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Q8IWZ5 (TRI42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 42
Gene names
Name:TRIM42
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length723 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 2 B box-type zinc fingers.

Contains 1 COS domain.

Contains 1 fibronectin type-III domain.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence BAC05042.1 differs from that shown. Reason: Erroneous termination at position 709. Translated as Trp.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IWZ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IWZ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     347-369: VRYEIDNDLMEFNILKNSFKADK → GPPLFHSFSLTSSSGTHGEDGVG
     370-723: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 723723Tripartite motif-containing protein 42
PRO_0000056263

Regions

Domain434 – 49259COS
Domain603 – 70199Fibronectin type-III
Zinc finger146 – 19247RING-type
Zinc finger235 – 28046B box-type 1
Zinc finger285 – 32642B box-type 2
Coiled coil382 – 40726 Potential
Compositional bias6 – 9691Cys-rich

Natural variations

Alternative sequence347 – 36923VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2.
VSP_012066
Alternative sequence370 – 723354Missing in isoform 2.
VSP_012067
Natural variant2441K → R. Ref.1 Ref.2 Ref.4 Ref.5 Ref.6
Corresponds to variant rs698673 [ dbSNP | Ensembl ].
VAR_052143
Natural variant4751V → M.
Corresponds to variant rs28594654 [ dbSNP | Ensembl ].
VAR_034468
Natural variant5791A → E.
Corresponds to variant rs9876490 [ dbSNP | Ensembl ].
VAR_034469

Experimental info

Sequence conflict5161I → T in BAC05042. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 40897D5AF9B186A9

FASTA72382,745
        10         20         30         40         50         60 
METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC QFCHCTCSES 

        70         80         90        100        110        120 
PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI ITFHKGRLRS IHTSSKTALR 

       130        140        150        160        170        180 
TGSSDTQVDE VKSIPANSHL VNHLNCPMCS RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT 

       190        200        210        220        230        240 
ENFFILICPV CDRSHCMPYS NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV 

       250        260        270        280        290        300 
CRNKRIAYKR CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE 

       310        320        330        340        350        360 
YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE IDNDLMEFNI 

       370        380        390        400        410        420 
LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN LEVSRQKEIE KYVYVTTMKV 

       430        440        450        460        470        480 
NEMDGLIAYS KEALKETGQV AFLQSAKILV DQIEDGIQTT YRPDPQLRLH SINYVPLDFV 

       490        500        510        520        530        540 
ELSSAIHELF PTGPKKVRSS GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML 

       550        560        570        580        590        600 
SFSNTDKKAK VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS 

       610        620        630        640        650        660 
VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM ELCGQIRDIM 

       670        680        690        700        710        720 
QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD GHGKNRAKWG LLKNIQSALQ 


KHF 

« Hide

Isoform 2 [UniParc].

Checksum: 0824C770CC920AD5
Show »

FASTA36942,200

References

« Hide 'large scale' references
[1]"Novel tripartite motif family members."
Meroni G.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-244.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
Tissue: Testis.
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-244.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-244.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF521868 mRNA. Translation: AAO14945.1.
AK097416 mRNA. Translation: BAC05042.1. Sequence problems.
AC026324 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79015.1.
BC130472 mRNA. Translation: AAI30473.1.
AL833848 mRNA. Translation: CAD38707.1.
RefSeqNP_689829.3. NM_152616.4.
UniGeneHs.343487.

3D structure databases

ProteinModelPortalQ8IWZ5.
SMRQ8IWZ5. Positions 138-195, 229-328, 615-702.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130425. 1 interaction.
IntActQ8IWZ5. 1 interaction.
STRING9606.ENSP00000286349.

PTM databases

PhosphoSiteQ8IWZ5.

Polymorphism databases

DMDM296452851.

Proteomic databases

PaxDbQ8IWZ5.
PRIDEQ8IWZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000286349; ENSP00000286349; ENSG00000155890. [Q8IWZ5-1]
GeneID287015.
KEGGhsa:287015.
UCSCuc003eto.2. human. [Q8IWZ5-1]

Organism-specific databases

CTD287015.
GeneCardsGC03P140396.
H-InvDBHIX0003722.
HGNCHGNC:19014. TRIM42.
HPAHPA003581.
HPA022481.
neXtProtNX_Q8IWZ5.
PharmGKBPA134894780.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277899.
HOGENOMHOG000168411.
HOVERGENHBG056782.
InParanoidQ8IWZ5.
KOK12018.
OMAKFKAVRY.
OrthoDBEOG7JX33P.
TreeFamTF336556.

Gene expression databases

BgeeQ8IWZ5.
CleanExHS_TRIM42.
GenevestigatorQ8IWZ5.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi287015.
NextBio96321.
PROQ8IWZ5.

Entry information

Entry nameTRI42_HUMAN
AccessionPrimary (citable) accession number: Q8IWZ5
Secondary accession number(s): A1L4B4, Q8N832, Q8NDL3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 18, 2010
Last modified: March 19, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM