TTBK2

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein kinase activity Source: InterPro
structural molecule activity Source: InterPro

Keywords - Molecular functionⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Tau-tubulin kinaseImported Automatic assertion inferred from database entriesⁱ EMBL:AAO14996.1 Submitted name: Tau-tubulin kinase 2Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000479984
Gene namesⁱ	Name:TTBK2Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000479984
Organismⁱ	Homo sapiens (Human)Imported Automatic assertion inferred from database entriesⁱ EMBL:AAO14996.1
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

HGNCⁱ	HGNC:19141. TTBK2.

HGNCⁱ

HGNC:19141. TTBK2.

Subcellular locationⁱ

GO - Cellular componentⁱ

keratin filament Source: InterPro

Complete GO annotation...

Keywords - Cellular componentⁱ

Intermediate filamentUniRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA134913925.

PharmGKBⁱ

PA134913925.

PTM / Processingⁱ

Proteomic databases

EPDⁱ	Q8IWY7.
MaxQBⁱ	Q8IWY7.
PeptideAtlasⁱ	Q8IWY7.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000267890.

STRINGⁱ

9606.ENSP00000267890.

Structureⁱ

3D structure databases

SMRⁱ	Q8IWY7. Positions 48-265, 526-587.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	1 – 264	264	Protein kinaseInterPro annotation Automatic assertion inferred from signature matchⁱ PROSITE:PS50011			Add BLAST

Coiled coil

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Coiled coilⁱ	452 – 479	28	Sequence analysis Automatic assertion according to rulesⁱ SAM:Coils			Add BLAST
Coiled coilⁱ	529 – 570	42	Sequence analysis Automatic assertion according to rulesⁱ SAM:Coils			Add BLAST

Sequence similaritiesⁱ

Belongs to the intermediate filament family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG1164. Eukaryota. ENOG410XPGP. LUCA.
GeneTreeⁱ	ENSGT00760000119040.
HOGENOMⁱ	HOG000232043.
HOVERGENⁱ	HBG061812.
KOⁱ	K08815.
OMAⁱ	HCKPSKN.
OrthoDBⁱ	EOG091G03H8.
PhylomeDBⁱ	Q8IWY7.

Family and domain databases

InterProⁱ	IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR032444. Keratin_2_head. IPR003054. Keratin_II. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. [Graphical view]
Pfamⁱ	PF00038. Filament. 2 hits. PF16208. Keratin_2_head. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTSⁱ	PR01276. TYPE2KERATIN.
SMARTⁱ	SM01391. Filament. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	PS00226. IF. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8IWY7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MESVEKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCCFEK 
        60         70         80         90        100
AARKDHVCRF IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR 
       110        120        130        140        150
LGRQILESIE SIHSVGFLHR DIKPSNFAMG RFPSTCRKCY MLDFGLARQF 
       160        170        180        190        200
TNSCGDVRPP RAVAGFRGTV RYASINAHRN REMGRHDDLW SLFYMLVEFV 
       210        220        230        240        250
VGQLPWRKIK DKEQVGSIKE RYDHRLMLKH LPPEFSIFLD HISSLDYFTK 
       260        270        280        290        300
PDYQMSIRVT RKSYKVSTSG PQAFNSLSYT SGPGACISSS SFSRMGSSSF 
       310        320        330        340        350
RGGLGAGYGG ASGGITTITV NQSLLSPLNL EVDPNIQAVR TQEEKQIKTL 
       360        370        380        390        400
NNKFFSFIDK VRFLEQQNKM LETKWSLVQQ QKMARSNMDN MFESYINNLK 
       410        420        430        440        450
WQLETLGQEK LKLEAELGNM HGLVEDFRNK YEVEISKCTE MENEFVLIKE 
       460        470        480        490        500
YVDEAYMNKM ELESSLKELT AKISFLRQLY EEEIGSCSPR SRIHLWCCSW 
       510        520        530        540        550
TTAASWTWTA SSLRSRPEGF PGGCHADTEQ RGELAIKDAN AKLSELEAAL 
       560        570        580        590        600
QLASQDMARQ LREYQELMNV KLALDIKIAT YRKLLEGEES WLESGMQNMS 
       610        620        630        640        650
IHMKTTSSYA GGQSLAYGGL TSPGLSYGLG SSFGSGMGSS SFSHTSSSRA 
       660        670        680        690        700
VVMKKIETRD GKLVSESSNV LPNLRITATL LTSVFDNSIK TFGVIESDPF 
       710        720        730        740        750
DWEKTGNDGS LTTTTTSTTP QLHTRLTPAA IGIANATPIP GDLLRENTDE 
       760        770        780        790        800
VFPDEQLSDG ENGIPVGVSP DKLPGSLGHP RPQEKDVWEE MDANKNKIKL 
       810        820        830        840        850
GICKAATEEE NSHGQANGLL NAPSLGSPIR VRSEITQPDR DIPLVRKLRS 
       860        870        880        890        900
IHSFELEKRL TLEPKPDTDK FLETCLEKMQ KDTSAGKESI LPALLHKPCV 
       910        920        930        940        950
PAVSRTDHIW HYDEEYLPDA SKPASANTPE QADGGGSNGF IAVNLSSCKQ 
       960        970        980        990       1000
EIDSKEWVIV DKEQDLQDFR TNEAVGHKTT GSPSDEEPEV LQVLEASPQD 
      1010       1020       1030       1040       1050
EKLQLGPWAE NDHLKKETSG VVLALSAEGP PTAASEQYTD RLELQPGAAS 
      1060       1070       1080       1090       1100
QFIAATPTSL MEAQAEGPLT AITIPRPSVA STQSTSGSFH CGQQPEKKDL 
      1110       1120       1130       1140       1150
QPMEPTVELY SPRENFSGLV VTEGEPPSGG SRTDLGLQID HIGHDMLPNI 
      1160       1170       1180       1190       1200
RESNKSQDLG PKELPDHNRL VVREFENLPG ETEEKSILLE SDNEDEKLSR 
      1210       1220       1230       1240       1250
GQHCIEISSL PGDLVIVEKD HSATTEPLDV TKTQTFSVVP NQDKNNEIMK 
      1260       1270       1280       1290       1300
LLTVGTSEIS SRDIDPHVEG QIGQVAEMQK NKISKDDDIM SEDLPGHQGD 
      1310       1320       1330       1340       1350
LSTFLHQEGK REKITPRNGE LFHCVSENEH GAPTRKDMVR SSFVTRHSRI 
      1360       1370       1380       1390       1400
PVLAQEIDST LESSSPVSAK EKLLQKKAYQ PDLVKLLVEK RQFKSFLGDL 
      1410       1420       1430       1440       1450
SSASDKLLEE KLATVPAPFC EEEVLTPFSR LTVDSHLSRS AEDSFLSPII 
      1460       1470       1480       1490       1500
SQSRKSKIPR PVSWVNTDQV NSSTSSQFFP RPPPGKPPTR PGVEARLRRY 
      1510       1520       1530       1540       1550
KVLGSSNSDS DLFSRLAQIL QNGSQKPRST TQCKSPGSPH NPKTPPKSPV 
      1560       1570       1580       1590       1600
VPRRSPSASP RSSSLPRTSS SSPSRAGRPH HDQRSSSPHL GRSKSPPSHS 
      1610       1620       1630       1640 
GSSSSRRSCQ QEHCKPSKNG LKGSGSLHHH SASTKTPQGK SKPASKLSR

Length:1,649

Mass (Da):182,467

Last modified:March 1, 2003 - v1

Checksum:ⁱ48730481D24E58CE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC068727 Genomic DNA. No translation available. AC090510 Genomic DNA. No translation available. AC090514 Genomic DNA. No translation available. AF525400 mRNA. Translation: AAO14996.1.
RefSeqⁱ	NP_775771.3. NM_173500.3.
UniGeneⁱ	Hs.646511. Hs.727864. Hs.733489.

Genome annotation databases

Ensemblⁱ	ENST00000622375; ENSP00000479984; ENSG00000128881.
GeneIDⁱ	146057.
KEGGⁱ	hsa:146057.
UCSCⁱ	uc059igh.1. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC068727 Genomic DNA. No translation available. AC090510 Genomic DNA. No translation available. AC090514 Genomic DNA. No translation available. AF525400 mRNA. Translation: AAO14996.1.
RefSeqⁱ	NP_775771.3. NM_173500.3.
UniGeneⁱ	Hs.646511. Hs.727864. Hs.733489.

3D structure databases

SMRⁱ	Q8IWY7. Positions 48-265, 526-587.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000267890.

STRINGⁱ

9606.ENSP00000267890.

Proteomic databases

EPDⁱ	Q8IWY7.
MaxQBⁱ	Q8IWY7.
PeptideAtlasⁱ	Q8IWY7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000622375; ENSP00000479984; ENSG00000128881.
GeneIDⁱ	146057.
KEGGⁱ	hsa:146057.
UCSCⁱ	uc059igh.1. human.

Organism-specific databases

CTDⁱ	146057.
HGNCⁱ	HGNC:19141. TTBK2.
PharmGKBⁱ	PA134913925.
GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1164. Eukaryota. ENOG410XPGP. LUCA.
GeneTreeⁱ	ENSGT00760000119040.
HOGENOMⁱ	HOG000232043.
HOVERGENⁱ	HBG061812.
KOⁱ	K08815.
OMAⁱ	HCKPSKN.
OrthoDBⁱ	EOG091G03H8.
PhylomeDBⁱ	Q8IWY7.

Miscellaneous databases

GenomeRNAiⁱ	146057.

GenomeRNAiⁱ

146057.

Family and domain databases

InterProⁱ	IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR032444. Keratin_2_head. IPR003054. Keratin_II. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. [Graphical view]
Pfamⁱ	PF00038. Filament. 2 hits. PF16208. Keratin_2_head. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTSⁱ	PR01276. TYPE2KERATIN.
SMARTⁱ	SM01391. Filament. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	PS00226. IF. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

Q8IWY7_HUMAN

Accessionⁱ

Primary (citable) accession number: Q8IWY7

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IWY7 (Q8IWY7_HUMAN)

UniProt

Q8IWY7 - Q8IWY7_HUMAN

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Tau-tubulin kinase

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ