Q8IX01 (SUGP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SURP and G-patch domain-containing protein 2

Alternative name(s):
Arginine/serine-rich-splicing factor 14
Splicing factor, arginine/serine-rich 14

Gene names

Name:	SUGP2
Synonyms:	KIAA0365, SFRS14

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1082 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in mRNA splicing Potential.
Subcellular location	Nucleus Potential.
Tissue specificity	Detected in adult testis, and in fetal brain and kidney. Ref.1
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7 Ref.8 Ref.9 Ref.10 Ref.11
Sequence similarities	Contains 1 G-patch domain. Contains 2 SURP motif repeats.
Sequence caution	The sequence AAC06129.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAH20586.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA20820.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IX01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q8IX01-3)

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.
     1044-1082: GTPSEGEGLG...QMYRHKRANK → YAAGSLGWEW...LNRRHLQMRS

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8IX01-4)

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1082

1082

SURP and G-patch domain-containing protein 2

PRO_0000097708

Regions

Repeat

590 – 633

44

SURP motif 1

Repeat

787 – 830

44

SURP motif 2

Domain

1011 – 1057

47

G-patch

Motif

995 – 1000

6

Nuclear localization signal Potential

Compositional bias

738 – 776

39

Pro/Ser-rich

Compositional bias

869 – 905

37

Asp/Glu-rich

Amino acid modifications

Modified residue

7

1

Phosphothreonine Ref.9

Modified residue

275

1

Phosphothreonine Ref.10

Modified residue

277

1

Phosphoserine Ref.7 Ref.8 Ref.10 Ref.11

Modified residue

315

1

Phosphoserine Ref.10

Modified residue

773

1

Phosphoserine Ref.11

Modified residue

940

1

Phosphoserine Ref.9

Natural variations

Alternative sequence

890 – 941

52

Missing in isoform 3 and isoform 4.

VSP_013112

Alternative sequence

1044 – 1082

39

GTPSE…KRANK → YAAGSLGWEWVGPQSFHLQP AAWLLHSQDGLQLAVDFCFL NRRHLQMRS in isoform 3.

VSP_013113

Natural variant

206

1

G → S. Ref.1 Ref.4 Ref.6
Corresponds to variant rs4808907 [ dbSNP | Ensembl ].

VAR_023711

Natural variant

552

1

M → T.
Corresponds to variant rs10404860 [ dbSNP | Ensembl ].

VAR_051341

Natural variant

649

1

Q → R.
Corresponds to variant rs10414535 [ dbSNP | Ensembl ].

VAR_051342

Natural variant

722

1

Q → R.
Corresponds to variant rs34540303 [ dbSNP | Ensembl ].

VAR_051343

Natural variant

881

1

R → Q.
Corresponds to variant rs35646935 [ dbSNP | Ensembl ].

VAR_051344

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

1082

Helix Strand Turn

Details...

Helix

588 – 599

12

Helix

604 – 612

9

Helix

614 – 616

3

Turn

618 – 620

3

Beta strand

623 – 625

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: 619AE0AC087761BD	FASTA	1,082	120,207
	10 20 30 40 50 60 MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR AEMYDDVHSD 70 80 90 100 110 120 GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD SYFRKECGRD LEFSHSDSRD 130 140 150 160 170 180 QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE 190 200 210 220 230 240 KECLEKESRD YDVDHPGEAD SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG 250 260 270 280 290 300 VGKLVTLRNV STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL 310 320 330 340 350 360 GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL FQTLFELETE 370 380 390 400 410 420 TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN EFLNMLLDKG AVKTKNCFFE 430 440 450 460 470 480 IIKPFDKYIM RLQDRLLKSV TPLLMACNAY ELSVKMKTLS NPLDLALALE TTNSLCRKSL 490 500 510 520 530 540 ALLGQTFSLA SSFRQEKILE AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC 550 560 570 580 590 600 PLQVKKAEPE PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG 610 620 630 640 650 660 SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK PTSADCAVRA 670 680 690 700 710 720 MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT QTLLSSGTRL KHHGRQAPGL 730 740 750 760 770 780 SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS LEASGPSPKP AGVDISEAPQ TSSPCPSADI 790 800 810 820 830 840 DMKTMETAEK LARFVAQVGP EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS 850 860 870 880 890 900 ICFTSSPHNL HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEV MPEEEDEDDE 910 920 930 940 950 960 DGGEEAPAPG GAGKSEGSTP ADGLPGEAAE DDLAGAPALS QASSGTCFPR KRISSKSLKV 970 980 990 1000 1010 1020 GMIPAPKRVC LIQEPKVHEP VRIAYDRPRG RPMSKKKKPK DLDFAQQKLT DKNLGFQMLQ 1030 1040 1050 1060 1070 1080 KMGWKEGHGL GSLGKGIREP VSVGTPSEGE GLGADGQEHK EDTFDVFRQR MMQMYRHKRA NK
	Isoform 3 [UniParc]. Checksum: 4C4AF9C44F68DA88	FASTA	1,040	116,286
	10 20 30 40 50 60 MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR AEMYDDVHSD 70 80 90 100 110 120 GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD SYFRKECGRD LEFSHSDSRD 130 140 150 160 170 180 QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE 190 200 210 220 230 240 KECLEKESRD YDVDHPGEAD SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG 250 260 270 280 290 300 VGKLVTLRNV STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL 310 320 330 340 350 360 GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL FQTLFELETE 370 380 390 400 410 420 TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN EFLNMLLDKG AVKTKNCFFE 430 440 450 460 470 480 IIKPFDKYIM RLQDRLLKSV TPLLMACNAY ELSVKMKTLS NPLDLALALE TTNSLCRKSL 490 500 510 520 530 540 ALLGQTFSLA SSFRQEKILE AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC 550 560 570 580 590 600 PLQVKKAEPE PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG 610 620 630 640 650 660 SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK PTSADCAVRA 670 680 690 700 710 720 MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT QTLLSSGTRL KHHGRQAPGL 730 740 750 760 770 780 SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS LEASGPSPKP AGVDISEAPQ TSSPCPSADI 790 800 810 820 830 840 DMKTMETAEK LARFVAQVGP EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS 850 860 870 880 890 900 ICFTSSPHNL HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEA SSGTCFPRKR 910 920 930 940 950 960 ISSKSLKVGM IPAPKRVCLI QEPKVHEPVR IAYDRPRGRP MSKKKKPKDL DFAQQKLTDK 970 980 990 1000 1010 1020 NLGFQMLQKM GWKEGHGLGS LGKGIREPVS VYAAGSLGWE WVGPQSFHLQ PAAWLLHSQD 1030 1040 GLQLAVDFCF LNRRHLQMRS
	Isoform 4 [UniParc]. Checksum: DBC51336F08F75F9	FASTA	1,030	115,186
	10 20 30 40 50 60 MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR AEMYDDVHSD 70 80 90 100 110 120 GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD SYFRKECGRD LEFSHSDSRD 130 140 150 160 170 180 QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE 190 200 210 220 230 240 KECLEKESRD YDVDHPGEAD SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG 250 260 270 280 290 300 VGKLVTLRNV STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL 310 320 330 340 350 360 GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL FQTLFELETE 370 380 390 400 410 420 TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN EFLNMLLDKG AVKTKNCFFE 430 440 450 460 470 480 IIKPFDKYIM RLQDRLLKSV TPLLMACNAY ELSVKMKTLS NPLDLALALE TTNSLCRKSL 490 500 510 520 530 540 ALLGQTFSLA SSFRQEKILE AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC 550 560 570 580 590 600 PLQVKKAEPE PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG 610 620 630 640 650 660 SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK PTSADCAVRA 670 680 690 700 710 720 MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT QTLLSSGTRL KHHGRQAPGL 730 740 750 760 770 780 SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS LEASGPSPKP AGVDISEAPQ TSSPCPSADI 790 800 810 820 830 840 DMKTMETAEK LARFVAQVGP EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS 850 860 870 880 890 900 ICFTSSPHNL HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEA SSGTCFPRKR 910 920 930 940 950 960 ISSKSLKVGM IPAPKRVCLI QEPKVHEPVR IAYDRPRGRP MSKKKKPKDL DFAQQKLTDK 970 980 990 1000 1010 1020 NLGFQMLQKM GWKEGHGLGS LGKGIREPVS VGTPSEGEGL GADGQEHKED TFDVFRQRMM 1030 QMYRHKRANK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11." Sampson N.D., Hewitt J.E. Gene 305:91-100(2003) [PubMed: 12594045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY, VARIANT SER-206.
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	Ohara O., Nagase T., Kikuno R., Nomura N. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT SER-206. Tissue: Endometrial tumor and Testis.
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT SER-206. Tissue: Duodenum.
[7]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, MASS SPECTROMETRY. Tissue: Cervix adenocarcinoma.
[9]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7 AND SER-940, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-275; SER-277 AND SER-315, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277 AND SER-773, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[12]	"Solution structure of SURP domain in SFRS14 protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 587-639.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF518874 mRNA. Translation: AAN77117.1.
AB002363 mRNA. Translation: BAA20820.2. Different initiation.
BX647813 mRNA. Translation: CAI46012.1.
AL832488 mRNA. Translation: CAI46117.1.
AC004447 Genomic DNA. Translation: AAC06129.1. Sequence problems.
BC020586 mRNA. Translation: AAH20586.1. Different initiation.

IPI

IPI00158020.
IPI00293162.
IPI00554438.

PIR

T03030.

RefSeq

NP_001017392.2. NM_001017392.3.
NP_055699.2. NM_014884.3.

UniGene

Hs.515271.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X4P	NMR	-	A	587-639	[»]

ProteinModelPortal

Q8IX01.

SMR

Q8IX01. Positions 589-639, 778-841.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IX01. 5 interactions.

MINT

MINT-2867991.

STRING

Q8IX01.

PTM databases

PhosphoSite

Q8IX01.

Polymorphism databases

DMDM

308153496.

Proteomic databases

PRIDE

Q8IX01.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000337018; ENSP00000337926; ENSG00000064607.
ENST00000392342; ENSP00000376153; ENSG00000064607.
ENST00000452918; ENSP00000389380; ENSG00000064607.

GeneID

10147.

KEGG

hsa:10147.

UCSC

uc002nkx.1. human.

Organism-specific databases

CTD

10147.

GeneCards

GC19M019103.

HGNC

HGNC:18641. SUGP2.

HPA

HPA041557.

MIM

607993. gene.

neXtProt

NX_Q8IX01.

PharmGKB

PA134983967.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG17702.

GeneTree

ENSGT00410000025695.

HOGENOM

HBG402969.

HOVERGEN

HBG079176.

InParanoid

Q8IX01.

OMA

ETTNSLC.

OrthoDB

EOG4QFWCG.

PhylomeDB

Q8IX01.

Gene expression databases

ArrayExpress

Q8IX01.

Bgee

Q8IX01.

CleanEx

HS_SFRS14.

Genevestigator

Q8IX01.

GermOnline

ENSG00000064607. Homo sapiens.

Family and domain databases

InterPro

IPR000467. G_patch.
IPR000061. Surp.
[Graphical view]

KO

K13166.

Pfam

PF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]

SMART

SM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]

PROSITE

PS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

38397.

SOURCE

Search...

Entry information

Entry name

SUGP2_HUMAN

Accession

Primary (citable) accession number: Q8IX01
Secondary accession number(s): C9JI71 , O15071, O60369, Q5JPH7, Q8WUF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.