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Q8IWZ5

- TRI42_HUMAN

UniProt

Q8IWZ5 - TRI42_HUMAN

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Protein

Tripartite motif-containing protein 42

Gene

TRIM42

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 19247RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 28046B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 32642B box-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 42
Gene namesi
Name:TRIM42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19014. TRIM42.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Tripartite motif-containing protein 42PRO_0000056263Add
BLAST

Proteomic databases

PaxDbiQ8IWZ5.
PRIDEiQ8IWZ5.

PTM databases

PhosphoSiteiQ8IWZ5.

Expressioni

Gene expression databases

BgeeiQ8IWZ5.
CleanExiHS_TRIM42.
GenevestigatoriQ8IWZ5.

Organism-specific databases

HPAiHPA003581.
HPA022481.

Interactioni

Protein-protein interaction databases

BioGridi130425. 3 interactions.
IntActiQ8IWZ5. 1 interaction.
STRINGi9606.ENSP00000286349.

Structurei

3D structure databases

ProteinModelPortaliQ8IWZ5.
SMRiQ8IWZ5. Positions 602-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 49259COSPROSITE-ProRule annotationAdd
BLAST
Domaini603 – 70199Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili382 – 40726Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 9691Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 19247RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 28046B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 32642B box-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG277899.
GeneTreeiENSGT00530000064220.
HOGENOMiHOG000168411.
HOVERGENiHBG056782.
InParanoidiQ8IWZ5.
KOiK12018.
OMAiKFKAVRY.
OrthoDBiEOG7JX33P.
PhylomeDBiQ8IWZ5.
TreeFamiTF336556.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWZ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC
60 70 80 90 100
QFCHCTCSES PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI
110 120 130 140 150
ITFHKGRLRS IHTSSKTALR TGSSDTQVDE VKSIPANSHL VNHLNCPMCS
160 170 180 190 200
RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT ENFFILICPV CDRSHCMPYS
210 220 230 240 250
NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV CRNKRIAYKR
260 270 280 290 300
CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE
310 320 330 340 350
YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE
360 370 380 390 400
IDNDLMEFNI LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN
410 420 430 440 450
LEVSRQKEIE KYVYVTTMKV NEMDGLIAYS KEALKETGQV AFLQSAKILV
460 470 480 490 500
DQIEDGIQTT YRPDPQLRLH SINYVPLDFV ELSSAIHELF PTGPKKVRSS
510 520 530 540 550
GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML SFSNTDKKAK
560 570 580 590 600
VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS
610 620 630 640 650
VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM
660 670 680 690 700
ELCGQIRDIM QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD
710 720
GHGKNRAKWG LLKNIQSALQ KHF
Length:723
Mass (Da):82,745
Last modified:May 18, 2010 - v2
Checksum:i40897D5AF9B186A9
GO
Isoform 2 (identifier: Q8IWZ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-369: VRYEIDNDLMEFNILKNSFKADK → GPPLFHSFSLTSSSGTHGEDGVG
     370-723: Missing.

Note: No experimental confirmation available.

Show »
Length:369
Mass (Da):42,200
Checksum:i0824C770CC920AD5
GO

Sequence cautioni

The sequence BAC05042.1 differs from that shown. Reason: Erroneous termination at position 709. Translated as Trp.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti516 – 5161I → T in BAC05042. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti244 – 2441K → R.5 Publications
Corresponds to variant rs698673 [ dbSNP | Ensembl ].
VAR_052143
Natural varianti475 – 4751V → M.
Corresponds to variant rs28594654 [ dbSNP | Ensembl ].
VAR_034468
Natural varianti579 – 5791A → E.
Corresponds to variant rs9876490 [ dbSNP | Ensembl ].
VAR_034469

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei347 – 36923VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2. CuratedVSP_012066Add
BLAST
Alternative sequencei370 – 723354Missing in isoform 2. CuratedVSP_012067Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF521868 mRNA. Translation: AAO14945.1.
AK097416 mRNA. Translation: BAC05042.1. Sequence problems.
AC026324 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79015.1.
BC130472 mRNA. Translation: AAI30473.1.
AL833848 mRNA. Translation: CAD38707.1.
CCDSiCCDS3113.1. [Q8IWZ5-1]
RefSeqiNP_689829.3. NM_152616.4. [Q8IWZ5-1]
UniGeneiHs.343487.

Genome annotation databases

EnsembliENST00000286349; ENSP00000286349; ENSG00000155890. [Q8IWZ5-1]
GeneIDi287015.
KEGGihsa:287015.
UCSCiuc003eto.2. human. [Q8IWZ5-1]

Polymorphism databases

DMDMi296452851.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF521868 mRNA. Translation: AAO14945.1 .
AK097416 mRNA. Translation: BAC05042.1 . Sequence problems.
AC026324 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79015.1 .
BC130472 mRNA. Translation: AAI30473.1 .
AL833848 mRNA. Translation: CAD38707.1 .
CCDSi CCDS3113.1. [Q8IWZ5-1 ]
RefSeqi NP_689829.3. NM_152616.4. [Q8IWZ5-1 ]
UniGenei Hs.343487.

3D structure databases

ProteinModelPortali Q8IWZ5.
SMRi Q8IWZ5. Positions 602-699.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130425. 3 interactions.
IntActi Q8IWZ5. 1 interaction.
STRINGi 9606.ENSP00000286349.

PTM databases

PhosphoSitei Q8IWZ5.

Polymorphism databases

DMDMi 296452851.

Proteomic databases

PaxDbi Q8IWZ5.
PRIDEi Q8IWZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286349 ; ENSP00000286349 ; ENSG00000155890 . [Q8IWZ5-1 ]
GeneIDi 287015.
KEGGi hsa:287015.
UCSCi uc003eto.2. human. [Q8IWZ5-1 ]

Organism-specific databases

CTDi 287015.
GeneCardsi GC03P140396.
H-InvDB HIX0003722.
HGNCi HGNC:19014. TRIM42.
HPAi HPA003581.
HPA022481.
neXtProti NX_Q8IWZ5.
PharmGKBi PA134894780.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277899.
GeneTreei ENSGT00530000064220.
HOGENOMi HOG000168411.
HOVERGENi HBG056782.
InParanoidi Q8IWZ5.
KOi K12018.
OMAi KFKAVRY.
OrthoDBi EOG7JX33P.
PhylomeDBi Q8IWZ5.
TreeFami TF336556.

Miscellaneous databases

GenomeRNAii 287015.
NextBioi 96321.
PROi Q8IWZ5.

Gene expression databases

Bgeei Q8IWZ5.
CleanExi HS_TRIM42.
Genevestigatori Q8IWZ5.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel tripartite motif family members."
    Meroni G.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-244.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
    Tissue: Testis.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-244.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
  6. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-244.
    Tissue: Testis.

Entry informationi

Entry nameiTRI42_HUMAN
AccessioniPrimary (citable) accession number: Q8IWZ5
Secondary accession number(s): A1L4B4, Q8N832, Q8NDL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3