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Q8IWW6

- RHG12_HUMAN

UniProt

Q8IWW6 - RHG12_HUMAN

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Protein
Rho GTPase-activating protein 12
Gene
ARHGAP12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. morphogenesis of an epithelial sheet Source: UniProt
  2. regulation of small GTPase mediated signal transduction Source: Reactome
  3. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
SignaLinkiQ8IWW6.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 12
Alternative name(s):
Rho-type GTPase-activating protein 12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:16348. ARHGAP12.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846Rho GTPase-activating protein 12
PRO_0000056713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphoserine2 Publications
Modified residuei201 – 2011Phosphoserine1 Publication
Modified residuei213 – 2131Phosphoserine2 Publications
Modified residuei215 – 2151Phosphoserine2 Publications
Modified residuei240 – 2401Phosphoserine3 Publications
Modified residuei243 – 2431Phosphotyrosine2 Publications
Modified residuei592 – 5921Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IWW6.
PaxDbiQ8IWW6.
PRIDEiQ8IWW6.

PTM databases

PhosphoSiteiQ8IWW6.

Expressioni

Gene expression databases

ArrayExpressiQ8IWW6.
BgeeiQ8IWW6.
CleanExiHS_ARHGAP12.
GenevestigatoriQ8IWW6.