Q8IWX5 (SGPP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sphingosine-1-phosphate phosphatase 2
Short name=SPPase2
Short name=Spp2
Short name=hSPP2
EC=3.1.3.-

Alternative name(s):
Sphingosine-1-phosphatase 2

Gene names

Name:

SGPP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. Ref.1 Ref.4
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. Ref.1
Induction	Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors. Ref.4
Sequence similarities	Belongs to the type 2 lipid phosphate phosphatase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	sphingosine metabolic process Inferred from direct assay Ref.1. Source: UniProtKB
Cellular component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sphingosine-1-phosphate phosphatase activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWX5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWX5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Sphingosine-1-phosphate phosphatase 2		PRO_0000114480
Regions
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	121 – 141	21	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	219 – 239	21	Helical; Potential
	Transmembrane	247 – 267	21	Helical; Potential
	Transmembrane	280 – 300	21	Helical; Potential
	Transmembrane	318 – 338	21	Helical; Potential
	Transmembrane	371 – 391	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 128	128	Missing in isoform 2.		VSP_039385

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 7615BA231263D0B6	FASTA	399	44,741
	10 20 30 40 50 60 MAELLRSLQD SQLVARFQRR CGLFPAPDEG PRENGADPTE RAARVPGVEH LPAANGKGGE 70 80 90 100 110 120 APANGLRRAA APEAYVQKYV VKNYFYYYLF QFSAALGQEV FYITFLPFTH WNIDPYLSRR 130 140 150 160 170 180 LIIIWVLVMY IGQVAKDVLK WPRPSSPPVV KLEKRLIAEY GMPSTHAMAA TAIAFTLLIS 190 200 210 220 230 240 TMDRYQYPFV LGLVMAVVFS TLVCLSRLYT GMHTVLDVLG GVLITALLIV LTYPAWTFID 250 260 270 280 290 300 CLDSASPLFP VCVIVVPFFL CYNYPVSDYY SPTRADTTTI LAAGAGVTIG FWINHFFQLV 310 320 330 340 350 360 SKPAESLPVI QNIPPLTTYM LVLGLTKFAV GIVLILLVRQ LVQNLSLQVL YSWFKVVTRN 370 380 390 KEARRRLEIE VPYKFVTYTS VGICATTFVP MLHRFLGLP
	Isoform 2 [UniParc]. Checksum: C41E92B8D34CD03A	FASTA	271	30,239
	10 20 30 40 50 60 MYIGQVAKDV LKWPRPSSPP VVKLEKRLIA EYGMPSTHAM AATAIAFTLL ISTMDRYQYP 70 80 90 100 110 120 FVLGLVMAVV FSTLVCLSRL YTGMHTVLDV LGGVLITALL IVLTYPAWTF IDCLDSASPL 130 140 150 160 170 180 FPVCVIVVPF FLCYNYPVSD YYSPTRADTT TILAAGAGVT IGFWINHFFQ LVSKPAESLP 190 200 210 220 230 240 VIQNIPPLTT YMLVLGLTKF AVGIVLILLV RQLVQNLSLQ VLYSWFKVVT RNKEARRRLE 250 260 270 IEVPYKFVTY TSVGICATTF VPMLHRFLGL P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2." Ogawa C., Kihara A., Gokoh M., Igarashi Y. J. Biol. Chem. 278:1268-1272(2003) [PubMed: 12411432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Thalamus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses." Mechtcheriakova D., Wlachos A., Sobanov J., Kopp T., Reuschel R., Bornancin F., Cai R., Zemann B., Urtz N., Stingl G., Zlabinger G., Woisetschlager M., Baumruker T., Billich A. Cell. Signal. 19:748-760(2007) [PubMed: 17113265] [Abstract] Cited for: FUNCTION, INDUCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF542512 mRNA. Translation: AAN28731.1. AK096323 mRNA. Translation: BAC04762.1. AK314322 mRNA. Translation: BAG36970.1. BC134342 mRNA. Translation: AAI34343.1.
IPI	IPI00217427. IPI00787315.
RefSeq	NP_689599.2. NM_152386.2.
UniGene	Hs.591604.
3D structure databases
ProteinModelPortal	Q8IWX5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IWX5.
Polymorphism databases
DMDM	41700844.
Proteomic databases
PRIDE	Q8IWX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321276; ENSP00000315137; ENSG00000163082.
GeneID	130367.
KEGG	hsa:130367.
NMPDR	fig|9606.3.peg.19407.
UCSC	uc002vnd.1. human.
Organism-specific databases
CTD	130367.
GeneCards	GC02P223288.
H-InvDB	HIX0002876.
HGNC	HGNC:19953. SGPP2.
MIM	612827. gene.
neXtProt	NX_Q8IWX5.
PharmGKB	PA134956234.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000017322.
HOGENOM	HBG713817.
HOVERGEN	HBG079185.
InParanoid	Q8IWX5.
OMA	RYQYPFV.
OrthoDB	EOG4CZBGJ.
PhylomeDB	Q8IWX5.
Enzyme and pathway databases
Reactome	REACT_22258. Metabolism of lipids and lipoproteins.
Gene expression databases
ArrayExpress	Q8IWX5.
Bgee	Q8IWX5.
CleanEx	HS_SGPP2.
Genevestigator	Q8IWX5.
Family and domain databases
InterPro	IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Gene3D	G3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
KO	K04717.
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
SUPFAM	SSF48317. AcPase_VanPerase. 1 hit.
ProtoNet	Search...
Other
NextBio	82733.
SOURCE	Search...

Entry information

Entry name

SGPP2_HUMAN

Accession

Primary (citable) accession number: Q8IWX5
Secondary accession number(s): A3KPB4, Q8N8Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.