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Q8IWZ5

- TRI42_HUMAN

UniProt

Q8IWZ5 - TRI42_HUMAN

Protein

Tripartite motif-containing protein 42

Gene

TRIM42

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri146 – 19247RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri235 – 28046B box-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri285 – 32642B box-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 42
    Gene namesi
    Name:TRIM42
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:19014. TRIM42.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134894780.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 723723Tripartite motif-containing protein 42PRO_0000056263Add
    BLAST

    Proteomic databases

    PaxDbiQ8IWZ5.
    PRIDEiQ8IWZ5.

    PTM databases

    PhosphoSiteiQ8IWZ5.

    Expressioni

    Gene expression databases

    BgeeiQ8IWZ5.
    CleanExiHS_TRIM42.
    GenevestigatoriQ8IWZ5.

    Organism-specific databases

    HPAiHPA003581.
    HPA022481.

    Interactioni

    Protein-protein interaction databases

    BioGridi130425. 1 interaction.
    IntActiQ8IWZ5. 1 interaction.
    STRINGi9606.ENSP00000286349.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWZ5.
    SMRiQ8IWZ5. Positions 136-196, 603-702.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini434 – 49259COSPROSITE-ProRule annotationAdd
    BLAST
    Domaini603 – 70199Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili382 – 40726Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 9691Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 COS domain.PROSITE-ProRule annotation
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri146 – 19247RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri235 – 28046B box-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri285 – 32642B box-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG277899.
    HOGENOMiHOG000168411.
    HOVERGENiHBG056782.
    InParanoidiQ8IWZ5.
    KOiK12018.
    OMAiKFKAVRY.
    OrthoDBiEOG7JX33P.
    PhylomeDBiQ8IWZ5.
    TreeFamiTF336556.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR017903. COS_domain.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS51262. COS. 1 hit.
    PS50853. FN3. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWZ5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC    50
    QFCHCTCSES PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI 100
    ITFHKGRLRS IHTSSKTALR TGSSDTQVDE VKSIPANSHL VNHLNCPMCS 150
    RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT ENFFILICPV CDRSHCMPYS 200
    NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV CRNKRIAYKR 250
    CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE 300
    YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE 350
    IDNDLMEFNI LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN 400
    LEVSRQKEIE KYVYVTTMKV NEMDGLIAYS KEALKETGQV AFLQSAKILV 450
    DQIEDGIQTT YRPDPQLRLH SINYVPLDFV ELSSAIHELF PTGPKKVRSS 500
    GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML SFSNTDKKAK 550
    VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS 600
    VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM 650
    ELCGQIRDIM QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD 700
    GHGKNRAKWG LLKNIQSALQ KHF 723
    Length:723
    Mass (Da):82,745
    Last modified:May 18, 2010 - v2
    Checksum:i40897D5AF9B186A9
    GO
    Isoform 2 (identifier: Q8IWZ5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         347-369: VRYEIDNDLMEFNILKNSFKADK → GPPLFHSFSLTSSSGTHGEDGVG
         370-723: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:369
    Mass (Da):42,200
    Checksum:i0824C770CC920AD5
    GO

    Sequence cautioni

    The sequence BAC05042.1 differs from that shown. Reason: Erroneous termination at position 709. Translated as Trp.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti516 – 5161I → T in BAC05042. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti244 – 2441K → R.5 Publications
    Corresponds to variant rs698673 [ dbSNP | Ensembl ].
    VAR_052143
    Natural varianti475 – 4751V → M.
    Corresponds to variant rs28594654 [ dbSNP | Ensembl ].
    VAR_034468
    Natural varianti579 – 5791A → E.
    Corresponds to variant rs9876490 [ dbSNP | Ensembl ].
    VAR_034469

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei347 – 36923VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2. CuratedVSP_012066Add
    BLAST
    Alternative sequencei370 – 723354Missing in isoform 2. CuratedVSP_012067Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF521868 mRNA. Translation: AAO14945.1.
    AK097416 mRNA. Translation: BAC05042.1. Sequence problems.
    AC026324 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79015.1.
    BC130472 mRNA. Translation: AAI30473.1.
    AL833848 mRNA. Translation: CAD38707.1.
    CCDSiCCDS3113.1. [Q8IWZ5-1]
    RefSeqiNP_689829.3. NM_152616.4. [Q8IWZ5-1]
    UniGeneiHs.343487.

    Genome annotation databases

    EnsembliENST00000286349; ENSP00000286349; ENSG00000155890. [Q8IWZ5-1]
    GeneIDi287015.
    KEGGihsa:287015.
    UCSCiuc003eto.2. human. [Q8IWZ5-1]

    Polymorphism databases

    DMDMi296452851.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF521868 mRNA. Translation: AAO14945.1 .
    AK097416 mRNA. Translation: BAC05042.1 . Sequence problems.
    AC026324 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79015.1 .
    BC130472 mRNA. Translation: AAI30473.1 .
    AL833848 mRNA. Translation: CAD38707.1 .
    CCDSi CCDS3113.1. [Q8IWZ5-1 ]
    RefSeqi NP_689829.3. NM_152616.4. [Q8IWZ5-1 ]
    UniGenei Hs.343487.

    3D structure databases

    ProteinModelPortali Q8IWZ5.
    SMRi Q8IWZ5. Positions 136-196, 603-702.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130425. 1 interaction.
    IntActi Q8IWZ5. 1 interaction.
    STRINGi 9606.ENSP00000286349.

    PTM databases

    PhosphoSitei Q8IWZ5.

    Polymorphism databases

    DMDMi 296452851.

    Proteomic databases

    PaxDbi Q8IWZ5.
    PRIDEi Q8IWZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286349 ; ENSP00000286349 ; ENSG00000155890 . [Q8IWZ5-1 ]
    GeneIDi 287015.
    KEGGi hsa:287015.
    UCSCi uc003eto.2. human. [Q8IWZ5-1 ]

    Organism-specific databases

    CTDi 287015.
    GeneCardsi GC03P140396.
    H-InvDB HIX0003722.
    HGNCi HGNC:19014. TRIM42.
    HPAi HPA003581.
    HPA022481.
    neXtProti NX_Q8IWZ5.
    PharmGKBi PA134894780.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277899.
    HOGENOMi HOG000168411.
    HOVERGENi HBG056782.
    InParanoidi Q8IWZ5.
    KOi K12018.
    OMAi KFKAVRY.
    OrthoDBi EOG7JX33P.
    PhylomeDBi Q8IWZ5.
    TreeFami TF336556.

    Miscellaneous databases

    GenomeRNAii 287015.
    NextBioi 96321.
    PROi Q8IWZ5.

    Gene expression databases

    Bgeei Q8IWZ5.
    CleanExi HS_TRIM42.
    Genevestigatori Q8IWZ5.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR017903. COS_domain.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS51262. COS. 1 hit.
    PS50853. FN3. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel tripartite motif family members."
      Meroni G.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-244.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
      Tissue: Testis.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-244.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-244.
    6. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-244.
      Tissue: Testis.

    Entry informationi

    Entry nameiTRI42_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWZ5
    Secondary accession number(s): A1L4B4, Q8N832, Q8NDL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3