Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho GTPase-activating protein 12

Gene

ARHGAP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. morphogenesis of an epithelial sheet Source: UniProtKB
  2. regulation of small GTPase mediated signal transduction Source: Reactome
  3. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
SignaLinkiQ8IWW6.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 12
Alternative name(s):
Rho-type GTPase-activating protein 12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16348. ARHGAP12.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846Rho GTPase-activating protein 12PRO_0000056713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphoserine2 Publications
Modified residuei176 – 1761Phosphoserine1 Publication
Modified residuei201 – 2011Phosphoserine1 Publication
Modified residuei213 – 2131Phosphoserine2 Publications
Modified residuei215 – 2151Phosphoserine2 Publications
Modified residuei230 – 2301Phosphothreonine1 Publication
Modified residuei231 – 2311Phosphothreonine1 Publication
Modified residuei240 – 2401Phosphoserine4 Publications
Modified residuei243 – 2431Phosphotyrosine2 Publications
Modified residuei592 – 5921Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IWW6.
PaxDbiQ8IWW6.
PRIDEiQ8IWW6.

PTM databases

PhosphoSiteiQ8IWW6.

Expressioni

Gene expression databases

BgeeiQ8IWW6.
CleanExiHS_ARHGAP12.
ExpressionAtlasiQ8IWW6. baseline and differential.
GenevestigatoriQ8IWW6.

Organism-specific databases

HPAiHPA000412.

Interactioni

Protein-protein interaction databases

BioGridi125122. 6 interactions.
IntActiQ8IWW6. 3 interactions.
MINTiMINT-3037739.
STRINGi9606.ENSP00000345808.

Structurei

3D structure databases

ProteinModelPortaliQ8IWW6.
SMRiQ8IWW6. Positions 13-72, 267-297, 357-391, 465-574, 637-845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 7463SH3PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 29834WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini358 – 39134WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini463 – 575113PHPROSITE-ProRule annotationAdd
BLAST
Domaini656 – 844189Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG279563.
GeneTreeiENSGT00780000121833.
HOVERGENiHBG005328.
InParanoidiQ8IWW6.
OMAiQSCDSAG.
OrthoDBiEOG7CZK7R.
PhylomeDBiQ8IWW6.
TreeFamiTF329345.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015767. Rho_GTPase_act.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
IPR001202. WW_dom.
[Graphical view]
PANTHERiPTHR23181. PTHR23181. 1 hit.
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWW6-1) [UniParc]FASTAAdd to basket

Also known as: ARHGAP12b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMADRSGKI IPGQVYIEVE YDYEYEAKDR KIVIKQGERY ILVKKTNDDW
60 70 80 90 100
WQVKPDENSK AFYVPAQYVK EVTRKALMPP VKQVAGLPNN STKIMQSLHL
110 120 130 140 150
QRSTENVNKL PELSSFGKPS SSVQGTGLIR DANQNFGPSY NQGQTVNLSL
160 170 180 190 200
DLTHNNGKFN NDSHSPKVSS QNRTRSFGHF PGPEFLDVEK TSFSQEQSCD
210 220 230 240 250
SAGEGSERIH QDSESGDELS SSSTEQIRAT TPPNQGRPDS PVYANLQELK
260 270 280 290 300
ISQSALPPLP GSPAIQINGE WETHKDSSGR CYYYNRGTQE RTWKPPRWTR
310 320 330 340 350
DASISKGDFQ NPGDQELLSS EENYYSTSYS QSDSQCGSPP RGWSEELDER
360 370 380 390 400
GHTLYTSDYT NEKWLKHVDD QGRQYYYSAD GSRSEWELPK YNASSQQQRE
410 420 430 440 450
IIKSRSLDRR LQEPIVLTKW RHSTIVLDTN DKESPTASKP CFPENESSPS
460 470 480 490 500
SPKHQDTASS PKDQEKYGLL NVTKIAENGK KVRKNWLSSW AVLQGSSLLF
510 520 530 540 550
TKTQGSSTSW FGSNQSKPEF TVDLKGATIE MASKDKSSKK NVFELKTRQG
560 570 580 590 600
TELLIQSDND TVINDWFKVL SSTINNQAVE TDEGIEEEIP DSPGIEKHDK
610 620 630 640 650
EKEQKDPKKL RSFKVSSIDS SEQKKTKKNL KKFLTRRPTL QAVREKGYIK
660 670 680 690 700
DQVFGSNLAN LCQRENGTVP KFVKLCIEHV EEHGLDIDGI YRVSGNLAVI
710 720 730 740 750
QKLRFAVNHD EKLDLNDSKW EDIHVITGAL KMFFRELPEP LFTFNHFNDF
760 770 780 790 800
VNAIKQEPRQ RVAAVKDLIR QLPKPNQDTM QILFRHLRRV IENGEKNRMT
810 820 830 840
YQSIAIVFGP TLLKPEKETG NIAVHTVYQN QIVELILLEL SSIFGR
Length:846
Mass (Da):96,254
Last modified:February 28, 2003 - v1
Checksum:i274CF06B47F02DDC
GO
Isoform 2 (identifier: Q8IWW6-2) [UniParc]FASTAAdd to basket

Also known as: ARHGAP12a

The sequence of this isoform differs from the canonical sequence as follows:
     433-462: Missing.

Show »
Length:816
Mass (Da):93,114
Checksum:iA948E9F7904B8DC7
GO
Isoform 3 (identifier: Q8IWW6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-363: Missing.
     458-462: Missing.

Show »
Length:794
Mass (Da):90,403
Checksum:i330029A7C1C294B3
GO
Isoform 4 (identifier: Q8IWW6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-462: Missing.

Show »
Length:841
Mass (Da):95,784
Checksum:i5C07E44111C30C1C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701K → R in CAD38926 (PubMed:17974005).Curated
Sequence conflicti760 – 7601Q → P in CAD38926 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti442 – 4421F → S.
Corresponds to variant rs2808096 [ dbSNP | Ensembl ].
VAR_024454

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei317 – 36347Missing in isoform 3. 1 PublicationVSP_010326Add
BLAST
Alternative sequencei433 – 46230Missing in isoform 2. 1 PublicationVSP_010327Add
BLAST
Alternative sequencei458 – 4625Missing in isoform 3 and isoform 4. 2 PublicationsVSP_010328

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033594 mRNA. Translation: AAK52311.1.
AY033595 mRNA. Translation: AAK52312.1.
AL390715 Genomic DNA. Translation: CAI12371.1.
AL390715 Genomic DNA. Translation: CAI12372.1.
AL390715 Genomic DNA. Translation: CAI12373.1.
AL834250 mRNA. Translation: CAD38926.2.
AL137485 mRNA. Translation: CAB70766.1.
CH471072 Genomic DNA. Translation: EAW85980.1.
CH471072 Genomic DNA. Translation: EAW85983.1.
CH471072 Genomic DNA. Translation: EAW85985.1.
BC051811 mRNA. Translation: AAH51811.1.
BC094719 mRNA. Translation: AAH94719.1.
CCDSiCCDS59214.1. [Q8IWW6-3]
CCDS59215.1. [Q8IWW6-2]
CCDS59216.1. [Q8IWW6-4]
CCDS7170.1. [Q8IWW6-1]
PIRiT46471.
RefSeqiNP_001257624.1. NM_001270695.1. [Q8IWW6-4]
NP_001257625.1. NM_001270696.1. [Q8IWW6-2]
NP_001257626.1. NM_001270697.1.
NP_001257627.1. NM_001270698.1.
NP_001257628.1. NM_001270699.1. [Q8IWW6-3]
NP_060757.4. NM_018287.6. [Q8IWW6-1]
XP_005252701.1. XM_005252644.1. [Q8IWW6-3]
XP_006717603.1. XM_006717540.1. [Q8IWW6-1]
UniGeneiHs.499264.
Hs.741991.

Genome annotation databases

EnsembliENST00000311380; ENSP00000310984; ENSG00000165322. [Q8IWW6-3]
ENST00000344936; ENSP00000345808; ENSG00000165322. [Q8IWW6-1]
ENST00000375250; ENSP00000364399; ENSG00000165322. [Q8IWW6-2]
ENST00000396144; ENSP00000379448; ENSG00000165322. [Q8IWW6-4]
GeneIDi94134.
KEGGihsa:94134.
UCSCiuc001ivy.2. human. [Q8IWW6-3]
uc001ivz.2. human. [Q8IWW6-1]
uc001iwb.2. human.
uc001iwc.2. human. [Q8IWW6-2]

Polymorphism databases

DMDMi47117238.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033594 mRNA. Translation: AAK52311.1.
AY033595 mRNA. Translation: AAK52312.1.
AL390715 Genomic DNA. Translation: CAI12371.1.
AL390715 Genomic DNA. Translation: CAI12372.1.
AL390715 Genomic DNA. Translation: CAI12373.1.
AL834250 mRNA. Translation: CAD38926.2.
AL137485 mRNA. Translation: CAB70766.1.
CH471072 Genomic DNA. Translation: EAW85980.1.
CH471072 Genomic DNA. Translation: EAW85983.1.
CH471072 Genomic DNA. Translation: EAW85985.1.
BC051811 mRNA. Translation: AAH51811.1.
BC094719 mRNA. Translation: AAH94719.1.
CCDSiCCDS59214.1. [Q8IWW6-3]
CCDS59215.1. [Q8IWW6-2]
CCDS59216.1. [Q8IWW6-4]
CCDS7170.1. [Q8IWW6-1]
PIRiT46471.
RefSeqiNP_001257624.1. NM_001270695.1. [Q8IWW6-4]
NP_001257625.1. NM_001270696.1. [Q8IWW6-2]
NP_001257626.1. NM_001270697.1.
NP_001257627.1. NM_001270698.1.
NP_001257628.1. NM_001270699.1. [Q8IWW6-3]
NP_060757.4. NM_018287.6. [Q8IWW6-1]
XP_005252701.1. XM_005252644.1. [Q8IWW6-3]
XP_006717603.1. XM_006717540.1. [Q8IWW6-1]
UniGeneiHs.499264.
Hs.741991.

3D structure databases

ProteinModelPortaliQ8IWW6.
SMRiQ8IWW6. Positions 13-72, 267-297, 357-391, 465-574, 637-845.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125122. 6 interactions.
IntActiQ8IWW6. 3 interactions.
MINTiMINT-3037739.
STRINGi9606.ENSP00000345808.

PTM databases

PhosphoSiteiQ8IWW6.

Polymorphism databases

DMDMi47117238.

Proteomic databases

MaxQBiQ8IWW6.
PaxDbiQ8IWW6.
PRIDEiQ8IWW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311380; ENSP00000310984; ENSG00000165322. [Q8IWW6-3]
ENST00000344936; ENSP00000345808; ENSG00000165322. [Q8IWW6-1]
ENST00000375250; ENSP00000364399; ENSG00000165322. [Q8IWW6-2]
ENST00000396144; ENSP00000379448; ENSG00000165322. [Q8IWW6-4]
GeneIDi94134.
KEGGihsa:94134.
UCSCiuc001ivy.2. human. [Q8IWW6-3]
uc001ivz.2. human. [Q8IWW6-1]
uc001iwb.2. human.
uc001iwc.2. human. [Q8IWW6-2]

Organism-specific databases

CTDi94134.
GeneCardsiGC10M032134.
HGNCiHGNC:16348. ARHGAP12.
HPAiHPA000412.
MIMi610577. gene.
neXtProtiNX_Q8IWW6.
PharmGKBiPA24957.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279563.
GeneTreeiENSGT00780000121833.
HOVERGENiHBG005328.
InParanoidiQ8IWW6.
OMAiQSCDSAG.
OrthoDBiEOG7CZK7R.
PhylomeDBiQ8IWW6.
TreeFamiTF329345.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
SignaLinkiQ8IWW6.

Miscellaneous databases

ChiTaRSiARHGAP12. human.
GenomeRNAii94134.
NextBioi78410.
PROiQ8IWW6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IWW6.
CleanExiHS_ARHGAP12.
ExpressionAtlasiQ8IWW6. baseline and differential.
GenevestigatoriQ8IWW6.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015767. Rho_GTPase_act.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
IPR001202. WW_dom.
[Graphical view]
PANTHERiPTHR23181. PTHR23181. 1 hit.
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human gene."
    Mao Y., Xie Y., Zhang Z.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-846 (ISOFORM 3).
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Placenta and Uterus.
  6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240 AND TYR-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; SER-213; SER-215; SER-240 AND SER-592, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-215; SER-240 AND TYR-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176; THR-230; THR-231; SER-240 AND SER-592, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRHG12_HUMAN
AccessioniPrimary (citable) accession number: Q8IWW6
Secondary accession number(s): B1ANY0
, B1ANY1, B1ANY2, Q504X1, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2004
Last sequence update: February 28, 2003
Last modified: March 3, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.