Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8IWV2

- CNTN4_HUMAN

UniProt

Q8IWV2 - CNTN4_HUMAN

Protein

Contactin-4

Gene

CNTN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.

    GO - Biological processi

    1. axonal fasciculation Source: UniProtKB
    2. axon guidance Source: UniProtKB
    3. axonogenesis Source: UniProtKB
    4. brain development Source: UniProtKB
    5. negative regulation of neuron differentiation Source: UniProtKB
    6. nervous system development Source: UniProtKB
    7. neuron cell-cell adhesion Source: UniProtKB
    8. neuron projection development Source: UniProtKB
    9. regulation of synaptic plasticity Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Contactin-4
    Alternative name(s):
    Brain-derived immunoglobulin superfamily protein 2
    Short name:
    BIG-2
    Gene namesi
    Name:CNTN4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:2174. CNTN4.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. axon Source: UniProtKB
    3. extracellular region Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.

    Organism-specific databases

    Orphaneti1620. Distal monosomy 3p.
    PharmGKBiPA26688.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 1000982Contactin-4PRO_0000014711Add
    BLAST
    Propeptidei1001 – 102626Removed in mature formSequence AnalysisPRO_0000014712Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
    Glycosylationi65 – 651N-linked (GlcNAc...)1 Publication
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi144 ↔ 194PROSITE-ProRule annotation
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi247 ↔ 295PROSITE-ProRule annotation
    Disulfide bondi337 ↔ 384PROSITE-ProRule annotation
    Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi429 ↔ 477PROSITE-ProRule annotation
    Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi519 ↔ 576PROSITE-ProRule annotation
    Glycosylationi705 – 7051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi764 – 7641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi858 – 8581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi893 – 8931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi954 – 9541N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1000 – 10001GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ8IWV2.
    PRIDEiQ8IWV2.

    PTM databases

    PhosphoSiteiQ8IWV2.

    Expressioni

    Tissue specificityi

    Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.2 Publications

    Inductioni

    By retinoic acid, suggesting that it may act in response to differentiating agents.1 Publication

    Gene expression databases

    ArrayExpressiQ8IWV2.
    BgeeiQ8IWV2.
    CleanExiHS_CNTN4.
    GenevestigatoriQ8IWV2.

    Organism-specific databases

    HPAiHPA021068.

    Interactioni

    Subunit structurei

    Interacts with PTPRG.1 Publication

    Protein-protein interaction databases

    BioGridi127444. 4 interactions.
    IntActiQ8IWV2. 3 interactions.
    STRINGi9606.ENSP00000380602.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWV2.
    SMRiQ8IWV2. Positions 25-995.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 11786Ig-like C2-type 1Add
    BLAST
    Domaini122 – 20786Ig-like C2-type 2Add
    BLAST
    Domaini225 – 31187Ig-like C2-type 3Add
    BLAST
    Domaini316 – 40085Ig-like C2-type 4Add
    BLAST
    Domaini406 – 49388Ig-like C2-type 5Add
    BLAST
    Domaini497 – 58690Ig-like C2-type 6Add
    BLAST
    Domaini599 – 69799Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini702 – 79998Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini804 – 89996Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini900 – 99596Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG293951.
    HOGENOMiHOG000059617.
    HOVERGENiHBG051047.
    InParanoidiQ8IWV2.
    KOiK06762.
    OMAiFMLCLAD.
    OrthoDBiEOG7J17Z5.
    PhylomeDBiQ8IWV2.
    TreeFamiTF351103.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF07679. I-set. 5 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWV2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLPWELLVL QSFILCLADD STLHGPIFIQ EPSPVMFPLD SEEKKVKLNC     50
    EVKGNPKPHI RWKLNGTDVD TGMDFRYSVV EGSLLINNPN KTQDAGTYQC 100
    TATNSFGTIV SREAKLQFAY LDNFKTRTRS TVSVRRGQGM VLLCGPPPHS 150
    GELSYAWIFN EYPSYQDNRR FVSQETGNLY IAKVEKSDVG NYTCVVTNTV 200
    TNHKVLGPPT PLILRNDGVM GEYEPKIEVQ FPETVPTAKG ATVKLECFAL 250
    GNPVPTIIWR RADGKPIARK ARRHKSNGIL EIPNFQQEDA GLYECVAENS 300
    RGKNVARGQL TFYAQPNWIQ KINDIHVAME ENVFWECKAN GRPKPTYKWL 350
    KNGEPLLTRD RIQIEQGTLN ITIVNLSDAG MYQCLAENKH GVIFSNAELS 400
    VIAVGPDFSR TLLKRVTLVK VGGEVVIECK PKASPKPVYT WKKGRDILKE 450
    NERITISEDG NLRIINVTKS DAGSYTCIAT NHFGTASSTG NLVVKDPTRV 500
    MVPPSSMDVT VGESIVLPCQ VTHDHSLDIV FTWSFNGHLI DFDRDGDHFE 550
    RVGGQDSAGD LMIRNIQLKH AGKYVCMVQT SVDRLSAAAD LIVRGPPGPP 600
    EAVTIDEITD TTAQLSWRPG PDNHSPITMY VIQARTPFSV GWQAVSTVPE 650
    LIDGKTFTAT VVGLNPWVEY EFRTVAANVI GIGEPSRPSE KRRTEEALPE 700
    VTPANVSGGG GSKSELVITW ETVPEELQNG RGFGYVVAFR PYGKMIWMLT 750
    VLASADASRY VFRNESVHPF SPFEVKVGVF NNKGEGPFSP TTVVYSAEEE 800
    PTKPPASIFA RSLSATDIEV FWASPLEKNR GRIQGYEVKY WRHEDKEENA 850
    RKIRTVGNQT STKITNLKGS VLYHLAVKAY NSAGTGPSSA TVNVTTRKPP 900
    PSQPPGNIIW NSSDSKIILN WDQVKALDNE SEVKGYKVLY RWNRQSSTSV 950
    IETNKTSVEL SLPFDEDYII EIKPFSDGGD GSSSEQIRIP KISNAYARGS 1000
    GASTSNACTL SAISTIMISL TARSSL 1026
    Length:1,026
    Mass (Da):113,454
    Last modified:March 1, 2003 - v1
    Checksum:i2B53D15665B4287B
    GO
    Isoform 2 (identifier: Q8IWV2-2) [UniParc]FASTAAdd to Basket

    Also known as: CNTN4A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-744: Missing.

    Show »
    Length:282
    Mass (Da):31,066
    Checksum:iFC0BD80B86F9E048
    GO
    Isoform 3 (identifier: Q8IWV2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-328: Missing.
         555-555: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:697
    Mass (Da):76,527
    Checksum:i9984789B5E5334F9
    GO
    Isoform 4 (identifier: Q8IWV2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-328: Missing.

    Show »
    Length:698
    Mass (Da):76,655
    Checksum:iBA1E4A8521B5D6FF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti176 – 1761T → P in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035507
    Natural varianti420 – 4201K → N in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035508

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 744744Missing in isoform 2. 1 PublicationVSP_011961Add
    BLAST
    Alternative sequencei1 – 328328Missing in isoform 3 and isoform 4. 2 PublicationsVSP_044270Add
    BLAST
    Alternative sequencei555 – 5551Missing in isoform 3. CuratedVSP_011962

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF464063 mRNA. Translation: AAN86141.1.
    AY090737 mRNA. Translation: AAM00025.1.
    AF549455 mRNA. Translation: AAP05786.1.
    AK314396 mRNA. Translation: BAG37020.1.
    AC018842 Genomic DNA. No translation available.
    AC022002 Genomic DNA. No translation available.
    AC022008 Genomic DNA. No translation available.
    AC024057 Genomic DNA. No translation available.
    AC026882 Genomic DNA. No translation available.
    AC066608 Genomic DNA. No translation available.
    AC087094 Genomic DNA. No translation available.
    AC087427 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW63874.1.
    BC026119 mRNA. Translation: AAH26119.1.
    CCDSiCCDS2558.1. [Q8IWV2-4]
    CCDS43041.1. [Q8IWV2-1]
    RefSeqiNP_001193884.1. NM_001206955.1. [Q8IWV2-1]
    NP_001193885.1. NM_001206956.1. [Q8IWV2-3]
    NP_783200.1. NM_175607.2. [Q8IWV2-1]
    NP_783302.1. NM_175613.2. [Q8IWV2-4]
    UniGeneiHs.298705.
    Hs.626418.

    Genome annotation databases

    EnsembliENST00000397459; ENSP00000380600; ENSG00000144619. [Q8IWV2-4]
    ENST00000397461; ENSP00000380602; ENSG00000144619. [Q8IWV2-1]
    ENST00000418658; ENSP00000396010; ENSG00000144619. [Q8IWV2-1]
    ENST00000427331; ENSP00000413642; ENSG00000144619. [Q8IWV2-1]
    GeneIDi152330.
    KEGGihsa:152330.
    UCSCiuc003bpb.1. human. [Q8IWV2-3]
    uc003bpc.3. human. [Q8IWV2-1]
    uc003bpg.3. human. [Q8IWV2-2]

    Polymorphism databases

    DMDMi55976529.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF464063 mRNA. Translation: AAN86141.1 .
    AY090737 mRNA. Translation: AAM00025.1 .
    AF549455 mRNA. Translation: AAP05786.1 .
    AK314396 mRNA. Translation: BAG37020.1 .
    AC018842 Genomic DNA. No translation available.
    AC022002 Genomic DNA. No translation available.
    AC022008 Genomic DNA. No translation available.
    AC024057 Genomic DNA. No translation available.
    AC026882 Genomic DNA. No translation available.
    AC066608 Genomic DNA. No translation available.
    AC087094 Genomic DNA. No translation available.
    AC087427 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW63874.1 .
    BC026119 mRNA. Translation: AAH26119.1 .
    CCDSi CCDS2558.1. [Q8IWV2-4 ]
    CCDS43041.1. [Q8IWV2-1 ]
    RefSeqi NP_001193884.1. NM_001206955.1. [Q8IWV2-1 ]
    NP_001193885.1. NM_001206956.1. [Q8IWV2-3 ]
    NP_783200.1. NM_175607.2. [Q8IWV2-1 ]
    NP_783302.1. NM_175613.2. [Q8IWV2-4 ]
    UniGenei Hs.298705.
    Hs.626418.

    3D structure databases

    ProteinModelPortali Q8IWV2.
    SMRi Q8IWV2. Positions 25-995.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127444. 4 interactions.
    IntActi Q8IWV2. 3 interactions.
    STRINGi 9606.ENSP00000380602.

    PTM databases

    PhosphoSitei Q8IWV2.

    Polymorphism databases

    DMDMi 55976529.

    Proteomic databases

    PaxDbi Q8IWV2.
    PRIDEi Q8IWV2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397459 ; ENSP00000380600 ; ENSG00000144619 . [Q8IWV2-4 ]
    ENST00000397461 ; ENSP00000380602 ; ENSG00000144619 . [Q8IWV2-1 ]
    ENST00000418658 ; ENSP00000396010 ; ENSG00000144619 . [Q8IWV2-1 ]
    ENST00000427331 ; ENSP00000413642 ; ENSG00000144619 . [Q8IWV2-1 ]
    GeneIDi 152330.
    KEGGi hsa:152330.
    UCSCi uc003bpb.1. human. [Q8IWV2-3 ]
    uc003bpc.3. human. [Q8IWV2-1 ]
    uc003bpg.3. human. [Q8IWV2-2 ]

    Organism-specific databases

    CTDi 152330.
    GeneCardsi GC03P002117.
    HGNCi HGNC:2174. CNTN4.
    HPAi HPA021068.
    MIMi 607280. gene.
    neXtProti NX_Q8IWV2.
    Orphaneti 1620. Distal monosomy 3p.
    PharmGKBi PA26688.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293951.
    HOGENOMi HOG000059617.
    HOVERGENi HBG051047.
    InParanoidi Q8IWV2.
    KOi K06762.
    OMAi FMLCLAD.
    OrthoDBi EOG7J17Z5.
    PhylomeDBi Q8IWV2.
    TreeFami TF351103.

    Miscellaneous databases

    ChiTaRSi CNTN4. human.
    GeneWikii CNTN4.
    GenomeRNAii 152330.
    NextBioi 86944.
    PROi Q8IWV2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IWV2.
    Bgeei Q8IWV2.
    CleanExi HS_CNTN4.
    Genevestigatori Q8IWV2.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF07679. I-set. 5 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel splice variant of the cell adhesion molecule contactin 4 (CNTN4) is mainly expressed in human brain."
      Zeng L., Zhang C., Xu J., Ye X., Wu Q., Dai J., Ji C., Gu S., Xie Y., Mao Y.
      J. Hum. Genet. 47:497-499(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2)."
      Hansford L.M., Smith S.A., Haber M., Norris M.D., Cheung B., Marshall G.M.
      Cytogenet. Genome Res. 101:17-23(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    7. "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members."
      Kamei Y., Takeda Y., Teramoto K., Tsutsumi O., Taketani Y., Watanabe K.
      Genomics 69:113-119(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome."
      Fernandez T., Morgan T., Davis N., Klin A., Morris A., Farhi A., Lifton R.P., State M.W.
      Am. J. Hum. Genet. 74:1286-1293(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION, INVOLVEMENT IN 3PDS.
    9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65.
      Tissue: Plasma.
    10. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
      Bouyain S., Watkins D.J.
      Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTPRG.
    11. Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-176 AND ASN-420.

    Entry informationi

    Entry nameiCNTN4_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWV2
    Secondary accession number(s): B2RAX3, Q8IX14, Q8TC35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3