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Protein

Tripartite motif-containing protein 42

Gene

TRIM42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 19247RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 28046B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 32642B box-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 42
Gene namesi
Name:TRIM42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19014. TRIM42.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894780.

Polymorphism and mutation databases

BioMutaiTRIM42.
DMDMi296452851.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Tripartite motif-containing protein 42PRO_0000056263Add
BLAST

Proteomic databases

PaxDbiQ8IWZ5.
PRIDEiQ8IWZ5.

PTM databases

PhosphoSiteiQ8IWZ5.

Expressioni

Gene expression databases

BgeeiQ8IWZ5.
CleanExiHS_TRIM42.
GenevisibleiQ8IWZ5. HS.

Organism-specific databases

HPAiHPA003581.
HPA022481.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-5235829,EBI-10173507
GLRX3O760033EBI-5235829,EBI-374781
HOXA1P496393EBI-5235829,EBI-740785
KRTAP10-9P604113EBI-5235829,EBI-10172052
KRTAP3-2Q9BYR73EBI-5235829,EBI-751260
KRTAP4-2Q9BYR53EBI-5235829,EBI-10172511
MEOX2A4D1273EBI-5235829,EBI-10172134
NOTCH2NLQ7Z3S93EBI-5235829,EBI-945833
PLSCR1O151623EBI-5235829,EBI-740019
VPS37AQ8NEZ2-23EBI-5235829,EBI-10270911

Protein-protein interaction databases

BioGridi130425. 65 interactions.
IntActiQ8IWZ5. 11 interactions.
STRINGi9606.ENSP00000286349.

Structurei

3D structure databases

ProteinModelPortaliQ8IWZ5.
SMRiQ8IWZ5. Positions 143-196, 616-700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 49259COSPROSITE-ProRule annotationAdd
BLAST
Domaini603 – 70199Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili382 – 40726Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 9691Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 19247RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 28046B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 32642B box-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG277899.
GeneTreeiENSGT00530000064220.
HOGENOMiHOG000168411.
HOVERGENiHBG056782.
InParanoidiQ8IWZ5.
KOiK12018.
OMAiRLTKRYM.
OrthoDBiEOG7JX33P.
PhylomeDBiQ8IWZ5.
TreeFamiTF336556.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC
60 70 80 90 100
QFCHCTCSES PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI
110 120 130 140 150
ITFHKGRLRS IHTSSKTALR TGSSDTQVDE VKSIPANSHL VNHLNCPMCS
160 170 180 190 200
RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT ENFFILICPV CDRSHCMPYS
210 220 230 240 250
NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV CRNKRIAYKR
260 270 280 290 300
CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE
310 320 330 340 350
YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE
360 370 380 390 400
IDNDLMEFNI LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN
410 420 430 440 450
LEVSRQKEIE KYVYVTTMKV NEMDGLIAYS KEALKETGQV AFLQSAKILV
460 470 480 490 500
DQIEDGIQTT YRPDPQLRLH SINYVPLDFV ELSSAIHELF PTGPKKVRSS
510 520 530 540 550
GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML SFSNTDKKAK
560 570 580 590 600
VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS
610 620 630 640 650
VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM
660 670 680 690 700
ELCGQIRDIM QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD
710 720
GHGKNRAKWG LLKNIQSALQ KHF
Length:723
Mass (Da):82,745
Last modified:May 18, 2010 - v2
Checksum:i40897D5AF9B186A9
GO
Isoform 2 (identifier: Q8IWZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-369: VRYEIDNDLMEFNILKNSFKADK → GPPLFHSFSLTSSSGTHGEDGVG
     370-723: Missing.

Note: No experimental confirmation available.
Show »
Length:369
Mass (Da):42,200
Checksum:i0824C770CC920AD5
GO

Sequence cautioni

The sequence BAC05042.1 differs from that shown. Reason: Erroneous termination at position 709. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti516 – 5161I → T in BAC05042 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti244 – 2441K → R.5 Publications
Corresponds to variant rs698673 [ dbSNP | Ensembl ].
VAR_052143
Natural varianti475 – 4751V → M.
Corresponds to variant rs28594654 [ dbSNP | Ensembl ].
VAR_034468
Natural varianti579 – 5791A → E.
Corresponds to variant rs9876490 [ dbSNP | Ensembl ].
VAR_034469

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei347 – 36923VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2. CuratedVSP_012066Add
BLAST
Alternative sequencei370 – 723354Missing in isoform 2. CuratedVSP_012067Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521868 mRNA. Translation: AAO14945.1.
AK097416 mRNA. Translation: BAC05042.1. Sequence problems.
AC026324 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79015.1.
BC130472 mRNA. Translation: AAI30473.1.
AL833848 mRNA. Translation: CAD38707.1.
CCDSiCCDS3113.1. [Q8IWZ5-1]
RefSeqiNP_689829.3. NM_152616.4. [Q8IWZ5-1]
UniGeneiHs.343487.

Genome annotation databases

EnsembliENST00000286349; ENSP00000286349; ENSG00000155890.
GeneIDi287015.
KEGGihsa:287015.
UCSCiuc003eto.2. human. [Q8IWZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521868 mRNA. Translation: AAO14945.1.
AK097416 mRNA. Translation: BAC05042.1. Sequence problems.
AC026324 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79015.1.
BC130472 mRNA. Translation: AAI30473.1.
AL833848 mRNA. Translation: CAD38707.1.
CCDSiCCDS3113.1. [Q8IWZ5-1]
RefSeqiNP_689829.3. NM_152616.4. [Q8IWZ5-1]
UniGeneiHs.343487.

3D structure databases

ProteinModelPortaliQ8IWZ5.
SMRiQ8IWZ5. Positions 143-196, 616-700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130425. 65 interactions.
IntActiQ8IWZ5. 11 interactions.
STRINGi9606.ENSP00000286349.

PTM databases

PhosphoSiteiQ8IWZ5.

Polymorphism and mutation databases

BioMutaiTRIM42.
DMDMi296452851.

Proteomic databases

PaxDbiQ8IWZ5.
PRIDEiQ8IWZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286349; ENSP00000286349; ENSG00000155890.
GeneIDi287015.
KEGGihsa:287015.
UCSCiuc003eto.2. human. [Q8IWZ5-1]

Organism-specific databases

CTDi287015.
GeneCardsiGC03P140396.
H-InvDBHIX0003722.
HGNCiHGNC:19014. TRIM42.
HPAiHPA003581.
HPA022481.
neXtProtiNX_Q8IWZ5.
PharmGKBiPA134894780.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG277899.
GeneTreeiENSGT00530000064220.
HOGENOMiHOG000168411.
HOVERGENiHBG056782.
InParanoidiQ8IWZ5.
KOiK12018.
OMAiRLTKRYM.
OrthoDBiEOG7JX33P.
PhylomeDBiQ8IWZ5.
TreeFamiTF336556.

Miscellaneous databases

GenomeRNAii287015.
NextBioi96321.
PROiQ8IWZ5.

Gene expression databases

BgeeiQ8IWZ5.
CleanExiHS_TRIM42.
GenevisibleiQ8IWZ5. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel tripartite motif family members."
    Meroni G.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-244.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
    Tissue: Testis.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-244.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
  6. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-244.
    Tissue: Testis.

Entry informationi

Entry nameiTRI42_HUMAN
AccessioniPrimary (citable) accession number: Q8IWZ5
Secondary accession number(s): A1L4B4, Q8N832, Q8NDL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 18, 2010
Last modified: July 22, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.