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Q8IWX5

- SGPP2_HUMAN

UniProt

Q8IWX5 - SGPP2_HUMAN

Protein

Sphingosine-1-phosphate phosphatase 2

Gene

SGPP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.2 Publications

    GO - Molecular functioni

    1. sphingosine-1-phosphate phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. small molecule metabolic process Source: Reactome
    3. sphingolipid biosynthetic process Source: Reactome
    4. sphingolipid metabolic process Source: Reactome
    5. sphingosine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_115810. Sphingolipid de novo biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sphingosine-1-phosphate phosphatase 2 (EC:3.1.3.-)
    Short name:
    SPPase2
    Short name:
    Spp2
    Short name:
    hSPP2
    Alternative name(s):
    Sphingosine-1-phosphatase 2
    Gene namesi
    Name:SGPP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:19953. SGPP2.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134956234.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Sphingosine-1-phosphate phosphatase 2PRO_0000114480Add
    BLAST

    Proteomic databases

    PaxDbiQ8IWX5.
    PRIDEiQ8IWX5.

    Expressioni

    Tissue specificityi

    Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.1 Publication

    Inductioni

    Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors.1 Publication

    Gene expression databases

    ArrayExpressiQ8IWX5.
    BgeeiQ8IWX5.
    CleanExiHS_SGPP2.
    GenevestigatoriQ8IWX5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000315137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0671.
    HOGENOMiHOG000234228.
    HOVERGENiHBG079185.
    InParanoidiQ8IWX5.
    KOiK04717.
    OMAiVVTRNKE.
    OrthoDBiEOG72VH66.
    PhylomeDBiQ8IWX5.
    TreeFamiTF323419.

    Family and domain databases

    Gene3Di1.20.144.10. 1 hit.
    InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view]
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    SMARTiSM00014. acidPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWX5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAELLRSLQD SQLVARFQRR CGLFPAPDEG PRENGADPTE RAARVPGVEH    50
    LPAANGKGGE APANGLRRAA APEAYVQKYV VKNYFYYYLF QFSAALGQEV 100
    FYITFLPFTH WNIDPYLSRR LIIIWVLVMY IGQVAKDVLK WPRPSSPPVV 150
    KLEKRLIAEY GMPSTHAMAA TAIAFTLLIS TMDRYQYPFV LGLVMAVVFS 200
    TLVCLSRLYT GMHTVLDVLG GVLITALLIV LTYPAWTFID CLDSASPLFP 250
    VCVIVVPFFL CYNYPVSDYY SPTRADTTTI LAAGAGVTIG FWINHFFQLV 300
    SKPAESLPVI QNIPPLTTYM LVLGLTKFAV GIVLILLVRQ LVQNLSLQVL 350
    YSWFKVVTRN KEARRRLEIE VPYKFVTYTS VGICATTFVP MLHRFLGLP 399
    Length:399
    Mass (Da):44,741
    Last modified:March 1, 2003 - v1
    Checksum:i7615BA231263D0B6
    GO
    Isoform 2 (identifier: Q8IWX5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-128: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:271
    Mass (Da):30,239
    Checksum:iC41E92B8D34CD03A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 128128Missing in isoform 2. 1 PublicationVSP_039385Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF542512 mRNA. Translation: AAN28731.1.
    AK096323 mRNA. Translation: BAC04762.1.
    AK314322 mRNA. Translation: BAG36970.1.
    BC134342 mRNA. Translation: AAI34343.1.
    CCDSiCCDS2453.1. [Q8IWX5-1]
    RefSeqiNP_689599.2. NM_152386.2. [Q8IWX5-1]
    XP_005246354.1. XM_005246297.1. [Q8IWX5-2]
    UniGeneiHs.591604.

    Genome annotation databases

    EnsembliENST00000321276; ENSP00000315137; ENSG00000163082. [Q8IWX5-1]
    GeneIDi130367.
    KEGGihsa:130367.
    UCSCiuc010zlo.2. human. [Q8IWX5-1]

    Polymorphism databases

    DMDMi41700844.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF542512 mRNA. Translation: AAN28731.1 .
    AK096323 mRNA. Translation: BAC04762.1 .
    AK314322 mRNA. Translation: BAG36970.1 .
    BC134342 mRNA. Translation: AAI34343.1 .
    CCDSi CCDS2453.1. [Q8IWX5-1 ]
    RefSeqi NP_689599.2. NM_152386.2. [Q8IWX5-1 ]
    XP_005246354.1. XM_005246297.1. [Q8IWX5-2 ]
    UniGenei Hs.591604.

    3D structure databases

    ProteinModelPortali Q8IWX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000315137.

    Polymorphism databases

    DMDMi 41700844.

    Proteomic databases

    PaxDbi Q8IWX5.
    PRIDEi Q8IWX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321276 ; ENSP00000315137 ; ENSG00000163082 . [Q8IWX5-1 ]
    GeneIDi 130367.
    KEGGi hsa:130367.
    UCSCi uc010zlo.2. human. [Q8IWX5-1 ]

    Organism-specific databases

    CTDi 130367.
    GeneCardsi GC02P223288.
    HGNCi HGNC:19953. SGPP2.
    MIMi 612827. gene.
    neXtProti NX_Q8IWX5.
    PharmGKBi PA134956234.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0671.
    HOGENOMi HOG000234228.
    HOVERGENi HBG079185.
    InParanoidi Q8IWX5.
    KOi K04717.
    OMAi VVTRNKE.
    OrthoDBi EOG72VH66.
    PhylomeDBi Q8IWX5.
    TreeFami TF323419.

    Enzyme and pathway databases

    Reactomei REACT_115810. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    ChiTaRSi SGPP2. human.
    GenomeRNAii 130367.
    NextBioi 82733.
    PROi Q8IWX5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IWX5.
    Bgeei Q8IWX5.
    CleanExi HS_SGPP2.
    Genevestigatori Q8IWX5.

    Family and domain databases

    Gene3Di 1.20.144.10. 1 hit.
    InterProi IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view ]
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    SMARTi SM00014. acidPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2."
      Ogawa C., Kihara A., Gokoh M., Igarashi Y.
      J. Biol. Chem. 278:1268-1272(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thalamus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiSGPP2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWX5
    Secondary accession number(s): A3KPB4, Q8N8Q6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3