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Q8IWY7 (Q8IWY7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:TTBK2 HGNC 19141
OrganismHomo sapiens (Human) EMBL AAO14996.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1649 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the intermediate filament family. RuleBase RU000685

Sequences

Sequence LengthMass (Da)Tools
Q8IWY7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 48730481D24E58CE

FASTA1,649182,467
        10         20         30         40         50         60 
MESVEKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCCFEK AARKDHVCRF 

        70         80         90        100        110        120 
IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR LGRQILESIE SIHSVGFLHR 

       130        140        150        160        170        180 
DIKPSNFAMG RFPSTCRKCY MLDFGLARQF TNSCGDVRPP RAVAGFRGTV RYASINAHRN 

       190        200        210        220        230        240 
REMGRHDDLW SLFYMLVEFV VGQLPWRKIK DKEQVGSIKE RYDHRLMLKH LPPEFSIFLD 

       250        260        270        280        290        300 
HISSLDYFTK PDYQMSIRVT RKSYKVSTSG PQAFNSLSYT SGPGACISSS SFSRMGSSSF 

       310        320        330        340        350        360 
RGGLGAGYGG ASGGITTITV NQSLLSPLNL EVDPNIQAVR TQEEKQIKTL NNKFFSFIDK 

       370        380        390        400        410        420 
VRFLEQQNKM LETKWSLVQQ QKMARSNMDN MFESYINNLK WQLETLGQEK LKLEAELGNM 

       430        440        450        460        470        480 
HGLVEDFRNK YEVEISKCTE MENEFVLIKE YVDEAYMNKM ELESSLKELT AKISFLRQLY 

       490        500        510        520        530        540 
EEEIGSCSPR SRIHLWCCSW TTAASWTWTA SSLRSRPEGF PGGCHADTEQ RGELAIKDAN 

       550        560        570        580        590        600 
AKLSELEAAL QLASQDMARQ LREYQELMNV KLALDIKIAT YRKLLEGEES WLESGMQNMS 

       610        620        630        640        650        660 
IHMKTTSSYA GGQSLAYGGL TSPGLSYGLG SSFGSGMGSS SFSHTSSSRA VVMKKIETRD 

       670        680        690        700        710        720 
GKLVSESSNV LPNLRITATL LTSVFDNSIK TFGVIESDPF DWEKTGNDGS LTTTTTSTTP 

       730        740        750        760        770        780 
QLHTRLTPAA IGIANATPIP GDLLRENTDE VFPDEQLSDG ENGIPVGVSP DKLPGSLGHP 

       790        800        810        820        830        840 
RPQEKDVWEE MDANKNKIKL GICKAATEEE NSHGQANGLL NAPSLGSPIR VRSEITQPDR 

       850        860        870        880        890        900 
DIPLVRKLRS IHSFELEKRL TLEPKPDTDK FLETCLEKMQ KDTSAGKESI LPALLHKPCV 

       910        920        930        940        950        960 
PAVSRTDHIW HYDEEYLPDA SKPASANTPE QADGGGSNGF IAVNLSSCKQ EIDSKEWVIV 

       970        980        990       1000       1010       1020 
DKEQDLQDFR TNEAVGHKTT GSPSDEEPEV LQVLEASPQD EKLQLGPWAE NDHLKKETSG 

      1030       1040       1050       1060       1070       1080 
VVLALSAEGP PTAASEQYTD RLELQPGAAS QFIAATPTSL MEAQAEGPLT AITIPRPSVA 

      1090       1100       1110       1120       1130       1140 
STQSTSGSFH CGQQPEKKDL QPMEPTVELY SPRENFSGLV VTEGEPPSGG SRTDLGLQID 

      1150       1160       1170       1180       1190       1200 
HIGHDMLPNI RESNKSQDLG PKELPDHNRL VVREFENLPG ETEEKSILLE SDNEDEKLSR 

      1210       1220       1230       1240       1250       1260 
GQHCIEISSL PGDLVIVEKD HSATTEPLDV TKTQTFSVVP NQDKNNEIMK LLTVGTSEIS 

      1270       1280       1290       1300       1310       1320 
SRDIDPHVEG QIGQVAEMQK NKISKDDDIM SEDLPGHQGD LSTFLHQEGK REKITPRNGE 

      1330       1340       1350       1360       1370       1380 
LFHCVSENEH GAPTRKDMVR SSFVTRHSRI PVLAQEIDST LESSSPVSAK EKLLQKKAYQ 

      1390       1400       1410       1420       1430       1440 
PDLVKLLVEK RQFKSFLGDL SSASDKLLEE KLATVPAPFC EEEVLTPFSR LTVDSHLSRS 

      1450       1460       1470       1480       1490       1500 
AEDSFLSPII SQSRKSKIPR PVSWVNTDQV NSSTSSQFFP RPPPGKPPTR PGVEARLRRY 

      1510       1520       1530       1540       1550       1560 
KVLGSSNSDS DLFSRLAQIL QNGSQKPRST TQCKSPGSPH NPKTPPKSPV VPRRSPSASP 

      1570       1580       1590       1600       1610       1620 
RSSSLPRTSS SSPSRAGRPH HDQRSSSPHL GRSKSPPSHS GSSSSRRSCQ QEHCKPSKNG 

      1630       1640 
LKGSGSLHHH SASTKTPQGK SKPASKLSR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF525400 mRNA. Translation: AAO14996.1.
RefSeqNP_775771.3. NM_173500.3.
UniGeneHs.646511.
Hs.727864.
Hs.733489.

3D structure databases

ProteinModelPortalQ8IWY7.
SMRQ8IWY7. Positions 526-587.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8IWY7. 2 interactions.

Proteomic databases

MaxQBQ8IWY7.
PRIDEQ8IWY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID146057.
KEGGhsa:146057.

Organism-specific databases

CTD146057.
PharmGKBPA134913925.

Phylogenomic databases

HOGENOMHOG000232043.
HOVERGENHBG061812.
KOK08815.
PhylomeDBQ8IWY7.

Enzyme and pathway databases

SignaLinkQ8IWY7.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamPF00038. Filament. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00226. IF. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi146057.
NextBio85251.

Entry information

Entry nameQ8IWY7_HUMAN
AccessionPrimary (citable) accession number: Q8IWY7
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.