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Protein

Rho GTPase-activating protein 12

Gene

ARHGAP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

  • morphogenesis of an epithelial sheet Source: UniProtKB
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.
SignaLinkiQ8IWW6.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 12
Alternative name(s):
Rho-type GTPase-activating protein 12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16348. ARHGAP12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165322.
PharmGKBiPA24957.

Polymorphism and mutation databases

DMDMi47117238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567131 – 846Rho GTPase-activating protein 12Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei165PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei230PhosphothreonineCombined sources1
Modified residuei231PhosphothreonineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei243PhosphotyrosineCombined sources1
Modified residuei592PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IWW6.
MaxQBiQ8IWW6.
PaxDbiQ8IWW6.
PeptideAtlasiQ8IWW6.
PRIDEiQ8IWW6.

PTM databases

iPTMnetiQ8IWW6.
PhosphoSitePlusiQ8IWW6.

Expressioni

Gene expression databases

BgeeiENSG00000165322.
CleanExiHS_ARHGAP12.
ExpressionAtlasiQ8IWW6. baseline and differential.
GenevisibleiQ8IWW6. HS.

Organism-specific databases

HPAiHPA000412.

Interactioni

Protein-protein interaction databases

BioGridi125122. 10 interactors.
IntActiQ8IWW6. 7 interactors.
MINTiMINT-3037739.
STRINGi9606.ENSP00000345808.

Structurei

3D structure databases

ProteinModelPortaliQ8IWW6.
SMRiQ8IWW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 74SH3PROSITE-ProRule annotationAdd BLAST63
Domaini265 – 298WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini358 – 391WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini463 – 575PHPROSITE-ProRule annotationAdd BLAST113
Domaini656 – 844Rho-GAPPROSITE-ProRule annotationAdd BLAST189

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IQ9D. Eukaryota.
ENOG410ZTHP. LUCA.
GeneTreeiENSGT00840000129684.
HOVERGENiHBG005328.
InParanoidiQ8IWW6.
KOiK20636.
OMAiQSCDSAG.
OrthoDBiEOG091G164H.
PhylomeDBiQ8IWW6.
TreeFamiTF329345.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR015767. Rho_GTPase_act.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
IPR001202. WW_dom.
[Graphical view]
PANTHERiPTHR23181. PTHR23181. 3 hits.
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWW6-1) [UniParc]FASTAAdd to basket
Also known as: ARHGAP12b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMADRSGKI IPGQVYIEVE YDYEYEAKDR KIVIKQGERY ILVKKTNDDW
60 70 80 90 100
WQVKPDENSK AFYVPAQYVK EVTRKALMPP VKQVAGLPNN STKIMQSLHL
110 120 130 140 150
QRSTENVNKL PELSSFGKPS SSVQGTGLIR DANQNFGPSY NQGQTVNLSL
160 170 180 190 200
DLTHNNGKFN NDSHSPKVSS QNRTRSFGHF PGPEFLDVEK TSFSQEQSCD
210 220 230 240 250
SAGEGSERIH QDSESGDELS SSSTEQIRAT TPPNQGRPDS PVYANLQELK
260 270 280 290 300
ISQSALPPLP GSPAIQINGE WETHKDSSGR CYYYNRGTQE RTWKPPRWTR
310 320 330 340 350
DASISKGDFQ NPGDQELLSS EENYYSTSYS QSDSQCGSPP RGWSEELDER
360 370 380 390 400
GHTLYTSDYT NEKWLKHVDD QGRQYYYSAD GSRSEWELPK YNASSQQQRE
410 420 430 440 450
IIKSRSLDRR LQEPIVLTKW RHSTIVLDTN DKESPTASKP CFPENESSPS
460 470 480 490 500
SPKHQDTASS PKDQEKYGLL NVTKIAENGK KVRKNWLSSW AVLQGSSLLF
510 520 530 540 550
TKTQGSSTSW FGSNQSKPEF TVDLKGATIE MASKDKSSKK NVFELKTRQG
560 570 580 590 600
TELLIQSDND TVINDWFKVL SSTINNQAVE TDEGIEEEIP DSPGIEKHDK
610 620 630 640 650
EKEQKDPKKL RSFKVSSIDS SEQKKTKKNL KKFLTRRPTL QAVREKGYIK
660 670 680 690 700
DQVFGSNLAN LCQRENGTVP KFVKLCIEHV EEHGLDIDGI YRVSGNLAVI
710 720 730 740 750
QKLRFAVNHD EKLDLNDSKW EDIHVITGAL KMFFRELPEP LFTFNHFNDF
760 770 780 790 800
VNAIKQEPRQ RVAAVKDLIR QLPKPNQDTM QILFRHLRRV IENGEKNRMT
810 820 830 840
YQSIAIVFGP TLLKPEKETG NIAVHTVYQN QIVELILLEL SSIFGR
Length:846
Mass (Da):96,254
Last modified:March 1, 2003 - v1
Checksum:i274CF06B47F02DDC
GO
Isoform 2 (identifier: Q8IWW6-2) [UniParc]FASTAAdd to basket
Also known as: ARHGAP12a

The sequence of this isoform differs from the canonical sequence as follows:
     433-462: Missing.

Show »
Length:816
Mass (Da):93,114
Checksum:iA948E9F7904B8DC7
GO
Isoform 3 (identifier: Q8IWW6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-363: Missing.
     458-462: Missing.

Show »
Length:794
Mass (Da):90,403
Checksum:i330029A7C1C294B3
GO
Isoform 4 (identifier: Q8IWW6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-462: Missing.

Show »
Length:841
Mass (Da):95,784
Checksum:i5C07E44111C30C1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70K → R in CAD38926 (PubMed:17974005).Curated1
Sequence conflicti760Q → P in CAD38926 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024454442F → S.Corresponds to variant rs2808096dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010326317 – 363Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_010327433 – 462Missing in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_010328458 – 462Missing in isoform 3 and isoform 4. 2 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033594 mRNA. Translation: AAK52311.1.
AY033595 mRNA. Translation: AAK52312.1.
AL390715 Genomic DNA. Translation: CAI12371.1.
AL390715 Genomic DNA. Translation: CAI12372.1.
AL390715 Genomic DNA. Translation: CAI12373.1.
AL834250 mRNA. Translation: CAD38926.2.
AL137485 mRNA. Translation: CAB70766.1.
CH471072 Genomic DNA. Translation: EAW85980.1.
CH471072 Genomic DNA. Translation: EAW85983.1.
CH471072 Genomic DNA. Translation: EAW85985.1.
BC051811 mRNA. Translation: AAH51811.1.
BC094719 mRNA. Translation: AAH94719.1.
CCDSiCCDS59214.1. [Q8IWW6-3]
CCDS59215.1. [Q8IWW6-2]
CCDS59216.1. [Q8IWW6-4]
CCDS7170.1. [Q8IWW6-1]
PIRiT46471.
RefSeqiNP_001257624.1. NM_001270695.1. [Q8IWW6-4]
NP_001257625.1. NM_001270696.1. [Q8IWW6-2]
NP_001257626.1. NM_001270697.1.
NP_001257627.1. NM_001270698.1.
NP_001257628.1. NM_001270699.1. [Q8IWW6-3]
NP_060757.4. NM_018287.6. [Q8IWW6-1]
XP_005252701.1. XM_005252644.1. [Q8IWW6-3]
UniGeneiHs.499264.
Hs.741991.

Genome annotation databases

EnsembliENST00000311380; ENSP00000310984; ENSG00000165322. [Q8IWW6-3]
ENST00000344936; ENSP00000345808; ENSG00000165322. [Q8IWW6-1]
ENST00000375250; ENSP00000364399; ENSG00000165322. [Q8IWW6-2]
ENST00000396144; ENSP00000379448; ENSG00000165322. [Q8IWW6-4]
GeneIDi94134.
KEGGihsa:94134.
UCSCiuc001ivy.3. human. [Q8IWW6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033594 mRNA. Translation: AAK52311.1.
AY033595 mRNA. Translation: AAK52312.1.
AL390715 Genomic DNA. Translation: CAI12371.1.
AL390715 Genomic DNA. Translation: CAI12372.1.
AL390715 Genomic DNA. Translation: CAI12373.1.
AL834250 mRNA. Translation: CAD38926.2.
AL137485 mRNA. Translation: CAB70766.1.
CH471072 Genomic DNA. Translation: EAW85980.1.
CH471072 Genomic DNA. Translation: EAW85983.1.
CH471072 Genomic DNA. Translation: EAW85985.1.
BC051811 mRNA. Translation: AAH51811.1.
BC094719 mRNA. Translation: AAH94719.1.
CCDSiCCDS59214.1. [Q8IWW6-3]
CCDS59215.1. [Q8IWW6-2]
CCDS59216.1. [Q8IWW6-4]
CCDS7170.1. [Q8IWW6-1]
PIRiT46471.
RefSeqiNP_001257624.1. NM_001270695.1. [Q8IWW6-4]
NP_001257625.1. NM_001270696.1. [Q8IWW6-2]
NP_001257626.1. NM_001270697.1.
NP_001257627.1. NM_001270698.1.
NP_001257628.1. NM_001270699.1. [Q8IWW6-3]
NP_060757.4. NM_018287.6. [Q8IWW6-1]
XP_005252701.1. XM_005252644.1. [Q8IWW6-3]
UniGeneiHs.499264.
Hs.741991.

3D structure databases

ProteinModelPortaliQ8IWW6.
SMRiQ8IWW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125122. 10 interactors.
IntActiQ8IWW6. 7 interactors.
MINTiMINT-3037739.
STRINGi9606.ENSP00000345808.

PTM databases

iPTMnetiQ8IWW6.
PhosphoSitePlusiQ8IWW6.

Polymorphism and mutation databases

DMDMi47117238.

Proteomic databases

EPDiQ8IWW6.
MaxQBiQ8IWW6.
PaxDbiQ8IWW6.
PeptideAtlasiQ8IWW6.
PRIDEiQ8IWW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311380; ENSP00000310984; ENSG00000165322. [Q8IWW6-3]
ENST00000344936; ENSP00000345808; ENSG00000165322. [Q8IWW6-1]
ENST00000375250; ENSP00000364399; ENSG00000165322. [Q8IWW6-2]
ENST00000396144; ENSP00000379448; ENSG00000165322. [Q8IWW6-4]
GeneIDi94134.
KEGGihsa:94134.
UCSCiuc001ivy.3. human. [Q8IWW6-1]

Organism-specific databases

CTDi94134.
GeneCardsiARHGAP12.
HGNCiHGNC:16348. ARHGAP12.
HPAiHPA000412.
MIMi610577. gene.
neXtProtiNX_Q8IWW6.
OpenTargetsiENSG00000165322.
PharmGKBiPA24957.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ9D. Eukaryota.
ENOG410ZTHP. LUCA.
GeneTreeiENSGT00840000129684.
HOVERGENiHBG005328.
InParanoidiQ8IWW6.
KOiK20636.
OMAiQSCDSAG.
OrthoDBiEOG091G164H.
PhylomeDBiQ8IWW6.
TreeFamiTF329345.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.
SignaLinkiQ8IWW6.

Miscellaneous databases

ChiTaRSiARHGAP12. human.
GenomeRNAii94134.
PROiQ8IWW6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165322.
CleanExiHS_ARHGAP12.
ExpressionAtlasiQ8IWW6. baseline and differential.
GenevisibleiQ8IWW6. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR015767. Rho_GTPase_act.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
IPR001202. WW_dom.
[Graphical view]
PANTHERiPTHR23181. PTHR23181. 3 hits.
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG12_HUMAN
AccessioniPrimary (citable) accession number: Q8IWW6
Secondary accession number(s): B1ANY0
, B1ANY1, B1ANY2, Q504X1, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.