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Q8IWY7

- Q8IWY7_HUMAN

UniProt

Q8IWY7 - Q8IWY7_HUMAN

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Protein
Submitted name:

Tau-tubulin kinase

Gene

TTBK2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein kinase activity Source: InterPro
  3. structural molecule activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

SignaLinkiQ8IWY7.

Names & Taxonomyi

Protein namesi
Submitted name:
Tau-tubulin kinaseImported
Submitted name:
Tau-tubulin kinase 2Imported
Gene namesi
Name:TTBK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:19141. TTBK2.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filamentUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913925.

PTM / Processingi

Proteomic databases

MaxQBiQ8IWY7.
PRIDEiQ8IWY7.

Expressioni

Gene expression databases

ExpressionAtlasiQ8IWY7. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ8IWY7. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8IWY7.
SMRiQ8IWY7. Positions 526-587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intermediate filament family.UniRule annotation

Keywords - Domaini

Coiled coilSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119040.
HOGENOMiHOG000232043.
HOVERGENiHBG061812.
KOiK08815.
PhylomeDBiQ8IWY7.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00038. Filament. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00226. IF. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWY7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESVEKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCCFEK
60 70 80 90 100
AARKDHVCRF IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR
110 120 130 140 150
LGRQILESIE SIHSVGFLHR DIKPSNFAMG RFPSTCRKCY MLDFGLARQF
160 170 180 190 200
TNSCGDVRPP RAVAGFRGTV RYASINAHRN REMGRHDDLW SLFYMLVEFV
210 220 230 240 250
VGQLPWRKIK DKEQVGSIKE RYDHRLMLKH LPPEFSIFLD HISSLDYFTK
260 270 280 290 300
PDYQMSIRVT RKSYKVSTSG PQAFNSLSYT SGPGACISSS SFSRMGSSSF
310 320 330 340 350
RGGLGAGYGG ASGGITTITV NQSLLSPLNL EVDPNIQAVR TQEEKQIKTL
360 370 380 390 400
NNKFFSFIDK VRFLEQQNKM LETKWSLVQQ QKMARSNMDN MFESYINNLK
410 420 430 440 450
WQLETLGQEK LKLEAELGNM HGLVEDFRNK YEVEISKCTE MENEFVLIKE
460 470 480 490 500
YVDEAYMNKM ELESSLKELT AKISFLRQLY EEEIGSCSPR SRIHLWCCSW
510 520 530 540 550
TTAASWTWTA SSLRSRPEGF PGGCHADTEQ RGELAIKDAN AKLSELEAAL
560 570 580 590 600
QLASQDMARQ LREYQELMNV KLALDIKIAT YRKLLEGEES WLESGMQNMS
610 620 630 640 650
IHMKTTSSYA GGQSLAYGGL TSPGLSYGLG SSFGSGMGSS SFSHTSSSRA
660 670 680 690 700
VVMKKIETRD GKLVSESSNV LPNLRITATL LTSVFDNSIK TFGVIESDPF
710 720 730 740 750
DWEKTGNDGS LTTTTTSTTP QLHTRLTPAA IGIANATPIP GDLLRENTDE
760 770 780 790 800
VFPDEQLSDG ENGIPVGVSP DKLPGSLGHP RPQEKDVWEE MDANKNKIKL
810 820 830 840 850
GICKAATEEE NSHGQANGLL NAPSLGSPIR VRSEITQPDR DIPLVRKLRS
860 870 880 890 900
IHSFELEKRL TLEPKPDTDK FLETCLEKMQ KDTSAGKESI LPALLHKPCV
910 920 930 940 950
PAVSRTDHIW HYDEEYLPDA SKPASANTPE QADGGGSNGF IAVNLSSCKQ
960 970 980 990 1000
EIDSKEWVIV DKEQDLQDFR TNEAVGHKTT GSPSDEEPEV LQVLEASPQD
1010 1020 1030 1040 1050
EKLQLGPWAE NDHLKKETSG VVLALSAEGP PTAASEQYTD RLELQPGAAS
1060 1070 1080 1090 1100
QFIAATPTSL MEAQAEGPLT AITIPRPSVA STQSTSGSFH CGQQPEKKDL
1110 1120 1130 1140 1150
QPMEPTVELY SPRENFSGLV VTEGEPPSGG SRTDLGLQID HIGHDMLPNI
1160 1170 1180 1190 1200
RESNKSQDLG PKELPDHNRL VVREFENLPG ETEEKSILLE SDNEDEKLSR
1210 1220 1230 1240 1250
GQHCIEISSL PGDLVIVEKD HSATTEPLDV TKTQTFSVVP NQDKNNEIMK
1260 1270 1280 1290 1300
LLTVGTSEIS SRDIDPHVEG QIGQVAEMQK NKISKDDDIM SEDLPGHQGD
1310 1320 1330 1340 1350
LSTFLHQEGK REKITPRNGE LFHCVSENEH GAPTRKDMVR SSFVTRHSRI
1360 1370 1380 1390 1400
PVLAQEIDST LESSSPVSAK EKLLQKKAYQ PDLVKLLVEK RQFKSFLGDL
1410 1420 1430 1440 1450
SSASDKLLEE KLATVPAPFC EEEVLTPFSR LTVDSHLSRS AEDSFLSPII
1460 1470 1480 1490 1500
SQSRKSKIPR PVSWVNTDQV NSSTSSQFFP RPPPGKPPTR PGVEARLRRY
1510 1520 1530 1540 1550
KVLGSSNSDS DLFSRLAQIL QNGSQKPRST TQCKSPGSPH NPKTPPKSPV
1560 1570 1580 1590 1600
VPRRSPSASP RSSSLPRTSS SSPSRAGRPH HDQRSSSPHL GRSKSPPSHS
1610 1620 1630 1640
GSSSSRRSCQ QEHCKPSKNG LKGSGSLHHH SASTKTPQGK SKPASKLSR
Length:1,649
Mass (Da):182,467
Last modified:March 1, 2003 - v1
Checksum:i48730481D24E58CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068727 Genomic DNA. No translation available.
AC090510 Genomic DNA. No translation available.
AC090514 Genomic DNA. No translation available.
AF525400 mRNA. Translation: AAO14996.1.
RefSeqiNP_775771.3. NM_173500.3.
UniGeneiHs.646511.
Hs.727864.
Hs.733489.

Genome annotation databases

EnsembliENST00000622375; ENSP00000479984; ENSG00000128881.
GeneIDi146057.
KEGGihsa:146057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068727 Genomic DNA. No translation available.
AC090510 Genomic DNA. No translation available.
AC090514 Genomic DNA. No translation available.
AF525400 mRNA. Translation: AAO14996.1 .
RefSeqi NP_775771.3. NM_173500.3.
UniGenei Hs.646511.
Hs.727864.
Hs.733489.

3D structure databases

ProteinModelPortali Q8IWY7.
SMRi Q8IWY7. Positions 526-587.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8IWY7. 2 interactions.

Proteomic databases

MaxQBi Q8IWY7.
PRIDEi Q8IWY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000622375 ; ENSP00000479984 ; ENSG00000128881 .
GeneIDi 146057.
KEGGi hsa:146057.

Organism-specific databases

CTDi 146057.
HGNCi HGNC:19141. TTBK2.
PharmGKBi PA134913925.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119040.
HOGENOMi HOG000232043.
HOVERGENi HBG061812.
KOi K08815.
PhylomeDBi Q8IWY7.

Enzyme and pathway databases

SignaLinki Q8IWY7.

Miscellaneous databases

GenomeRNAii 146057.
NextBioi 85251.

Gene expression databases

ExpressionAtlasi Q8IWY7. baseline and differential.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00038. Filament. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00226. IF. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ8IWY7_HUMAN
AccessioniPrimary (citable) accession number: Q8IWY7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3