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Protein

SURP and G-patch domain-containing protein 1

Gene

SUGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in pre-mRNA splicing.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 1
Alternative name(s):
RNA-binding protein RBP
Splicing factor 4
Gene namesi
Name:SUGP1
Synonyms:SF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18643. SUGP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi57794.
OpenTargetsiENSG00000105705.
PharmGKBiPA165394338.

Polymorphism and mutation databases

BioMutaiSUGP1.
DMDMi61216666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977011 – 645SURP and G-patch domain-containing protein 1Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132PhosphothreonineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IWZ8.
MaxQBiQ8IWZ8.
PaxDbiQ8IWZ8.
PeptideAtlasiQ8IWZ8.
PRIDEiQ8IWZ8.

PTM databases

iPTMnetiQ8IWZ8.
PhosphoSitePlusiQ8IWZ8.

Expressioni

Tissue specificityi

Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000105705.
CleanExiHS_SF4.
ExpressionAtlasiQ8IWZ8. baseline and differential.
GenevisibleiQ8IWZ8. HS.

Organism-specific databases

HPAiHPA004890.

Interactioni

Subunit structurei

Component of the spliceosome.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DHX15O431432EBI-2691671,EBI-1237044
RBM10P981752EBI-2691671,EBI-721525
RBM17Q96I252EBI-2691671,EBI-740272
U2AF2P263683EBI-2691671,EBI-742339

Protein-protein interaction databases

BioGridi121767. 63 interactors.
IntActiQ8IWZ8. 14 interactors.
MINTiMINT-3047702.
STRINGi9606.ENSP00000247001.

Structurei

3D structure databases

ProteinModelPortaliQ8IWZ8.
SMRiQ8IWZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati191 – 233SURP motif 1Add BLAST43
Repeati266 – 309SURP motif 2Add BLAST44
Domaini562 – 609G-patchPROSITE-ProRule annotationAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi380 – 386Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi330 – 373Pro-richAdd BLAST44
Compositional biasi441 – 480Gln/Met-richAdd BLAST40

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 SURP motif repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG410ZSH4. LUCA.
GeneTreeiENSGT00410000025695.
HOVERGENiHBG079172.
InParanoidiQ8IWZ8.
KOiK13096.
OMAiNYKDNPA.
OrthoDBiEOG091G04E7.
PhylomeDBiQ8IWZ8.
TreeFamiTF326321.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWZ8-1) [UniParc]FASTAAdd to basket
Also known as: RNA-binding protein splice variant A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLKMDNRDV AGKANRWFGV APPKSGKMNM NILHQEELIA QKKREIEAKM
60 70 80 90 100
EQKAKQNQVA SPQPPHPGEI TNAHNSSCIS NKFANDGSFL QQFLKLQKAQ
110 120 130 140 150
TSTDAPTSAP SAPPSTPTPS AGKRSLLISR RTGLGLASLP GPVKSYSHAK
160 170 180 190 200
QLPVAHRPSV FQSPDEDEEE DYEQWLEIKV SPPEGAETRK VIEKLARFVA
210 220 230 240 250
EGGPELEKVA MEDYKDNPAF AFLHDKNSRE FLYYRKKVAE IRKEAQKSQA
260 270 280 290 300
ASQKVSPPED EEVKNLAEKL ARFIADGGPE VETIALQNNR ENQAFSFLYE
310 320 330 340 350
PNSQGYKYYR QKLEEFRKAK ASSTGSFTAP DPGLKRKSPP EALSGSLPPA
360 370 380 390 400
TTCPASSTPA PTIIPAPAAP GKPASAATVK RKRKSRWGPE EDKVELPPAE
410 420 430 440 450
LVQRDVDASP SPLSVQDLKG LGYEKGKPVG LVGVTELSDA QKKQLKEQQE
460 470 480 490 500
MQQMYDMIMQ HKRAMQDMQL LWEKAVQQHQ HGYDSDEEVD SELGTWEHQL
510 520 530 540 550
RRMEMDKTRE WAEQLTKMGR GKHFIGDFLP PDELEKFMET FKALKEGREP
560 570 580 590 600
DYSEYKEFKL TVENIGYQML MKMGWKEGEG LGSEGQGIKN PVNKGTTTVD
610 620 630 640
GAGFGIDRPA ELSKEDDEYE AFRKRMMLAY RFRPNPLNNP RRPYY
Length:645
Mass (Da):72,471
Last modified:March 15, 2005 - v2
Checksum:i27AF5ED41DFDDCB7
GO
Isoform 2 (identifier: Q8IWZ8-2) [UniParc]FASTAAdd to basket
Also known as: RNA-binding protein splice variant B

The sequence of this isoform differs from the canonical sequence as follows:
     181-222: SPPEGAETRK...DYKDNPAFAF → CLTKTVRPTP...SPHPLCRCGP
     223-645: Missing.

Show »
Length:222
Mass (Da):24,297
Checksum:i6CA11F2F5AC40E8E
GO

Sequence cautioni

The sequence AAC08052 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAL68960 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL68961 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti497E → K in AAN77123 (PubMed:12594045).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051339290R → H.Corresponds to variant rs17751061dbSNPEnsembl.1
Natural variantiVAR_051340568Q → H.Corresponds to variant rs1044980dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013109181 – 222SPPEG…PAFAF → CLTKTVRPTPPSSWCFVPGL GTPDSLLHLTLFSPHPLCRC GP in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_013110223 – 645Missing in isoform 2. 1 PublicationAdd BLAST423

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521128 mRNA. Translation: AAN77123.1.
AY072916 mRNA. Translation: AAL68960.1. Different initiation.
AY072917 mRNA. Translation: AAL68961.1. Different initiation.
AC004475 Genomic DNA. Translation: AAC08052.1. Sequence problems.
BC063784 mRNA. Translation: AAH63784.1.
AL137286 mRNA. Translation: CAB70678.1.
AL713757 mRNA. Translation: CAD28528.1.
CCDSiCCDS12399.1. [Q8IWZ8-1]
PIRiT02299.
RefSeqiNP_757386.2. NM_172231.3. [Q8IWZ8-1]
UniGeneiHs.515274.

Genome annotation databases

EnsembliENST00000247001; ENSP00000247001; ENSG00000105705. [Q8IWZ8-1]
ENST00000588731; ENSP00000465413; ENSG00000105705. [Q8IWZ8-2]
GeneIDi57794.
KEGGihsa:57794.
UCSCiuc002nmh.4. human. [Q8IWZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521128 mRNA. Translation: AAN77123.1.
AY072916 mRNA. Translation: AAL68960.1. Different initiation.
AY072917 mRNA. Translation: AAL68961.1. Different initiation.
AC004475 Genomic DNA. Translation: AAC08052.1. Sequence problems.
BC063784 mRNA. Translation: AAH63784.1.
AL137286 mRNA. Translation: CAB70678.1.
AL713757 mRNA. Translation: CAD28528.1.
CCDSiCCDS12399.1. [Q8IWZ8-1]
PIRiT02299.
RefSeqiNP_757386.2. NM_172231.3. [Q8IWZ8-1]
UniGeneiHs.515274.

3D structure databases

ProteinModelPortaliQ8IWZ8.
SMRiQ8IWZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121767. 63 interactors.
IntActiQ8IWZ8. 14 interactors.
MINTiMINT-3047702.
STRINGi9606.ENSP00000247001.

PTM databases

iPTMnetiQ8IWZ8.
PhosphoSitePlusiQ8IWZ8.

Polymorphism and mutation databases

BioMutaiSUGP1.
DMDMi61216666.

Proteomic databases

EPDiQ8IWZ8.
MaxQBiQ8IWZ8.
PaxDbiQ8IWZ8.
PeptideAtlasiQ8IWZ8.
PRIDEiQ8IWZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247001; ENSP00000247001; ENSG00000105705. [Q8IWZ8-1]
ENST00000588731; ENSP00000465413; ENSG00000105705. [Q8IWZ8-2]
GeneIDi57794.
KEGGihsa:57794.
UCSCiuc002nmh.4. human. [Q8IWZ8-1]

Organism-specific databases

CTDi57794.
DisGeNETi57794.
GeneCardsiSUGP1.
HGNCiHGNC:18643. SUGP1.
HPAiHPA004890.
MIMi607992. gene.
neXtProtiNX_Q8IWZ8.
OpenTargetsiENSG00000105705.
PharmGKBiPA165394338.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG410ZSH4. LUCA.
GeneTreeiENSGT00410000025695.
HOVERGENiHBG079172.
InParanoidiQ8IWZ8.
KOiK13096.
OMAiNYKDNPA.
OrthoDBiEOG091G04E7.
PhylomeDBiQ8IWZ8.
TreeFamiTF326321.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiSUGP1. human.
GenomeRNAii57794.
PROiQ8IWZ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105705.
CleanExiHS_SF4.
ExpressionAtlasiQ8IWZ8. baseline and differential.
GenevisibleiQ8IWZ8. HS.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUGP1_HUMAN
AccessioniPrimary (citable) accession number: Q8IWZ8
Secondary accession number(s): O60378
, Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.