Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Codanin-1

Gene

CDAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a negative regulator of ASF1 in chromatin assembly.1 Publication

GO - Biological processi

  • chromatin assembly Source: UniProtKB
  • chromatin organization Source: MGI
  • negative regulation of DNA replication Source: UniProtKB
  • protein localization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124762-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Codanin-1
Gene namesi
Name:CDAN1
ORF Names:UNQ664/PRO1295
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:1713. CDAN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endomembrane system Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Anemia, congenital dyserythropoietic, 1A (CDAN1A)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts.
See also OMIM:224120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017218599N → S in CDAN1A. 1 PublicationCorresponds to variant rs120074166dbSNPEnsembl.1
Natural variantiVAR_017219672P → L in CDAN1A. 1 PublicationCorresponds to variant rs120074167dbSNPEnsembl.1
Natural variantiVAR_017220698E → K in CDAN1A. 1 Publication1
Natural variantiVAR_017221714R → W in CDAN1A; partially disrupts ASF1 binding and loss the ability to arrest cells in S phase and inhibit DNA synthesis. 2 PublicationsCorresponds to variant rs80338696dbSNPEnsembl.1
Natural variantiVAR_017222868F → I in CDAN1A. 1 PublicationCorresponds to variant rs120074168dbSNPEnsembl.1
Natural variantiVAR_017223869V → M in CDAN1A. 1 PublicationCorresponds to variant rs370895637dbSNPEnsembl.1
Natural variantiVAR_0172241042R → W in CDAN1A; partially disrupts ASF1 binding. 2 PublicationsCorresponds to variant rs80338697dbSNPEnsembl.1
Natural variantiVAR_0172251043D → V in CDAN1A. 1 PublicationCorresponds to variant rs80338698dbSNPEnsembl.1
Natural variantiVAR_0172261130P → L in CDAN1A. 1 PublicationCorresponds to variant rs80338699dbSNPEnsembl.1

Keywords - Diseasei

Congenital dyserythropoietic anemia, Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNETi146059.
MalaCardsiCDAN1.
MIMi224120. phenotype.
OpenTargetsiENSG00000140326.
Orphaneti98869. Congenital dyserythropoietic anemia type I.
PharmGKBiPA26249.

Polymorphism and mutation databases

BioMutaiCDAN1.
DMDMi296439465.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000894392 – 1227Codanin-1Add BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei71PhosphothreonineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IWY9.
PaxDbiQ8IWY9.
PeptideAtlasiQ8IWY9.
PRIDEiQ8IWY9.

PTM databases

iPTMnetiQ8IWY9.
PhosphoSitePlusiQ8IWY9.

Expressioni

Tissue specificityi

Ubiquitously expressed. Isoform 3 is not found in erythroid cells.1 Publication

Gene expression databases

BgeeiENSG00000140326.
CleanExiHS_CDAN1.
ExpressionAtlasiQ8IWY9. baseline and differential.
GenevisibleiQ8IWY9. HS.

Organism-specific databases

HPAiHPA039404.
HPA040787.

Interactioni

Subunit structurei

Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.1 Publication

Protein-protein interaction databases

BioGridi126963. 12 interactors.
DIPiDIP-24225N.
IntActiQ8IWY9. 4 interactors.
MINTiMINT-1377874.
STRINGi9606.ENSP00000348564.

Structurei

3D structure databases

ProteinModelPortaliQ8IWY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 208Interaction with ASF1A/B1 PublicationAdd BLAST21

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHV. Eukaryota.
ENOG410XXWY. LUCA.
GeneTreeiENSGT00390000000491.
HOGENOMiHOG000111492.
HOVERGENiHBG107631.
InParanoidiQ8IWY9.
KOiK19531.
OMAiLSKPKTC.
OrthoDBiEOG091G03X8.
PhylomeDBiQ8IWY9.
TreeFamiTF328405.

Family and domain databases

InterProiIPR028171. Codanin-1_C.
[Graphical view]
PfamiPF15296. Codanin-1_C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q8IWY9-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVLESLLR EEVSVAAVVR WIARSTQGSE DNAGEAAALS SLRALRKEFV
60 70 80 90 100
PFLLNFLREQ SSRVLPQGPP TPAKTPGASA ALPGRPGGPP RGSRGARSQL
110 120 130 140 150
FPPTEAQSTA AEAPLARRGG RRRGPGPARE RGGRGLEEGV SGESLPGAGG
160 170 180 190 200
RRLRGSGSPS RPSLTLSDPP NLSNLEEFPP VGSVPPGPTG TKPSRRINPT
210 220 230 240 250
PVSEERSLSK PKTCFTSPPI SCVPSSQPSA LDTSPWGLGL PPGCRSLQEE
260 270 280 290 300
REMLRKERSK QLQQSPTPTC PTPELGSPLP SRTGSLTDEP ADPARVSSRQ
310 320 330 340 350
RLELVALVYS SCIAENLVPN LFLELFFVFQ LLTARRMVTA KDSDPELSPA
360 370 380 390 400
VLDSLESPLF QSIHDCVFFA VQVLECHFQV LSNLDKGTLK LLAENERLLC
410 420 430 440 450
FSPALQGRLR AAYEGSVAKV SLVMPPSTQA VSFQPETDNR ANFSSDRAFH
460 470 480 490 500
TFKKQRDVFY EVLREWEDHH EEPGWDFEKG LGSRIRAMMG QLSAACSHSH
510 520 530 540 550
FVRLFQKQLL QMCQSPGGAG GTVLGEAPDV LSMLGADKLG RLWRLQERLM
560 570 580 590 600
APQSSGGPCP PPTFPGCQGF FRDFILSASS FQFNQHLMDS LSLKIQELNG
610 620 630 640 650
LALPQHEPND EDGESDVDWQ GERKQFAVVL LSLRLLAKFL GFVAFLPYRG
660 670 680 690 700
PEPPPTGELQ DSILALRSQV PPVLDVRTLL QRGLQARRAV LTVPWLVEFL
710 720 730 740 750
SFADHVVPLL EYYRDIFTLL LRLHRSLVLS QESEGKMCFL NKLLLLAVLG
760 770 780 790 800
WLFQIPTVPE DLFFLEEGPS YAFEVDTVAP EHGLDNAPVV DQQLLYTCCP
810 820 830 840 850
YIGELRKLLA SWVSGSSGRS GGFMRKITPT TTTSLGAQPS QTSQGLQAQL
860 870 880 890 900
AQAFFHNQPP SLRRTVEFVA ERIGSNCVKH IKATLVADLV RQAESLLQEQ
910 920 930 940 950
LVTQGEEGGD PAQLLEILCS QLCPHGAQAL ALGREFCQRK SPGAVRALLP
960 970 980 990 1000
EETPAAVLSS AENIAVGLAT EKACAWLSAN ITALIRREVK AAVSRTLRAQ
1010 1020 1030 1040 1050
GPEPAARGER RGCSRACEHH APLPSHLISE IKDVLSLAVG PRDPDEGVSP
1060 1070 1080 1090 1100
EHLEQLLGQL GQTLRCRQFL CPPAEQHLAK CSVELASLLV ADQIPILGPP
1110 1120 1130 1140 1150
AQYRLERGQA RRLLHMLLSL WKEDFQGPVP LQLLLSPRNV GLLADTRPRE
1160 1170 1180 1190 1200
WDLLLFLLRE LVEKGLMGRM EIEACLGSLH QAQWPGDFAE ELATLSNLFL
1210 1220
AEPHLPEPQL RACELVQPNR GTVLAQS
Length:1,227
Mass (Da):134,120
Last modified:May 18, 2010 - v4
Checksum:iE2BC04ACD669DF6F
GO
Isoform 1 (identifier: Q8IWY9-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: G → GETQLSCRRWVPRRLWGVSHSSSALRSGAPGCR
     226-258: Missing.

Show »
Length:1,226
Mass (Da):133,992
Checksum:i0674D569F19BCD52
GO
Isoform 3 (identifier: Q8IWY9-3)
Sequence is not available
Length:
Mass (Da):

Sequence cautioni

The sequence AAH52568 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAO14994 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAQ88832 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31 – 32DN → VT in AAO14994 (PubMed:12434312).Curated2
Sequence conflicti39L → V in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti42 – 45LRAL → FGAW in AAO14994 (PubMed:12434312).Curated4
Sequence conflicti51 – 52PF → RS in AAO14994 (PubMed:12434312).Curated2
Sequence conflicti55N → T in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti73A → P in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti76P → R in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti82L → C in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti93S → T in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti380V → F in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti421S → F in AAH52568 (PubMed:15489334).Curated1
Sequence conflicti421S → F in AAH66640 (PubMed:15489334).Curated1
Sequence conflicti669Q → P in AAQ88832 (PubMed:12975309).Curated1
Sequence conflicti726S → C in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti946R → W in AAH01092 (PubMed:15489334).Curated1
Sequence conflicti946R → W in AAH08333 (PubMed:15489334).Curated1
Sequence conflicti946R → W in AAH08334 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059602107Q → L.Corresponds to variant rs4265781dbSNPEnsembl.1
Natural variantiVAR_056785596Q → R.Corresponds to variant rs12917189dbSNPEnsembl.1
Natural variantiVAR_017218599N → S in CDAN1A. 1 PublicationCorresponds to variant rs120074166dbSNPEnsembl.1
Natural variantiVAR_017219672P → L in CDAN1A. 1 PublicationCorresponds to variant rs120074167dbSNPEnsembl.1
Natural variantiVAR_017220698E → K in CDAN1A. 1 Publication1
Natural variantiVAR_017221714R → W in CDAN1A; partially disrupts ASF1 binding and loss the ability to arrest cells in S phase and inhibit DNA synthesis. 2 PublicationsCorresponds to variant rs80338696dbSNPEnsembl.1
Natural variantiVAR_017222868F → I in CDAN1A. 1 PublicationCorresponds to variant rs120074168dbSNPEnsembl.1
Natural variantiVAR_017223869V → M in CDAN1A. 1 PublicationCorresponds to variant rs370895637dbSNPEnsembl.1
Natural variantiVAR_056786891R → C.Corresponds to variant rs8023524dbSNPEnsembl.1
Natural variantiVAR_0172241042R → W in CDAN1A; partially disrupts ASF1 binding. 2 PublicationsCorresponds to variant rs80338697dbSNPEnsembl.1
Natural variantiVAR_0172251043D → V in CDAN1A. 1 PublicationCorresponds to variant rs80338698dbSNPEnsembl.1
Natural variantiVAR_0172261130P → L in CDAN1A. 1 PublicationCorresponds to variant rs80338699dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027097190G → GETQLSCRRWVPRRLWGVSH SSSALRSGAPGCR in isoform 1. 1 Publication1
Alternative sequenceiVSP_027098226 – 258Missing in isoform 1. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525398 mRNA. Translation: AAO14994.1. Different initiation.
AC090510 Genomic DNA. No translation available.
BC001092 mRNA. Translation: AAH01092.1.
BC008333 mRNA. Translation: AAH08333.1.
BC008334 mRNA. Translation: AAH08334.1.
BC052568 mRNA. Translation: AAH52568.1. Different initiation.
BC066640 mRNA. Translation: AAH66640.1.
AY358467 mRNA. Translation: AAQ88832.1. Different initiation.
CCDSiCCDS32209.1. [Q8IWY9-2]
RefSeqiNP_612486.2. NM_138477.2. [Q8IWY9-2]
UniGeneiHs.599232.

Genome annotation databases

EnsembliENST00000356231; ENSP00000348564; ENSG00000140326. [Q8IWY9-2]
GeneIDi146059.
KEGGihsa:146059.
UCSCiuc001zql.4. human. [Q8IWY9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525398 mRNA. Translation: AAO14994.1. Different initiation.
AC090510 Genomic DNA. No translation available.
BC001092 mRNA. Translation: AAH01092.1.
BC008333 mRNA. Translation: AAH08333.1.
BC008334 mRNA. Translation: AAH08334.1.
BC052568 mRNA. Translation: AAH52568.1. Different initiation.
BC066640 mRNA. Translation: AAH66640.1.
AY358467 mRNA. Translation: AAQ88832.1. Different initiation.
CCDSiCCDS32209.1. [Q8IWY9-2]
RefSeqiNP_612486.2. NM_138477.2. [Q8IWY9-2]
UniGeneiHs.599232.

3D structure databases

ProteinModelPortaliQ8IWY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126963. 12 interactors.
DIPiDIP-24225N.
IntActiQ8IWY9. 4 interactors.
MINTiMINT-1377874.
STRINGi9606.ENSP00000348564.

PTM databases

iPTMnetiQ8IWY9.
PhosphoSitePlusiQ8IWY9.

Polymorphism and mutation databases

BioMutaiCDAN1.
DMDMi296439465.

Proteomic databases

EPDiQ8IWY9.
PaxDbiQ8IWY9.
PeptideAtlasiQ8IWY9.
PRIDEiQ8IWY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356231; ENSP00000348564; ENSG00000140326. [Q8IWY9-2]
GeneIDi146059.
KEGGihsa:146059.
UCSCiuc001zql.4. human. [Q8IWY9-2]

Organism-specific databases

CTDi146059.
DisGeNETi146059.
GeneCardsiCDAN1.
GeneReviewsiCDAN1.
H-InvDBHIX0202162.
HGNCiHGNC:1713. CDAN1.
HPAiHPA039404.
HPA040787.
MalaCardsiCDAN1.
MIMi224120. phenotype.
607465. gene.
neXtProtiNX_Q8IWY9.
OpenTargetsiENSG00000140326.
Orphaneti98869. Congenital dyserythropoietic anemia type I.
PharmGKBiPA26249.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGHV. Eukaryota.
ENOG410XXWY. LUCA.
GeneTreeiENSGT00390000000491.
HOGENOMiHOG000111492.
HOVERGENiHBG107631.
InParanoidiQ8IWY9.
KOiK19531.
OMAiLSKPKTC.
OrthoDBiEOG091G03X8.
PhylomeDBiQ8IWY9.
TreeFamiTF328405.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124762-MONOMER.

Miscellaneous databases

ChiTaRSiCDAN1. human.
GenomeRNAii146059.
PROiQ8IWY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140326.
CleanExiHS_CDAN1.
ExpressionAtlasiQ8IWY9. baseline and differential.
GenevisibleiQ8IWY9. HS.

Family and domain databases

InterProiIPR028171. Codanin-1_C.
[Graphical view]
PfamiPF15296. Codanin-1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDAN1_HUMAN
AccessioniPrimary (citable) accession number: Q8IWY9
Secondary accession number(s): Q6NYD0, Q7Z7L5, Q969N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.