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Protein

Tripartite motif-containing protein 42

Gene

TRIM42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 192RING-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri235 – 280B box-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri285 – 326B box-type 2PROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 42
Gene namesi
Name:TRIM42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19014. TRIM42.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi287015.
OpenTargetsiENSG00000155890.
PharmGKBiPA134894780.

Polymorphism and mutation databases

BioMutaiTRIM42.
DMDMi296452851.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562631 – 723Tripartite motif-containing protein 42Add BLAST723

Proteomic databases

PaxDbiQ8IWZ5.
PeptideAtlasiQ8IWZ5.
PRIDEiQ8IWZ5.

PTM databases

iPTMnetiQ8IWZ5.
PhosphoSitePlusiQ8IWZ5.

Expressioni

Gene expression databases

BgeeiENSG00000155890.
CleanExiHS_TRIM42.
GenevisibleiQ8IWZ5. HS.

Organism-specific databases

HPAiHPA003581.
HPA022481.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-5235829,EBI-10173507
ARMC7Q9H6L43EBI-5235829,EBI-742909
ARRDC3Q96B673EBI-5235829,EBI-2875665
BEX2Q9BXY83EBI-5235829,EBI-745073
C1orf109Q9NX043EBI-5235829,EBI-8643161
CARD9Q9H2573EBI-5235829,EBI-751319
CCDC36Q8IYA83EBI-5235829,EBI-8638439
CDCA7LQ96GN53EBI-5235829,EBI-5278764
CEP70Q8NHQ13EBI-5235829,EBI-739624
EFHC2Q5JST63EBI-5235829,EBI-2349927
EMDP504026EBI-5235829,EBI-489887
FAM103A1Q9BTL33EBI-5235829,EBI-744023
FAM208BQ5VWN6-23EBI-5235829,EBI-10172380
GLI1P081513EBI-5235829,EBI-308084
GLRX3O760036EBI-5235829,EBI-374781
GLYCTKQ8IVS83EBI-5235829,EBI-748515
GOLGA2Q083793EBI-5235829,EBI-618309
HOXA1P4963910EBI-5235829,EBI-740785
IKZF3Q9UKT93EBI-5235829,EBI-747204
IQUBQ8NA543EBI-5235829,EBI-10220600
KCTD9Q7L2735EBI-5235829,EBI-4397613
KLHL38Q2WGJ67EBI-5235829,EBI-6426443
KRT13A1A4E93EBI-5235829,EBI-10171552
KRT15P190123EBI-5235829,EBI-739566
KRT40Q6A1623EBI-5235829,EBI-10171697
KRTAP10-7P604093EBI-5235829,EBI-10172290
KRTAP10-9P604116EBI-5235829,EBI-10172052
KRTAP26-1Q6PEX33EBI-5235829,EBI-3957672
KRTAP3-2Q9BYR73EBI-5235829,EBI-751260
KRTAP4-2Q9BYR56EBI-5235829,EBI-10172511
L3MBTL2Q969R53EBI-5235829,EBI-739909
LCE1BQ5T7P34EBI-5235829,EBI-10245913
LCE1FQ5T7544EBI-5235829,EBI-11958008
LCE2CQ5TA814EBI-5235829,EBI-11973993
LCE5AQ5TCM94EBI-5235829,EBI-11955689
LONRF1Q17RB85EBI-5235829,EBI-2341787
LZTS2Q9BRK43EBI-5235829,EBI-741037
MAGOHBQ96A723EBI-5235829,EBI-746778
MEOX2P502225EBI-5235829,EBI-748397
MFAP1P550813EBI-5235829,EBI-1048159
MID2Q9UJV3-23EBI-5235829,EBI-10172526
MTUS2Q5JR593EBI-5235829,EBI-742948
NOTCH2NLQ7Z3S98EBI-5235829,EBI-945833
PLSCR1O151623EBI-5235829,EBI-740019
PNMA1Q8ND903EBI-5235829,EBI-302345
PSMA1P257863EBI-5235829,EBI-359352
PSMD9O002333EBI-5235829,EBI-750973
PTGER3P43115-123EBI-5235829,EBI-10234038
RCOR3Q9P2K33EBI-5235829,EBI-743428
RUNX1T1Q06455-43EBI-5235829,EBI-10224192
SCNM1Q9BWG63EBI-5235829,EBI-748391
SPERTQ8NA613EBI-5235829,EBI-741724
SSX2IPQ9Y2D83EBI-5235829,EBI-2212028
STK16O757165EBI-5235829,EBI-749295
TRAF1Q130773EBI-5235829,EBI-359224
TRAF2Q129333EBI-5235829,EBI-355744
TRAPPC2P0DI813EBI-5235829,EBI-5663373
TRIM23P364063EBI-5235829,EBI-740098
TRIM27P143733EBI-5235829,EBI-719493
TXNDC5Q86UY05EBI-5235829,EBI-2825190
VPS37AQ8NEZ2-23EBI-5235829,EBI-10270911
YWHAQP273483EBI-5235829,EBI-359854
ZBTB1Q9Y2K13EBI-5235829,EBI-2682961

Protein-protein interaction databases

BioGridi130425. 65 interactors.
IntActiQ8IWZ5. 115 interactors.
STRINGi9606.ENSP00000286349.

Structurei

3D structure databases

ProteinModelPortaliQ8IWZ5.
SMRiQ8IWZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini434 – 492COSPROSITE-ProRule annotationAdd BLAST59
Domaini603 – 701Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili382 – 407Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 96Cys-richAdd BLAST91

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 192RING-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri235 – 280B box-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri285 – 326B box-type 2PROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF3. Eukaryota.
ENOG410YJTN. LUCA.
GeneTreeiENSGT00530000064220.
HOGENOMiHOG000168411.
HOVERGENiHBG056782.
InParanoidiQ8IWZ5.
KOiK12018.
OMAiRLTKRYM.
OrthoDBiEOG091G02EW.
PhylomeDBiQ8IWZ5.
TreeFamiTF336556.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
SMARTiView protein in SMART
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiView protein in PROSITE
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC
60 70 80 90 100
QFCHCTCSES PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI
110 120 130 140 150
ITFHKGRLRS IHTSSKTALR TGSSDTQVDE VKSIPANSHL VNHLNCPMCS
160 170 180 190 200
RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT ENFFILICPV CDRSHCMPYS
210 220 230 240 250
NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV CRNKRIAYKR
260 270 280 290 300
CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE
310 320 330 340 350
YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE
360 370 380 390 400
IDNDLMEFNI LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN
410 420 430 440 450
LEVSRQKEIE KYVYVTTMKV NEMDGLIAYS KEALKETGQV AFLQSAKILV
460 470 480 490 500
DQIEDGIQTT YRPDPQLRLH SINYVPLDFV ELSSAIHELF PTGPKKVRSS
510 520 530 540 550
GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML SFSNTDKKAK
560 570 580 590 600
VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS
610 620 630 640 650
VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM
660 670 680 690 700
ELCGQIRDIM QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD
710 720
GHGKNRAKWG LLKNIQSALQ KHF
Length:723
Mass (Da):82,745
Last modified:May 18, 2010 - v2
Checksum:i40897D5AF9B186A9
GO
Isoform 2 (identifier: Q8IWZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-369: VRYEIDNDLMEFNILKNSFKADK → GPPLFHSFSLTSSSGTHGEDGVG
     370-723: Missing.

Note: No experimental confirmation available.
Show »
Length:369
Mass (Da):42,200
Checksum:i0824C770CC920AD5
GO

Sequence cautioni

The sequence BAC05042 differs from that shown. Reason: Erroneous termination at position 709. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti516I → T in BAC05042 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052143244K → R5 PublicationsCorresponds to variant dbSNP:rs698673Ensembl.1
Natural variantiVAR_034468475V → M1 PublicationCorresponds to variant dbSNP:rs28594654Ensembl.1
Natural variantiVAR_034469579A → E1 PublicationCorresponds to variant dbSNP:rs9876490Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012066347 – 369VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_012067370 – 723Missing in isoform 2. CuratedAdd BLAST354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521868 mRNA. Translation: AAO14945.1.
AK097416 mRNA. Translation: BAC05042.1. Sequence problems.
AC026324 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79015.1.
BC130472 mRNA. Translation: AAI30473.1.
BC130474 mRNA. Translation: AAI30475.1.
AL833848 mRNA. Translation: CAD38707.1.
CCDSiCCDS3113.1. [Q8IWZ5-1]
RefSeqiNP_689829.3. NM_152616.4. [Q8IWZ5-1]
UniGeneiHs.343487.

Genome annotation databases

EnsembliENST00000286349; ENSP00000286349; ENSG00000155890. [Q8IWZ5-1]
GeneIDi287015.
KEGGihsa:287015.
UCSCiuc003eto.3. human. [Q8IWZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI42_HUMAN
AccessioniPrimary (citable) accession number: Q8IWZ5
Secondary accession number(s): A1L4B4
, A1L4B6, Q8N832, Q8NDL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 18, 2010
Last modified: August 30, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families