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UniProtKB - Q8IWY7 (Q8IWY7_HUMAN)

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Protein
Submitted name:

Tau-tubulin kinase

Gene

TTBK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Tau-tubulin kinaseImported
Submitted name:
Tau-tubulin kinase 2Imported
Gene namesi
Name:TTBK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:19141. TTBK2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filamentUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128881.
PharmGKBiPA134913925.

Interactioni

Protein-protein interaction databases

IntActiQ8IWY7. 2 interactors.
STRINGi9606.ENSP00000267890.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 264Protein kinaseInterPro annotationAdd BLAST264

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili452 – 479Sequence analysisAdd BLAST28
Coiled coili529 – 570Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the intermediate filament family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1164. Eukaryota.
ENOG410XPGP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000232043.
HOVERGENiHBG061812.
KOiK08815.
OMAiHCKPSKN.
OrthoDBiEOG091G03H8.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
PfamiView protein in Pfam
PF00038. Filament. 2 hits.
PF16208. Keratin_2_head. 1 hit.
PF00069. Pkinase. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IWY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVEKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCCFEK 
        60         70         80         90        100
AARKDHVCRF IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR 
       110        120        130        140        150
LGRQILESIE SIHSVGFLHR DIKPSNFAMG RFPSTCRKCY MLDFGLARQF 
       160        170        180        190        200
TNSCGDVRPP RAVAGFRGTV RYASINAHRN REMGRHDDLW SLFYMLVEFV 
       210        220        230        240        250
VGQLPWRKIK DKEQVGSIKE RYDHRLMLKH LPPEFSIFLD HISSLDYFTK 
       260        270        280        290        300
PDYQMSIRVT RKSYKVSTSG PQAFNSLSYT SGPGACISSS SFSRMGSSSF 
       310        320        330        340        350
RGGLGAGYGG ASGGITTITV NQSLLSPLNL EVDPNIQAVR TQEEKQIKTL 
       360        370        380        390        400
NNKFFSFIDK VRFLEQQNKM LETKWSLVQQ QKMARSNMDN MFESYINNLK 
       410        420        430        440        450
WQLETLGQEK LKLEAELGNM HGLVEDFRNK YEVEISKCTE MENEFVLIKE 
       460        470        480        490        500
YVDEAYMNKM ELESSLKELT AKISFLRQLY EEEIGSCSPR SRIHLWCCSW 
       510        520        530        540        550
TTAASWTWTA SSLRSRPEGF PGGCHADTEQ RGELAIKDAN AKLSELEAAL 
       560        570        580        590        600
QLASQDMARQ LREYQELMNV KLALDIKIAT YRKLLEGEES WLESGMQNMS 
       610        620        630        640        650
IHMKTTSSYA GGQSLAYGGL TSPGLSYGLG SSFGSGMGSS SFSHTSSSRA 
       660        670        680        690        700
VVMKKIETRD GKLVSESSNV LPNLRITATL LTSVFDNSIK TFGVIESDPF 
       710        720        730        740        750
DWEKTGNDGS LTTTTTSTTP QLHTRLTPAA IGIANATPIP GDLLRENTDE 
       760        770        780        790        800
VFPDEQLSDG ENGIPVGVSP DKLPGSLGHP RPQEKDVWEE MDANKNKIKL 
       810        820        830        840        850
GICKAATEEE NSHGQANGLL NAPSLGSPIR VRSEITQPDR DIPLVRKLRS 
       860        870        880        890        900
IHSFELEKRL TLEPKPDTDK FLETCLEKMQ KDTSAGKESI LPALLHKPCV 
       910        920        930        940        950
PAVSRTDHIW HYDEEYLPDA SKPASANTPE QADGGGSNGF IAVNLSSCKQ 
       960        970        980        990       1000
EIDSKEWVIV DKEQDLQDFR TNEAVGHKTT GSPSDEEPEV LQVLEASPQD 
      1010       1020       1030       1040       1050
EKLQLGPWAE NDHLKKETSG VVLALSAEGP PTAASEQYTD RLELQPGAAS 
      1060       1070       1080       1090       1100
QFIAATPTSL MEAQAEGPLT AITIPRPSVA STQSTSGSFH CGQQPEKKDL 
      1110       1120       1130       1140       1150
QPMEPTVELY SPRENFSGLV VTEGEPPSGG SRTDLGLQID HIGHDMLPNI 
      1160       1170       1180       1190       1200
RESNKSQDLG PKELPDHNRL VVREFENLPG ETEEKSILLE SDNEDEKLSR 
      1210       1220       1230       1240       1250
GQHCIEISSL PGDLVIVEKD HSATTEPLDV TKTQTFSVVP NQDKNNEIMK 
      1260       1270       1280       1290       1300
LLTVGTSEIS SRDIDPHVEG QIGQVAEMQK NKISKDDDIM SEDLPGHQGD 
      1310       1320       1330       1340       1350
LSTFLHQEGK REKITPRNGE LFHCVSENEH GAPTRKDMVR SSFVTRHSRI 
      1360       1370       1380       1390       1400
PVLAQEIDST LESSSPVSAK EKLLQKKAYQ PDLVKLLVEK RQFKSFLGDL 
      1410       1420       1430       1440       1450
SSASDKLLEE KLATVPAPFC EEEVLTPFSR LTVDSHLSRS AEDSFLSPII 
      1460       1470       1480       1490       1500
SQSRKSKIPR PVSWVNTDQV NSSTSSQFFP RPPPGKPPTR PGVEARLRRY 
      1510       1520       1530       1540       1550
KVLGSSNSDS DLFSRLAQIL QNGSQKPRST TQCKSPGSPH NPKTPPKSPV 
      1560       1570       1580       1590       1600
VPRRSPSASP RSSSLPRTSS SSPSRAGRPH HDQRSSSPHL GRSKSPPSHS 
      1610       1620       1630       1640 
GSSSSRRSCQ QEHCKPSKNG LKGSGSLHHH SASTKTPQGK SKPASKLSR
Length:1,649
Mass (Da):182,467
Last modified:March 1, 2003 - v1
Checksum:i48730481D24E58CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068727 Genomic DNA. No translation available.
AC090510 Genomic DNA. No translation available.
AC090514 Genomic DNA. No translation available.
AF525400 mRNA. Translation: AAO14996.1.
RefSeqiNP_775771.3. NM_173500.3.
UniGeneiHs.646511.
Hs.727864.
Hs.733489.

Genome annotation databases

EnsembliENST00000622375; ENSP00000479984; ENSG00000128881.
GeneIDi146057.
KEGGihsa:146057.
UCSCiuc059igh.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068727 Genomic DNA. No translation available.
AC090510 Genomic DNA. No translation available.
AC090514 Genomic DNA. No translation available.
AF525400 mRNA. Translation: AAO14996.1.
RefSeqiNP_775771.3. NM_173500.3.
UniGeneiHs.646511.
Hs.727864.
Hs.733489.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IWY7. 2 interactors.
STRINGi9606.ENSP00000267890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000622375; ENSP00000479984; ENSG00000128881.
GeneIDi146057.
KEGGihsa:146057.
UCSCiuc059igh.1. human.

Organism-specific databases

CTDi146057.
HGNCiHGNC:19141. TTBK2.
OpenTargetsiENSG00000128881.
PharmGKBiPA134913925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1164. Eukaryota.
ENOG410XPGP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000232043.
HOVERGENiHBG061812.
KOiK08815.
OMAiHCKPSKN.
OrthoDBiEOG091G03H8.

Miscellaneous databases

GenomeRNAii146057.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
PfamiView protein in Pfam
PF00038. Filament. 2 hits.
PF16208. Keratin_2_head. 1 hit.
PF00069. Pkinase. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IWY7_HUMAN
AccessioniPrimary (citable) accession number: Q8IWY7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.