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Protein

Sphingosine-1-phosphate phosphatase 2

Gene

SGPP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.2 Publications

GO - Molecular functioni

  • sphingosine-1-phosphate phosphatase activity Source: UniProtKB

GO - Biological processi

  • dephosphorylation Source: GOC
  • small molecule metabolic process Source: Reactome
  • sphingolipid biosynthetic process Source: Reactome
  • sphingolipid metabolic process Source: Reactome
  • sphingosine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_115810. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine-1-phosphate phosphatase 2 (EC:3.1.3.-)
Short name:
SPPase2
Short name:
Spp2
Short name:
hSPP2
Alternative name(s):
Sphingosine-1-phosphatase 2
Gene namesi
Name:SGPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19953. SGPP2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956234.

Polymorphism and mutation databases

BioMutaiSGPP2.
DMDMi41700844.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Sphingosine-1-phosphate phosphatase 2PRO_0000114480Add
BLAST

Proteomic databases

PaxDbiQ8IWX5.
PRIDEiQ8IWX5.

PTM databases

DEPODiQ8IWX5.

Expressioni

Tissue specificityi

Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.1 Publication

Inductioni

Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors.1 Publication

Gene expression databases

BgeeiQ8IWX5.
CleanExiHS_SGPP2.
GenevisibleiQ8IWX5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000315137.

Structurei

3D structure databases

ProteinModelPortaliQ8IWX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0671.
GeneTreeiENSGT00390000017322.
HOGENOMiHOG000234228.
HOVERGENiHBG079185.
InParanoidiQ8IWX5.
KOiK04717.
OMAiLPCIHWN.
OrthoDBiEOG72VH66.
PhylomeDBiQ8IWX5.
TreeFamiTF323419.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELLRSLQD SQLVARFQRR CGLFPAPDEG PRENGADPTE RAARVPGVEH
60 70 80 90 100
LPAANGKGGE APANGLRRAA APEAYVQKYV VKNYFYYYLF QFSAALGQEV
110 120 130 140 150
FYITFLPFTH WNIDPYLSRR LIIIWVLVMY IGQVAKDVLK WPRPSSPPVV
160 170 180 190 200
KLEKRLIAEY GMPSTHAMAA TAIAFTLLIS TMDRYQYPFV LGLVMAVVFS
210 220 230 240 250
TLVCLSRLYT GMHTVLDVLG GVLITALLIV LTYPAWTFID CLDSASPLFP
260 270 280 290 300
VCVIVVPFFL CYNYPVSDYY SPTRADTTTI LAAGAGVTIG FWINHFFQLV
310 320 330 340 350
SKPAESLPVI QNIPPLTTYM LVLGLTKFAV GIVLILLVRQ LVQNLSLQVL
360 370 380 390
YSWFKVVTRN KEARRRLEIE VPYKFVTYTS VGICATTFVP MLHRFLGLP
Length:399
Mass (Da):44,741
Last modified:March 1, 2003 - v1
Checksum:i7615BA231263D0B6
GO
Isoform 2 (identifier: Q8IWX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):30,239
Checksum:iC41E92B8D34CD03A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 128128Missing in isoform 2. 1 PublicationVSP_039385Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542512 mRNA. Translation: AAN28731.1.
AK096323 mRNA. Translation: BAC04762.1.
AK314322 mRNA. Translation: BAG36970.1.
BC134342 mRNA. Translation: AAI34343.1.
CCDSiCCDS2453.1. [Q8IWX5-1]
RefSeqiNP_689599.2. NM_152386.2. [Q8IWX5-1]
XP_005246354.1. XM_005246297.2. [Q8IWX5-2]
UniGeneiHs.591604.

Genome annotation databases

EnsembliENST00000321276; ENSP00000315137; ENSG00000163082.
GeneIDi130367.
KEGGihsa:130367.
UCSCiuc010zlo.2. human. [Q8IWX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542512 mRNA. Translation: AAN28731.1.
AK096323 mRNA. Translation: BAC04762.1.
AK314322 mRNA. Translation: BAG36970.1.
BC134342 mRNA. Translation: AAI34343.1.
CCDSiCCDS2453.1. [Q8IWX5-1]
RefSeqiNP_689599.2. NM_152386.2. [Q8IWX5-1]
XP_005246354.1. XM_005246297.2. [Q8IWX5-2]
UniGeneiHs.591604.

3D structure databases

ProteinModelPortaliQ8IWX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000315137.

PTM databases

DEPODiQ8IWX5.

Polymorphism and mutation databases

BioMutaiSGPP2.
DMDMi41700844.

Proteomic databases

PaxDbiQ8IWX5.
PRIDEiQ8IWX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321276; ENSP00000315137; ENSG00000163082.
GeneIDi130367.
KEGGihsa:130367.
UCSCiuc010zlo.2. human. [Q8IWX5-1]

Organism-specific databases

CTDi130367.
GeneCardsiGC02P223288.
HGNCiHGNC:19953. SGPP2.
MIMi612827. gene.
neXtProtiNX_Q8IWX5.
PharmGKBiPA134956234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0671.
GeneTreeiENSGT00390000017322.
HOGENOMiHOG000234228.
HOVERGENiHBG079185.
InParanoidiQ8IWX5.
KOiK04717.
OMAiLPCIHWN.
OrthoDBiEOG72VH66.
PhylomeDBiQ8IWX5.
TreeFamiTF323419.

Enzyme and pathway databases

ReactomeiREACT_115810. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSiSGPP2. human.
GenomeRNAii130367.
NextBioi82733.
PROiQ8IWX5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IWX5.
CleanExiHS_SGPP2.
GenevisibleiQ8IWX5. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2."
    Ogawa C., Kihara A., Gokoh M., Igarashi Y.
    J. Biol. Chem. 278:1268-1272(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thalamus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiSGPP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWX5
Secondary accession number(s): A3KPB4, Q8N8Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.