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Q8IX05

- CD302_HUMAN

UniProt

Q8IX05 - CD302_HUMAN

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Protein
CD302 antigen
Gene
CD302, CLEC13A, DCL1, KIAA0022
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.1 Publication

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro

GO - Biological processi

  1. phagocytosis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
CD302 antigen
Alternative name(s):
C-type lectin BIMLEC
C-type lectin domain family 13 member A
DEC205-associated C-type lectin 1
Type I transmembrane C-type lectin receptor DCL-1
CD_antigen: CD302
Gene namesi
Name:CD302
Synonyms:CLEC13A, DCL1, KIAA0022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30843. CD302.

Subcellular locationi

Membrane; Single-pass type I membrane protein Reviewed prediction. Cell projectionfilopodium. Cytoplasmcell cortex. Cell projectionmicrovillus
Note: Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 168146Extracellular Reviewed prediction
Add
BLAST
Transmembranei169 – 18921Helical; Reviewed prediction
Add
BLAST
Topological domaini190 – 23243Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. filopodium Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. microvillus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672141.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 232210CD302 antigen
PRO_0000252332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi128 ↔ 143 By similarity

Post-translational modificationi

May be heterogeneously N-glycosylated in some cell types.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8IX05.
PaxDbiQ8IX05.
PRIDEiQ8IX05.

PTM databases

PhosphoSiteiQ8IX05.

Expressioni

Tissue specificityi

Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.2 Publications

Developmental stagei

Expressed at relatively high levels in fetal lung, liver, spleen and kidney with lower expression levels detected in heart, thymus and brain.1 Publication

Gene expression databases

BgeeiQ8IX05.
CleanExiHS_CD302.
GenevestigatoriQ8IX05.

Interactioni

Protein-protein interaction databases

BioGridi115262. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8IX05.
SMRiQ8IX05. Positions 24-154.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 152121C-type lectin
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288401.
HOGENOMiHOG000232049.
HOVERGENiHBG080529.
KOiK06722.
OMAiWKNSEES.
OrthoDBiEOG7FFMQR.
PhylomeDBiQ8IX05.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IX05-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLRAALPALL LPLLGLAAAA VADCPSSTWI QFQDSCYIFL QEAIKVESIE    50
DVRNQCTDHG ADMISIHNEE ENAFILDTLK KQWKGPDDIL LGMFYDTDDA 100
SFKWFDNSNM TFDKWTDQDD DEDLVDTCAF LHIKTGEWKK GNCEVSSVEG 150
TLCKTAIPYK RKYLSDNHIL ISALVIASTV ILTVLGAIIW FLYKKHSDSR 200
FTTVFSTAPQ SPYNEDCVLV VGEENEYPVQ FD 232

Note: Produced by intergenic splicing of LY75 and CD302.

Length:232
Mass (Da):26,183
Last modified:March 1, 2003 - v1
Checksum:i5C33C708345C3971
GO
Isoform 4 (identifier: O60449-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,722
Mass (Da):198,311
GO
Isoform 5 (identifier: Q8IX05-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-156: Missing.
     157-157: I → V

Show »
Length:174
Mass (Da):19,562
Checksum:iAF737C517D8B6931
GO
Isoform 2 (identifier: O60449-2) [UniParc]FASTAAdd to Basket

Also known as: Fusion protein variant V34-2

The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by intergenic splicing of LY75 and CD302.

Length:1,873
Mass (Da):215,781
GO
Isoform 3 (identifier: O60449-3) [UniParc]FASTAAdd to Basket

Also known as: Fusion protein variant V33-2

The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by intergenic splicing of LY75 and CD302.

Length:1,817
Mass (Da):209,438
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti200 – 2001R → S.
Corresponds to variant rs34068933 [ dbSNP | Ensembl ].
VAR_050101

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei99 – 15658Missing in isoform 5.
VSP_044258Add
BLAST
Alternative sequencei157 – 1571I → V in isoform 5.
VSP_044259

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391K → R in BAF83968. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY314007 mRNA. Translation: AAP79900.1.
AF499000 mRNA. Translation: AAN77050.1.
AK291279 mRNA. Translation: BAF83968.1.
AK304422 mRNA. Translation: BAG65251.1.
AC009961 Genomic DNA. Translation: AAY14942.1.
D14664 mRNA. Translation: BAA03498.1.
BC020646 mRNA. Translation: AAH20646.1.
CCDSiCCDS33308.1. [Q8IX05-1]
CCDS56139.1. [Q8IX05-2]
RefSeqiNP_001185692.1. NM_001198763.1. [Q8IX05-2]
NP_055695.2. NM_014880.4. [Q8IX05-1]
UniGeneiHs.130014.
Hs.153563.

Genome annotation databases

EnsembliENST00000259053; ENSP00000259053; ENSG00000241399. [Q8IX05-1]
ENST00000429078; ENSP00000394301; ENSG00000241399. [Q8IX05-2]
GeneIDi9936.
KEGGihsa:9936.
UCSCiuc002uba.3. human. [Q8IX05-1]
uc010zco.2. human. [Q8IX05-2]

Polymorphism databases

DMDMi74750720.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY314007 mRNA. Translation: AAP79900.1 .
AF499000 mRNA. Translation: AAN77050.1 .
AK291279 mRNA. Translation: BAF83968.1 .
AK304422 mRNA. Translation: BAG65251.1 .
AC009961 Genomic DNA. Translation: AAY14942.1 .
D14664 mRNA. Translation: BAA03498.1 .
BC020646 mRNA. Translation: AAH20646.1 .
CCDSi CCDS33308.1. [Q8IX05-1 ]
CCDS56139.1. [Q8IX05-2 ]
RefSeqi NP_001185692.1. NM_001198763.1. [Q8IX05-2 ]
NP_055695.2. NM_014880.4. [Q8IX05-1 ]
UniGenei Hs.130014.
Hs.153563.

3D structure databases

ProteinModelPortali Q8IX05.
SMRi Q8IX05. Positions 24-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115262. 3 interactions.

PTM databases

PhosphoSitei Q8IX05.

Polymorphism databases

DMDMi 74750720.

Proteomic databases

MaxQBi Q8IX05.
PaxDbi Q8IX05.
PRIDEi Q8IX05.

Protocols and materials databases

DNASUi 9936.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259053 ; ENSP00000259053 ; ENSG00000241399 . [Q8IX05-1 ]
ENST00000429078 ; ENSP00000394301 ; ENSG00000241399 . [Q8IX05-2 ]
GeneIDi 9936.
KEGGi hsa:9936.
UCSCi uc002uba.3. human. [Q8IX05-1 ]
uc010zco.2. human. [Q8IX05-2 ]

Organism-specific databases

CTDi 9936.
GeneCardsi GC02M160625.
H-InvDB HIX0002534.
HIX0161882.
HGNCi HGNC:30843. CD302.
MIMi 612246. gene.
neXtProti NX_Q8IX05.
PharmGKBi PA142672141.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288401.
HOGENOMi HOG000232049.
HOVERGENi HBG080529.
KOi K06722.
OMAi WKNSEES.
OrthoDBi EOG7FFMQR.
PhylomeDBi Q8IX05.

Miscellaneous databases

GeneWikii CD302.
GenomeRNAii 9936.
NextBioi 37484.
PROi Q8IX05.
SOURCEi Search...

Gene expression databases

Bgeei Q8IX05.
CleanExi HS_CD302.
Genevestigatori Q8IX05.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1."
    Kato M., Khan S., Gonzalez N., O'Neill B.P., McDonald K.J., Cooper B.J., Angel N.Z., Hart D.N.J.
    J. Biol. Chem. 278:34035-34041(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
  2. "Identification of a novel C-type lectin, BIMLEC, from BCG cell wall induced monocyte."
    Begum N.A.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Tissue: Teratocarcinoma and Trachea.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-232 (ISOFORM 1).
    Tissue: Bone marrow.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-232 (ISOFORM 1).
    Tissue: Liver.
  7. "The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration."
    Kato M., Khan S., d'Aniello E., McDonald K.J., Hart D.N.
    J. Immunol. 179:6052-6063(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.

Entry informationi

Entry nameiCD302_HUMAN
AccessioniPrimary (citable) accession number: Q8IX05
Secondary accession number(s): A8K5G4, B4E2T9, Q15009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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