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Protein

SURP and G-patch domain-containing protein 2

Gene

SUGP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mRNA splicing.Curated

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 2
Alternative name(s):
Arginine/serine-rich-splicing factor 14
Splicing factor, arginine/serine-rich 14
Gene namesi
Name:SUGP2
Synonyms:KIAA0365, SFRS14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18641. SUGP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064607.
PharmGKBiPA165394371.

Polymorphism and mutation databases

BioMutaiSUGP2.
DMDMi308153496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977081 – 1082SURP and G-patch domain-containing protein 2Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphothreonineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei275PhosphothreonineCombined sources1
Modified residuei277PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei757PhosphoserineBy similarity1
Modified residuei863PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IX01.
MaxQBiQ8IX01.
PaxDbiQ8IX01.
PeptideAtlasiQ8IX01.
PRIDEiQ8IX01.

PTM databases

iPTMnetiQ8IX01.
PhosphoSitePlusiQ8IX01.

Expressioni

Tissue specificityi

Detected in adult testis, and in fetal brain and kidney.1 Publication

Gene expression databases

BgeeiENSG00000064607.
CleanExiHS_SFRS14.
ExpressionAtlasiQ8IX01. baseline and differential.
GenevisibleiQ8IX01. HS.

Organism-specific databases

HPAiHPA041557.
HPA061111.

Interactioni

Protein-protein interaction databases

BioGridi115449. 35 interactors.
IntActiQ8IX01. 15 interactors.
MINTiMINT-2867991.
STRINGi9606.ENSP00000337926.

Structurei

Secondary structure

11082
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi588 – 599Combined sources12
Helixi604 – 612Combined sources9
Helixi614 – 616Combined sources3
Turni618 – 620Combined sources3
Beta strandi623 – 625Combined sources3
Helixi626 – 639Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4PNMR-A587-639[»]
ProteinModelPortaliQ8IX01.
SMRiQ8IX01.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX01.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati590 – 633SURP motif 1Add BLAST44
Repeati787 – 830SURP motif 2Add BLAST44
Domaini1011 – 1057G-patchPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi995 – 1000Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi738 – 776Pro/Ser-richAdd BLAST39
Compositional biasi869 – 905Asp/Glu-richAdd BLAST37

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 SURP motif repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG4111IFE. LUCA.
GeneTreeiENSGT00410000025695.
HOGENOMiHOG000168519.
HOVERGENiHBG079176.
InParanoidiQ8IX01.
KOiK13166.
PhylomeDBiQ8IX01.
TreeFamiTF326321.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IX01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR
60 70 80 90 100
AEMYDDVHSD GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD
110 120 130 140 150
SYFRKECGRD LEFSHSDSRD QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH
160 170 180 190 200
PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE KECLEKESRD YDVDHPGEAD
210 220 230 240 250
SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG VGKLVTLRNV
260 270 280 290 300
STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL
310 320 330 340 350
GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL
360 370 380 390 400
FQTLFELETE TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN
410 420 430 440 450
EFLNMLLDKG AVKTKNCFFE IIKPFDKYIM RLQDRLLKSV TPLLMACNAY
460 470 480 490 500
ELSVKMKTLS NPLDLALALE TTNSLCRKSL ALLGQTFSLA SSFRQEKILE
510 520 530 540 550
AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC PLQVKKAEPE
560 570 580 590 600
PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG
610 620 630 640 650
SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK
660 670 680 690 700
PTSADCAVRA MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT
710 720 730 740 750
QTLLSSGTRL KHHGRQAPGL SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS
760 770 780 790 800
LEASGPSPKP AGVDISEAPQ TSSPCPSADI DMKTMETAEK LARFVAQVGP
810 820 830 840 850
EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS ICFTSSPHNL
860 870 880 890 900
HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEV MPEEEDEDDE
910 920 930 940 950
DGGEEAPAPG GAGKSEGSTP ADGLPGEAAE DDLAGAPALS QASSGTCFPR
960 970 980 990 1000
KRISSKSLKV GMIPAPKRVC LIQEPKVHEP VRIAYDRPRG RPMSKKKKPK
1010 1020 1030 1040 1050
DLDFAQQKLT DKNLGFQMLQ KMGWKEGHGL GSLGKGIREP VSVGTPSEGE
1060 1070 1080
GLGADGQEHK EDTFDVFRQR MMQMYRHKRA NK
Length:1,082
Mass (Da):120,207
Last modified:October 5, 2010 - v2
Checksum:i619AE0AC087761BD
GO
Isoform 3 (identifier: Q8IX01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.
     1044-1082: GTPSEGEGLG...QMYRHKRANK → YAAGSLGWEW...LNRRHLQMRS

Note: No experimental confirmation available.
Show »
Length:1,040
Mass (Da):116,286
Checksum:i4C4AF9C44F68DA88
GO
Isoform 4 (identifier: Q8IX01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.

Note: No experimental confirmation available.
Show »
Length:1,030
Mass (Da):115,186
Checksum:iDBC51336F08F75F9
GO

Sequence cautioni

The sequence AAC06129 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH20586 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA20820 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023711206G → S.3 PublicationsCorresponds to variant rs4808907dbSNPEnsembl.1
Natural variantiVAR_051341552M → T.Corresponds to variant rs10404860dbSNPEnsembl.1
Natural variantiVAR_051342649Q → R.Corresponds to variant rs10414535dbSNPEnsembl.1
Natural variantiVAR_051343722Q → R.Corresponds to variant rs34540303dbSNPEnsembl.1
Natural variantiVAR_051344881R → Q.Corresponds to variant rs35646935dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013112890 – 941Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_0131131044 – 1082GTPSE…KRANK → YAAGSLGWEWVGPQSFHLQP AAWLLHSQDGLQLAVDFCFL NRRHLQMRS in isoform 3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518874 mRNA. Translation: AAN77117.1.
AB002363 mRNA. Translation: BAA20820.2. Different initiation.
BX647813 mRNA. Translation: CAI46012.1.
AL832488 mRNA. Translation: CAI46117.1.
AC004447 Genomic DNA. Translation: AAC06129.1. Sequence problems.
BC020586 mRNA. Translation: AAH20586.1. Different initiation.
CCDSiCCDS12392.1. [Q8IX01-1]
PIRiT03030.
RefSeqiNP_001017392.2. NM_001017392.4. [Q8IX01-1]
NP_001308626.1. NM_001321697.1. [Q8IX01-1]
NP_055699.2. NM_014884.4. [Q8IX01-1]
XP_016881626.1. XM_017026137.1. [Q8IX01-1]
UniGeneiHs.515271.
Hs.77876.

Genome annotation databases

EnsembliENST00000330854; ENSP00000332373; ENSG00000064607. [Q8IX01-4]
ENST00000337018; ENSP00000337926; ENSG00000064607. [Q8IX01-1]
ENST00000452918; ENSP00000389380; ENSG00000064607. [Q8IX01-1]
ENST00000594773; ENSP00000470915; ENSG00000064607. [Q8IX01-3]
ENST00000601879; ENSP00000472286; ENSG00000064607. [Q8IX01-1]
GeneIDi10147.
KEGGihsa:10147.
UCSCiuc002nkx.3. human. [Q8IX01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518874 mRNA. Translation: AAN77117.1.
AB002363 mRNA. Translation: BAA20820.2. Different initiation.
BX647813 mRNA. Translation: CAI46012.1.
AL832488 mRNA. Translation: CAI46117.1.
AC004447 Genomic DNA. Translation: AAC06129.1. Sequence problems.
BC020586 mRNA. Translation: AAH20586.1. Different initiation.
CCDSiCCDS12392.1. [Q8IX01-1]
PIRiT03030.
RefSeqiNP_001017392.2. NM_001017392.4. [Q8IX01-1]
NP_001308626.1. NM_001321697.1. [Q8IX01-1]
NP_055699.2. NM_014884.4. [Q8IX01-1]
XP_016881626.1. XM_017026137.1. [Q8IX01-1]
UniGeneiHs.515271.
Hs.77876.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4PNMR-A587-639[»]
ProteinModelPortaliQ8IX01.
SMRiQ8IX01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115449. 35 interactors.
IntActiQ8IX01. 15 interactors.
MINTiMINT-2867991.
STRINGi9606.ENSP00000337926.

PTM databases

iPTMnetiQ8IX01.
PhosphoSitePlusiQ8IX01.

Polymorphism and mutation databases

BioMutaiSUGP2.
DMDMi308153496.

Proteomic databases

EPDiQ8IX01.
MaxQBiQ8IX01.
PaxDbiQ8IX01.
PeptideAtlasiQ8IX01.
PRIDEiQ8IX01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330854; ENSP00000332373; ENSG00000064607. [Q8IX01-4]
ENST00000337018; ENSP00000337926; ENSG00000064607. [Q8IX01-1]
ENST00000452918; ENSP00000389380; ENSG00000064607. [Q8IX01-1]
ENST00000594773; ENSP00000470915; ENSG00000064607. [Q8IX01-3]
ENST00000601879; ENSP00000472286; ENSG00000064607. [Q8IX01-1]
GeneIDi10147.
KEGGihsa:10147.
UCSCiuc002nkx.3. human. [Q8IX01-1]

Organism-specific databases

CTDi10147.
GeneCardsiSUGP2.
H-InvDBHIX0014931.
HGNCiHGNC:18641. SUGP2.
HPAiHPA041557.
HPA061111.
MIMi607993. gene.
neXtProtiNX_Q8IX01.
OpenTargetsiENSG00000064607.
PharmGKBiPA165394371.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG4111IFE. LUCA.
GeneTreeiENSGT00410000025695.
HOGENOMiHOG000168519.
HOVERGENiHBG079176.
InParanoidiQ8IX01.
KOiK13166.
PhylomeDBiQ8IX01.
TreeFamiTF326321.

Miscellaneous databases

ChiTaRSiSUGP2. human.
EvolutionaryTraceiQ8IX01.
GeneWikiiSFRS14.
GenomeRNAii10147.
PROiQ8IX01.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064607.
CleanExiHS_SFRS14.
ExpressionAtlasiQ8IX01. baseline and differential.
GenevisibleiQ8IX01. HS.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUGP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IX01
Secondary accession number(s): C9JI71
, O15071, O60369, Q5JPH7, Q8WUF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.