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Q8IWZ8

- SUGP1_HUMAN

UniProt

Q8IWZ8 - SUGP1_HUMAN

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Protein

SURP and G-patch domain-containing protein 1

Gene

SUGP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in pre-mRNA splicing.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. gene expression Source: Reactome
  2. mRNA splicing, via spliceosome Source: Reactome
  3. RNA splicing Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiREACT_467. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 1
Alternative name(s):
RNA-binding protein RBP
Splicing factor 4
Gene namesi
Name:SUGP1
Synonyms:SF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:18643. SUGP1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 645645SURP and G-patch domain-containing protein 1PRO_0000097701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei409 – 4091Phosphoserine3 Publications
Modified residuei411 – 4111Phosphoserine2 Publications
Modified residuei414 – 4141Phosphoserine1 Publication
Modified residuei485 – 4851Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IWZ8.
PaxDbiQ8IWZ8.
PRIDEiQ8IWZ8.

PTM databases

PhosphoSiteiQ8IWZ8.

Expressioni

Tissue specificityi

Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8IWZ8.
CleanExiHS_SF4.
ExpressionAtlasiQ8IWZ8. baseline and differential.
GenevestigatoriQ8IWZ8.

Organism-specific databases

HPAiHPA004890.

Interactioni

Subunit structurei

Component of the spliceosome.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DHX15O431432EBI-2691671,EBI-1237044
RBM10P981752EBI-2691671,EBI-721525
RBM17Q96I252EBI-2691671,EBI-740272
U2AF2P263683EBI-2691671,EBI-742339

Protein-protein interaction databases

BioGridi121767. 51 interactions.
IntActiQ8IWZ8. 7 interactions.
MINTiMINT-3047702.

Structurei

3D structure databases

ProteinModelPortaliQ8IWZ8.
SMRiQ8IWZ8. Positions 169-248, 254-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati191 – 23343SURP motif 1Add
BLAST
Repeati266 – 30944SURP motif 2Add
BLAST
Domaini562 – 60948G-patchPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi380 – 3867Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi330 – 37344Pro-richAdd
BLAST
Compositional biasi441 – 48040Gln/Met-richAdd
BLAST

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 SURP motif repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG299701.
GeneTreeiENSGT00410000025695.
HOVERGENiHBG079172.
InParanoidiQ8IWZ8.
KOiK13096.
OMAiEKVAMEN.
OrthoDBiEOG7VX8VN.
PhylomeDBiQ8IWZ8.
TreeFamiTF326321.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWZ8-1) [UniParc]FASTAAdd to Basket

Also known as: RNA-binding protein splice variant A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLKMDNRDV AGKANRWFGV APPKSGKMNM NILHQEELIA QKKREIEAKM
60 70 80 90 100
EQKAKQNQVA SPQPPHPGEI TNAHNSSCIS NKFANDGSFL QQFLKLQKAQ
110 120 130 140 150
TSTDAPTSAP SAPPSTPTPS AGKRSLLISR RTGLGLASLP GPVKSYSHAK
160 170 180 190 200
QLPVAHRPSV FQSPDEDEEE DYEQWLEIKV SPPEGAETRK VIEKLARFVA
210 220 230 240 250
EGGPELEKVA MEDYKDNPAF AFLHDKNSRE FLYYRKKVAE IRKEAQKSQA
260 270 280 290 300
ASQKVSPPED EEVKNLAEKL ARFIADGGPE VETIALQNNR ENQAFSFLYE
310 320 330 340 350
PNSQGYKYYR QKLEEFRKAK ASSTGSFTAP DPGLKRKSPP EALSGSLPPA
360 370 380 390 400
TTCPASSTPA PTIIPAPAAP GKPASAATVK RKRKSRWGPE EDKVELPPAE
410 420 430 440 450
LVQRDVDASP SPLSVQDLKG LGYEKGKPVG LVGVTELSDA QKKQLKEQQE
460 470 480 490 500
MQQMYDMIMQ HKRAMQDMQL LWEKAVQQHQ HGYDSDEEVD SELGTWEHQL
510 520 530 540 550
RRMEMDKTRE WAEQLTKMGR GKHFIGDFLP PDELEKFMET FKALKEGREP
560 570 580 590 600
DYSEYKEFKL TVENIGYQML MKMGWKEGEG LGSEGQGIKN PVNKGTTTVD
610 620 630 640
GAGFGIDRPA ELSKEDDEYE AFRKRMMLAY RFRPNPLNNP RRPYY
Length:645
Mass (Da):72,471
Last modified:March 15, 2005 - v2
Checksum:i27AF5ED41DFDDCB7
GO
Isoform 2 (identifier: Q8IWZ8-2) [UniParc]FASTAAdd to Basket

Also known as: RNA-binding protein splice variant B

The sequence of this isoform differs from the canonical sequence as follows:
     181-222: SPPEGAETRK...DYKDNPAFAF → CLTKTVRPTP...SPHPLCRCGP
     223-645: Missing.

Show »
Length:222
Mass (Da):24,297
Checksum:i6CA11F2F5AC40E8E
GO

Sequence cautioni

The sequence AAL68960.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAL68961.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAC08052.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti497 – 4971E → K in AAN77123. (PubMed:12594045)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti290 – 2901R → H.
Corresponds to variant rs17751061 [ dbSNP | Ensembl ].
VAR_051339
Natural varianti568 – 5681Q → H.
Corresponds to variant rs1044980 [ dbSNP | Ensembl ].
VAR_051340

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei181 – 22242SPPEG…PAFAF → CLTKTVRPTPPSSWCFVPGL GTPDSLLHLTLFSPHPLCRC GP in isoform 2. 1 PublicationVSP_013109Add
BLAST
Alternative sequencei223 – 645423Missing in isoform 2. 1 PublicationVSP_013110Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF521128 mRNA. Translation: AAN77123.1.
AY072916 mRNA. Translation: AAL68960.1. Different initiation.
AY072917 mRNA. Translation: AAL68961.1. Different initiation.
AC004475 Genomic DNA. Translation: AAC08052.1. Sequence problems.
BC063784 mRNA. Translation: AAH63784.1.
AL137286 mRNA. Translation: CAB70678.1.
AL713757 mRNA. Translation: CAD28528.1.
CCDSiCCDS12399.1. [Q8IWZ8-1]
PIRiT02299.
RefSeqiNP_757386.2. NM_172231.3. [Q8IWZ8-1]
UniGeneiHs.515274.

Genome annotation databases

EnsembliENST00000247001; ENSP00000247001; ENSG00000105705. [Q8IWZ8-1]
ENST00000588731; ENSP00000465413; ENSG00000105705. [Q8IWZ8-2]
GeneIDi57794.
KEGGihsa:57794.
UCSCiuc002nmh.3. human. [Q8IWZ8-1]

Polymorphism databases

DMDMi61216666.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF521128 mRNA. Translation: AAN77123.1 .
AY072916 mRNA. Translation: AAL68960.1 . Different initiation.
AY072917 mRNA. Translation: AAL68961.1 . Different initiation.
AC004475 Genomic DNA. Translation: AAC08052.1 . Sequence problems.
BC063784 mRNA. Translation: AAH63784.1 .
AL137286 mRNA. Translation: CAB70678.1 .
AL713757 mRNA. Translation: CAD28528.1 .
CCDSi CCDS12399.1. [Q8IWZ8-1 ]
PIRi T02299.
RefSeqi NP_757386.2. NM_172231.3. [Q8IWZ8-1 ]
UniGenei Hs.515274.

3D structure databases

ProteinModelPortali Q8IWZ8.
SMRi Q8IWZ8. Positions 169-248, 254-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121767. 51 interactions.
IntActi Q8IWZ8. 7 interactions.
MINTi MINT-3047702.

PTM databases

PhosphoSitei Q8IWZ8.

Polymorphism databases

DMDMi 61216666.

Proteomic databases

MaxQBi Q8IWZ8.
PaxDbi Q8IWZ8.
PRIDEi Q8IWZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000247001 ; ENSP00000247001 ; ENSG00000105705 . [Q8IWZ8-1 ]
ENST00000588731 ; ENSP00000465413 ; ENSG00000105705 . [Q8IWZ8-2 ]
GeneIDi 57794.
KEGGi hsa:57794.
UCSCi uc002nmh.3. human. [Q8IWZ8-1 ]

Organism-specific databases

CTDi 57794.
GeneCardsi GC19M019389.
HGNCi HGNC:18643. SUGP1.
HPAi HPA004890.
MIMi 607992. gene.
neXtProti NX_Q8IWZ8.
PharmGKBi PA165394338.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299701.
GeneTreei ENSGT00410000025695.
HOVERGENi HBG079172.
InParanoidi Q8IWZ8.
KOi K13096.
OMAi EKVAMEN.
OrthoDBi EOG7VX8VN.
PhylomeDBi Q8IWZ8.
TreeFami TF326321.

Enzyme and pathway databases

Reactomei REACT_467. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSi SUGP1. human.
GenomeRNAii 57794.
NextBioi 64730.
PROi Q8IWZ8.
SOURCEi Search...

Gene expression databases

Bgeei Q8IWZ8.
CleanExi HS_SF4.
ExpressionAtlasi Q8IWZ8. baseline and differential.
Genevestigatori Q8IWZ8.

Family and domain databases

InterProi IPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view ]
Pfami PF01585. G-patch. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view ]
SUPFAMi SSF109905. SSF109905. 2 hits.
PROSITEi PS50174. G_PATCH. 1 hit.
PS50128. SURP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11."
    Sampson N.D., Hewitt J.E.
    Gene 305:91-100(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Novel isoforms of a human RNA-binding protein."
    Gu Y., Nguyen C.-T.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-645 (ISOFORMS 1 AND 2).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-645 (ISOFORM 1).
    Tissue: PNS.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-645.
    Tissue: Testis.
  6. "Large-scale proteomic analysis of the human spliceosome."
    Rappsilber J., Ryder U., Lamond A.I., Mann M.
    Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH THE SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-411 AND SER-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-411 AND SER-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSUGP1_HUMAN
AccessioniPrimary (citable) accession number: Q8IWZ8
Secondary accession number(s): O60378
, Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3