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Q8IWX5

- SGPP2_HUMAN

UniProt

Q8IWX5 - SGPP2_HUMAN

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Protein

Sphingosine-1-phosphate phosphatase 2

Gene
SGPP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.2 Publications

GO - Molecular functioni

  1. sphingosine-1-phosphate phosphatase activity Source: UniProtKB

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. small molecule metabolic process Source: Reactome
  3. sphingolipid biosynthetic process Source: Reactome
  4. sphingolipid metabolic process Source: Reactome
  5. sphingosine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_115810. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine-1-phosphate phosphatase 2 (EC:3.1.3.-)
Short name:
SPPase2
Short name:
Spp2
Short name:
hSPP2
Alternative name(s):
Sphingosine-1-phosphatase 2
Gene namesi
Name:SGPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:19953. SGPP2.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10821Helical; Reviewed predictionAdd
BLAST
Transmembranei121 – 14121Helical; Reviewed predictionAdd
BLAST
Transmembranei160 – 18021Helical; Reviewed predictionAdd
BLAST
Transmembranei185 – 20521Helical; Reviewed predictionAdd
BLAST
Transmembranei219 – 23921Helical; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST
Transmembranei280 – 30021Helical; Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Reviewed predictionAdd
BLAST
Transmembranei371 – 39121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Sphingosine-1-phosphate phosphatase 2PRO_0000114480Add
BLAST

Proteomic databases

PaxDbiQ8IWX5.
PRIDEiQ8IWX5.

Expressioni

Tissue specificityi

Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.1 Publication

Inductioni

Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors.1 Publication

Gene expression databases

ArrayExpressiQ8IWX5.
BgeeiQ8IWX5.
CleanExiHS_SGPP2.
GenevestigatoriQ8IWX5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000315137.

Structurei

3D structure databases

ProteinModelPortaliQ8IWX5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0671.
HOGENOMiHOG000234228.
HOVERGENiHBG079185.
InParanoidiQ8IWX5.
KOiK04717.
OMAiVVTRNKE.
OrthoDBiEOG72VH66.
PhylomeDBiQ8IWX5.
TreeFamiTF323419.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWX5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAELLRSLQD SQLVARFQRR CGLFPAPDEG PRENGADPTE RAARVPGVEH    50
LPAANGKGGE APANGLRRAA APEAYVQKYV VKNYFYYYLF QFSAALGQEV 100
FYITFLPFTH WNIDPYLSRR LIIIWVLVMY IGQVAKDVLK WPRPSSPPVV 150
KLEKRLIAEY GMPSTHAMAA TAIAFTLLIS TMDRYQYPFV LGLVMAVVFS 200
TLVCLSRLYT GMHTVLDVLG GVLITALLIV LTYPAWTFID CLDSASPLFP 250
VCVIVVPFFL CYNYPVSDYY SPTRADTTTI LAAGAGVTIG FWINHFFQLV 300
SKPAESLPVI QNIPPLTTYM LVLGLTKFAV GIVLILLVRQ LVQNLSLQVL 350
YSWFKVVTRN KEARRRLEIE VPYKFVTYTS VGICATTFVP MLHRFLGLP 399
Length:399
Mass (Da):44,741
Last modified:March 1, 2003 - v1
Checksum:i7615BA231263D0B6
GO
Isoform 2 (identifier: Q8IWX5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: No experimental confirmation available.

Show »
Length:271
Mass (Da):30,239
Checksum:iC41E92B8D34CD03A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 128128Missing in isoform 2. VSP_039385Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF542512 mRNA. Translation: AAN28731.1.
AK096323 mRNA. Translation: BAC04762.1.
AK314322 mRNA. Translation: BAG36970.1.
BC134342 mRNA. Translation: AAI34343.1.
CCDSiCCDS2453.1. [Q8IWX5-1]
RefSeqiNP_689599.2. NM_152386.2. [Q8IWX5-1]
XP_005246354.1. XM_005246297.1. [Q8IWX5-2]
UniGeneiHs.591604.

Genome annotation databases

EnsembliENST00000321276; ENSP00000315137; ENSG00000163082. [Q8IWX5-1]
GeneIDi130367.
KEGGihsa:130367.
UCSCiuc010zlo.2. human. [Q8IWX5-1]

Polymorphism databases

DMDMi41700844.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF542512 mRNA. Translation: AAN28731.1 .
AK096323 mRNA. Translation: BAC04762.1 .
AK314322 mRNA. Translation: BAG36970.1 .
BC134342 mRNA. Translation: AAI34343.1 .
CCDSi CCDS2453.1. [Q8IWX5-1 ]
RefSeqi NP_689599.2. NM_152386.2. [Q8IWX5-1 ]
XP_005246354.1. XM_005246297.1. [Q8IWX5-2 ]
UniGenei Hs.591604.

3D structure databases

ProteinModelPortali Q8IWX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000315137.

Polymorphism databases

DMDMi 41700844.

Proteomic databases

PaxDbi Q8IWX5.
PRIDEi Q8IWX5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321276 ; ENSP00000315137 ; ENSG00000163082 . [Q8IWX5-1 ]
GeneIDi 130367.
KEGGi hsa:130367.
UCSCi uc010zlo.2. human. [Q8IWX5-1 ]

Organism-specific databases

CTDi 130367.
GeneCardsi GC02P223288.
HGNCi HGNC:19953. SGPP2.
MIMi 612827. gene.
neXtProti NX_Q8IWX5.
PharmGKBi PA134956234.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0671.
HOGENOMi HOG000234228.
HOVERGENi HBG079185.
InParanoidi Q8IWX5.
KOi K04717.
OMAi VVTRNKE.
OrthoDBi EOG72VH66.
PhylomeDBi Q8IWX5.
TreeFami TF323419.

Enzyme and pathway databases

Reactomei REACT_115810. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSi SGPP2. human.
GenomeRNAii 130367.
NextBioi 82733.
PROi Q8IWX5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IWX5.
Bgeei Q8IWX5.
CleanExi HS_SGPP2.
Genevestigatori Q8IWX5.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2."
    Ogawa C., Kihara A., Gokoh M., Igarashi Y.
    J. Biol. Chem. 278:1268-1272(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thalamus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiSGPP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWX5
Secondary accession number(s): A3KPB4, Q8N8Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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