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Protein

Zinc finger protein ZFPM1

Gene

ZFPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri235 – 268CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri290 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri320 – 342C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 371C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri571 – 604CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri677 – 710CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri811 – 844CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri854 – 877C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri968 – 1001CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM1
Alternative name(s):
Friend of GATA protein 1
Short name:
FOG-1
Short name:
Friend of GATA 1
Zinc finger protein 89A
Zinc finger protein multitype 1
Gene namesi
Name:ZFPM1
Synonyms:FOG1, ZFN89A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19762. ZFPM1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • nucleoplasm Source: Reactome
  • nucleus Source: GO_Central
  • transcriptional repressor complex Source: BHF-UCL
  • transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi161882.
OpenTargetsiENSG00000179588.
PharmGKBiPA134920282.

Polymorphism and mutation databases

BioMutaiZFPM1.
DMDMi296434508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210411 – 1006Zinc finger protein ZFPM1Add BLAST1006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineCombined sources1
Modified residuei128PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei491PhosphoserineBy similarity1
Modified residuei494PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei786PhosphoserineCombined sources1
Modified residuei901PhosphoserineCombined sources1
Modified residuei909PhosphoserineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Modified residuei935PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IX07.
MaxQBiQ8IX07.
PaxDbiQ8IX07.
PeptideAtlasiQ8IX07.
PRIDEiQ8IX07.

PTM databases

iPTMnetiQ8IX07.
PhosphoSitePlusiQ8IX07.

Expressioni

Tissue specificityi

Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.1 Publication

Gene expression databases

BgeeiENSG00000179588.
CleanExiHS_ZFPM1.
ExpressionAtlasiQ8IX07. baseline and differential.
GenevisibleiQ8IX07. HS.

Organism-specific databases

HPAiHPA046603.

Interactioni

Subunit structurei

Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GSK3BP498412EBI-3942619,EBI-373586
RBBP4Q090284EBI-3942619,EBI-620823

GO - Molecular functioni

  • RNA polymerase II transcription factor binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi127806. 10 interactors.
DIPiDIP-48415N.
IntActiQ8IX07. 3 interactors.
STRINGi9606.ENSP00000326630.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XU7X-ray1.90C/D1-15[»]
ProteinModelPortaliQ8IX07.
SMRiQ8IX07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni330 – 341Interaction with TACC3By similarityAdd BLAST12
Regioni794 – 800Interaction with CTBP2By similarity7

Domaini

The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).By similarity

Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 5 CCHC FOG-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri235 – 268CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri290 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri320 – 342C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 371C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri571 – 604CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri677 – 710CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri811 – 844CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri854 – 877C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri968 – 1001CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063823.
HOGENOMiHOG000112626.
HOVERGENiHBG101018.
InParanoidiQ8IX07.
KOiK17441.
OMAiYSCPAAP.
OrthoDBiEOG091G00RC.
PhylomeDBiQ8IX07.
TreeFamiTF331342.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS51810. ZF_CCHC_FOG. 5 hits.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IX07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKQSNPR QIKRSLGDME AREEVQLVGA SHMEQKATAP EAPSPPSADV
60 70 80 90 100
NSPPPLPPPT SPGGPKELEG QEPEPRPTEE EPGSPWSGPD ELEPVVQDGQ
110 120 130 140 150
RRIRARLSLA TGLSWGPFHG SVQTRASSPR QAEPSPALTL LLVDEACWLR
160 170 180 190 200
TLPQALTEAE ANTEIHRKDD ALWCRVTKPV PAGGLLSVLL TAEPHSTPGH
210 220 230 240 250
PVKKEPAEPT CPAPAHDLQL LPQQAGMASI LATAVINKDV FPCKDCGIWY
260 270 280 290 300
RSERNLQAHL LYYCASRQGT GSPAAAATDE KPKETYPNER VCPFPQCRKS
310 320 330 340 350
CPSASSLEIH MRSHSGERPF VCLICLSAFT TKANCERHLK VHTDTLSGVC
360 370 380 390 400
HSCGFISTTR DILYSHLVTN HMVCQPGSKG EIYSPGAGHP ATKLPPDSLG
410 420 430 440 450
SFQQQHTALQ GPLASADLGL APTPSPGLDR KALAEATNGE ARAEPLAQNG
460 470 480 490 500
GSSEPPAAPR SIKVEAVEEP EAAPILGPGE PGPQAPSRTP SPRSPAPARV
510 520 530 540 550
KAELSSPTPG SSPVPGELGL AGALFLPQYV FGPDAAPPAS EILAKMSELV
560 570 580 590 600
HSRLQQGAGA GAGGAQTGLF PGAPKGATCF ECEITFSNVN NYYVHKRLYC
610 620 630 640 650
SGRRAPEDAP AARRPKAPPG PARAPPGQPA EPDAPRSSPG PGAREEGAGG
660 670 680 690 700
AATPEDGAGG RGSEGSQSPG SSVDDAEDDP SRTLCEACNI RFSRHETYTV
710 720 730 740 750
HKRYYCASRH DPPPRRPAAP PGPPGPAAPP APSPAAPVRT RRRRKLYELH
760 770 780 790 800
AAGAPPPPPP GHAPAPESPR PGSGSGSGPG LAPARSPGPA ADGPIDLSKK
810 820 830 840 850
PRRPLPGAPA PALADYHECT ACRVSFHSLE AYLAHKKYSC PAAPPPGALG
860 870 880 890 900
LPAAACPYCP PNGPVRGDLL EHFRLAHGLL LGAPLAGPGV EARTPADRGP
910 920 930 940 950
SPAPAPAASP QPGSRGPRDG LGPEPQEPPP GPPPSPAAAP EAVPPPPAPP
960 970 980 990 1000
SYSDKGVQTP SKGTPAPLPN GNHRYCRLCN IKFSSLSTFI AHKKYYCSSH

AAEHVK
Length:1,006
Mass (Da):104,888
Last modified:May 18, 2010 - v2
Checksum:iE9C2363503A64898
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22R → G in AAN45858 (PubMed:12483298).Curated1
Sequence conflicti444 – 447EPLA → AP in AAN45858 (PubMed:12483298).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05749170G → A.Corresponds to variant rs34916016dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488691 mRNA. Translation: AAN45858.1.
AC116552 Genomic DNA. No translation available.
AC135049 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66806.1.
CCDSiCCDS32502.1.
RefSeqiNP_722520.2. NM_153813.2.
UniGeneiHs.632218.

Genome annotation databases

EnsembliENST00000319555; ENSP00000326630; ENSG00000179588.
GeneIDi161882.
KEGGihsa:161882.
UCSCiuc002fkv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488691 mRNA. Translation: AAN45858.1.
AC116552 Genomic DNA. No translation available.
AC135049 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66806.1.
CCDSiCCDS32502.1.
RefSeqiNP_722520.2. NM_153813.2.
UniGeneiHs.632218.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XU7X-ray1.90C/D1-15[»]
ProteinModelPortaliQ8IX07.
SMRiQ8IX07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127806. 10 interactors.
DIPiDIP-48415N.
IntActiQ8IX07. 3 interactors.
STRINGi9606.ENSP00000326630.

PTM databases

iPTMnetiQ8IX07.
PhosphoSitePlusiQ8IX07.

Polymorphism and mutation databases

BioMutaiZFPM1.
DMDMi296434508.

Proteomic databases

EPDiQ8IX07.
MaxQBiQ8IX07.
PaxDbiQ8IX07.
PeptideAtlasiQ8IX07.
PRIDEiQ8IX07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319555; ENSP00000326630; ENSG00000179588.
GeneIDi161882.
KEGGihsa:161882.
UCSCiuc002fkv.4. human.

Organism-specific databases

CTDi161882.
DisGeNETi161882.
GeneCardsiZFPM1.
HGNCiHGNC:19762. ZFPM1.
HPAiHPA046603.
MIMi601950. gene.
neXtProtiNX_Q8IX07.
OpenTargetsiENSG00000179588.
PharmGKBiPA134920282.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063823.
HOGENOMiHOG000112626.
HOVERGENiHBG101018.
InParanoidiQ8IX07.
KOiK17441.
OMAiYSCPAAP.
OrthoDBiEOG091G00RC.
PhylomeDBiQ8IX07.
TreeFamiTF331342.

Enzyme and pathway databases

ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSiZFPM1. human.
GeneWikiiZFPM1.
GenomeRNAii161882.
PROiQ8IX07.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179588.
CleanExiHS_ZFPM1.
ExpressionAtlasiQ8IX07. baseline and differential.
GenevisibleiQ8IX07. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS51810. ZF_CCHC_FOG. 5 hits.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOG1_HUMAN
AccessioniPrimary (citable) accession number: Q8IX07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.