true
2004-11-23
2024-03-27
168
CNTN4_HUMAN
A novel splice variant of the cell adhesion molecule contactin 4 (CNTN4) is mainly expressed in human brain.
Zeng L.
Zhang C.
Xu J.
Ye X.
Wu Q.
Dai J.
Ji C.
Gu S.
Xie Y.
Mao Y.
doi:10.1007/s100380200073
2002
J. Hum. Genet.
47
497-499
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2).
Hansford L.M.
Smith S.A.
Haber M.
Norris M.D.
Cheung B.
Marshall G.M.
doi:10.1159/000073412
2003
Cytogenet. Genome Res.
101
17-23
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
TISSUE SPECIFICITY
INDUCTION
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.
Suzuki Y.
Nishikawa T.
Otsuki T.
Sugiyama T.
Irie R.
Wakamatsu A.
Hayashi K.
Sato H.
Nagai K.
Kimura K.
Makita H.
Sekine M.
Obayashi M.
Nishi T.
Shibahara T.
Tanaka T.
Ishii S.
Yamamoto J.
Saito K.
Kawai Y.
Isono Y.
Nakamura Y.
Nagahari K.
Murakami K.
Yasuda T.
Iwayanagi T.
Wagatsuma M.
Shiratori A.
Sudo H.
Hosoiri T.
Kaku Y.
Kodaira H.
Kondo H.
Sugawara M.
Takahashi M.
Kanda K.
Yokoi T.
Furuya T.
Kikkawa E.
Omura Y.
Abe K.
Kamihara K.
Katsuta N.
Sato K.
Tanikawa M.
Yamazaki M.
Ninomiya K.
Ishibashi T.
Yamashita H.
Murakawa K.
Fujimori K.
Tanai H.
Kimata M.
Watanabe M.
Hiraoka S.
Chiba Y.
Ishida S.
Ono Y.
Takiguchi S.
Watanabe S.
Yosida M.
Hotuta T.
Kusano J.
Kanehori K.
Takahashi-Fujii A.
Hara H.
Tanase T.-O.
Nomura Y.
Togiya S.
Komai F.
Hara R.
Takeuchi K.
Arita M.
Imose N.
Musashino K.
Yuuki H.
Oshima A.
Sasaki N.
Aotsuka S.
Yoshikawa Y.
Matsunawa H.
Ichihara T.
Shiohata N.
Sano S.
Moriya S.
Momiyama H.
Satoh N.
Takami S.
Terashima Y.
Suzuki O.
Nakagawa S.
Senoh A.
Mizoguchi H.
Goto Y.
Shimizu F.
Wakebe H.
Hishigaki H.
Watanabe T.
Sugiyama A.
Takemoto M.
Kawakami B.
Yamazaki M.'
Watanabe K.
Kumagai A.
Itakura S.
Fukuzumi Y.
Fujimori Y.
Komiyama M.
Tashiro H.
Tanigami A.
Fujiwara T.
Ono T.
Yamada K.
Fujii Y.
Ozaki K.
Hirao M.
Ohmori Y.
Kawabata A.
Hikiji T.
Kobatake N.
Inagaki H.
Ikema Y.
Okamoto S.
Okitani R.
Kawakami T.
Noguchi S.
Itoh T.
Shigeta K.
Senba T.
Matsumura K.
Nakajima Y.
Mizuno T.
Morinaga M.
Sasaki M.
Togashi T.
Oyama M.
Hata H.
Watanabe M.'
Komatsu T.
Mizushima-Sugano J.
Satoh T.
Shirai Y.
Takahashi Y.
Nakagawa K.
Okumura K.
Nagase T.
Nomura N.
Kikuchi H.
Masuho Y.
Yamashita R.
Nakai K.
Yada T.
Nakamura Y.'
Ohara O.
Isogai T.
Sugano S.
doi:10.1038/ng1285
2004
Nat. Genet.
36
40-45
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
Testis
The DNA sequence, annotation and analysis of human chromosome 3.
Muzny D.M.
Scherer S.E.
Kaul R.
Wang J.
Yu J.
Sudbrak R.
Buhay C.J.
Chen R.
Cree A.
Ding Y.
Dugan-Rocha S.
Gill R.
Gunaratne P.
Harris R.A.
Hawes A.C.
Hernandez J.
Hodgson A.V.
Hume J.
Jackson A.
Khan Z.M.
Kovar-Smith C.
Lewis L.R.
Lozado R.J.
Metzker M.L.
Milosavljevic A.
Miner G.R.
Morgan M.B.
Nazareth L.V.
Scott G.
Sodergren E.
Song X.-Z.
Steffen D.
Wei S.
Wheeler D.A.
Wright M.W.
Worley K.C.
Yuan Y.
Zhang Z.
Adams C.Q.
Ansari-Lari M.A.
Ayele M.
Brown M.J.
Chen G.
Chen Z.
Clendenning J.
Clerc-Blankenburg K.P.
Chen R.'
Chen Z.'
Davis C.
Delgado O.
Dinh H.H.
Dong W.
Draper H.
Ernst S.
Fu G.
Gonzalez-Garay M.L.
Garcia D.K.
Gillett W.
Gu J.
Hao B.
Haugen E.
Havlak P.
He X.
Hennig S.
Hu S.
Huang W.
Jackson L.R.
Jacob L.S.
Kelly S.H.
Kube M.
Levy R.
Li Z.
Liu B.
Liu J.
Liu W.
Lu J.
Maheshwari M.
Nguyen B.-V.
Okwuonu G.O.
Palmeiri A.
Pasternak S.
Perez L.M.
Phelps K.A.
Plopper F.J.
Qiang B.
Raymond C.
Rodriguez R.
Saenphimmachak C.
Santibanez J.
Shen H.
Shen Y.
Subramanian S.
Tabor P.E.
Verduzco D.
Waldron L.
Wang J.'
Wang J.''
Wang Q.
Williams G.A.
Wong G.K.-S.
Yao Z.
Zhang J.
Zhang X.
Zhao G.
Zhou J.
Zhou Y.
Nelson D.
Lehrach H.
Reinhardt R.
Naylor S.L.
Yang H.
Olson M.
Weinstock G.
Gibbs R.A.
doi:10.1038/nature04728
2006
Nature
440
1194-1198
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Mural R.J.
Istrail S.
Sutton G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.
2005-07
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.
Kamei Y.
Takeda Y.
Teramoto K.
Tsutsumi O.
Taketani Y.
Watanabe K.
doi:10.1006/geno.2000.6310
2000
Genomics
69
113-119
TISSUE SPECIFICITY
Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome.
Fernandez T.
Morgan T.
Davis N.
Klin A.
Morris A.
Farhi A.
Lifton R.P.
State M.W.
doi:10.1086/421474
2004
Am. J. Hum. Genet.
74
1286-1293
CHROMOSOMAL TRANSLOCATION
INVOLVEMENT IN 3PDS
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
Liu T.
Qian W.-J.
Gritsenko M.A.
Camp D.G. II
Monroe M.E.
Moore R.J.
Smith R.D.
doi:10.1021/pr0502065
2005
J. Proteome Res.
4
2070-2080
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65
Plasma
The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.
Bouyain S.
Watkins D.J.
doi:10.1073/pnas.0911235107
2010
Proc. Natl. Acad. Sci. U.S.A.
107
2443-2448
INTERACTION WITH PTPRG
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.
Jones S.
Wood L.D.
Parsons D.W.
Lin J.
Barber T.D.
Mandelker D.
Leary R.J.
Ptak J.
Silliman N.
Szabo S.
Buckhaults P.
Farrell C.
Meeh P.
Markowitz S.D.
Willis J.
Dawson D.
Willson J.K.V.
Gazdar A.F.
Hartigan J.
Wu L.
Liu C.
Parmigiani G.
Park B.H.
Bachman K.E.
Papadopoulos N.
Vogelstein B.
Kinzler K.W.
Velculescu V.E.
doi:10.1126/science.1133427
2006
Science
314
268-274
VARIANTS [LARGE SCALE ANALYSIS] PRO-176 AND ASN-420
5
6
25 N-Linked glycans (7 sites)
14 sites, 27 glycans
14 sites, 27 N-linked glycans (7 sites)
249 antibodies from 31 providers
human
CNTN4
Tissue enhanced (parathyroid gland, retina)
gene
Eukaryota
Post-translational modification: synthesis of GPI-anchored proteins
12 hits in 1146 CRISPR screens
human
Tbio
Protein
Expressed in sperm and 154 other cell types or tissues
baseline and differential
FN3
Ig6_Contactin-4
Immunoglobulins
CNTN4_Ig6
FN3_dom
FN3_sf
Ig-like_dom
Ig-like_dom_sf
Ig-like_fold
Ig_I-set
Ig_sub
Ig_sub2
CONTACTIN 4-RELATED
PROTEIN SIDEKICK
fn3
I-set
Ig_3
FN3
IG
IGc2
Fibronectin type III
Immunoglobulin
FN3
IG_LIKE
HS
Contactin-4
Brain-derived immunoglobulin superfamily protein 2
BIG-2
CNTN4
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Interacts with PTPRG.
Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.
By retinoic acid, suggesting that it may act in response to differentiating agents.
A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
Belongs to the immunoglobulin superfamily. Contactin family.
1
18
Contactin-4
108787
19
1000
Removed in mature form
1001
1026
Ig-like C2-type 1
32
117
Ig-like C2-type 2
122
207
Ig-like C2-type 3
225
311
Ig-like C2-type 4
316
400
Ig-like C2-type 5
406
493
Ig-like C2-type 6
497
586
Fibronectin type-III 1
599
697
Fibronectin type-III 2
702
799
Fibronectin type-III 3
804
899
Fibronectin type-III 4
900
995
Disordered
685
710
Disordered
886
907
GPI-anchor amidated serine
N-linked (GlcNAc...) asparagine
65
N-linked (GlcNAc...) asparagine
90
N-linked (GlcNAc...) asparagine
191
N-linked (GlcNAc...) asparagine
370
N-linked (GlcNAc...) asparagine
375
N-linked (GlcNAc...) asparagine
466
N-linked (GlcNAc...) asparagine
705
N-linked (GlcNAc...) asparagine
764
N-linked (GlcNAc...) asparagine
858
N-linked (GlcNAc...) asparagine
893
N-linked (GlcNAc...) asparagine
911
N-linked (GlcNAc...) asparagine
929
N-linked (GlcNAc...) asparagine
954
50
100
144
194
247
295
337
384
429
477
519
576
In isoform 2.
744
In isoform 3 and isoform 4.
328
In isoform 3.
555
In a colorectal cancer sample; somatic mutation.
P
176
In a colorectal cancer sample; somatic mutation.
N
420
2003-03-01
1
true
113454
3246cbce25bab8c3521a98fe06896f7f
1
MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
2
CNTN4A
MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
3
MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
4
MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true