##gff-version 3 Q8IWV7 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Q8IWV7 UniProtKB Chain 2 1749 . . . ID=PRO_0000056136;Note=E3 ubiquitin-protein ligase UBR1 Q8IWV7 UniProtKB Zinc finger 97 168 . . . Note=UBR-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00508 Q8IWV7 UniProtKB Zinc finger 1098 1201 . . . Note=RING-type%3B atypical Q8IWV7 UniProtKB Region 842 868 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IWV7 UniProtKB Compositional bias 842 861 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IWV7 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Q8IWV7 UniProtKB Modified residue 21 21 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18691976,PMID:19369195,PMID:19690332,PMID:23186163,PMID:24275569 Q8IWV7 UniProtKB Modified residue 1179 1179 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17525332;Dbxref=PMID:17525332 Q8IWV7 UniProtKB Alternative sequence 795 803 . . . ID=VSP_015164;Note=In isoform 2. NNETGLENV->TRCIRPWSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q8IWV7 UniProtKB Alternative sequence 804 1749 . . . ID=VSP_015165;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q8IWV7 UniProtKB Natural variant 122 122 . . . ID=VAR_075179;Note=In JBS%3B decreased%2C but detectable activity in a yeast-based assay. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21931868,ECO:0000269|PubMed:24599544;Dbxref=PMID:21931868,PMID:24599544 Q8IWV7 UniProtKB Natural variant 127 127 . . . ID=VAR_075180;Note=In JBS. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Natural variant 136 136 . . . ID=VAR_024741;Note=In JBS%3B prevents proper folding of the UBR-type zinc finger%3B may decrease protein stability%3B loss of activity in a yeast-based assay. H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16311597,ECO:0000269|PubMed:20835242,ECO:0000269|PubMed:21931868,ECO:0000269|PubMed:24599544;Dbxref=dbSNP:rs119477054,PMID:16311597,PMID:20835242,PMID:21931868,PMID:24599544 Q8IWV7 UniProtKB Natural variant 166 166 . . . ID=VAR_075181;Note=In JBS. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Natural variant 217 217 . . . ID=VAR_075182;Note=In JBS. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Natural variant 286 286 . . . ID=VAR_075183;Note=In JBS. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Natural variant 317 317 . . . ID=VAR_075184;Note=In JBS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Natural variant 389 392 . . . ID=VAR_075185;Note=In JBS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Natural variant 427 427 . . . ID=VAR_075186;Note=In JBS%3B uncertain significance. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26149651;Dbxref=dbSNP:rs1158249054,PMID:26149651 Q8IWV7 UniProtKB Natural variant 563 563 . . . ID=VAR_075187;Note=In JBS. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=dbSNP:rs768686147,PMID:24599544 Q8IWV7 UniProtKB Natural variant 596 596 . . . ID=VAR_034467;Note=K->M;Dbxref=dbSNP:rs34568456 Q8IWV7 UniProtKB Natural variant 660 660 . . . ID=VAR_075188;Note=In JBS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Natural variant 700 700 . . . ID=VAR_075189;Note=In JBS. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22072859,ECO:0000269|PubMed:24599544;Dbxref=PMID:22072859,PMID:24599544 Q8IWV7 UniProtKB Natural variant 754 754 . . . ID=VAR_075190;Note=In JBS. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=dbSNP:rs1388367359,PMID:24599544 Q8IWV7 UniProtKB Natural variant 754 754 . . . ID=VAR_075191;Note=In JBS. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=dbSNP:rs1567131023,PMID:24599544 Q8IWV7 UniProtKB Natural variant 899 899 . . . ID=VAR_052116;Note=I->V;Dbxref=dbSNP:rs35069201 Q8IWV7 UniProtKB Natural variant 1102 1102 . . . ID=VAR_075192;Note=In JBS%3B strong decrease in activity in a yeast-based assay. Q->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21931868,ECO:0000269|PubMed:24599544;Dbxref=PMID:21931868,PMID:24599544 Q8IWV7 UniProtKB Natural variant 1242 1242 . . . ID=VAR_075193;Note=In JBS. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=dbSNP:rs1235541565,PMID:24599544 Q8IWV7 UniProtKB Natural variant 1279 1279 . . . ID=VAR_024742;Note=In JBS. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16311597,ECO:0000269|PubMed:24599544;Dbxref=PMID:16311597,PMID:24599544 Q8IWV7 UniProtKB Natural variant 1426 1426 . . . ID=VAR_075194;Note=In JBS. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Natural variant 1427 1427 . . . ID=VAR_075195;Note=In JBS. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=dbSNP:rs1480939799,PMID:24599544 Q8IWV7 UniProtKB Natural variant 1431 1431 . . . ID=VAR_075196;Note=In JBS. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=dbSNP:rs140972409,PMID:24599544 Q8IWV7 UniProtKB Natural variant 1548 1548 . . . ID=VAR_061822;Note=T->A;Dbxref=dbSNP:rs3917223 Q8IWV7 UniProtKB Natural variant 1661 1661 . . . ID=VAR_075197;Note=In JBS. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24599544;Dbxref=PMID:24599544 Q8IWV7 UniProtKB Sequence conflict 201 201 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWV7 UniProtKB Sequence conflict 900 900 . . . Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWV7 UniProtKB Sequence conflict 973 973 . . . Note=D->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWV7 UniProtKB Sequence conflict 993 993 . . . Note=C->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWV7 UniProtKB Sequence conflict 1710 1719 . . . Note=LSRERYRKLH->FLVSGTEAP;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWV7 UniProtKB Sequence conflict 1722 1722 . . . Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWV7 UniProtKB Beta strand 108 112 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC Q8IWV7 UniProtKB Turn 113 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC Q8IWV7 UniProtKB Beta strand 116 118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC Q8IWV7 UniProtKB Helix 125 129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC Q8IWV7 UniProtKB Helix 132 135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC Q8IWV7 UniProtKB Beta strand 138 142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC Q8IWV7 UniProtKB Turn 154 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC Q8IWV7 UniProtKB Beta strand 157 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC Q8IWV7 UniProtKB Turn 164 166 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TDC