Q8IWY7 (Q8IWY7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tau-tubulin kinase EMBL AAO14996.1

Gene names

Name:

TTBK2 HGNC 19141

Organism

Homo sapiens (Human) EMBL AAO14996.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1649 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the intermediate filament family. RuleBase RU000685

Ontologies

Keywords
Cellular component	Intermediate filament SAAS SAAS018039 RuleBase RU000685
Domain	Coiled coil SAAS SAAS018039
Molecular function	Kinase EMBL AAO14996.1 Transferase
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro protein kinase activity Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IWY7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 48730481D24E58CE	FASTA	1,649	182,467
	10 20 30 40 50 60 MESVEKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCCFEK AARKDHVCRF 70 80 90 100 110 120 IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR LGRQILESIE SIHSVGFLHR 130 140 150 160 170 180 DIKPSNFAMG RFPSTCRKCY MLDFGLARQF TNSCGDVRPP RAVAGFRGTV RYASINAHRN 190 200 210 220 230 240 REMGRHDDLW SLFYMLVEFV VGQLPWRKIK DKEQVGSIKE RYDHRLMLKH LPPEFSIFLD 250 260 270 280 290 300 HISSLDYFTK PDYQMSIRVT RKSYKVSTSG PQAFNSLSYT SGPGACISSS SFSRMGSSSF 310 320 330 340 350 360 RGGLGAGYGG ASGGITTITV NQSLLSPLNL EVDPNIQAVR TQEEKQIKTL NNKFFSFIDK 370 380 390 400 410 420 VRFLEQQNKM LETKWSLVQQ QKMARSNMDN MFESYINNLK WQLETLGQEK LKLEAELGNM 430 440 450 460 470 480 HGLVEDFRNK YEVEISKCTE MENEFVLIKE YVDEAYMNKM ELESSLKELT AKISFLRQLY 490 500 510 520 530 540 EEEIGSCSPR SRIHLWCCSW TTAASWTWTA SSLRSRPEGF PGGCHADTEQ RGELAIKDAN 550 560 570 580 590 600 AKLSELEAAL QLASQDMARQ LREYQELMNV KLALDIKIAT YRKLLEGEES WLESGMQNMS 610 620 630 640 650 660 IHMKTTSSYA GGQSLAYGGL TSPGLSYGLG SSFGSGMGSS SFSHTSSSRA VVMKKIETRD 670 680 690 700 710 720 GKLVSESSNV LPNLRITATL LTSVFDNSIK TFGVIESDPF DWEKTGNDGS LTTTTTSTTP 730 740 750 760 770 780 QLHTRLTPAA IGIANATPIP GDLLRENTDE VFPDEQLSDG ENGIPVGVSP DKLPGSLGHP 790 800 810 820 830 840 RPQEKDVWEE MDANKNKIKL GICKAATEEE NSHGQANGLL NAPSLGSPIR VRSEITQPDR 850 860 870 880 890 900 DIPLVRKLRS IHSFELEKRL TLEPKPDTDK FLETCLEKMQ KDTSAGKESI LPALLHKPCV 910 920 930 940 950 960 PAVSRTDHIW HYDEEYLPDA SKPASANTPE QADGGGSNGF IAVNLSSCKQ EIDSKEWVIV 970 980 990 1000 1010 1020 DKEQDLQDFR TNEAVGHKTT GSPSDEEPEV LQVLEASPQD EKLQLGPWAE NDHLKKETSG 1030 1040 1050 1060 1070 1080 VVLALSAEGP PTAASEQYTD RLELQPGAAS QFIAATPTSL MEAQAEGPLT AITIPRPSVA 1090 1100 1110 1120 1130 1140 STQSTSGSFH CGQQPEKKDL QPMEPTVELY SPRENFSGLV VTEGEPPSGG SRTDLGLQID 1150 1160 1170 1180 1190 1200 HIGHDMLPNI RESNKSQDLG PKELPDHNRL VVREFENLPG ETEEKSILLE SDNEDEKLSR 1210 1220 1230 1240 1250 1260 GQHCIEISSL PGDLVIVEKD HSATTEPLDV TKTQTFSVVP NQDKNNEIMK LLTVGTSEIS 1270 1280 1290 1300 1310 1320 SRDIDPHVEG QIGQVAEMQK NKISKDDDIM SEDLPGHQGD LSTFLHQEGK REKITPRNGE 1330 1340 1350 1360 1370 1380 LFHCVSENEH GAPTRKDMVR SSFVTRHSRI PVLAQEIDST LESSSPVSAK EKLLQKKAYQ 1390 1400 1410 1420 1430 1440 PDLVKLLVEK RQFKSFLGDL SSASDKLLEE KLATVPAPFC EEEVLTPFSR LTVDSHLSRS 1450 1460 1470 1480 1490 1500 AEDSFLSPII SQSRKSKIPR PVSWVNTDQV NSSTSSQFFP RPPPGKPPTR PGVEARLRRY 1510 1520 1530 1540 1550 1560 KVLGSSNSDS DLFSRLAQIL QNGSQKPRST TQCKSPGSPH NPKTPPKSPV VPRRSPSASP 1570 1580 1590 1600 1610 1620 RSSSLPRTSS SSPSRAGRPH HDQRSSSPHL GRSKSPPSHS GSSSSRRSCQ QEHCKPSKNG 1630 1640 LKGSGSLHHH SASTKTPQGK SKPASKLSR

References

[1]

"Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1." Dgany O., Avidan N., Delaunay J., Krasnov T., Shalmon L., Shalev H., Eidelitz-Markus T., Kapelushnik J., Cattan D., Pariente A., Tulliez M., Cretien A., Schischmanoff P.-O., Iolascon A., Fibach E., Koren A., Roessler J., Le Merrer M. , Yaniv I., Zaizov R., Ben-Asher E., Olender T., Lancet D., Beckmann J.S., Tamary H. Am. J. Hum. Genet. 71:1467-1474(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF525400 mRNA. Translation: AAO14996.1.
RefSeq	NP_775771.3. NM_173500.3.
UniGene	Hs.646511. Hs.727864.
3D structure databases
ProteinModelPortal	Q8IWY7.
SMR	Q8IWY7. Positions 526-587.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
IntAct	Q8IWY7. 2 interactions.
Proteomic databases
PRIDE	Q8IWY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	146057.
KEGG	hsa:146057.
Organism-specific databases
CTD	146057.
PharmGKB	PA134913925.
Phylogenomic databases
HOGENOM	HOG000232043.
HOVERGEN	HBG061812.
KO	K08815.
Enzyme and pathway databases
SignaLink	Q8IWY7.
Family and domain databases
InterPro	IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR003054. Keratin_II. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. [Graphical view]
Pfam	PF00038. Filament. 2 hits. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR01276. TYPE2KERATIN.
SUPFAM	SSF56112. SSF56112. 1 hit.
PROSITE	PS00226. IF. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	146057.
NextBio	85251.

Entry information

Entry name

Q8IWY7_HUMAN

Accession

Primary (citable) accession number: Q8IWY7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 22, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.