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Q8IX03

- KIBRA_HUMAN

UniProt

Q8IX03 - KIBRA_HUMAN

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Protein

Protein KIBRA

Gene

WWC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.7 Publications

GO - Molecular functioni

  1. kinase binding Source: BHF-UCL
  2. protein complex scaffold Source: BHF-UCL
  3. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. establishment of cell polarity Source: BHF-UCL
  3. hippo signaling Source: Reactome
  4. negative regulation of hippo signaling Source: BHF-UCL
  5. negative regulation of organ growth Source: BHF-UCL
  6. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  7. positive regulation of MAPK cascade Source: UniProtKB
  8. regulation of hippo signaling Source: UniProtKB
  9. regulation of intracellular transport Source: BHF-UCL
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_118607. Signaling by Hippo.
SignaLinkiQ8IX03.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KIBRA
Alternative name(s):
HBeAg-binding protein 3
Kidney and brain protein
Short name:
KIBRA
WW domain-containing protein 1
Gene namesi
Name:WWC1
Synonyms:KIAA0869
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:29435. WWC1.

Subcellular locationi

Cytoplasm. Cytoplasmperinuclear region. Nucleus. Cell projectionruffle membrane
Note: Colocalizes with PRKCZ in the perinuclear region.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: BHF-UCL
  3. nucleus Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
  5. protein complex Source: Ensembl
  6. ruffle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

MIMi615602. phenotype.
PharmGKBiPA143485670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11131113Protein KIBRAPRO_0000242153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei542 – 5421Phosphoserine; by CDK11 Publication
Modified residuei899 – 8991PhosphoserineBy similarity
Modified residuei912 – 9121Phosphothreonine1 Publication
Modified residuei929 – 9291Phosphothreonine1 Publication
Modified residuei931 – 9311Phosphoserine; by CDK12 Publications
Modified residuei947 – 9471Phosphoserine1 Publication
Modified residuei975 – 9751Phosphoserine; by PKC/PRKCZ1 Publication
Modified residuei978 – 9781Phosphoserine; by PKC/PRKCZ1 Publication

Post-translational modificationi

Phosphorylation at Ser-542 and Ser-931 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.6 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IX03.
PaxDbiQ8IX03.
PRIDEiQ8IX03.

PTM databases

PhosphoSiteiQ8IX03.

Expressioni

Tissue specificityi

Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct.4 Publications

Inductioni

Strongly up-regulated by progestin treatment.1 Publication

Gene expression databases

BgeeiQ8IX03.
CleanExiHS_WWC1.
ExpressionAtlasiQ8IX03. baseline and differential.
GenevestigatoriQ8IX03.

Organism-specific databases

HPAiHPA038016.
HPA038017.

Interactioni

Subunit structurei

Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.8 Publications

Protein-protein interaction databases

BioGridi116884. 17 interactions.
DIPiDIP-35287N.
IntActiQ8IX03. 23 interactions.
MINTiMINT-1405937.
STRINGi9606.ENSP00000265293.

Structurei

Secondary structure

1
1113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi660 – 66910Combined sources
Turni670 – 6734Combined sources
Beta strandi674 – 68310Combined sources
Helixi685 – 6873Combined sources
Beta strandi694 – 70411Combined sources
Helixi708 – 7114Combined sources
Beta strandi712 – 7143Combined sources
Beta strandi722 – 73312Combined sources
Helixi736 – 7416Combined sources
Beta strandi743 – 7519Combined sources
Beta strandi757 – 76610Combined sources
Beta strandi777 – 7848Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z0UX-ray2.20A/B638-785[»]
ProteinModelPortaliQ8IX03.
SMRiQ8IX03. Positions 7-86, 658-785.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX03.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 3934WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8634WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini655 – 783129C2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni839 – 1113275Interaction with histone H3Add
BLAST
Regioni953 – 99644Interaction with PRKCZAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili107 – 19387Sequence AnalysisAdd
BLAST
Coiled coili293 – 431139Sequence AnalysisAdd
BLAST
Coiled coili1001 – 103232Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1111 – 11133ADDV motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi261 – 2655Poly-Ser
Compositional biasi819 – 87355Glu-richAdd
BLAST

Domaini

The C2-domain mediates homodimerization. It is a calcium-sensitive lipid-binding domain with preference for PI3P.1 Publication

Sequence similaritiesi

Belongs to the WWC family. KIBRA subfamily.Curated
Contains 1 C2 domain.Curated
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5021.
GeneTreeiENSGT00410000025556.
HOGENOMiHOG000013211.
HOVERGENiHBG058082.
InParanoidiQ8IX03.
KOiK16685.
OMAiDPQVGDY.
OrthoDBiEOG7DJSNR.
PhylomeDBiQ8IX03.
TreeFamiTF324040.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IX03-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRPELPLPE GWEEARDFDG KVYYIDHTNR TTSWIDPRDR YTKPLTFADC
60 70 80 90 100
ISDELPLGWE EAYDPQVGDY FIDHNTKTTQ IEDPRVQWRR EQEHMLKDYL
110 120 130 140 150
VVAQEALSAQ KEIYQVKQQR LELAQQEYQQ LHAVWEHKLG SQVSLVSGSS
160 170 180 190 200
SSSKYDPEIL KAEIATAKSR VNKLKREMVH LQHELQFKER GFQTLKKIDK
210 220 230 240 250
KMSDAQGSYK LDEAQAVLRE TKAIKKAITC GEKEKQDLIK SLAMLKDGFR
260 270 280 290 300
TDRGSHSDLW SSSSSLESSS FPLPKQYLDV SSQTDISGSF GINSNNQLAE
310 320 330 340 350
KVRLRLRYEE AKRRIANLKI QLAKLDSEAW PGVLDSERDR LILINEKEEL
360 370 380 390 400
LKEMRFISPR KWTQGEVEQL EMARKRLEKD LQAARDTQSK ALTERLKLNS
410 420 430 440 450
KRNQLVRELE EATRQVATLH SQLKSLSSSM QSLSSGSSPG SLTSSRGSLV
460 470 480 490 500
ASSLDSSTSA SFTDLYYDPF EQLDSELQSK VEFLLLEGAT GFRPSGCITT
510 520 530 540 550
IHEDEVAKTQ KAEGGGRLQA LRSLSGTPKS MTSLSPRSSL SSPSPPCSPL
560 570 580 590 600
MADPLLAGDA FLNSLEFEDP ELSATLCELS LGNSAQERYR LEEPGTEGKQ
610 620 630 640 650
LGQAVNTAQG CGLKVACVSA AVSDESVAGD SGVYEASVQR LGASEAAAFD
660 670 680 690 700
SDESEAVGAT RIQIALKYDE KNKQFAILII QLSNLSALLQ QQDQKVNIRV
710 720 730 740 750
AVLPCSESTT CLFRTRPLDA SDTLVFNEVF WVSMSYPALH QKTLRVDVCT
760 770 780 790 800
TDRSHLEECL GGAQISLAEV CRSGERSTRW YNLLSYKYLK KQSRELKPVG
810 820 830 840 850
VMAPASGPAS TDAVSALLEQ TAVELEKRQE GRSSTQTLED SWRYEETSEN
860 870 880 890 900
EAVAEEEEEE VEEEEGEEDV FTEKASPDMD GYPALKVDKE TNTETPAPSP
910 920 930 940 950
TVVRPKDRRV GTPSQGPFLR GSTIIRSKTF SPGPQSQYVC RLNRSDSDSS
960 970 980 990 1000
TLSKKPPFVR NSLERRSVRM KRPSSVKSLR SERLIRTSLD LELDLQATRT
1010 1020 1030 1040 1050
WHSQLTQEIS VLKELKEQLE QAKSHGEKEL PQWLREDERF RLLLRMLEKR
1060 1070 1080 1090 1100
QMDRAEHKGE LQTDKMMRAA AKDVHRLRGQ SCKEPPEVQS FREKMAFFTR
1110
PRMNIPALSA DDV
Length:1,113
Mass (Da):125,301
Last modified:March 1, 2003 - v1
Checksum:i9010B9C127129165
GO
Isoform 2 (identifier: Q8IX03-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     974-974: S → SPPPQPS

Show »
Length:1,119
Mass (Da):125,905
Checksum:i0AB48E74AB261693
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti561 – 5611F → L in CAE45903. (PubMed:17974005)Curated
Sequence conflicti759 – 7591C → R in CAE45903. (PubMed:17974005)Curated
Sequence conflicti811 – 8111T → TVSWDQ in AAO73817. 1 PublicationCurated
Sequence conflicti834 – 8341S → N in CAE45903. (PubMed:17974005)Curated
Sequence conflicti865 – 8651Missing in AAO73817. 1 PublicationCurated
Sequence conflicti1051 – 10511Missing in CAE45903. (PubMed:17974005)Curated
Sequence conflicti1051 – 10511Missing in BAA74892. (PubMed:10048485)Curated
Sequence conflicti1064 – 10652DK → AR in AAO73817. 1 PublicationCurated

Polymorphismi

Genetic variations in WWC1 define the memory quantitative trait locus (MEMRYQTL) [MIMi:615602].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti250 – 2501R → C.
Corresponds to variant rs17551608 [ dbSNP | Ensembl ].
VAR_026844
Natural varianti734 – 7341M → I Polymorphism; associated with Ala-735; affects KIBRA lipid-binding specificity showing stronger interactions with PI(4)P and PI(5)P. 1 Publication
Corresponds to variant rs3822660 [ dbSNP | Ensembl ].
VAR_053449
Natural varianti735 – 7351S → A Polymorphism; associated with Ile-734; affects KIBRA lipid-binding specificity showing stronger interactions with PI(4)P and PI(5)P. 1 Publication
Corresponds to variant rs3822659 [ dbSNP | Ensembl ].
VAR_053450

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei974 – 9741S → SPPPQPS in isoform 2. 3 PublicationsVSP_019448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506799 mRNA. Translation: AAO15881.1.
AK296323 mRNA. Translation: BAG59017.1.
AC020894 Genomic DNA. No translation available.
AC026689 Genomic DNA. No translation available.
BX640827 mRNA. Translation: CAE45903.1.
AB020676 mRNA. Translation: BAA74892.1.
AF530058 mRNA. Translation: AAQ09942.1.
AY189820 mRNA. Translation: AAO73817.1.
BC004394 mRNA. Translation: AAH04394.1.
BC017746 mRNA. Translation: AAH17746.1.
CCDSiCCDS4366.1. [Q8IX03-1]
CCDS54945.1. [Q8IX03-2]
RefSeqiNP_001155133.1. NM_001161661.1. [Q8IX03-2]
NP_001155134.1. NM_001161662.1.
NP_056053.1. NM_015238.2. [Q8IX03-1]
UniGeneiHs.484047.

Genome annotation databases

EnsembliENST00000265293; ENSP00000265293; ENSG00000113645. [Q8IX03-1]
ENST00000521089; ENSP00000427772; ENSG00000113645. [Q8IX03-2]
GeneIDi23286.
KEGGihsa:23286.
UCSCiuc003lzu.3. human. [Q8IX03-1]
uc011den.2. human. [Q8IX03-2]

Polymorphism databases

DMDMi74714457.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506799 mRNA. Translation: AAO15881.1 .
AK296323 mRNA. Translation: BAG59017.1 .
AC020894 Genomic DNA. No translation available.
AC026689 Genomic DNA. No translation available.
BX640827 mRNA. Translation: CAE45903.1 .
AB020676 mRNA. Translation: BAA74892.1 .
AF530058 mRNA. Translation: AAQ09942.1 .
AY189820 mRNA. Translation: AAO73817.1 .
BC004394 mRNA. Translation: AAH04394.1 .
BC017746 mRNA. Translation: AAH17746.1 .
CCDSi CCDS4366.1. [Q8IX03-1 ]
CCDS54945.1. [Q8IX03-2 ]
RefSeqi NP_001155133.1. NM_001161661.1. [Q8IX03-2 ]
NP_001155134.1. NM_001161662.1.
NP_056053.1. NM_015238.2. [Q8IX03-1 ]
UniGenei Hs.484047.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Z0U X-ray 2.20 A/B 638-785 [» ]
ProteinModelPortali Q8IX03.
SMRi Q8IX03. Positions 7-86, 658-785.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116884. 17 interactions.
DIPi DIP-35287N.
IntActi Q8IX03. 23 interactions.
MINTi MINT-1405937.
STRINGi 9606.ENSP00000265293.

PTM databases

PhosphoSitei Q8IX03.

Polymorphism databases

DMDMi 74714457.

Proteomic databases

MaxQBi Q8IX03.
PaxDbi Q8IX03.
PRIDEi Q8IX03.

Protocols and materials databases

DNASUi 23286.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265293 ; ENSP00000265293 ; ENSG00000113645 . [Q8IX03-1 ]
ENST00000521089 ; ENSP00000427772 ; ENSG00000113645 . [Q8IX03-2 ]
GeneIDi 23286.
KEGGi hsa:23286.
UCSCi uc003lzu.3. human. [Q8IX03-1 ]
uc011den.2. human. [Q8IX03-2 ]

Organism-specific databases

CTDi 23286.
GeneCardsi GC05P167652.
HGNCi HGNC:29435. WWC1.
HPAi HPA038016.
HPA038017.
MIMi 610533. gene.
615602. phenotype.
neXtProti NX_Q8IX03.
PharmGKBi PA143485670.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5021.
GeneTreei ENSGT00410000025556.
HOGENOMi HOG000013211.
HOVERGENi HBG058082.
InParanoidi Q8IX03.
KOi K16685.
OMAi DPQVGDY.
OrthoDBi EOG7DJSNR.
PhylomeDBi Q8IX03.
TreeFami TF324040.

Enzyme and pathway databases

Reactomei REACT_118607. Signaling by Hippo.
SignaLinki Q8IX03.

Miscellaneous databases

ChiTaRSi WWC1. human.
EvolutionaryTracei Q8IX03.
GeneWikii WWC1.
GenomeRNAii 23286.
NextBioi 45094.
PROi Q8IX03.
SOURCEi Search...

Gene expression databases

Bgeei Q8IX03.
CleanExi HS_WWC1.
ExpressionAtlasi Q8IX03. baseline and differential.
Genevestigatori Q8IX03.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00397. WW. 2 hits.
[Graphical view ]
SMARTi SM00456. WW. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEi PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH DDN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-1113 (ISOFORM 2).
    Tissue: Fetal brain.
  5. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-1113 (ISOFORM 2).
    Tissue: Brain.
  6. "Screening and cloning of interaction protein 3 of HBeAg."
    Lu Y., Liu Y., Cheng J.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-1113 (ISOFORM 1).
    Tissue: Liver.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 782-1113 (ISOFORM 1).
    Tissue: Liver and Placenta.
  8. Cited for: FUNCTION, SUBUNIT, INTERACTION WITH PRKCZ, PHOSPHORYLATION AT SER-975 AND SER-978.
  9. "Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells."
    Rayala S.K., den Hollander P., Manavathi B., Talukder A.H., Song C., Peng S., Barnekow A., Kremerskothen J., Kumar R.
    J. Biol. Chem. 281:19092-19099(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH DYNLL1 AND HISTONE H3.
  10. Cited for: POLYMORPHISM, INVOLVEMENT IN MEMRYQTL.
  11. "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment."
    Traer C.J., Rutherford A.C., Palmer K.J., Wassmer T., Oakley J., Attar N., Carlton J.G., Kremerskothen J., Stephens D.J., Cullen P.J.
    Nat. Cell Biol. 9:1370-1380(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNX4.
  12. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SYNPO AND INADL, TISSUE SPECIFICITY.
  13. "KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling."
    Hilton H.N., Stanford P.M., Harris J., Oakes S.R., Kaplan W., Daly R.J., Ormandy C.J.
    Biochim. Biophys. Acta 1783:383-393(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INDUCTION, INTERACTION WITH DDR1 AND PRKCZ, TISSUE SPECIFICITY.
  14. "Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA."
    Johannsen S., Duning K., Pavenstaedt H., Kremerskothen J., Boeckers T.M.
    Neuroscience 155:1165-1173(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY, DOMAIN C2.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-912; THR-929 AND SER-931, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded."
    Yu J., Zheng Y., Dong J., Klusza S., Deng W.-M., Pan D.
    Dev. Cell 18:288-299(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Kibra Is a regulator of the Salvador/Warts/Hippo signaling network."
    Genevet A., Wehr M.C., Brain R., Thompson B.J., Tapon N.
    Dev. Cell 18:300-308(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NF2.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-947, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. Cited for: POLYMORPHISM, INVOLVEMENT IN MEMRYQTL.
  20. "Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression."
    Ji M., Yang S., Chen Y., Xiao L., Zhang L., Dong J.
    Biochem. J. 447:93-102(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-542 AND SER-931 BY CDK1, DEPHOSPHORYLATION BY CDC14B.
  21. Cited for: FUNCTION OF C2 DOMAIN, VARIANTS ILE-734 AND ALA-735, CHARACTERIZATION OF VARIANTS ILE-734 AND ALA-735.
  22. "Crystal structure of C2 domain of KIBRA protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 638-785.

Entry informationi

Entry nameiKIBRA_HUMAN
AccessioniPrimary (citable) accession number: Q8IX03
Secondary accession number(s): B4DK05
, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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