi CCDS32502.1.
RefSeqi NP_722520.2. NM_153813.2.
UniGenei Hs.632218.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XU7 X-ray 1.90 C/D 1-15 [» ]
ProteinModelPortali Q8IX07.
SMRi Q8IX07. Positions 234-370, 847-875, 964-1003.
ModBasei Search...

Protein-protein interaction databases

BioGridi 127806. 8 interactions.
DIPi DIP-48415N.
IntActi Q8IX07. 3 interactions.
STRINGi 9606.ENSP00000326630.

PTM databases

PhosphoSitei Q8IX07.

Polymorphism databases

DMDMi 296434508.

Proteomic databases

MaxQBi Q8IX07.
PaxDbi Q8IX07.
PRIDEi Q8IX07.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319555 ; ENSP00000326630 ; ENSG00000179588 .
GeneIDi 161882.
KEGGi hsa:161882.
UCSCi uc002fkv.3. human.

Organism-specific databases

CTDi 161882.
GeneCardsi GC16P088519.
HGNCi HGNC:19762. ZFPM1.
HPAi HPA046603.
MIMi 601950. gene.
neXtProti NX_Q8IX07.
PharmGKBi PA134920282.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146797.
HOGENOMi HOG000112626.
HOVERGENi HBG101018.
InParanoidi Q8IX07.
KOi K17441.
OMAi KLYELHA.
OrthoDBi EOG74TWXR.
PhylomeDBi Q8IX07.
TreeFami TF331342.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi ZFPM1. human.
GeneWikii ZFPM1.
GenomeRNAii 161882.
NextBioi 88126.
PROi Q8IX07.
SOURCEi Search...

Gene expression databases

Bgeei Q8IX07.
CleanExi HS_ZFPM1.
Genevestigatori Q8IX07.

Family and domain databases

Gene3Di 3.30.160.60. 2 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
    Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
    Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH GATA1 AND GATA2.
    Tissue: Megakaryocyte.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
    Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.
    Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Prostate cancer.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-901 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiFOG1_HUMAN
AccessioniPrimary (citable) accession number: Q8IX07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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