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Protein

SURP and G-patch domain-containing protein 2

Gene

SUGP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mRNA splicing.Curated

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 2
Alternative name(s):
Arginine/serine-rich-splicing factor 14
Splicing factor, arginine/serine-rich 14
Gene namesi
Name:SUGP2
Synonyms:KIAA0365, SFRS14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18641. SUGP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394371.

Polymorphism and mutation databases

BioMutaiSUGP2.
DMDMi308153496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10821082SURP and G-patch domain-containing protein 2PRO_0000097708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphothreonineCombined sources
Modified residuei96 – 961PhosphoserineCombined sources
Modified residuei224 – 2241PhosphoserineCombined sources
Modified residuei275 – 2751PhosphothreonineCombined sources
Modified residuei277 – 2771PhosphoserineCombined sources
Modified residuei315 – 3151PhosphoserineCombined sources
Modified residuei573 – 5731PhosphoserineCombined sources
Modified residuei603 – 6031PhosphoserineCombined sources
Modified residuei754 – 7541PhosphoserineCombined sources
Modified residuei757 – 7571PhosphoserineBy similarity
Modified residuei863 – 8631PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IX01.
MaxQBiQ8IX01.
PaxDbiQ8IX01.
PeptideAtlasiQ8IX01.
PRIDEiQ8IX01.

PTM databases

iPTMnetiQ8IX01.
PhosphoSiteiQ8IX01.

Expressioni

Tissue specificityi

Detected in adult testis, and in fetal brain and kidney.1 Publication

Gene expression databases

BgeeiENSG00000064607.
CleanExiHS_SFRS14.
ExpressionAtlasiQ8IX01. baseline and differential.
GenevisibleiQ8IX01. HS.

Organism-specific databases

HPAiHPA041557.
HPA061111.

Interactioni

Protein-protein interaction databases

BioGridi115449. 35 interactions.
IntActiQ8IX01. 14 interactions.
MINTiMINT-2867991.
STRINGi9606.ENSP00000337926.

Structurei

Secondary structure

1
1082
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi588 – 59912Combined sources
Helixi604 – 6129Combined sources
Helixi614 – 6163Combined sources
Turni618 – 6203Combined sources
Beta strandi623 – 6253Combined sources
Helixi626 – 63914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4PNMR-A587-639[»]
ProteinModelPortaliQ8IX01.
SMRiQ8IX01. Positions 589-639.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX01.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati590 – 63344SURP motif 1Add
BLAST
Repeati787 – 83044SURP motif 2Add
BLAST
Domaini1011 – 105747G-patchPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi995 – 10006Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi738 – 77639Pro/Ser-richAdd
BLAST
Compositional biasi869 – 90537Asp/Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 SURP motif repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG4111IFE. LUCA.
GeneTreeiENSGT00410000025695.
HOGENOMiHOG000168519.
HOVERGENiHBG079176.
InParanoidiQ8IX01.
KOiK13166.
PhylomeDBiQ8IX01.
TreeFamiTF326321.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IX01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR
60 70 80 90 100
AEMYDDVHSD GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD
110 120 130 140 150
SYFRKECGRD LEFSHSDSRD QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH
160 170 180 190 200
PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE KECLEKESRD YDVDHPGEAD
210 220 230 240 250
SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG VGKLVTLRNV
260 270 280 290 300
STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL
310 320 330 340 350
GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL
360 370 380 390 400
FQTLFELETE TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN
410 420 430 440 450
EFLNMLLDKG AVKTKNCFFE IIKPFDKYIM RLQDRLLKSV TPLLMACNAY
460 470 480 490 500
ELSVKMKTLS NPLDLALALE TTNSLCRKSL ALLGQTFSLA SSFRQEKILE
510 520 530 540 550
AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC PLQVKKAEPE
560 570 580 590 600
PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG
610 620 630 640 650
SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK
660 670 680 690 700
PTSADCAVRA MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT
710 720 730 740 750
QTLLSSGTRL KHHGRQAPGL SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS
760 770 780 790 800
LEASGPSPKP AGVDISEAPQ TSSPCPSADI DMKTMETAEK LARFVAQVGP
810 820 830 840 850
EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS ICFTSSPHNL
860 870 880 890 900
HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEV MPEEEDEDDE
910 920 930 940 950
DGGEEAPAPG GAGKSEGSTP ADGLPGEAAE DDLAGAPALS QASSGTCFPR
960 970 980 990 1000
KRISSKSLKV GMIPAPKRVC LIQEPKVHEP VRIAYDRPRG RPMSKKKKPK
1010 1020 1030 1040 1050
DLDFAQQKLT DKNLGFQMLQ KMGWKEGHGL GSLGKGIREP VSVGTPSEGE
1060 1070 1080
GLGADGQEHK EDTFDVFRQR MMQMYRHKRA NK
Length:1,082
Mass (Da):120,207
Last modified:October 5, 2010 - v2
Checksum:i619AE0AC087761BD
GO
Isoform 3 (identifier: Q8IX01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.
     1044-1082: GTPSEGEGLG...QMYRHKRANK → YAAGSLGWEW...LNRRHLQMRS

Note: No experimental confirmation available.
Show »
Length:1,040
Mass (Da):116,286
Checksum:i4C4AF9C44F68DA88
GO
Isoform 4 (identifier: Q8IX01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.

Note: No experimental confirmation available.
Show »
Length:1,030
Mass (Da):115,186
Checksum:iDBC51336F08F75F9
GO

Sequence cautioni

The sequence AAC06129 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAH20586 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA20820 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti206 – 2061G → S.3 Publications
Corresponds to variant rs4808907 [ dbSNP | Ensembl ].
VAR_023711
Natural varianti552 – 5521M → T.
Corresponds to variant rs10404860 [ dbSNP | Ensembl ].
VAR_051341
Natural varianti649 – 6491Q → R.
Corresponds to variant rs10414535 [ dbSNP | Ensembl ].
VAR_051342
Natural varianti722 – 7221Q → R.
Corresponds to variant rs34540303 [ dbSNP | Ensembl ].
VAR_051343
Natural varianti881 – 8811R → Q.
Corresponds to variant rs35646935 [ dbSNP | Ensembl ].
VAR_051344

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei890 – 94152Missing in isoform 3 and isoform 4. 2 PublicationsVSP_013112Add
BLAST
Alternative sequencei1044 – 108239GTPSE…KRANK → YAAGSLGWEWVGPQSFHLQP AAWLLHSQDGLQLAVDFCFL NRRHLQMRS in isoform 3. 1 PublicationVSP_013113Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518874 mRNA. Translation: AAN77117.1.
AB002363 mRNA. Translation: BAA20820.2. Different initiation.
BX647813 mRNA. Translation: CAI46012.1.
AL832488 mRNA. Translation: CAI46117.1.
AC004447 Genomic DNA. Translation: AAC06129.1. Sequence problems.
BC020586 mRNA. Translation: AAH20586.1. Different initiation.
CCDSiCCDS12392.1. [Q8IX01-1]
PIRiT03030.
RefSeqiNP_001017392.2. NM_001017392.4. [Q8IX01-1]
NP_001308626.1. NM_001321697.1. [Q8IX01-1]
NP_055699.2. NM_014884.4. [Q8IX01-1]
UniGeneiHs.515271.
Hs.77876.

Genome annotation databases

EnsembliENST00000330854; ENSP00000332373; ENSG00000064607. [Q8IX01-4]
ENST00000337018; ENSP00000337926; ENSG00000064607. [Q8IX01-1]
ENST00000452918; ENSP00000389380; ENSG00000064607. [Q8IX01-1]
ENST00000594773; ENSP00000470915; ENSG00000064607. [Q8IX01-3]
ENST00000601879; ENSP00000472286; ENSG00000064607. [Q8IX01-1]
GeneIDi10147.
KEGGihsa:10147.
UCSCiuc002nkx.3. human. [Q8IX01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518874 mRNA. Translation: AAN77117.1.
AB002363 mRNA. Translation: BAA20820.2. Different initiation.
BX647813 mRNA. Translation: CAI46012.1.
AL832488 mRNA. Translation: CAI46117.1.
AC004447 Genomic DNA. Translation: AAC06129.1. Sequence problems.
BC020586 mRNA. Translation: AAH20586.1. Different initiation.
CCDSiCCDS12392.1. [Q8IX01-1]
PIRiT03030.
RefSeqiNP_001017392.2. NM_001017392.4. [Q8IX01-1]
NP_001308626.1. NM_001321697.1. [Q8IX01-1]
NP_055699.2. NM_014884.4. [Q8IX01-1]
UniGeneiHs.515271.
Hs.77876.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4PNMR-A587-639[»]
ProteinModelPortaliQ8IX01.
SMRiQ8IX01. Positions 589-639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115449. 35 interactions.
IntActiQ8IX01. 14 interactions.
MINTiMINT-2867991.
STRINGi9606.ENSP00000337926.

PTM databases

iPTMnetiQ8IX01.
PhosphoSiteiQ8IX01.

Polymorphism and mutation databases

BioMutaiSUGP2.
DMDMi308153496.

Proteomic databases

EPDiQ8IX01.
MaxQBiQ8IX01.
PaxDbiQ8IX01.
PeptideAtlasiQ8IX01.
PRIDEiQ8IX01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330854; ENSP00000332373; ENSG00000064607. [Q8IX01-4]
ENST00000337018; ENSP00000337926; ENSG00000064607. [Q8IX01-1]
ENST00000452918; ENSP00000389380; ENSG00000064607. [Q8IX01-1]
ENST00000594773; ENSP00000470915; ENSG00000064607. [Q8IX01-3]
ENST00000601879; ENSP00000472286; ENSG00000064607. [Q8IX01-1]
GeneIDi10147.
KEGGihsa:10147.
UCSCiuc002nkx.3. human. [Q8IX01-1]

Organism-specific databases

CTDi10147.
GeneCardsiSUGP2.
H-InvDBHIX0014931.
HGNCiHGNC:18641. SUGP2.
HPAiHPA041557.
HPA061111.
MIMi607993. gene.
neXtProtiNX_Q8IX01.
PharmGKBiPA165394371.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG4111IFE. LUCA.
GeneTreeiENSGT00410000025695.
HOGENOMiHOG000168519.
HOVERGENiHBG079176.
InParanoidiQ8IX01.
KOiK13166.
PhylomeDBiQ8IX01.
TreeFamiTF326321.

Miscellaneous databases

ChiTaRSiSUGP2. human.
EvolutionaryTraceiQ8IX01.
GeneWikiiSFRS14.
GenomeRNAii10147.
PROiQ8IX01.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064607.
CleanExiHS_SFRS14.
ExpressionAtlasiQ8IX01. baseline and differential.
GenevisibleiQ8IX01. HS.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUGP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IX01
Secondary accession number(s): C9JI71
, O15071, O60369, Q5JPH7, Q8WUF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 5, 2010
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.