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Q8IWY7

- Q8IWY7_HUMAN

UniProt

Q8IWY7 - Q8IWY7_HUMAN

Protein
Submitted name:

Tau-tubulin kinase

Gene

TTBK2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. protein kinase activity Source: InterPro
    3. structural molecule activity Source: InterPro

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Enzyme and pathway databases

    SignaLinkiQ8IWY7.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tau-tubulin kinaseImported
    Gene namesi
    Name:TTBK2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Intermediate filamentUniRule annotationSAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134913925.

    PTM / Processingi

    Proteomic databases

    MaxQBiQ8IWY7.
    PRIDEiQ8IWY7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8IWY7. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWY7.
    SMRiQ8IWY7. Positions 526-587.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the intermediate filament family.UniRule annotation

    Keywords - Domaini

    Coiled coilSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000232043.
    HOVERGENiHBG061812.
    KOiK08815.
    PhylomeDBiQ8IWY7.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00038. Filament. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00226. IF. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IWY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESVEKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCCFEK     50
    AARKDHVCRF IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR 100
    LGRQILESIE SIHSVGFLHR DIKPSNFAMG RFPSTCRKCY MLDFGLARQF 150
    TNSCGDVRPP RAVAGFRGTV RYASINAHRN REMGRHDDLW SLFYMLVEFV 200
    VGQLPWRKIK DKEQVGSIKE RYDHRLMLKH LPPEFSIFLD HISSLDYFTK 250
    PDYQMSIRVT RKSYKVSTSG PQAFNSLSYT SGPGACISSS SFSRMGSSSF 300
    RGGLGAGYGG ASGGITTITV NQSLLSPLNL EVDPNIQAVR TQEEKQIKTL 350
    NNKFFSFIDK VRFLEQQNKM LETKWSLVQQ QKMARSNMDN MFESYINNLK 400
    WQLETLGQEK LKLEAELGNM HGLVEDFRNK YEVEISKCTE MENEFVLIKE 450
    YVDEAYMNKM ELESSLKELT AKISFLRQLY EEEIGSCSPR SRIHLWCCSW 500
    TTAASWTWTA SSLRSRPEGF PGGCHADTEQ RGELAIKDAN AKLSELEAAL 550
    QLASQDMARQ LREYQELMNV KLALDIKIAT YRKLLEGEES WLESGMQNMS 600
    IHMKTTSSYA GGQSLAYGGL TSPGLSYGLG SSFGSGMGSS SFSHTSSSRA 650
    VVMKKIETRD GKLVSESSNV LPNLRITATL LTSVFDNSIK TFGVIESDPF 700
    DWEKTGNDGS LTTTTTSTTP QLHTRLTPAA IGIANATPIP GDLLRENTDE 750
    VFPDEQLSDG ENGIPVGVSP DKLPGSLGHP RPQEKDVWEE MDANKNKIKL 800
    GICKAATEEE NSHGQANGLL NAPSLGSPIR VRSEITQPDR DIPLVRKLRS 850
    IHSFELEKRL TLEPKPDTDK FLETCLEKMQ KDTSAGKESI LPALLHKPCV 900
    PAVSRTDHIW HYDEEYLPDA SKPASANTPE QADGGGSNGF IAVNLSSCKQ 950
    EIDSKEWVIV DKEQDLQDFR TNEAVGHKTT GSPSDEEPEV LQVLEASPQD 1000
    EKLQLGPWAE NDHLKKETSG VVLALSAEGP PTAASEQYTD RLELQPGAAS 1050
    QFIAATPTSL MEAQAEGPLT AITIPRPSVA STQSTSGSFH CGQQPEKKDL 1100
    QPMEPTVELY SPRENFSGLV VTEGEPPSGG SRTDLGLQID HIGHDMLPNI 1150
    RESNKSQDLG PKELPDHNRL VVREFENLPG ETEEKSILLE SDNEDEKLSR 1200
    GQHCIEISSL PGDLVIVEKD HSATTEPLDV TKTQTFSVVP NQDKNNEIMK 1250
    LLTVGTSEIS SRDIDPHVEG QIGQVAEMQK NKISKDDDIM SEDLPGHQGD 1300
    LSTFLHQEGK REKITPRNGE LFHCVSENEH GAPTRKDMVR SSFVTRHSRI 1350
    PVLAQEIDST LESSSPVSAK EKLLQKKAYQ PDLVKLLVEK RQFKSFLGDL 1400
    SSASDKLLEE KLATVPAPFC EEEVLTPFSR LTVDSHLSRS AEDSFLSPII 1450
    SQSRKSKIPR PVSWVNTDQV NSSTSSQFFP RPPPGKPPTR PGVEARLRRY 1500
    KVLGSSNSDS DLFSRLAQIL QNGSQKPRST TQCKSPGSPH NPKTPPKSPV 1550
    VPRRSPSASP RSSSLPRTSS SSPSRAGRPH HDQRSSSPHL GRSKSPPSHS 1600
    GSSSSRRSCQ QEHCKPSKNG LKGSGSLHHH SASTKTPQGK SKPASKLSR 1649
    Length:1,649
    Mass (Da):182,467
    Last modified:March 1, 2003 - v1
    Checksum:i48730481D24E58CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF525400 mRNA. Translation: AAO14996.1.
    RefSeqiNP_775771.3. NM_173500.3.
    UniGeneiHs.646511.
    Hs.727864.
    Hs.733489.

    Genome annotation databases

    GeneIDi146057.
    KEGGihsa:146057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF525400 mRNA. Translation: AAO14996.1 .
    RefSeqi NP_775771.3. NM_173500.3.
    UniGenei Hs.646511.
    Hs.727864.
    Hs.733489.

    3D structure databases

    ProteinModelPortali Q8IWY7.
    SMRi Q8IWY7. Positions 526-587.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8IWY7. 2 interactions.

    Proteomic databases

    MaxQBi Q8IWY7.
    PRIDEi Q8IWY7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 146057.
    KEGGi hsa:146057.

    Organism-specific databases

    CTDi 146057.
    PharmGKBi PA134913925.

    Phylogenomic databases

    HOGENOMi HOG000232043.
    HOVERGENi HBG061812.
    KOi K08815.
    PhylomeDBi Q8IWY7.

    Enzyme and pathway databases

    SignaLinki Q8IWY7.

    Miscellaneous databases

    GenomeRNAii 146057.
    NextBioi 85251.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00038. Filament. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00226. IF. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8IWY7_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWY7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.