Q8IWZ5 (TRI42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tripartite motif-containing protein 42

Gene names

Name:

TRIM42

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the TRIM/RBCC family. Contains 2 B box-type zinc fingers. Contains 1 COS domain. Contains 1 fibronectin type-III domain. Contains 1 RING-type zinc finger.
Sequence caution	The sequence BAC05042.1 differs from that shown. Reason: Erroneous termination at position 709. Translated as Trp.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWZ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWZ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     347-369: VRYEIDNDLMEFNILKNSFKADK → GPPLFHSFSLTSSSGTHGEDGVG
     370-723: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 723	723	Tripartite motif-containing protein 42		PRO_0000056263
Regions
	Domain	434 – 492	59	COS
	Domain	600 – 698	99	Fibronectin type-III
	Zinc finger	146 – 192	47	RING-type
	Zinc finger	235 – 280	46	B box-type 1
	Zinc finger	285 – 326	42	B box-type 2
	Coiled coil	382 – 407	26	Potential
	Compositional bias	6 – 96	91	Cys-rich
Natural variations
	Alternative sequence	347 – 369	23	VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2.		VSP_012066
	Alternative sequence	370 – 723	354	Missing in isoform 2.		VSP_012067
	Natural variant	244	1	K → R. Ref.1 Ref.2 Ref.4 Ref.5 Ref.6 Corresponds to variant rs698673 [ dbSNP | Ensembl ].		VAR_052143
	Natural variant	475	1	V → M. Corresponds to variant rs28594654 [ dbSNP | Ensembl ].		VAR_034468
	Natural variant	579	1	A → E. Corresponds to variant rs9876490 [ dbSNP | Ensembl ].		VAR_034469
Experimental info
	Sequence conflict	516	1	I → T in BAC05042. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 40897D5AF9B186A9	FASTA	723	82,745
	10 20 30 40 50 60 METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC QFCHCTCSES 70 80 90 100 110 120 PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI ITFHKGRLRS IHTSSKTALR 130 140 150 160 170 180 TGSSDTQVDE VKSIPANSHL VNHLNCPMCS RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT 190 200 210 220 230 240 ENFFILICPV CDRSHCMPYS NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV 250 260 270 280 290 300 CRNKRIAYKR CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE 310 320 330 340 350 360 YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE IDNDLMEFNI 370 380 390 400 410 420 LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN LEVSRQKEIE KYVYVTTMKV 430 440 450 460 470 480 NEMDGLIAYS KEALKETGQV AFLQSAKILV DQIEDGIQTT YRPDPQLRLH SINYVPLDFV 490 500 510 520 530 540 ELSSAIHELF PTGPKKVRSS GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML 550 560 570 580 590 600 SFSNTDKKAK VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS 610 620 630 640 650 660 VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM ELCGQIRDIM 670 680 690 700 710 720 QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD GHGKNRAKWG LLKNIQSALQ KHF
	Isoform 2 [UniParc]. Checksum: 0824C770CC920AD5	FASTA	369	42,200
	10 20 30 40 50 60 METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC QFCHCTCSES 70 80 90 100 110 120 PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI ITFHKGRLRS IHTSSKTALR 130 140 150 160 170 180 TGSSDTQVDE VKSIPANSHL VNHLNCPMCS RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT 190 200 210 220 230 240 ENFFILICPV CDRSHCMPYS NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV 250 260 270 280 290 300 CRNKRIAYKR CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE 310 320 330 340 350 360 YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAGPPL FHSFSLTSSS GTHGEDGVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel tripartite motif family members." Meroni G. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-244.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244. Tissue: Testis.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-244.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-244. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF521868 mRNA. Translation: AAO14945.1. AK097416 mRNA. Translation: BAC05042.1. Sequence problems. AC026324 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW79015.1. BC130472 mRNA. Translation: AAI30473.1. AL833848 mRNA. Translation: CAD38707.1.
IPI	IPI00217444. IPI00386076.
RefSeq	NP_689829.3. NM_152616.4.
UniGene	Hs.343487.
3D structure databases
ProteinModelPortal	Q8IWZ5.
SMR	Q8IWZ5. Positions 236-326, 602-699.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IWZ5. 1 interaction.
STRING	9606.ENSP00000286349.
PTM databases
PhosphoSite	Q8IWZ5.
Polymorphism databases
DMDM	296452851.
Proteomic databases
PaxDb	Q8IWZ5.
PRIDE	Q8IWZ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286349; ENSP00000286349; ENSG00000155890.
GeneID	287015.
KEGG	hsa:287015.
UCSC	uc003eto.2. human.
Organism-specific databases
CTD	287015.
GeneCards	GC03P140396.
H-InvDB	HIX0003722.
HGNC	HGNC:19014. TRIM42.
HPA	HPA003581. HPA022481.
neXtProt	NX_Q8IWZ5.
PharmGKB	PA134894780.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG277899.
HOGENOM	HOG000168411.
HOVERGEN	HBG056782.
InParanoid	Q8IWZ5.
KO	K12018.
OMA	KFKAVRY.
OrthoDB	EOG46T30X.
Gene expression databases
Bgee	Q8IWZ5.
CleanEx	HS_TRIM42.
Genevestigator	Q8IWZ5.
GermOnline	ENSG00000155890. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR017903. COS_domain. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00041. fn3. 1 hit. PF00643. zf-B_box. 1 hit. [Graphical view]
SMART	SM00060. FN3. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 1 hit.
PROSITE	PS51262. COS. 1 hit. PS50853. FN3. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	287015.
NextBio	96321.

Entry information

Entry name

TRI42_HUMAN

Accession

Primary (citable) accession number: Q8IWZ5
Secondary accession number(s): A1L4B4, Q8N832, Q8NDL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.