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Q8IWZ8 (SUGP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SURP and G-patch domain-containing protein 1
Alternative name(s):
RNA-binding protein RBP
Splicing factor 4
Gene names
Name:SUGP1
Synonyms:SF4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length645 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in pre-mRNA splicing.

Subunit structure

Component of the spliceosome. Ref.6

Subcellular location

Nucleus Probable.

Tissue specificity

Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle. Ref.1

Sequence similarities

Contains 1 G-patch domain.

Contains 2 SURP motif repeats.

Sequence caution

The sequence AAC08052.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAL68960.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAL68961.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
Spliceosome
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA splicing

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA splicing, via spliceosome

Traceable author statement. Source: Reactome

   Cellular_componentnucleoplasm

Traceable author statement. Source: Reactome

spliceosomal complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IWZ8-1)

Also known as: RNA-binding protein splice variant A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IWZ8-2)

Also known as: RNA-binding protein splice variant B;

The sequence of this isoform differs from the canonical sequence as follows:
     181-222: SPPEGAETRK...DYKDNPAFAF → CLTKTVRPTP...SPHPLCRCGP
     223-645: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 645645SURP and G-patch domain-containing protein 1
PRO_0000097701

Regions

Repeat191 – 23343SURP motif 1
Repeat266 – 30944SURP motif 2
Domain562 – 60948G-patch
Motif380 – 3867Nuclear localization signal Potential
Compositional bias330 – 37344Pro-rich
Compositional bias441 – 48040Gln/Met-rich

Amino acid modifications

Modified residue4091Phosphoserine Ref.8 Ref.10 Ref.11
Modified residue4111Phosphoserine Ref.10 Ref.11
Modified residue4141Phosphoserine Ref.10
Modified residue4851Phosphoserine Ref.8 Ref.11

Natural variations

Alternative sequence181 – 22242SPPEG…PAFAF → CLTKTVRPTPPSSWCFVPGL GTPDSLLHLTLFSPHPLCRC GP in isoform 2.
VSP_013109
Alternative sequence223 – 645423Missing in isoform 2.
VSP_013110
Natural variant2901R → H.
Corresponds to variant rs17751061 [ dbSNP | Ensembl ].
VAR_051339
Natural variant5681Q → H.
Corresponds to variant rs1044980 [ dbSNP | Ensembl ].
VAR_051340

Experimental info

Sequence conflict4971E → K in AAN77123. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (RNA-binding protein splice variant A) [UniParc].

Last modified March 15, 2005. Version 2.
Checksum: 27AF5ED41DFDDCB7

FASTA64572,471
        10         20         30         40         50         60 
MSLKMDNRDV AGKANRWFGV APPKSGKMNM NILHQEELIA QKKREIEAKM EQKAKQNQVA 

        70         80         90        100        110        120 
SPQPPHPGEI TNAHNSSCIS NKFANDGSFL QQFLKLQKAQ TSTDAPTSAP SAPPSTPTPS 

       130        140        150        160        170        180 
AGKRSLLISR RTGLGLASLP GPVKSYSHAK QLPVAHRPSV FQSPDEDEEE DYEQWLEIKV 

       190        200        210        220        230        240 
SPPEGAETRK VIEKLARFVA EGGPELEKVA MEDYKDNPAF AFLHDKNSRE FLYYRKKVAE 

       250        260        270        280        290        300 
IRKEAQKSQA ASQKVSPPED EEVKNLAEKL ARFIADGGPE VETIALQNNR ENQAFSFLYE 

       310        320        330        340        350        360 
PNSQGYKYYR QKLEEFRKAK ASSTGSFTAP DPGLKRKSPP EALSGSLPPA TTCPASSTPA 

       370        380        390        400        410        420 
PTIIPAPAAP GKPASAATVK RKRKSRWGPE EDKVELPPAE LVQRDVDASP SPLSVQDLKG 

       430        440        450        460        470        480 
LGYEKGKPVG LVGVTELSDA QKKQLKEQQE MQQMYDMIMQ HKRAMQDMQL LWEKAVQQHQ 

       490        500        510        520        530        540 
HGYDSDEEVD SELGTWEHQL RRMEMDKTRE WAEQLTKMGR GKHFIGDFLP PDELEKFMET 

       550        560        570        580        590        600 
FKALKEGREP DYSEYKEFKL TVENIGYQML MKMGWKEGEG LGSEGQGIKN PVNKGTTTVD 

       610        620        630        640 
GAGFGIDRPA ELSKEDDEYE AFRKRMMLAY RFRPNPLNNP RRPYY 

« Hide

Isoform 2 (RNA-binding protein splice variant B) [UniParc].

Checksum: 6CA11F2F5AC40E8E
Show »

FASTA22224,297

References

« Hide 'large scale' references
[1]"SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11."
Sampson N.D., Hewitt J.E.
Gene 305:91-100(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Novel isoforms of a human RNA-binding protein."
Gu Y., Nguyen C.-T.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-645 (ISOFORMS 1 AND 2).
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-645 (ISOFORM 1).
Tissue: PNS.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-645.
Tissue: Testis.
[6]"Large-scale proteomic analysis of the human spliceosome."
Rappsilber J., Ryder U., Lamond A.I., Mann M.
Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH THE SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-411 AND SER-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-411 AND SER-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF521128 mRNA. Translation: AAN77123.1.
AY072916 mRNA. Translation: AAL68960.1. Different initiation.
AY072917 mRNA. Translation: AAL68961.1. Different initiation.
AC004475 Genomic DNA. Translation: AAC08052.1. Sequence problems.
BC063784 mRNA. Translation: AAH63784.1.
AL137286 mRNA. Translation: CAB70678.1.
AL713757 mRNA. Translation: CAD28528.1.
PIRT02299.
RefSeqNP_757386.2. NM_172231.3.
UniGeneHs.515274.

3D structure databases

ProteinModelPortalQ8IWZ8.
SMRQ8IWZ8. Positions 169-248, 254-323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121767. 45 interactions.
IntActQ8IWZ8. 7 interactions.
MINTMINT-3047702.

PTM databases

PhosphoSiteQ8IWZ8.

Polymorphism databases

DMDM61216666.

Proteomic databases

PaxDbQ8IWZ8.
PRIDEQ8IWZ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000247001; ENSP00000247001; ENSG00000105705. [Q8IWZ8-1]
ENST00000334782; ENSP00000334032; ENSG00000105705. [Q8IWZ8-2]
ENST00000588731; ENSP00000465413; ENSG00000105705. [Q8IWZ8-2]
GeneID57794.
KEGGhsa:57794.
UCSCuc002nmh.3. human. [Q8IWZ8-1]

Organism-specific databases

CTD57794.
GeneCardsGC19M019389.
HGNCHGNC:18643. SUGP1.
HPAHPA004890.
MIM607992. gene.
neXtProtNX_Q8IWZ8.
PharmGKBPA165394338.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299701.
HOVERGENHBG079172.
InParanoidQ8IWZ8.
KOK13096.
OMAEKVAMEN.
OrthoDBEOG7VX8VN.
PhylomeDBQ8IWZ8.
TreeFamTF326321.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8IWZ8.
BgeeQ8IWZ8.
CleanExHS_SF4.
GenevestigatorQ8IWZ8.

Family and domain databases

InterProIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamPF01585. G-patch. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]
SMARTSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMSSF109905. SSF109905. 2 hits.
PROSITEPS50174. G_PATCH. 1 hit.
PS50128. SURP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSUGP1. human.
GenomeRNAi57794.
NextBio64730.
PROQ8IWZ8.
SOURCESearch...

Entry information

Entry nameSUGP1_HUMAN
AccessionPrimary (citable) accession number: Q8IWZ8
Secondary accession number(s): O60378 expand/collapse secondary AC list , Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM