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Q8IWW6

- RHG12_HUMAN

UniProt

Q8IWW6 - RHG12_HUMAN

Protein

Rho GTPase-activating protein 12

Gene

ARHGAP12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW

    GO - Biological processi

    1. morphogenesis of an epithelial sheet Source: UniProt
    2. regulation of small GTPase mediated signal transduction Source: Reactome
    3. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    SignaLinkiQ8IWW6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GTPase-activating protein 12
    Alternative name(s):
    Rho-type GTPase-activating protein 12
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:16348. ARHGAP12.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24957.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 846846Rho GTPase-activating protein 12PRO_0000056713Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei165 – 1651Phosphoserine2 Publications
    Modified residuei201 – 2011Phosphoserine1 Publication
    Modified residuei213 – 2131Phosphoserine2 Publications
    Modified residuei215 – 2151Phosphoserine2 Publications
    Modified residuei240 – 2401Phosphoserine3 Publications
    Modified residuei243 – 2431Phosphotyrosine2 Publications
    Modified residuei592 – 5921Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IWW6.
    PaxDbiQ8IWW6.
    PRIDEiQ8IWW6.

    PTM databases

    PhosphoSiteiQ8IWW6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IWW6.
    BgeeiQ8IWW6.
    CleanExiHS_ARHGAP12.
    GenevestigatoriQ8IWW6.

    Organism-specific databases

    HPAiHPA000412.

    Interactioni

    Protein-protein interaction databases

    BioGridi125122. 5 interactions.
    IntActiQ8IWW6. 3 interactions.
    MINTiMINT-3037739.
    STRINGi9606.ENSP00000345808.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWW6.
    SMRiQ8IWW6. Positions 13-72, 465-574, 637-845.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 7463SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini265 – 29834WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini358 – 39134WW 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini463 – 575113PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini656 – 844189Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation
    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG279563.
    HOVERGENiHBG005328.
    InParanoidiQ8IWW6.
    OMAiQSCDSAG.
    OrthoDBiEOG7CZK7R.
    PhylomeDBiQ8IWW6.
    TreeFamiTF329345.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015767. Rho_GTPase_act.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    IPR001202. WW_dom.
    [Graphical view]
    PANTHERiPTHR23181. PTHR23181. 1 hit.
    PfamiPF00169. PH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF14604. SH3_9. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    SM00456. WW. 2 hits.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF51045. SSF51045. 2 hits.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWW6-1) [UniParc]FASTAAdd to Basket

    Also known as: ARHGAP12b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKMADRSGKI IPGQVYIEVE YDYEYEAKDR KIVIKQGERY ILVKKTNDDW    50
    WQVKPDENSK AFYVPAQYVK EVTRKALMPP VKQVAGLPNN STKIMQSLHL 100
    QRSTENVNKL PELSSFGKPS SSVQGTGLIR DANQNFGPSY NQGQTVNLSL 150
    DLTHNNGKFN NDSHSPKVSS QNRTRSFGHF PGPEFLDVEK TSFSQEQSCD 200
    SAGEGSERIH QDSESGDELS SSSTEQIRAT TPPNQGRPDS PVYANLQELK 250
    ISQSALPPLP GSPAIQINGE WETHKDSSGR CYYYNRGTQE RTWKPPRWTR 300
    DASISKGDFQ NPGDQELLSS EENYYSTSYS QSDSQCGSPP RGWSEELDER 350
    GHTLYTSDYT NEKWLKHVDD QGRQYYYSAD GSRSEWELPK YNASSQQQRE 400
    IIKSRSLDRR LQEPIVLTKW RHSTIVLDTN DKESPTASKP CFPENESSPS 450
    SPKHQDTASS PKDQEKYGLL NVTKIAENGK KVRKNWLSSW AVLQGSSLLF 500
    TKTQGSSTSW FGSNQSKPEF TVDLKGATIE MASKDKSSKK NVFELKTRQG 550
    TELLIQSDND TVINDWFKVL SSTINNQAVE TDEGIEEEIP DSPGIEKHDK 600
    EKEQKDPKKL RSFKVSSIDS SEQKKTKKNL KKFLTRRPTL QAVREKGYIK 650
    DQVFGSNLAN LCQRENGTVP KFVKLCIEHV EEHGLDIDGI YRVSGNLAVI 700
    QKLRFAVNHD EKLDLNDSKW EDIHVITGAL KMFFRELPEP LFTFNHFNDF 750
    VNAIKQEPRQ RVAAVKDLIR QLPKPNQDTM QILFRHLRRV IENGEKNRMT 800
    YQSIAIVFGP TLLKPEKETG NIAVHTVYQN QIVELILLEL SSIFGR 846
    Length:846
    Mass (Da):96,254
    Last modified:March 1, 2003 - v1
    Checksum:i274CF06B47F02DDC
    GO
    Isoform 2 (identifier: Q8IWW6-2) [UniParc]FASTAAdd to Basket

    Also known as: ARHGAP12a

    The sequence of this isoform differs from the canonical sequence as follows:
         433-462: Missing.

    Show »
    Length:816
    Mass (Da):93,114
    Checksum:iA948E9F7904B8DC7
    GO
    Isoform 3 (identifier: Q8IWW6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         317-363: Missing.
         458-462: Missing.

    Show »
    Length:794
    Mass (Da):90,403
    Checksum:i330029A7C1C294B3
    GO
    Isoform 4 (identifier: Q8IWW6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         458-462: Missing.

    Show »
    Length:841
    Mass (Da):95,784
    Checksum:i5C07E44111C30C1C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701K → R in CAD38926. (PubMed:17974005)Curated
    Sequence conflicti760 – 7601Q → P in CAD38926. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti442 – 4421F → S.
    Corresponds to variant rs2808096 [ dbSNP | Ensembl ].
    VAR_024454

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei317 – 36347Missing in isoform 3. 1 PublicationVSP_010326Add
    BLAST
    Alternative sequencei433 – 46230Missing in isoform 2. 1 PublicationVSP_010327Add
    BLAST
    Alternative sequencei458 – 4625Missing in isoform 3 and isoform 4. 2 PublicationsVSP_010328

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033594 mRNA. Translation: AAK52311.1.
    AY033595 mRNA. Translation: AAK52312.1.
    AL390715 Genomic DNA. Translation: CAI12371.1.
    AL390715 Genomic DNA. Translation: CAI12372.1.
    AL390715 Genomic DNA. Translation: CAI12373.1.
    AL834250 mRNA. Translation: CAD38926.2.
    AL137485 mRNA. Translation: CAB70766.1.
    CH471072 Genomic DNA. Translation: EAW85980.1.
    CH471072 Genomic DNA. Translation: EAW85983.1.
    CH471072 Genomic DNA. Translation: EAW85985.1.
    BC051811 mRNA. Translation: AAH51811.1.
    BC094719 mRNA. Translation: AAH94719.1.
    CCDSiCCDS59214.1. [Q8IWW6-3]
    CCDS59215.1. [Q8IWW6-2]
    CCDS59216.1. [Q8IWW6-4]
    CCDS7170.1. [Q8IWW6-1]
    PIRiT46471.
    RefSeqiNP_001257624.1. NM_001270695.1. [Q8IWW6-4]
    NP_001257625.1. NM_001270696.1. [Q8IWW6-2]
    NP_001257626.1. NM_001270697.1.
    NP_001257627.1. NM_001270698.1.
    NP_001257628.1. NM_001270699.1. [Q8IWW6-3]
    NP_060757.4. NM_018287.6. [Q8IWW6-1]
    XP_005252701.1. XM_005252644.1. [Q8IWW6-3]
    XP_006717603.1. XM_006717540.1. [Q8IWW6-1]
    UniGeneiHs.499264.
    Hs.741991.

    Genome annotation databases

    EnsembliENST00000311380; ENSP00000310984; ENSG00000165322. [Q8IWW6-3]
    ENST00000344936; ENSP00000345808; ENSG00000165322. [Q8IWW6-1]
    ENST00000375245; ENSP00000364394; ENSG00000165322. [Q8IWW6-3]
    ENST00000375250; ENSP00000364399; ENSG00000165322. [Q8IWW6-2]
    ENST00000396144; ENSP00000379448; ENSG00000165322. [Q8IWW6-4]
    GeneIDi94134.
    KEGGihsa:94134.
    UCSCiuc001ivy.2. human. [Q8IWW6-3]
    uc001ivz.2. human. [Q8IWW6-1]
    uc001iwb.2. human.
    uc001iwc.2. human. [Q8IWW6-2]

    Polymorphism databases

    DMDMi47117238.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033594 mRNA. Translation: AAK52311.1 .
    AY033595 mRNA. Translation: AAK52312.1 .
    AL390715 Genomic DNA. Translation: CAI12371.1 .
    AL390715 Genomic DNA. Translation: CAI12372.1 .
    AL390715 Genomic DNA. Translation: CAI12373.1 .
    AL834250 mRNA. Translation: CAD38926.2 .
    AL137485 mRNA. Translation: CAB70766.1 .
    CH471072 Genomic DNA. Translation: EAW85980.1 .
    CH471072 Genomic DNA. Translation: EAW85983.1 .
    CH471072 Genomic DNA. Translation: EAW85985.1 .
    BC051811 mRNA. Translation: AAH51811.1 .
    BC094719 mRNA. Translation: AAH94719.1 .
    CCDSi CCDS59214.1. [Q8IWW6-3 ]
    CCDS59215.1. [Q8IWW6-2 ]
    CCDS59216.1. [Q8IWW6-4 ]
    CCDS7170.1. [Q8IWW6-1 ]
    PIRi T46471.
    RefSeqi NP_001257624.1. NM_001270695.1. [Q8IWW6-4 ]
    NP_001257625.1. NM_001270696.1. [Q8IWW6-2 ]
    NP_001257626.1. NM_001270697.1.
    NP_001257627.1. NM_001270698.1.
    NP_001257628.1. NM_001270699.1. [Q8IWW6-3 ]
    NP_060757.4. NM_018287.6. [Q8IWW6-1 ]
    XP_005252701.1. XM_005252644.1. [Q8IWW6-3 ]
    XP_006717603.1. XM_006717540.1. [Q8IWW6-1 ]
    UniGenei Hs.499264.
    Hs.741991.

    3D structure databases

    ProteinModelPortali Q8IWW6.
    SMRi Q8IWW6. Positions 13-72, 465-574, 637-845.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125122. 5 interactions.
    IntActi Q8IWW6. 3 interactions.
    MINTi MINT-3037739.
    STRINGi 9606.ENSP00000345808.

    PTM databases

    PhosphoSitei Q8IWW6.

    Polymorphism databases

    DMDMi 47117238.

    Proteomic databases

    MaxQBi Q8IWW6.
    PaxDbi Q8IWW6.
    PRIDEi Q8IWW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311380 ; ENSP00000310984 ; ENSG00000165322 . [Q8IWW6-3 ]
    ENST00000344936 ; ENSP00000345808 ; ENSG00000165322 . [Q8IWW6-1 ]
    ENST00000375245 ; ENSP00000364394 ; ENSG00000165322 . [Q8IWW6-3 ]
    ENST00000375250 ; ENSP00000364399 ; ENSG00000165322 . [Q8IWW6-2 ]
    ENST00000396144 ; ENSP00000379448 ; ENSG00000165322 . [Q8IWW6-4 ]
    GeneIDi 94134.
    KEGGi hsa:94134.
    UCSCi uc001ivy.2. human. [Q8IWW6-3 ]
    uc001ivz.2. human. [Q8IWW6-1 ]
    uc001iwb.2. human.
    uc001iwc.2. human. [Q8IWW6-2 ]

    Organism-specific databases

    CTDi 94134.
    GeneCardsi GC10M032134.
    HGNCi HGNC:16348. ARHGAP12.
    HPAi HPA000412.
    MIMi 610577. gene.
    neXtProti NX_Q8IWW6.
    PharmGKBi PA24957.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279563.
    HOVERGENi HBG005328.
    InParanoidi Q8IWW6.
    OMAi QSCDSAG.
    OrthoDBi EOG7CZK7R.
    PhylomeDBi Q8IWW6.
    TreeFami TF329345.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    SignaLinki Q8IWW6.

    Miscellaneous databases

    ChiTaRSi ARHGAP12. human.
    GenomeRNAii 94134.
    NextBioi 78410.
    PROi Q8IWW6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IWW6.
    Bgeei Q8IWW6.
    CleanExi HS_ARHGAP12.
    Genevestigatori Q8IWW6.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015767. Rho_GTPase_act.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    IPR001202. WW_dom.
    [Graphical view ]
    PANTHERi PTHR23181. PTHR23181. 1 hit.
    Pfami PF00169. PH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF14604. SH3_9. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    SM00456. WW. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF51045. SSF51045. 2 hits.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel human gene."
      Mao Y., Xie Y., Zhang Z.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-846 (ISOFORM 3).
      Tissue: Testis.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Placenta and Uterus.
    6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240 AND TYR-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; SER-213; SER-215; SER-240 AND SER-592, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-215; SER-240 AND TYR-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRHG12_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWW6
    Secondary accession number(s): B1ANY0
    , B1ANY1, B1ANY2, Q504X1, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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