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Protein

Putative exonuclease GOR

Gene

REXO1L1P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Putative exonuclease GOR (EC:3.1.-.-)
Alternative name(s):
Antigen GOR homolog
RNA exonuclease 1 homolog-like 1
Gene namesi
Name:REXO1L1P
Synonyms:GOR, REXO1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24660. REXO1L1P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671078.

Polymorphism and mutation databases

DMDMi205831276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 675675Putative exonuclease GORPRO_0000120938Add
BLAST

Proteomic databases

MaxQBiQ8IX06.
PaxDbiQ8IX06.
PRIDEiQ8IX06.

PTM databases

iPTMnetiQ8IX06.
PhosphoSiteiQ8IX06.

Expressioni

Gene expression databases

BgeeiQ8IX06.
CleanExiHS_REXO1L1.

Organism-specific databases

HPAiHPA048397.
HPA049344.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10262361,EBI-307352
TCF4P158843EBI-10262361,EBI-533224
TEX11Q8IYF33EBI-10262361,EBI-742397
TRAF4Q9BUZ43EBI-10262361,EBI-3650647

Protein-protein interaction databases

IntActiQ8IX06. 4 interactions.
STRINGi9606.ENSP00000368295.

Structurei

3D structure databases

ProteinModelPortaliQ8IX06.
SMRiQ8IX06. Positions 501-659.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni358 – 483126GOR1-125 epitopeAdd
BLAST

Sequence similaritiesi

Belongs to the REXO1/REXO3 family.Curated
Contains 1 exonuclease domain.Curated

Phylogenomic databases

eggNOGiKOG2248. Eukaryota.
COG0847. LUCA.
HOGENOMiHOG000112759.
HOVERGENiHBG107960.
InParanoidiQ8IX06.
OrthoDBiEOG73RB9W.
PhylomeDBiQ8IX06.
TreeFamiTF331871.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR031736. EloA-BP1.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF15870. EloA-BP1. 2 hits.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IX06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRATAPCWF PPGYPEAKKV AEEAALEASR HLGGEQSQAG APEGSKMLRA
60 70 80 90 100
TAPCWFRPGY PEAKKVAKEA APEASRHLGA EQSPAGAPEG SKMLRATAPC
110 120 130 140 150
WFPPGYPEAK KVAEEAALEA PEFPLPSHQP AQSFGLWVPQ MHKQASAFVD
160 170 180 190 200
IQAEPQNRGP AVPPAWPKMV TESCYFPAQR GSACRLPAAP RLTERPSGVR
210 220 230 240 250
ISAPRKRKTI AHSSSPCLVT GYTDAKRTRV ASSSQRSRGS KVGRQPGKTR
260 270 280 290 300
NRSGMACKTT ATTSSKRIVR RASLPSLSLK KPIILRSSGC QVPTVLRRGY
310 320 330 340 350
LQLFTEECLK FCASKQEAEE KALNEEKVAY DCSPNKNRYL NVVLNTLKRL
360 370 380 390 400
KGLTPSSMPG LSRAALYSRL QEFLLTQDQL KENGYPFPHP ERPGGAVLFT
410 420 430 440 450
GQGKGPGDSS CRVCCRCGTE YLVSSSGRCV RDQLCYYHWG RVRSSQVAGG
460 470 480 490 500
RVSQYTCCAA APGSVGCQVA KQHVRDGRKE SLDGFVETFK KELSRDAYPG
510 520 530 540 550
IYALDCEMCY TTHGLELTRV TVVDADMRVV YDTFVKPDNE IVDYNTRFSG
560 570 580 590 600
VTEADVAKTS ITLPQVQAIL LSFFSAQTIL IGHSLESDLL ALKLIHSTVV
610 620 630 640 650
DTAVLFPHYL GFPYKRSLRN LAADYLAQII QDSQDGHNSS EDASACLQLV
660 670
MWKVRQRAQI QPRHRSASPA ALACP
Length:675
Mass (Da):73,855
Last modified:July 22, 2008 - v2
Checksum:i8397A52718FF6FCB
GO

Sequence cautioni

The sequence AAN77012.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721A → P in AAN77012 (Ref. 2) Curated
Sequence conflicti635 – 6351D → N in AAN77012 (Ref. 2) Curated
Sequence conflicti644 – 6441S → N in AAN77012 (Ref. 2) Curated
Sequence conflicti667 – 6671A → V in AAN77012 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093331 Genomic DNA. No translation available.
AF495523 mRNA. Translation: AAN77012.1. Sequence problems.
AF023669 Genomic DNA. Translation: AAC98149.1.
UniGeneiHs.373854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093331 Genomic DNA. No translation available.
AF495523 mRNA. Translation: AAN77012.1. Sequence problems.
AF023669 Genomic DNA. Translation: AAC98149.1.
UniGeneiHs.373854.

3D structure databases

ProteinModelPortaliQ8IX06.
SMRiQ8IX06. Positions 501-659.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IX06. 4 interactions.
STRINGi9606.ENSP00000368295.

PTM databases

iPTMnetiQ8IX06.
PhosphoSiteiQ8IX06.

Polymorphism and mutation databases

DMDMi205831276.

Proteomic databases

MaxQBiQ8IX06.
PaxDbiQ8IX06.
PRIDEiQ8IX06.

Protocols and materials databases

DNASUi254958.
Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiREXO1L1P.
H-InvDBHIX0034285.
HIX0168820.
HIX0188684.
HIX0188686.
HIX0188687.
HIX0188688.
HIX0188689.
HIX0188690.
HGNCiHGNC:24660. REXO1L1P.
HPAiHPA048397.
HPA049344.
neXtProtiNX_Q8IX06.
PharmGKBiPA142671078.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2248. Eukaryota.
COG0847. LUCA.
HOGENOMiHOG000112759.
HOVERGENiHBG107960.
InParanoidiQ8IX06.
OrthoDBiEOG73RB9W.
PhylomeDBiQ8IX06.
TreeFamiTF331871.

Miscellaneous databases

PROiQ8IX06.

Gene expression databases

BgeeiQ8IX06.
CleanExiHS_REXO1L1.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR031736. EloA-BP1.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF15870. EloA-BP1. 2 hits.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A mariner transposon is located near the human GOR gene."
    Gomez-Gonzalez O., Rodriguez R.E., Gonzalez-Sarmiento R.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-675.
    Tissue: Liver.
  3. "Identification of a novel human gene (GOR) localized to 8q13-8q22."
    DeBella L.R., Schertzer M., Wood S.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 490-658.
  4. "The GOR gene product cannot cross-react with hepatitis C virus in humans."
    Koike R., Iizuka T., Watanabe T., Miyasaka N.
    Clin. Exp. Immunol. 124:429-434(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGOR_HUMAN
AccessioniPrimary (citable) accession number: Q8IX06
Secondary accession number(s): A6NK34, O95107
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: July 22, 2008
Last modified: June 8, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. N-terminally truncated compared to the protein-coding REXO1 gene. Originally thought to encode human GOR47-1, an antigenic epitope identified from the serum of virus infected chimpanzee (see AC P48778), which was apparently also expressed in human and used in ELISA tests to detect hepatitis C virus infection in patients. It turns out that the peptide identified in chimpanzee cannot be produced by human REXO1L1/GOR gene, due to a premature stop codon in the gene (PubMed:11472404) and therefore the basis of the tests remains unclear. However, the same authors provide evidence of the expression of a different N-terminal peptide from the human REXO1L1/GOR gene, the GOR1-125 antigen (PubMed:11472404).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.