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Q8IWZ8

- SUGP1_HUMAN

UniProt

Q8IWZ8 - SUGP1_HUMAN

Protein

SURP and G-patch domain-containing protein 1

Gene

SUGP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Plays a role in pre-mRNA splicing.

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA splicing, via spliceosome Source: Reactome
    3. RNA splicing Source: Reactome

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    ReactomeiREACT_467. mRNA Splicing - Major Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SURP and G-patch domain-containing protein 1
    Alternative name(s):
    RNA-binding protein RBP
    Splicing factor 4
    Gene namesi
    Name:SUGP1
    Synonyms:SF4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18643. SUGP1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. spliceosomal complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165394338.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 645645SURP and G-patch domain-containing protein 1PRO_0000097701Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei409 – 4091Phosphoserine3 Publications
    Modified residuei411 – 4111Phosphoserine2 Publications
    Modified residuei414 – 4141Phosphoserine1 Publication
    Modified residuei485 – 4851Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IWZ8.
    PaxDbiQ8IWZ8.
    PRIDEiQ8IWZ8.

    PTM databases

    PhosphoSiteiQ8IWZ8.

    Expressioni

    Tissue specificityi

    Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ8IWZ8.
    BgeeiQ8IWZ8.
    CleanExiHS_SF4.
    GenevestigatoriQ8IWZ8.

    Organism-specific databases

    HPAiHPA004890.

    Interactioni

    Subunit structurei

    Component of the spliceosome.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DHX15O431432EBI-2691671,EBI-1237044
    RBM10P981752EBI-2691671,EBI-721525
    RBM17Q96I252EBI-2691671,EBI-740272
    U2AF2P263683EBI-2691671,EBI-742339

    Protein-protein interaction databases

    BioGridi121767. 46 interactions.
    IntActiQ8IWZ8. 7 interactions.
    MINTiMINT-3047702.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWZ8.
    SMRiQ8IWZ8. Positions 169-248, 254-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati191 – 23343SURP motif 1Add
    BLAST
    Repeati266 – 30944SURP motif 2Add
    BLAST
    Domaini562 – 60948G-patchPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi380 – 3867Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi330 – 37344Pro-richAdd
    BLAST
    Compositional biasi441 – 48040Gln/Met-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 G-patch domain.PROSITE-ProRule annotation
    Contains 2 SURP motif repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG299701.
    HOVERGENiHBG079172.
    InParanoidiQ8IWZ8.
    KOiK13096.
    OMAiEKVAMEN.
    OrthoDBiEOG7VX8VN.
    PhylomeDBiQ8IWZ8.
    TreeFamiTF326321.

    Family and domain databases

    InterProiIPR000467. G_patch_dom.
    IPR000061. Surp.
    [Graphical view]
    PfamiPF01585. G-patch. 1 hit.
    PF01805. Surp. 2 hits.
    [Graphical view]
    SMARTiSM00443. G_patch. 1 hit.
    SM00648. SWAP. 2 hits.
    [Graphical view]
    SUPFAMiSSF109905. SSF109905. 2 hits.
    PROSITEiPS50174. G_PATCH. 1 hit.
    PS50128. SURP. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWZ8-1) [UniParc]FASTAAdd to Basket

    Also known as: RNA-binding protein splice variant A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLKMDNRDV AGKANRWFGV APPKSGKMNM NILHQEELIA QKKREIEAKM    50
    EQKAKQNQVA SPQPPHPGEI TNAHNSSCIS NKFANDGSFL QQFLKLQKAQ 100
    TSTDAPTSAP SAPPSTPTPS AGKRSLLISR RTGLGLASLP GPVKSYSHAK 150
    QLPVAHRPSV FQSPDEDEEE DYEQWLEIKV SPPEGAETRK VIEKLARFVA 200
    EGGPELEKVA MEDYKDNPAF AFLHDKNSRE FLYYRKKVAE IRKEAQKSQA 250
    ASQKVSPPED EEVKNLAEKL ARFIADGGPE VETIALQNNR ENQAFSFLYE 300
    PNSQGYKYYR QKLEEFRKAK ASSTGSFTAP DPGLKRKSPP EALSGSLPPA 350
    TTCPASSTPA PTIIPAPAAP GKPASAATVK RKRKSRWGPE EDKVELPPAE 400
    LVQRDVDASP SPLSVQDLKG LGYEKGKPVG LVGVTELSDA QKKQLKEQQE 450
    MQQMYDMIMQ HKRAMQDMQL LWEKAVQQHQ HGYDSDEEVD SELGTWEHQL 500
    RRMEMDKTRE WAEQLTKMGR GKHFIGDFLP PDELEKFMET FKALKEGREP 550
    DYSEYKEFKL TVENIGYQML MKMGWKEGEG LGSEGQGIKN PVNKGTTTVD 600
    GAGFGIDRPA ELSKEDDEYE AFRKRMMLAY RFRPNPLNNP RRPYY 645
    Length:645
    Mass (Da):72,471
    Last modified:March 15, 2005 - v2
    Checksum:i27AF5ED41DFDDCB7
    GO
    Isoform 2 (identifier: Q8IWZ8-2) [UniParc]FASTAAdd to Basket

    Also known as: RNA-binding protein splice variant B

    The sequence of this isoform differs from the canonical sequence as follows:
         181-222: SPPEGAETRK...DYKDNPAFAF → CLTKTVRPTP...SPHPLCRCGP
         223-645: Missing.

    Show »
    Length:222
    Mass (Da):24,297
    Checksum:i6CA11F2F5AC40E8E
    GO

    Sequence cautioni

    The sequence AAL68960.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAL68961.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAC08052.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti497 – 4971E → K in AAN77123. (PubMed:12594045)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti290 – 2901R → H.
    Corresponds to variant rs17751061 [ dbSNP | Ensembl ].
    VAR_051339
    Natural varianti568 – 5681Q → H.
    Corresponds to variant rs1044980 [ dbSNP | Ensembl ].
    VAR_051340

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei181 – 22242SPPEG…PAFAF → CLTKTVRPTPPSSWCFVPGL GTPDSLLHLTLFSPHPLCRC GP in isoform 2. 1 PublicationVSP_013109Add
    BLAST
    Alternative sequencei223 – 645423Missing in isoform 2. 1 PublicationVSP_013110Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF521128 mRNA. Translation: AAN77123.1.
    AY072916 mRNA. Translation: AAL68960.1. Different initiation.
    AY072917 mRNA. Translation: AAL68961.1. Different initiation.
    AC004475 Genomic DNA. Translation: AAC08052.1. Sequence problems.
    BC063784 mRNA. Translation: AAH63784.1.
    AL137286 mRNA. Translation: CAB70678.1.
    AL713757 mRNA. Translation: CAD28528.1.
    CCDSiCCDS12399.1. [Q8IWZ8-1]
    PIRiT02299.
    RefSeqiNP_757386.2. NM_172231.3. [Q8IWZ8-1]
    UniGeneiHs.515274.

    Genome annotation databases

    EnsembliENST00000247001; ENSP00000247001; ENSG00000105705. [Q8IWZ8-1]
    ENST00000588731; ENSP00000465413; ENSG00000105705. [Q8IWZ8-2]
    GeneIDi57794.
    KEGGihsa:57794.
    UCSCiuc002nmh.3. human. [Q8IWZ8-1]

    Polymorphism databases

    DMDMi61216666.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF521128 mRNA. Translation: AAN77123.1 .
    AY072916 mRNA. Translation: AAL68960.1 . Different initiation.
    AY072917 mRNA. Translation: AAL68961.1 . Different initiation.
    AC004475 Genomic DNA. Translation: AAC08052.1 . Sequence problems.
    BC063784 mRNA. Translation: AAH63784.1 .
    AL137286 mRNA. Translation: CAB70678.1 .
    AL713757 mRNA. Translation: CAD28528.1 .
    CCDSi CCDS12399.1. [Q8IWZ8-1 ]
    PIRi T02299.
    RefSeqi NP_757386.2. NM_172231.3. [Q8IWZ8-1 ]
    UniGenei Hs.515274.

    3D structure databases

    ProteinModelPortali Q8IWZ8.
    SMRi Q8IWZ8. Positions 169-248, 254-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121767. 46 interactions.
    IntActi Q8IWZ8. 7 interactions.
    MINTi MINT-3047702.

    PTM databases

    PhosphoSitei Q8IWZ8.

    Polymorphism databases

    DMDMi 61216666.

    Proteomic databases

    MaxQBi Q8IWZ8.
    PaxDbi Q8IWZ8.
    PRIDEi Q8IWZ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247001 ; ENSP00000247001 ; ENSG00000105705 . [Q8IWZ8-1 ]
    ENST00000588731 ; ENSP00000465413 ; ENSG00000105705 . [Q8IWZ8-2 ]
    GeneIDi 57794.
    KEGGi hsa:57794.
    UCSCi uc002nmh.3. human. [Q8IWZ8-1 ]

    Organism-specific databases

    CTDi 57794.
    GeneCardsi GC19M019389.
    HGNCi HGNC:18643. SUGP1.
    HPAi HPA004890.
    MIMi 607992. gene.
    neXtProti NX_Q8IWZ8.
    PharmGKBi PA165394338.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299701.
    HOVERGENi HBG079172.
    InParanoidi Q8IWZ8.
    KOi K13096.
    OMAi EKVAMEN.
    OrthoDBi EOG7VX8VN.
    PhylomeDBi Q8IWZ8.
    TreeFami TF326321.

    Enzyme and pathway databases

    Reactomei REACT_467. mRNA Splicing - Major Pathway.

    Miscellaneous databases

    ChiTaRSi SUGP1. human.
    GenomeRNAii 57794.
    NextBioi 64730.
    PROi Q8IWZ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IWZ8.
    Bgeei Q8IWZ8.
    CleanExi HS_SF4.
    Genevestigatori Q8IWZ8.

    Family and domain databases

    InterProi IPR000467. G_patch_dom.
    IPR000061. Surp.
    [Graphical view ]
    Pfami PF01585. G-patch. 1 hit.
    PF01805. Surp. 2 hits.
    [Graphical view ]
    SMARTi SM00443. G_patch. 1 hit.
    SM00648. SWAP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF109905. SSF109905. 2 hits.
    PROSITEi PS50174. G_PATCH. 1 hit.
    PS50128. SURP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11."
      Sampson N.D., Hewitt J.E.
      Gene 305:91-100(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Novel isoforms of a human RNA-binding protein."
      Gu Y., Nguyen C.-T.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-645 (ISOFORMS 1 AND 2).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-645 (ISOFORM 1).
      Tissue: PNS.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-645.
      Tissue: Testis.
    6. "Large-scale proteomic analysis of the human spliceosome."
      Rappsilber J., Ryder U., Lamond A.I., Mann M.
      Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH THE SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-411 AND SER-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-411 AND SER-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSUGP1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWZ8
    Secondary accession number(s): O60378
    , Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3