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Q8IX07

- FOG1_HUMAN

UniProt

Q8IX07 - FOG1_HUMAN

Protein

Zinc finger protein ZFPM1

Gene

ZFPM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri241 – 26424C2HC-type 1Add
    BLAST
    Zinc fingeri290 – 31425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri320 – 34223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri348 – 37124C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri577 – 699123C2HC-type 2Add
    BLAST
    Zinc fingeri683 – 70523C2HC-type 3Add
    BLAST
    Zinc fingeri817 – 83923C2HC-type 4Add
    BLAST
    Zinc fingeri854 – 87724C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri974 – 100027C2HC-type 5Add
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: BHF-UCL
    5. RNA polymerase II transcription factor binding Source: BHF-UCL
    6. transcription factor binding Source: BHF-UCL

    GO - Biological processi

    1. atrial septum morphogenesis Source: BHF-UCL
    2. atrioventricular valve morphogenesis Source: BHF-UCL
    3. blood coagulation Source: Reactome
    4. cardiac muscle tissue morphogenesis Source: BHF-UCL
    5. definitive erythrocyte differentiation Source: Ensembl
    6. embryonic hemopoiesis Source: BHF-UCL
    7. erythrocyte differentiation Source: BHF-UCL
    8. granulocyte differentiation Source: Ensembl
    9. megakaryocyte development Source: Ensembl
    10. megakaryocyte differentiation Source: BHF-UCL
    11. mitral valve formation Source: BHF-UCL
    12. negative regulation of fat cell differentiation Source: BHF-UCL
    13. negative regulation of interleukin-4 biosynthetic process Source: BHF-UCL
    14. negative regulation of mast cell differentiation Source: BHF-UCL
    15. negative regulation of protein binding Source: BHF-UCL
    16. negative regulation of transcription from RNA polymerase II promoter Source: GOC
    17. outflow tract morphogenesis Source: BHF-UCL
    18. platelet formation Source: BHF-UCL
    19. positive regulation of interferon-gamma biosynthetic process Source: BHF-UCL
    20. primitive erythrocyte differentiation Source: Ensembl
    21. regulation of chemokine production Source: Ensembl
    22. regulation of definitive erythrocyte differentiation Source: BHF-UCL
    23. T-helper cell lineage commitment Source: BHF-UCL
    24. transcriptional activation by promoter-enhancer looping Source: BHF-UCL
    25. tricuspid valve formation Source: BHF-UCL
    26. ventricular septum morphogenesis Source: BHF-UCL

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein ZFPM1
    Alternative name(s):
    Friend of GATA protein 1
    Short name:
    FOG-1
    Short name:
    Friend of GATA 1
    Zinc finger protein 89A
    Zinc finger protein multitype 1
    Gene namesi
    Name:ZFPM1
    Synonyms:FOG1, ZFN89A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:19762. ZFPM1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleoplasm Source: Reactome
    3. transcriptional repressor complex Source: BHF-UCL
    4. transcription factor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134920282.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10061006Zinc finger protein ZFPM1PRO_0000221041Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei786 – 7861Phosphoserine1 Publication
    Modified residuei901 – 9011Phosphoserine1 Publication
    Modified residuei909 – 9091Phosphoserine1 Publication
    Modified residuei935 – 9351PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IX07.
    PaxDbiQ8IX07.
    PRIDEiQ8IX07.

    PTM databases

    PhosphoSiteiQ8IX07.

    Expressioni

    Tissue specificityi

    Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.1 Publication

    Gene expression databases

    BgeeiQ8IX07.
    CleanExiHS_ZFPM1.
    GenevestigatoriQ8IX07.

    Organism-specific databases

    HPAiHPA046603.

    Interactioni

    Subunit structurei

    Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity By similarity. Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GSK3BP498412EBI-3942619,EBI-373586
    RBBP4Q090284EBI-3942619,EBI-620823

    Protein-protein interaction databases

    BioGridi127806. 8 interactions.
    DIPiDIP-48415N.
    IntActiQ8IX07. 3 interactions.
    STRINGi9606.ENSP00000326630.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XU7X-ray1.90C/D1-15[»]
    ProteinModelPortaliQ8IX07.
    SMRiQ8IX07. Positions 234-370, 847-875, 964-1003.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni330 – 34112Interaction with TACC3By similarityAdd
    BLAST
    Regioni794 – 8007Interaction with CTBP2By similarity

    Domaini

    The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers By similarity.By similarity

    Sequence similaritiesi

    Belongs to the FOG (Friend of GATA) family.Curated
    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 5 C2HC-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri241 – 26424C2HC-type 1Add
    BLAST
    Zinc fingeri290 – 31425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri320 – 34223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri348 – 37124C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri577 – 699123C2HC-type 2Add
    BLAST
    Zinc fingeri683 – 70523C2HC-type 3Add
    BLAST
    Zinc fingeri817 – 83923C2HC-type 4Add
    BLAST
    Zinc fingeri854 – 87724C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri974 – 100027C2HC-type 5Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG146797.
    HOGENOMiHOG000112626.
    HOVERGENiHBG101018.
    InParanoidiQ8IX07.
    KOiK17441.
    OMAiKLYELHA.
    OrthoDBiEOG74TWXR.
    PhylomeDBiQ8IX07.
    TreeFamiTF331342.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IX07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRKQSNPR QIKRSLGDME AREEVQLVGA SHMEQKATAP EAPSPPSADV     50
    NSPPPLPPPT SPGGPKELEG QEPEPRPTEE EPGSPWSGPD ELEPVVQDGQ 100
    RRIRARLSLA TGLSWGPFHG SVQTRASSPR QAEPSPALTL LLVDEACWLR 150
    TLPQALTEAE ANTEIHRKDD ALWCRVTKPV PAGGLLSVLL TAEPHSTPGH 200
    PVKKEPAEPT CPAPAHDLQL LPQQAGMASI LATAVINKDV FPCKDCGIWY 250
    RSERNLQAHL LYYCASRQGT GSPAAAATDE KPKETYPNER VCPFPQCRKS 300
    CPSASSLEIH MRSHSGERPF VCLICLSAFT TKANCERHLK VHTDTLSGVC 350
    HSCGFISTTR DILYSHLVTN HMVCQPGSKG EIYSPGAGHP ATKLPPDSLG 400
    SFQQQHTALQ GPLASADLGL APTPSPGLDR KALAEATNGE ARAEPLAQNG 450
    GSSEPPAAPR SIKVEAVEEP EAAPILGPGE PGPQAPSRTP SPRSPAPARV 500
    KAELSSPTPG SSPVPGELGL AGALFLPQYV FGPDAAPPAS EILAKMSELV 550
    HSRLQQGAGA GAGGAQTGLF PGAPKGATCF ECEITFSNVN NYYVHKRLYC 600
    SGRRAPEDAP AARRPKAPPG PARAPPGQPA EPDAPRSSPG PGAREEGAGG 650
    AATPEDGAGG RGSEGSQSPG SSVDDAEDDP SRTLCEACNI RFSRHETYTV 700
    HKRYYCASRH DPPPRRPAAP PGPPGPAAPP APSPAAPVRT RRRRKLYELH 750
    AAGAPPPPPP GHAPAPESPR PGSGSGSGPG LAPARSPGPA ADGPIDLSKK 800
    PRRPLPGAPA PALADYHECT ACRVSFHSLE AYLAHKKYSC PAAPPPGALG 850
    LPAAACPYCP PNGPVRGDLL EHFRLAHGLL LGAPLAGPGV EARTPADRGP 900
    SPAPAPAASP QPGSRGPRDG LGPEPQEPPP GPPPSPAAAP EAVPPPPAPP 950
    SYSDKGVQTP SKGTPAPLPN GNHRYCRLCN IKFSSLSTFI AHKKYYCSSH 1000
    AAEHVK 1006
    Length:1,006
    Mass (Da):104,888
    Last modified:May 18, 2010 - v2
    Checksum:iE9C2363503A64898
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221R → G in AAN45858. (PubMed:12483298)Curated
    Sequence conflicti444 – 4474EPLA → AP in AAN45858. (PubMed:12483298)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti70 – 701G → A.
    Corresponds to variant rs34916016 [ dbSNP | Ensembl ].
    VAR_057491

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF488691 mRNA. Translation: AAN45858.1.
    AC116552 Genomic DNA. No translation available.
    AC135049 Genomic DNA. No translation available.
    CH471184 Genomic DNA. Translation: EAW66806.1.
    CCDSiCCDS32502.1.
    RefSeqiNP_722520.2. NM_153813.2.
    UniGeneiHs.632218.

    Genome annotation databases

    EnsembliENST00000319555; ENSP00000326630; ENSG00000179588.
    GeneIDi161882.
    KEGGihsa:161882.
    UCSCiuc002fkv.3. human.

    Polymorphism databases

    DMDMi296434508.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF488691 mRNA. Translation: AAN45858.1 .
    AC116552 Genomic DNA. No translation available.
    AC135049 Genomic DNA. No translation available.
    CH471184 Genomic DNA. Translation: EAW66806.1 .
    CCDSi CCDS32502.1.
    RefSeqi NP_722520.2. NM_153813.2.
    UniGenei Hs.632218.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XU7 X-ray 1.90 C/D 1-15 [» ]
    ProteinModelPortali Q8IX07.
    SMRi Q8IX07. Positions 234-370, 847-875, 964-1003.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127806. 8 interactions.
    DIPi DIP-48415N.
    IntActi Q8IX07. 3 interactions.
    STRINGi 9606.ENSP00000326630.

    PTM databases

    PhosphoSitei Q8IX07.

    Polymorphism databases

    DMDMi 296434508.

    Proteomic databases

    MaxQBi Q8IX07.
    PaxDbi Q8IX07.
    PRIDEi Q8IX07.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319555 ; ENSP00000326630 ; ENSG00000179588 .
    GeneIDi 161882.
    KEGGi hsa:161882.
    UCSCi uc002fkv.3. human.

    Organism-specific databases

    CTDi 161882.
    GeneCardsi GC16P088519.
    HGNCi HGNC:19762. ZFPM1.
    HPAi HPA046603.
    MIMi 601950. gene.
    neXtProti NX_Q8IX07.
    PharmGKBi PA134920282.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146797.
    HOGENOMi HOG000112626.
    HOVERGENi HBG101018.
    InParanoidi Q8IX07.
    KOi K17441.
    OMAi KLYELHA.
    OrthoDBi EOG74TWXR.
    PhylomeDBi Q8IX07.
    TreeFami TF331342.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi ZFPM1. human.
    GeneWikii ZFPM1.
    GenomeRNAii 161882.
    NextBioi 88126.
    PROi Q8IX07.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IX07.
    CleanExi HS_ZFPM1.
    Genevestigatori Q8IX07.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
      Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
      Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH GATA1 AND GATA2.
      Tissue: Megakaryocyte.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
      Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.
      Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Prostate cancer.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-901 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiFOG1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IX07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3