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Q8IWX5 (SGPP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sphingosine-1-phosphate phosphatase 2

Short name=SPPase2
Short name=Spp2
Short name=hSPP2
EC=3.1.3.-
Alternative name(s):
Sphingosine-1-phosphatase 2
Gene names
Name:SGPP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. Ref.1 Ref.4

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. Ref.1

Induction

Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors. Ref.4

Sequence similarities

Belongs to the type 2 lipid phosphate phosphatase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IWX5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IWX5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Sphingosine-1-phosphate phosphatase 2
PRO_0000114480

Regions

Transmembrane88 – 10821Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane219 – 23921Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane280 – 30021Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane371 – 39121Helical; Potential

Natural variations

Alternative sequence1 – 128128Missing in isoform 2.
VSP_039385

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7615BA231263D0B6

FASTA39944,741
        10         20         30         40         50         60 
MAELLRSLQD SQLVARFQRR CGLFPAPDEG PRENGADPTE RAARVPGVEH LPAANGKGGE 

        70         80         90        100        110        120 
APANGLRRAA APEAYVQKYV VKNYFYYYLF QFSAALGQEV FYITFLPFTH WNIDPYLSRR 

       130        140        150        160        170        180 
LIIIWVLVMY IGQVAKDVLK WPRPSSPPVV KLEKRLIAEY GMPSTHAMAA TAIAFTLLIS 

       190        200        210        220        230        240 
TMDRYQYPFV LGLVMAVVFS TLVCLSRLYT GMHTVLDVLG GVLITALLIV LTYPAWTFID 

       250        260        270        280        290        300 
CLDSASPLFP VCVIVVPFFL CYNYPVSDYY SPTRADTTTI LAAGAGVTIG FWINHFFQLV 

       310        320        330        340        350        360 
SKPAESLPVI QNIPPLTTYM LVLGLTKFAV GIVLILLVRQ LVQNLSLQVL YSWFKVVTRN 

       370        380        390 
KEARRRLEIE VPYKFVTYTS VGICATTFVP MLHRFLGLP 

« Hide

Isoform 2 [UniParc].

Checksum: C41E92B8D34CD03A
Show »

FASTA27130,239

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2."
Ogawa C., Kihara A., Gokoh M., Igarashi Y.
J. Biol. Chem. 278:1268-1272(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Thalamus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses."
Mechtcheriakova D., Wlachos A., Sobanov J., Kopp T., Reuschel R., Bornancin F., Cai R., Zemann B., Urtz N., Stingl G., Zlabinger G., Woisetschlager M., Baumruker T., Billich A.
Cell. Signal. 19:748-760(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF542512 mRNA. Translation: AAN28731.1.
AK096323 mRNA. Translation: BAC04762.1.
AK314322 mRNA. Translation: BAG36970.1.
BC134342 mRNA. Translation: AAI34343.1.
RefSeqNP_689599.2. NM_152386.2.
XP_005246354.1. XM_005246297.1.
UniGeneHs.591604.

3D structure databases

ProteinModelPortalQ8IWX5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000315137.

Polymorphism databases

DMDM41700844.

Proteomic databases

PaxDbQ8IWX5.
PRIDEQ8IWX5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321276; ENSP00000315137; ENSG00000163082. [Q8IWX5-1]
GeneID130367.
KEGGhsa:130367.
UCSCuc010zlo.2. human. [Q8IWX5-1]

Organism-specific databases

CTD130367.
GeneCardsGC02P223288.
HGNCHGNC:19953. SGPP2.
MIM612827. gene.
neXtProtNX_Q8IWX5.
PharmGKBPA134956234.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0671.
HOGENOMHOG000234228.
HOVERGENHBG079185.
InParanoidQ8IWX5.
KOK04717.
OMAVVTRNKE.
OrthoDBEOG72VH66.
PhylomeDBQ8IWX5.
TreeFamTF323419.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ8IWX5.
BgeeQ8IWX5.
CleanExHS_SGPP2.
GenevestigatorQ8IWX5.

Family and domain databases

Gene3D1.20.144.10. 1 hit.
InterProIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamPF01569. PAP2. 1 hit.
[Graphical view]
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. SSF48317. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSGPP2. human.
GenomeRNAi130367.
NextBio82733.
PROQ8IWX5.
SOURCESearch...

Entry information

Entry nameSGPP2_HUMAN
AccessionPrimary (citable) accession number: Q8IWX5
Secondary accession number(s): A3KPB4, Q8N8Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM