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Q8IWY7

- Q8IWY7_HUMAN

UniProt

Q8IWY7 - Q8IWY7_HUMAN

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Protein
Submitted name:

Tau-tubulin kinase

Gene
TTBK2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein kinase activity Source: InterPro
  3. structural molecule activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

SignaLinkiQ8IWY7.

Names & Taxonomyi

Protein namesi
Submitted name:
Tau-tubulin kinaseImported
Gene namesi
Name:TTBK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filamentUniRule annotationSAAS annotations

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913925.

PTM / Processingi

Proteomic databases

MaxQBiQ8IWY7.
PRIDEiQ8IWY7.

Interactioni

Protein-protein interaction databases

IntActiQ8IWY7. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8IWY7.
SMRiQ8IWY7. Positions 526-587.

Family & Domainsi

Sequence similaritiesi

Belongs to the intermediate filament family.UniRule annotation

Keywords - Domaini

Coiled coilSAAS annotations

Phylogenomic databases

HOGENOMiHOG000232043.
HOVERGENiHBG061812.
KOiK08815.
PhylomeDBiQ8IWY7.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00038. Filament. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00226. IF. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWY7-1 [UniParc]FASTAAdd to Basket

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MESVEKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCCFEK     50
AARKDHVCRF IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR 100
LGRQILESIE SIHSVGFLHR DIKPSNFAMG RFPSTCRKCY MLDFGLARQF 150
TNSCGDVRPP RAVAGFRGTV RYASINAHRN REMGRHDDLW SLFYMLVEFV 200
VGQLPWRKIK DKEQVGSIKE RYDHRLMLKH LPPEFSIFLD HISSLDYFTK 250
PDYQMSIRVT RKSYKVSTSG PQAFNSLSYT SGPGACISSS SFSRMGSSSF 300
RGGLGAGYGG ASGGITTITV NQSLLSPLNL EVDPNIQAVR TQEEKQIKTL 350
NNKFFSFIDK VRFLEQQNKM LETKWSLVQQ QKMARSNMDN MFESYINNLK 400
WQLETLGQEK LKLEAELGNM HGLVEDFRNK YEVEISKCTE MENEFVLIKE 450
YVDEAYMNKM ELESSLKELT AKISFLRQLY EEEIGSCSPR SRIHLWCCSW 500
TTAASWTWTA SSLRSRPEGF PGGCHADTEQ RGELAIKDAN AKLSELEAAL 550
QLASQDMARQ LREYQELMNV KLALDIKIAT YRKLLEGEES WLESGMQNMS 600
IHMKTTSSYA GGQSLAYGGL TSPGLSYGLG SSFGSGMGSS SFSHTSSSRA 650
VVMKKIETRD GKLVSESSNV LPNLRITATL LTSVFDNSIK TFGVIESDPF 700
DWEKTGNDGS LTTTTTSTTP QLHTRLTPAA IGIANATPIP GDLLRENTDE 750
VFPDEQLSDG ENGIPVGVSP DKLPGSLGHP RPQEKDVWEE MDANKNKIKL 800
GICKAATEEE NSHGQANGLL NAPSLGSPIR VRSEITQPDR DIPLVRKLRS 850
IHSFELEKRL TLEPKPDTDK FLETCLEKMQ KDTSAGKESI LPALLHKPCV 900
PAVSRTDHIW HYDEEYLPDA SKPASANTPE QADGGGSNGF IAVNLSSCKQ 950
EIDSKEWVIV DKEQDLQDFR TNEAVGHKTT GSPSDEEPEV LQVLEASPQD 1000
EKLQLGPWAE NDHLKKETSG VVLALSAEGP PTAASEQYTD RLELQPGAAS 1050
QFIAATPTSL MEAQAEGPLT AITIPRPSVA STQSTSGSFH CGQQPEKKDL 1100
QPMEPTVELY SPRENFSGLV VTEGEPPSGG SRTDLGLQID HIGHDMLPNI 1150
RESNKSQDLG PKELPDHNRL VVREFENLPG ETEEKSILLE SDNEDEKLSR 1200
GQHCIEISSL PGDLVIVEKD HSATTEPLDV TKTQTFSVVP NQDKNNEIMK 1250
LLTVGTSEIS SRDIDPHVEG QIGQVAEMQK NKISKDDDIM SEDLPGHQGD 1300
LSTFLHQEGK REKITPRNGE LFHCVSENEH GAPTRKDMVR SSFVTRHSRI 1350
PVLAQEIDST LESSSPVSAK EKLLQKKAYQ PDLVKLLVEK RQFKSFLGDL 1400
SSASDKLLEE KLATVPAPFC EEEVLTPFSR LTVDSHLSRS AEDSFLSPII 1450
SQSRKSKIPR PVSWVNTDQV NSSTSSQFFP RPPPGKPPTR PGVEARLRRY 1500
KVLGSSNSDS DLFSRLAQIL QNGSQKPRST TQCKSPGSPH NPKTPPKSPV 1550
VPRRSPSASP RSSSLPRTSS SSPSRAGRPH HDQRSSSPHL GRSKSPPSHS 1600
GSSSSRRSCQ QEHCKPSKNG LKGSGSLHHH SASTKTPQGK SKPASKLSR 1649
Length:1,649
Mass (Da):182,467
Last modified:March 1, 2003 - v1
Checksum:i48730481D24E58CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF525400 mRNA. Translation: AAO14996.1.
RefSeqiNP_775771.3. NM_173500.3.
UniGeneiHs.646511.
Hs.727864.
Hs.733489.

Genome annotation databases

GeneIDi146057.
KEGGihsa:146057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF525400 mRNA. Translation: AAO14996.1 .
RefSeqi NP_775771.3. NM_173500.3.
UniGenei Hs.646511.
Hs.727864.
Hs.733489.

3D structure databases

ProteinModelPortali Q8IWY7.
SMRi Q8IWY7. Positions 526-587.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8IWY7. 2 interactions.

Proteomic databases

MaxQBi Q8IWY7.
PRIDEi Q8IWY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 146057.
KEGGi hsa:146057.

Organism-specific databases

CTDi 146057.
PharmGKBi PA134913925.

Phylogenomic databases

HOGENOMi HOG000232043.
HOVERGENi HBG061812.
KOi K08815.
PhylomeDBi Q8IWY7.

Enzyme and pathway databases

SignaLinki Q8IWY7.

Miscellaneous databases

GenomeRNAii 146057.
NextBioi 85251.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00038. Filament. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00226. IF. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8IWY7_HUMAN
AccessioniPrimary (citable) accession number: Q8IWY7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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