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Protein

Zinc finger and SCAN domain-containing protein 29

Gene

ZSCAN29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri678 – 70023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri706 – 72823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri734 – 75623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri762 – 78423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri790 – 81223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri818 – 84023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 29
Alternative name(s):
Zinc finger protein 690
Gene namesi
Name:ZSCAN29
Synonyms:ZNF690
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26673. ZSCAN29.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162411015.

Polymorphism and mutation databases

BioMutaiZSCAN29.
DMDMi259016454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Zinc finger and SCAN domain-containing protein 29PRO_0000234011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei153 – 1531PhosphoserineCombined sources
Modified residuei561 – 5611PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IWY8.
MaxQBiQ8IWY8.
PaxDbiQ8IWY8.
PeptideAtlasiQ8IWY8.
PRIDEiQ8IWY8.

PTM databases

iPTMnetiQ8IWY8.
PhosphoSiteiQ8IWY8.

Expressioni

Gene expression databases

BgeeiENSG00000140265.
CleanExiHS_ZSCAN29.
ExpressionAtlasiQ8IWY8. baseline and differential.
GenevisibleiQ8IWY8. HS.

Organism-specific databases

HPAiHPA007241.
HPA011109.

Interactioni

Protein-protein interaction databases

BioGridi126960. 12 interactions.
STRINGi9606.ENSP00000380174.

Structurei

3D structure databases

ProteinModelPortaliQ8IWY8.
SMRiQ8IWY8. Positions 13-99, 621-844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 10083SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri678 – 70023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri706 – 72823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri734 – 75623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri762 – 78423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri790 – 81223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri818 – 84023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOGENOMiHOG000234618.
HOVERGENiHBG018163.
InParanoidiQ8IWY8.
KOiK09230.
OMAiGEPWIPD.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8IWY8.
TreeFamiTF336839.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAKSALREN GTNSETFRQR FRRFHYQEVA GPREAFSQLW ELCCRWLRPE
60 70 80 90 100
VRTKEQIVEL LVLEQFLTVL PGEIQNWVQE QCPENGEEAV TLVEDLEREP
110 120 130 140 150
GRPRSSVTVS VKGQEVRLEK MTPPKSSQEL LSVRQESVEP QPRGVPKKER
160 170 180 190 200
ARSPDLGPQE QMNPKEKLKP FQRSGLPFPK SGVVSRLEQG EPWIPDLLGS
210 220 230 240 250
KEKELPSGSH IGDRRVHADL LPSKKDRRSW VEQDHWSFED EKVAGVHWGY
260 270 280 290 300
EETRTLLAIL SQTEFYEALR NCHRNSQVYG AVAERLREYG FLRTLEQCRT
310 320 330 340 350
KFKGLQKSYR KVKSGHPPET CPFFEEMEAL MSAQVIALPS NGLEAAASHS
360 370 380 390 400
GLVGSDAETE EPGQRGWQHE EGAEEAVAQE SDSDDMDLEA TPQDPNSAAP
410 420 430 440 450
VVFRSPGGVH WGYEETKTYL AILSETQFYE ALRNCHRNSQ LYGAVAERLW
460 470 480 490 500
EYGFLRTPEQ CRTKFKSLQT SYRKVKNGQA PETCPFFEEM DALVSVRVAA
510 520 530 540 550
PPNDGQEETA SCPVQGTSEA EAQKQAEEAD EATEEDSDDD EEDTEIPPGA
560 570 580 590 600
VITRAPVLFQ SPRGFEAGFE NEDNSKRDIS EEVQLHRTLL ARSERKIPRY
610 620 630 640 650
LHQGKGNESD CRSGRQWAKT SGEKRGKLTL PEKSLSEVLS QQRPCLGERP
660 670 680 690 700
YKYLKYSKSF GPNSLLMHQV SHQVENPYKC ADCGKSFSRS ARLIRHRRIH
710 720 730 740 750
TGEKPYKCLD CGKSFRDSSN FITHRRIHTG EKPYQCGECG KCFNQSSSLI
760 770 780 790 800
IHQRTHTGEK PYQCEECGKS FNNSSHFSAH RRIHTGERPH VCPDCGKSFS
810 820 830 840 850
KSSDLRAHHR THTGEKPYGC HDCGKCFSKS SALNKHGEIH AREKLLTQSA

PK
Length:852
Mass (Da):96,719
Last modified:September 22, 2009 - v2
Checksum:iB92BE704821F8EC8
GO
Isoform 2 (identifier: Q8IWY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Note: No experimental confirmation available.
Show »
Length:732
Mass (Da):82,648
Checksum:iA5A7F252E61FA07D
GO
Isoform 3 (identifier: Q8IWY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-557: SVRVAAPPND...PGAVITRAPV → LKLDLRMKII...QRPQGRKEEN
     558-852: Missing.

Note: No experimental confirmation available.
Show »
Length:557
Mass (Da):63,856
Checksum:iE948F6EBC8BE2A5D
GO
Isoform 4 (identifier: Q8IWY8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-564: Missing.

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):53,209
Checksum:i901979E3BA4759DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821G → S in AAI09271 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041R → G.1 Publication
Corresponds to variant rs3809482 [ dbSNP | Ensembl ].
VAR_059949
Natural varianti199 – 1991G → S.1 Publication
Corresponds to variant rs12912744 [ dbSNP | Ensembl ].
VAR_057459

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120Missing in isoform 2. 1 PublicationVSP_018179Add
BLAST
Alternative sequencei176 – 564389Missing in isoform 4. 1 PublicationVSP_018180Add
BLAST
Alternative sequencei495 – 55763SVRVA…TRAPV → LKLDLRMKIIQNGIFLRKYN CIGHYLQDLKGKFPGIFIRV KAMRVTVDQEDSGQRPQGRK EEN in isoform 3. 1 PublicationVSP_018181Add
BLAST
Alternative sequencei558 – 852295Missing in isoform 3. 1 PublicationVSP_018182Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093186 mRNA. Translation: BAC04088.1.
AK122788 mRNA. Translation: BAG53731.1.
AF525399 mRNA. Translation: AAO14995.1.
BC109270 mRNA. Translation: AAI09271.1.
BC109271 mRNA. Translation: AAI09272.1.
CCDSiCCDS10095.2. [Q8IWY8-1]
RefSeqiNP_689668.3. NM_152455.3. [Q8IWY8-1]
XP_006720464.1. XM_006720401.3. [Q8IWY8-1]
XP_011519568.1. XM_011521266.2. [Q8IWY8-1]
UniGeneiHs.418287.

Genome annotation databases

EnsembliENST00000396976; ENSP00000380174; ENSG00000140265. [Q8IWY8-1]
GeneIDi146050.
KEGGihsa:146050.
UCSCiuc001zrk.2. human. [Q8IWY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093186 mRNA. Translation: BAC04088.1.
AK122788 mRNA. Translation: BAG53731.1.
AF525399 mRNA. Translation: AAO14995.1.
BC109270 mRNA. Translation: AAI09271.1.
BC109271 mRNA. Translation: AAI09272.1.
CCDSiCCDS10095.2. [Q8IWY8-1]
RefSeqiNP_689668.3. NM_152455.3. [Q8IWY8-1]
XP_006720464.1. XM_006720401.3. [Q8IWY8-1]
XP_011519568.1. XM_011521266.2. [Q8IWY8-1]
UniGeneiHs.418287.

3D structure databases

ProteinModelPortaliQ8IWY8.
SMRiQ8IWY8. Positions 13-99, 621-844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126960. 12 interactions.
STRINGi9606.ENSP00000380174.

PTM databases

iPTMnetiQ8IWY8.
PhosphoSiteiQ8IWY8.

Polymorphism and mutation databases

BioMutaiZSCAN29.
DMDMi259016454.

Proteomic databases

EPDiQ8IWY8.
MaxQBiQ8IWY8.
PaxDbiQ8IWY8.
PeptideAtlasiQ8IWY8.
PRIDEiQ8IWY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396976; ENSP00000380174; ENSG00000140265. [Q8IWY8-1]
GeneIDi146050.
KEGGihsa:146050.
UCSCiuc001zrk.2. human. [Q8IWY8-1]

Organism-specific databases

CTDi146050.
GeneCardsiZSCAN29.
HGNCiHGNC:26673. ZSCAN29.
HPAiHPA007241.
HPA011109.
neXtProtiNX_Q8IWY8.
PharmGKBiPA162411015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOGENOMiHOG000234618.
HOVERGENiHBG018163.
InParanoidiQ8IWY8.
KOiK09230.
OMAiGEPWIPD.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8IWY8.
TreeFamiTF336839.

Miscellaneous databases

ChiTaRSiZSCAN29. human.
GenomeRNAii146050.
PROiQ8IWY8.

Gene expression databases

BgeeiENSG00000140265.
CleanExiHS_ZSCAN29.
ExpressionAtlasiQ8IWY8. baseline and differential.
GenevisibleiQ8IWY8. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSC29_HUMAN
AccessioniPrimary (citable) accession number: Q8IWY8
Secondary accession number(s): B3KVB9
, Q32M75, Q32M76, Q8NA40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 22, 2009
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.