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Protein

CD302 antigen

Gene

CD302

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.1 Publication

GO - Molecular functioni

GO - Biological processi

  • phagocytosis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:G66-31742-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CD302 antigen
Alternative name(s):
C-type lectin BIMLEC
C-type lectin domain family 13 member A
DEC205-associated C-type lectin 1
Type I transmembrane C-type lectin receptor DCL-1
CD_antigen: CD302
Gene namesi
Name:CD302
Synonyms:CLEC13A, DCL1, KIAA0022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30843. CD302.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 168ExtracellularSequence analysisAdd BLAST146
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 232CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • cell cortex Source: MGI
  • filopodium Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • microvillus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9936.
OpenTargetsiENSG00000241399.
PharmGKBiPA142672141.

Polymorphism and mutation databases

BioMutaiCD302.
DMDMi74750720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025233223 – 232CD302 antigenAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi128 ↔ 143PROSITE-ProRule annotation

Post-translational modificationi

May be heterogeneously N-glycosylated in some cell types.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8IX05.
PaxDbiQ8IX05.
PeptideAtlasiQ8IX05.
PRIDEiQ8IX05.

PTM databases

iPTMnetiQ8IX05.
PhosphoSitePlusiQ8IX05.

Expressioni

Tissue specificityi

Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.2 Publications

Developmental stagei

Expressed at relatively high levels in fetal lung, liver, spleen and kidney with lower expression levels detected in heart, thymus and brain.1 Publication

Gene expression databases

BgeeiENSG00000241399.
CleanExiHS_CD302.
ExpressionAtlasiQ8IX05. baseline and differential.
GenevisibleiQ8IX05. HS.

Organism-specific databases

HPAiCAB046020.

Interactioni

Protein-protein interaction databases

BioGridi115262. 2 interactors.
STRINGi9606.ENSP00000259053.

Structurei

3D structure databases

ProteinModelPortaliQ8IX05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 152C-type lectinPROSITE-ProRule annotationAdd BLAST121

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS40. Eukaryota.
ENOG41126J3. LUCA.
GeneTreeiENSGT00680000100098.
HOGENOMiHOG000232049.
HOVERGENiHBG080529.
InParanoidiQ8IX05.
KOiK06722.
OrthoDBiEOG091G0PMQ.
PhylomeDBiQ8IX05.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IX05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRAALPALL LPLLGLAAAA VADCPSSTWI QFQDSCYIFL QEAIKVESIE
60 70 80 90 100
DVRNQCTDHG ADMISIHNEE ENAFILDTLK KQWKGPDDIL LGMFYDTDDA
110 120 130 140 150
SFKWFDNSNM TFDKWTDQDD DEDLVDTCAF LHIKTGEWKK GNCEVSSVEG
160 170 180 190 200
TLCKTAIPYK RKYLSDNHIL ISALVIASTV ILTVLGAIIW FLYKKHSDSR
210 220 230
FTTVFSTAPQ SPYNEDCVLV VGEENEYPVQ FD
Note: Produced by intergenic splicing of LY75 and CD302.
Length:232
Mass (Da):26,183
Last modified:March 1, 2003 - v1
Checksum:i5C33C708345C3971
GO
Isoform 4 (identifier: O60449-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,722
Mass (Da):198,311
GO
Isoform 5 (identifier: Q8IX05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-156: Missing.
     157-157: I → V

Show »
Length:174
Mass (Da):19,562
Checksum:iAF737C517D8B6931
GO
Isoform 2 (identifier: O60449-2) [UniParc]FASTAAdd to basket
Also known as: Fusion protein variant V34-2
The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by intergenic splicing of LY75 and CD302.
Length:1,873
Mass (Da):215,781
GO
Isoform 3 (identifier: O60449-3) [UniParc]FASTAAdd to basket
Also known as: Fusion protein variant V33-2
The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by intergenic splicing of LY75 and CD302.
Length:1,817
Mass (Da):209,438
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139K → R in BAF83968 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050101200R → S.Corresponds to variant rs34068933dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04425899 – 156Missing in isoform 5. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_044259157I → V in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY314007 mRNA. Translation: AAP79900.1.
AF499000 mRNA. Translation: AAN77050.1.
AK291279 mRNA. Translation: BAF83968.1.
AK304422 mRNA. Translation: BAG65251.1.
AC009961 Genomic DNA. Translation: AAY14942.1.
D14664 mRNA. Translation: BAA03498.1.
BC020646 mRNA. Translation: AAH20646.1.
CCDSiCCDS33308.1. [Q8IX05-1]
CCDS56139.1. [Q8IX05-2]
RefSeqiNP_001185692.1. NM_001198763.1. [Q8IX05-2]
NP_055695.2. NM_014880.4. [Q8IX05-1]
UniGeneiHs.130014.
Hs.153563.

Genome annotation databases

EnsembliENST00000259053; ENSP00000259053; ENSG00000241399. [Q8IX05-1]
ENST00000429078; ENSP00000394301; ENSG00000241399. [Q8IX05-2]
GeneIDi9936.
KEGGihsa:9936.
UCSCiuc002uba.4. human. [Q8IX05-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY314007 mRNA. Translation: AAP79900.1.
AF499000 mRNA. Translation: AAN77050.1.
AK291279 mRNA. Translation: BAF83968.1.
AK304422 mRNA. Translation: BAG65251.1.
AC009961 Genomic DNA. Translation: AAY14942.1.
D14664 mRNA. Translation: BAA03498.1.
BC020646 mRNA. Translation: AAH20646.1.
CCDSiCCDS33308.1. [Q8IX05-1]
CCDS56139.1. [Q8IX05-2]
RefSeqiNP_001185692.1. NM_001198763.1. [Q8IX05-2]
NP_055695.2. NM_014880.4. [Q8IX05-1]
UniGeneiHs.130014.
Hs.153563.

3D structure databases

ProteinModelPortaliQ8IX05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115262. 2 interactors.
STRINGi9606.ENSP00000259053.

PTM databases

iPTMnetiQ8IX05.
PhosphoSitePlusiQ8IX05.

Polymorphism and mutation databases

BioMutaiCD302.
DMDMi74750720.

Proteomic databases

MaxQBiQ8IX05.
PaxDbiQ8IX05.
PeptideAtlasiQ8IX05.
PRIDEiQ8IX05.

Protocols and materials databases

DNASUi9936.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259053; ENSP00000259053; ENSG00000241399. [Q8IX05-1]
ENST00000429078; ENSP00000394301; ENSG00000241399. [Q8IX05-2]
GeneIDi9936.
KEGGihsa:9936.
UCSCiuc002uba.4. human. [Q8IX05-1]

Organism-specific databases

CTDi9936.
DisGeNETi9936.
GeneCardsiCD302.
H-InvDBHIX0002534.
HIX0161882.
HGNCiHGNC:30843. CD302.
HPAiCAB046020.
MIMi612246. gene.
neXtProtiNX_Q8IX05.
OpenTargetsiENSG00000241399.
PharmGKBiPA142672141.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS40. Eukaryota.
ENOG41126J3. LUCA.
GeneTreeiENSGT00680000100098.
HOGENOMiHOG000232049.
HOVERGENiHBG080529.
InParanoidiQ8IX05.
KOiK06722.
OrthoDBiEOG091G0PMQ.
PhylomeDBiQ8IX05.

Enzyme and pathway databases

BioCyciZFISH:G66-31742-MONOMER.

Miscellaneous databases

GeneWikiiCD302.
GenomeRNAii9936.
PROiQ8IX05.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241399.
CleanExiHS_CD302.
ExpressionAtlasiQ8IX05. baseline and differential.
GenevisibleiQ8IX05. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD302_HUMAN
AccessioniPrimary (citable) accession number: Q8IX05
Secondary accession number(s): A8K5G4, B4E2T9, Q15009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.