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Protein

Ubiquitin-conjugating enzyme E2 variant 3

Gene

UEVLD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible negative regulator of polyubiquitination.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi191 – 219NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciZFISH:HS07708-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 3
Short name:
UEV-3
Alternative name(s):
EV and lactate/malate dehydrogenase domain-containing protein
Gene namesi
Name:UEVLDImported
Synonyms:UEV3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30866. UEVLD.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55293.
OpenTargetsiENSG00000151116.
PharmGKBiPA147357188.

Polymorphism and mutation databases

BioMutaiUEVLD.
DMDMi126253820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786511 – 471Ubiquitin-conjugating enzyme E2 variant 3Add BLAST471

Proteomic databases

EPDiQ8IX04.
MaxQBiQ8IX04.
PaxDbiQ8IX04.
PeptideAtlasiQ8IX04.
PRIDEiQ8IX04.

PTM databases

iPTMnetiQ8IX04.
PhosphoSitePlusiQ8IX04.

Expressioni

Tissue specificityi

Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000151116.
CleanExiHS_UEVLD.
ExpressionAtlasiQ8IX04. baseline and differential.
GenevisibleiQ8IX04. HS.

Organism-specific databases

HPAiHPA047134.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi120580. 7 interactors.
IntActiQ8IX04. 7 interactors.
STRINGi9606.ENSP00000379500.

Structurei

Secondary structure

1471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi184 – 188Combined sources5
Helixi192 – 204Combined sources13
Beta strandi208 – 213Combined sources6
Helixi218 – 220Combined sources3
Helixi223 – 229Combined sources7
Beta strandi234 – 238Combined sources5
Helixi240 – 243Combined sources4
Beta strandi247 – 251Combined sources5
Helixi262 – 283Combined sources22
Turni284 – 286Combined sources3
Beta strandi288 – 291Combined sources4
Beta strandi293 – 295Combined sources3
Helixi296 – 307Combined sources12
Helixi311 – 313Combined sources3
Beta strandi314 – 316Combined sources3
Helixi320 – 332Combined sources13
Helixi339 – 342Combined sources4
Beta strandi343 – 348Combined sources6
Beta strandi350 – 352Combined sources3
Beta strandi354 – 358Combined sources5
Helixi366 – 377Combined sources12
Beta strandi380 – 382Combined sources3
Helixi387 – 402Combined sources16
Beta strandi407 – 414Combined sources8
Beta strandi426 – 434Combined sources9
Beta strandi437 – 441Combined sources5
Helixi450 – 468Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I6TX-ray2.10A/B171-471[»]
3DL2X-ray2.10A/B171-471[»]
ProteinModelPortaliQ8IX04.
SMRiQ8IX04.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX04.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 145UEVPROSITE-ProRule annotationAdd BLAST144

Sequence similaritiesi

In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.Curated
In the C-terminal section; belongs to the LDH/MDH superfamily.Curated
Contains 1 UEV (ubiquitin E2 variant) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
KOG2391. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ8IX04.
OMAiNIPIRLW.
OrthoDBiEOG091G0HRA.
PhylomeDBiQ8IX04.
TreeFamiTF314963.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR008883. UEV_N.
[Graphical view]
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PF05743. UEV. 1 hit.
[Graphical view]
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF54495. SSF54495. 1 hit.
SSF56327. SSF56327. 1 hit.
PROSITEiPS51322. UEV. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8IX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK
60 70 80 90 100
DLLNFTGTIP VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG
110 120 130 140 150
KHVDAQGRIY LPYLQNWSHP KSVIVGLIKE MIAKFQEELP MYSLSSSDEA
160 170 180 190 200
RQVDLLAYIA KITEGVSDTN SKSWANHENK TVNKITVVGG GELGIACTLA
210 220 230 240 250
ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL SASAHSKVVI
260 270 280 290 300
FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
310 320 330 340 350
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG
360 370 380 390 400
EDKVLTWSGQ EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS
410 420 430 440 450
IVNNKKKVHS VSALAKGYYD INSEVFLSLP CILGTNGVSE VIKTTLKEDT
460 470
VTEKLQSSAS SIHSLQQQLK L
Length:471
Mass (Da):52,264
Last modified:February 20, 2007 - v2
Checksum:i2502659A566E7DDD
GO
Isoform 21 Publication (identifier: Q8IX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:379
Mass (Da):42,292
Checksum:i100BCD1FA295FC60
GO
Isoform 31 Publication (identifier: Q8IX04-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:357
Mass (Da):39,778
Checksum:iB906E3358B342190
GO
Isoform 4 (identifier: Q8IX04-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:341
Mass (Da):37,611
Checksum:i7D5CD535296471FA
GO
Isoform 5 (identifier: Q8IX04-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-215: GIADRLVLLDL → VESRSVTQAGV
     216-471: Missing.

Show »
Length:215
Mass (Da):24,233
Checksum:iB82D7775A32AAB67
GO
Isoform 6 (identifier: Q8IX04-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.

Note: No experimental confirmation available.
Show »
Length:449
Mass (Da):49,750
Checksum:i2B5D772AEA5B1F51
GO
Isoform 7 (identifier: Q8IX04-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-164: Missing.
     239-295: Missing.
     354-470: VLTWSGQEEV...SIHSLQQQLK → GI

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):22,240
Checksum:iA8FC6744B9B89325
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148D → G in BAG59405 (PubMed:14702039).Curated1
Sequence conflicti248V → A in BAG59405 (PubMed:14702039).Curated1
Sequence conflicti366H → L in AAN32950 (PubMed:12427560).Curated1
Sequence conflicti366H → L in BAA91985 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0233461 – 38Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_02334743 – 64Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_04598665 – 164Missing in isoform 7. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_023348205 – 215GIADRLVLLDL → VESRSVTQAGV in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023349216 – 471Missing in isoform 5. 1 PublicationAdd BLAST256
Alternative sequenceiVSP_045987239 – 295Missing in isoform 7. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_045988354 – 470VLTWS…QQQLK → GI in isoform 7. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_023350376 – 379AMEL → DIMI in isoform 2, isoform 3 and isoform 4. 3 Publications4
Alternative sequenceiVSP_023351380 – 471Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503350 mRNA. Translation: AAN32950.1.
CR616778 mRNA. No translation available.
AK001930 mRNA. Translation: BAA91985.1.
AK296835 mRNA. Translation: BAG59405.1.
AK314521 mRNA. Translation: BAG37116.1.
AC027544 Genomic DNA. No translation available.
AC112694 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68380.1.
BC011011 mRNA. Translation: AAH11011.2.
BC064566 mRNA. Translation: AAH64566.1.
CD109744 mRNA. No translation available.
CCDSiCCDS41624.1. [Q8IX04-1]
CCDS58122.1. [Q8IX04-4]
CCDS58123.1. [Q8IX04-3]
CCDS58124.1. [Q8IX04-6]
CCDS58125.1. [Q8IX04-7]
CCDS73266.1. [Q8IX04-5]
CCDS7843.1. [Q8IX04-2]
RefSeqiNP_001035787.1. NM_001040697.2. [Q8IX04-1]
NP_001248311.1. NM_001261382.1. [Q8IX04-6]
NP_001248312.1. NM_001261383.1. [Q8IX04-3]
NP_001248313.1. NM_001261384.1.
NP_001248314.1. NM_001261385.1. [Q8IX04-4]
NP_001248315.1. NM_001261386.1. [Q8IX04-7]
NP_001284700.1. NM_001297771.1.
NP_060784.3. NM_018314.4. [Q8IX04-2]
UniGeneiHs.407991.

Genome annotation databases

EnsembliENST00000300038; ENSP00000300038; ENSG00000151116. [Q8IX04-5]
ENST00000320750; ENSP00000323353; ENSG00000151116. [Q8IX04-3]
ENST00000379387; ENSP00000368697; ENSG00000151116. [Q8IX04-6]
ENST00000396197; ENSP00000379500; ENSG00000151116. [Q8IX04-1]
ENST00000535484; ENSP00000441092; ENSG00000151116. [Q8IX04-4]
ENST00000541984; ENSP00000437538; ENSG00000151116. [Q8IX04-7]
ENST00000543987; ENSP00000442974; ENSG00000151116. [Q8IX04-2]
GeneIDi55293.
KEGGihsa:55293.
UCSCiuc001mot.5. human. [Q8IX04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503350 mRNA. Translation: AAN32950.1.
CR616778 mRNA. No translation available.
AK001930 mRNA. Translation: BAA91985.1.
AK296835 mRNA. Translation: BAG59405.1.
AK314521 mRNA. Translation: BAG37116.1.
AC027544 Genomic DNA. No translation available.
AC112694 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68380.1.
BC011011 mRNA. Translation: AAH11011.2.
BC064566 mRNA. Translation: AAH64566.1.
CD109744 mRNA. No translation available.
CCDSiCCDS41624.1. [Q8IX04-1]
CCDS58122.1. [Q8IX04-4]
CCDS58123.1. [Q8IX04-3]
CCDS58124.1. [Q8IX04-6]
CCDS58125.1. [Q8IX04-7]
CCDS73266.1. [Q8IX04-5]
CCDS7843.1. [Q8IX04-2]
RefSeqiNP_001035787.1. NM_001040697.2. [Q8IX04-1]
NP_001248311.1. NM_001261382.1. [Q8IX04-6]
NP_001248312.1. NM_001261383.1. [Q8IX04-3]
NP_001248313.1. NM_001261384.1.
NP_001248314.1. NM_001261385.1. [Q8IX04-4]
NP_001248315.1. NM_001261386.1. [Q8IX04-7]
NP_001284700.1. NM_001297771.1.
NP_060784.3. NM_018314.4. [Q8IX04-2]
UniGeneiHs.407991.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I6TX-ray2.10A/B171-471[»]
3DL2X-ray2.10A/B171-471[»]
ProteinModelPortaliQ8IX04.
SMRiQ8IX04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120580. 7 interactors.
IntActiQ8IX04. 7 interactors.
STRINGi9606.ENSP00000379500.

PTM databases

iPTMnetiQ8IX04.
PhosphoSitePlusiQ8IX04.

Polymorphism and mutation databases

BioMutaiUEVLD.
DMDMi126253820.

Proteomic databases

EPDiQ8IX04.
MaxQBiQ8IX04.
PaxDbiQ8IX04.
PeptideAtlasiQ8IX04.
PRIDEiQ8IX04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300038; ENSP00000300038; ENSG00000151116. [Q8IX04-5]
ENST00000320750; ENSP00000323353; ENSG00000151116. [Q8IX04-3]
ENST00000379387; ENSP00000368697; ENSG00000151116. [Q8IX04-6]
ENST00000396197; ENSP00000379500; ENSG00000151116. [Q8IX04-1]
ENST00000535484; ENSP00000441092; ENSG00000151116. [Q8IX04-4]
ENST00000541984; ENSP00000437538; ENSG00000151116. [Q8IX04-7]
ENST00000543987; ENSP00000442974; ENSG00000151116. [Q8IX04-2]
GeneIDi55293.
KEGGihsa:55293.
UCSCiuc001mot.5. human. [Q8IX04-1]

Organism-specific databases

CTDi55293.
DisGeNETi55293.
GeneCardsiUEVLD.
HGNCiHGNC:30866. UEVLD.
HPAiHPA047134.
MIMi610985. gene.
neXtProtiNX_Q8IX04.
OpenTargetsiENSG00000151116.
PharmGKBiPA147357188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
KOG2391. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ8IX04.
OMAiNIPIRLW.
OrthoDBiEOG091G0HRA.
PhylomeDBiQ8IX04.
TreeFamiTF314963.

Enzyme and pathway databases

BioCyciZFISH:HS07708-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8IX04.
GenomeRNAii55293.
PROiQ8IX04.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151116.
CleanExiHS_UEVLD.
ExpressionAtlasiQ8IX04. baseline and differential.
GenevisibleiQ8IX04. HS.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR008883. UEV_N.
[Graphical view]
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PF05743. UEV. 1 hit.
[Graphical view]
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF54495. SSF54495. 1 hit.
SSF56327. SSF56327. 1 hit.
PROSITEiPS51322. UEV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUEVLD_HUMAN
AccessioniPrimary (citable) accession number: Q8IX04
Secondary accession number(s): B2RB69
, B4DL43, F5H6L6, H7BYD6, Q6P2F0, Q96FF5, Q9NUX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.