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Q8IX05

- CD302_HUMAN

UniProt

Q8IX05 - CD302_HUMAN

Protein

CD302 antigen

Gene

CD302

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.1 Publication

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. phagocytosis Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD302 antigen
    Alternative name(s):
    C-type lectin BIMLEC
    C-type lectin domain family 13 member A
    DEC205-associated C-type lectin 1
    Type I transmembrane C-type lectin receptor DCL-1
    CD_antigen: CD302
    Gene namesi
    Name:CD302
    Synonyms:CLEC13A, DCL1, KIAA0022
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:30843. CD302.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated. Cell projectionfilopodium 1 Publication. Cytoplasmcell cortex 1 Publication. Cell projectionmicrovillus 1 Publication
    Note: Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.

    GO - Cellular componenti

    1. cell cortex Source: MGI
    2. filopodium Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB
    5. microvillus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672141.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 232210CD302 antigenPRO_0000252332Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi128 ↔ 143PROSITE-ProRule annotation

    Post-translational modificationi

    May be heterogeneously N-glycosylated in some cell types.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8IX05.
    PaxDbiQ8IX05.
    PRIDEiQ8IX05.

    PTM databases

    PhosphoSiteiQ8IX05.

    Expressioni

    Tissue specificityi

    Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.2 Publications

    Developmental stagei

    Expressed at relatively high levels in fetal lung, liver, spleen and kidney with lower expression levels detected in heart, thymus and brain.1 Publication

    Gene expression databases

    BgeeiQ8IX05.
    CleanExiHS_CD302.
    GenevestigatoriQ8IX05.

    Interactioni

    Protein-protein interaction databases

    BioGridi115262. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IX05.
    SMRiQ8IX05. Positions 24-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 168146ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini190 – 23243CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 152121C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288401.
    HOGENOMiHOG000232049.
    HOVERGENiHBG080529.
    KOiK06722.
    OMAiWKNSEES.
    OrthoDBiEOG7FFMQR.
    PhylomeDBiQ8IX05.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IX05-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRAALPALL LPLLGLAAAA VADCPSSTWI QFQDSCYIFL QEAIKVESIE    50
    DVRNQCTDHG ADMISIHNEE ENAFILDTLK KQWKGPDDIL LGMFYDTDDA 100
    SFKWFDNSNM TFDKWTDQDD DEDLVDTCAF LHIKTGEWKK GNCEVSSVEG 150
    TLCKTAIPYK RKYLSDNHIL ISALVIASTV ILTVLGAIIW FLYKKHSDSR 200
    FTTVFSTAPQ SPYNEDCVLV VGEENEYPVQ FD 232

    Note: Produced by intergenic splicing of LY75 and CD302.

    Length:232
    Mass (Da):26,183
    Last modified:March 1, 2003 - v1
    Checksum:i5C33C708345C3971
    GO
    Isoform 4 (identifier: O60449-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry O60449.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:1,722
    Mass (Da):198,311
    GO
    Isoform 5 (identifier: Q8IX05-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         99-156: Missing.
         157-157: I → V

    Show »
    Length:174
    Mass (Da):19,562
    Checksum:iAF737C517D8B6931
    GO
    Isoform 2 (identifier: O60449-2) [UniParc]FASTAAdd to Basket

    Also known as: Fusion protein variant V34-2

    The sequence of this isoform can be found in the external entry O60449.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by intergenic splicing of LY75 and CD302.

    Length:1,873
    Mass (Da):215,781
    GO
    Isoform 3 (identifier: O60449-3) [UniParc]FASTAAdd to Basket

    Also known as: Fusion protein variant V33-2

    The sequence of this isoform can be found in the external entry O60449.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by intergenic splicing of LY75 and CD302.

    Length:1,817
    Mass (Da):209,438
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391K → R in BAF83968. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti200 – 2001R → S.
    Corresponds to variant rs34068933 [ dbSNP | Ensembl ].
    VAR_050101

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei99 – 15658Missing in isoform 5. 1 PublicationVSP_044258Add
    BLAST
    Alternative sequencei157 – 1571I → V in isoform 5. 1 PublicationVSP_044259

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY314007 mRNA. Translation: AAP79900.1.
    AF499000 mRNA. Translation: AAN77050.1.
    AK291279 mRNA. Translation: BAF83968.1.
    AK304422 mRNA. Translation: BAG65251.1.
    AC009961 Genomic DNA. Translation: AAY14942.1.
    D14664 mRNA. Translation: BAA03498.1.
    BC020646 mRNA. Translation: AAH20646.1.
    CCDSiCCDS33308.1. [Q8IX05-1]
    CCDS56139.1. [Q8IX05-2]
    RefSeqiNP_001185692.1. NM_001198763.1. [Q8IX05-2]
    NP_055695.2. NM_014880.4. [Q8IX05-1]
    UniGeneiHs.130014.
    Hs.153563.

    Genome annotation databases

    EnsembliENST00000259053; ENSP00000259053; ENSG00000241399. [Q8IX05-1]
    ENST00000429078; ENSP00000394301; ENSG00000241399. [Q8IX05-2]
    GeneIDi9936.
    KEGGihsa:9936.
    UCSCiuc002uba.3. human. [Q8IX05-1]
    uc010zco.2. human. [Q8IX05-2]

    Polymorphism databases

    DMDMi74750720.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY314007 mRNA. Translation: AAP79900.1 .
    AF499000 mRNA. Translation: AAN77050.1 .
    AK291279 mRNA. Translation: BAF83968.1 .
    AK304422 mRNA. Translation: BAG65251.1 .
    AC009961 Genomic DNA. Translation: AAY14942.1 .
    D14664 mRNA. Translation: BAA03498.1 .
    BC020646 mRNA. Translation: AAH20646.1 .
    CCDSi CCDS33308.1. [Q8IX05-1 ]
    CCDS56139.1. [Q8IX05-2 ]
    RefSeqi NP_001185692.1. NM_001198763.1. [Q8IX05-2 ]
    NP_055695.2. NM_014880.4. [Q8IX05-1 ]
    UniGenei Hs.130014.
    Hs.153563.

    3D structure databases

    ProteinModelPortali Q8IX05.
    SMRi Q8IX05. Positions 24-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115262. 3 interactions.

    PTM databases

    PhosphoSitei Q8IX05.

    Polymorphism databases

    DMDMi 74750720.

    Proteomic databases

    MaxQBi Q8IX05.
    PaxDbi Q8IX05.
    PRIDEi Q8IX05.

    Protocols and materials databases

    DNASUi 9936.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259053 ; ENSP00000259053 ; ENSG00000241399 . [Q8IX05-1 ]
    ENST00000429078 ; ENSP00000394301 ; ENSG00000241399 . [Q8IX05-2 ]
    GeneIDi 9936.
    KEGGi hsa:9936.
    UCSCi uc002uba.3. human. [Q8IX05-1 ]
    uc010zco.2. human. [Q8IX05-2 ]

    Organism-specific databases

    CTDi 9936.
    GeneCardsi GC02M160625.
    H-InvDB HIX0002534.
    HIX0161882.
    HGNCi HGNC:30843. CD302.
    MIMi 612246. gene.
    neXtProti NX_Q8IX05.
    PharmGKBi PA142672141.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288401.
    HOGENOMi HOG000232049.
    HOVERGENi HBG080529.
    KOi K06722.
    OMAi WKNSEES.
    OrthoDBi EOG7FFMQR.
    PhylomeDBi Q8IX05.

    Miscellaneous databases

    GeneWikii CD302.
    GenomeRNAii 9936.
    NextBioi 37484.
    PROi Q8IX05.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IX05.
    CleanExi HS_CD302.
    Genevestigatori Q8IX05.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1."
      Kato M., Khan S., Gonzalez N., O'Neill B.P., McDonald K.J., Cooper B.J., Angel N.Z., Hart D.N.J.
      J. Biol. Chem. 278:34035-34041(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
    2. "Identification of a novel C-type lectin, BIMLEC, from BCG cell wall induced monocyte."
      Begum N.A.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
      Tissue: Teratocarcinoma and Trachea.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-232 (ISOFORM 1).
      Tissue: Bone marrow.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-232 (ISOFORM 1).
      Tissue: Liver.
    7. "The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration."
      Kato M., Khan S., d'Aniello E., McDonald K.J., Hart D.N.
      J. Immunol. 179:6052-6063(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.

    Entry informationi

    Entry nameiCD302_HUMAN
    AccessioniPrimary (citable) accession number: Q8IX05
    Secondary accession number(s): A8K5G4, B4E2T9, Q15009
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3