Q8IWV2 (CNTN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Contactin-4

Alternative name(s):
Brain-derived immunoglobulin superfamily protein 2
Short name=BIG-2

Gene names

Name:

CNTN4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1026 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor. Secreted By similarity.
Tissue specificity	Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex. Ref.2 Ref.7
Induction	By retinoic acid, suggesting that it may act in response to differentiating agents. Ref.2
Involvement in disease	A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features. Ref.8
Sequence similarities	Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement Ref.8. Source: UniProtKB axonal fasciculation Traceable author statement Ref.8. Source: UniProtKB brain development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of neuron differentiation Inferred from mutant phenotype Ref.2. Source: UniProtKB neuron cell-cell adhesion Traceable author statement Ref.2. Source: UniProtKB regulation of synaptic plasticity Traceable author statement Ref.8. Source: UniProtKB
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW axon Non-traceable author statement Ref.2. Source: UniProtKB extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Non-traceable author statement Ref.8. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWV2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWV2-2)

Also known as: CNTN4A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-744: Missing.

Isoform 3 (identifier: Q8IWV2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-328: Missing.
     555-555: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8IWV2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-328: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 1000	982	Contactin-4		PRO_0000014711
	Propeptide	1001 – 1026	26	Removed in mature form Potential		PRO_0000014712
Regions
	Domain	32 – 117	86	Ig-like C2-type 1
	Domain	122 – 207	86	Ig-like C2-type 2
	Domain	225 – 311	87	Ig-like C2-type 3
	Domain	316 – 400	85	Ig-like C2-type 4
	Domain	406 – 493	88	Ig-like C2-type 5
	Domain	497 – 586	90	Ig-like C2-type 6
	Domain	596 – 692	97	Fibronectin type-III 1
	Domain	699 – 797	99	Fibronectin type-III 2
	Domain	801 – 896	96	Fibronectin type-III 3
	Domain	901 – 990	90	Fibronectin type-III 4
Amino acid modifications
	Lipidation	1000	1	GPI-anchor amidated serine Potential
	Glycosylation	65	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	191	1	N-linked (GlcNAc...) Potential
	Glycosylation	370	1	N-linked (GlcNAc...) Potential
	Glycosylation	375	1	N-linked (GlcNAc...) Potential
	Glycosylation	466	1	N-linked (GlcNAc...) Potential
	Glycosylation	705	1	N-linked (GlcNAc...) Potential
	Glycosylation	764	1	N-linked (GlcNAc...) Potential
	Glycosylation	858	1	N-linked (GlcNAc...) Potential
	Glycosylation	893	1	N-linked (GlcNAc...) Potential
	Glycosylation	911	1	N-linked (GlcNAc...) Potential
	Glycosylation	929	1	N-linked (GlcNAc...) Potential
	Glycosylation	954	1	N-linked (GlcNAc...) Potential
	Disulfide bond	50 ↔ 100		By similarity
	Disulfide bond	144 ↔ 194		By similarity
	Disulfide bond	247 ↔ 295		By similarity
	Disulfide bond	337 ↔ 384		By similarity
	Disulfide bond	429 ↔ 477		By similarity
	Disulfide bond	519 ↔ 576		By similarity
Natural variations
	Alternative sequence	1 – 744	744	Missing in isoform 2.		VSP_011961
	Alternative sequence	1 – 328	328	Missing in isoform 3 and isoform 4.		VSP_044270
	Alternative sequence	555	1	Missing in isoform 3.		VSP_011962
	Natural variant	176	1	T → P in a colorectal cancer sample; somatic mutation. Ref.10		VAR_035507
	Natural variant	420	1	K → N in a colorectal cancer sample; somatic mutation. Ref.10		VAR_035508

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2B53D15665B4287B	FASTA	1,026	113,454
	10 20 30 40 50 60 MRLPWELLVL QSFILCLADD STLHGPIFIQ EPSPVMFPLD SEEKKVKLNC EVKGNPKPHI 70 80 90 100 110 120 RWKLNGTDVD TGMDFRYSVV EGSLLINNPN KTQDAGTYQC TATNSFGTIV SREAKLQFAY 130 140 150 160 170 180 LDNFKTRTRS TVSVRRGQGM VLLCGPPPHS GELSYAWIFN EYPSYQDNRR FVSQETGNLY 190 200 210 220 230 240 IAKVEKSDVG NYTCVVTNTV TNHKVLGPPT PLILRNDGVM GEYEPKIEVQ FPETVPTAKG 250 260 270 280 290 300 ATVKLECFAL GNPVPTIIWR RADGKPIARK ARRHKSNGIL EIPNFQQEDA GLYECVAENS 310 320 330 340 350 360 RGKNVARGQL TFYAQPNWIQ KINDIHVAME ENVFWECKAN GRPKPTYKWL KNGEPLLTRD 370 380 390 400 410 420 RIQIEQGTLN ITIVNLSDAG MYQCLAENKH GVIFSNAELS VIAVGPDFSR TLLKRVTLVK 430 440 450 460 470 480 VGGEVVIECK PKASPKPVYT WKKGRDILKE NERITISEDG NLRIINVTKS DAGSYTCIAT 490 500 510 520 530 540 NHFGTASSTG NLVVKDPTRV MVPPSSMDVT VGESIVLPCQ VTHDHSLDIV FTWSFNGHLI 550 560 570 580 590 600 DFDRDGDHFE RVGGQDSAGD LMIRNIQLKH AGKYVCMVQT SVDRLSAAAD LIVRGPPGPP 610 620 630 640 650 660 EAVTIDEITD TTAQLSWRPG PDNHSPITMY VIQARTPFSV GWQAVSTVPE LIDGKTFTAT 670 680 690 700 710 720 VVGLNPWVEY EFRTVAANVI GIGEPSRPSE KRRTEEALPE VTPANVSGGG GSKSELVITW 730 740 750 760 770 780 ETVPEELQNG RGFGYVVAFR PYGKMIWMLT VLASADASRY VFRNESVHPF SPFEVKVGVF 790 800 810 820 830 840 NNKGEGPFSP TTVVYSAEEE PTKPPASIFA RSLSATDIEV FWASPLEKNR GRIQGYEVKY 850 860 870 880 890 900 WRHEDKEENA RKIRTVGNQT STKITNLKGS VLYHLAVKAY NSAGTGPSSA TVNVTTRKPP 910 920 930 940 950 960 PSQPPGNIIW NSSDSKIILN WDQVKALDNE SEVKGYKVLY RWNRQSSTSV IETNKTSVEL 970 980 990 1000 1010 1020 SLPFDEDYII EIKPFSDGGD GSSSEQIRIP KISNAYARGS GASTSNACTL SAISTIMISL TARSSL
	Isoform 2 (CNTN4A) [UniParc]. Checksum: FC0BD80B86F9E048	FASTA	282	31,066
	10 20 30 40 50 60 MIWMLTVLAS ADASRYVFRN ESVHPFSPFE VKVGVFNNKG EGPFSPTTVV YSAEEEPTKP 70 80 90 100 110 120 PASIFARSLS ATDIEVFWAS PLEKNRGRIQ GYEVKYWRHE DKEENARKIR TVGNQTSTKI 130 140 150 160 170 180 TNLKGSVLYH LAVKAYNSAG TGPSSATVNV TTRKPPPSQP PGNIIWNSSD SKIILNWDQV 190 200 210 220 230 240 KALDNESEVK GYKVLYRWNR QSSTSVIETN KTSVELSLPF DEDYIIEIKP FSDGGDGSSS 250 260 270 280 EQIRIPKISN AYARGSGAST SNACTLSAIS TIMISLTARS SL
	Isoform 3 [UniParc]. Checksum: 9984789B5E5334F9	FASTA	697	76,527
	10 20 30 40 50 60 MEENVFWECK ANGRPKPTYK WLKNGEPLLT RDRIQIEQGT LNITIVNLSD AGMYQCLAEN 70 80 90 100 110 120 KHGVIFSNAE LSVIAVGPDF SRTLLKRVTL VKVGGEVVIE CKPKASPKPV YTWKKGRDIL 130 140 150 160 170 180 KENERITISE DGNLRIINVT KSDAGSYTCI ATNHFGTASS TGNLVVKDPT RVMVPPSSMD 190 200 210 220 230 240 VTVGESIVLP CQVTHDHSLD IVFTWSFNGH LIDFDRDGDH FERVGGDSAG DLMIRNIQLK 250 260 270 280 290 300 HAGKYVCMVQ TSVDRLSAAA DLIVRGPPGP PEAVTIDEIT DTTAQLSWRP GPDNHSPITM 310 320 330 340 350 360 YVIQARTPFS VGWQAVSTVP ELIDGKTFTA TVVGLNPWVE YEFRTVAANV IGIGEPSRPS 370 380 390 400 410 420 EKRRTEEALP EVTPANVSGG GGSKSELVIT WETVPEELQN GRGFGYVVAF RPYGKMIWML 430 440 450 460 470 480 TVLASADASR YVFRNESVHP FSPFEVKVGV FNNKGEGPFS PTTVVYSAEE EPTKPPASIF 490 500 510 520 530 540 ARSLSATDIE VFWASPLEKN RGRIQGYEVK YWRHEDKEEN ARKIRTVGNQ TSTKITNLKG 550 560 570 580 590 600 SVLYHLAVKA YNSAGTGPSS ATVNVTTRKP PPSQPPGNII WNSSDSKIIL NWDQVKALDN 610 620 630 640 650 660 ESEVKGYKVL YRWNRQSSTS VIETNKTSVE LSLPFDEDYI IEIKPFSDGG DGSSSEQIRI 670 680 690 PKISNAYARG SGASTSNACT LSAISTIMIS LTARSSL
	Isoform 4 [UniParc]. Checksum: BA1E4A8521B5D6FF	FASTA	698	76,655
	10 20 30 40 50 60 MEENVFWECK ANGRPKPTYK WLKNGEPLLT RDRIQIEQGT LNITIVNLSD AGMYQCLAEN 70 80 90 100 110 120 KHGVIFSNAE LSVIAVGPDF SRTLLKRVTL VKVGGEVVIE CKPKASPKPV YTWKKGRDIL 130 140 150 160 170 180 KENERITISE DGNLRIINVT KSDAGSYTCI ATNHFGTASS TGNLVVKDPT RVMVPPSSMD 190 200 210 220 230 240 VTVGESIVLP CQVTHDHSLD IVFTWSFNGH LIDFDRDGDH FERVGGQDSA GDLMIRNIQL 250 260 270 280 290 300 KHAGKYVCMV QTSVDRLSAA ADLIVRGPPG PPEAVTIDEI TDTTAQLSWR PGPDNHSPIT 310 320 330 340 350 360 MYVIQARTPF SVGWQAVSTV PELIDGKTFT ATVVGLNPWV EYEFRTVAAN VIGIGEPSRP 370 380 390 400 410 420 SEKRRTEEAL PEVTPANVSG GGGSKSELVI TWETVPEELQ NGRGFGYVVA FRPYGKMIWM 430 440 450 460 470 480 LTVLASADAS RYVFRNESVH PFSPFEVKVG VFNNKGEGPF SPTTVVYSAE EEPTKPPASI 490 500 510 520 530 540 FARSLSATDI EVFWASPLEK NRGRIQGYEV KYWRHEDKEE NARKIRTVGN QTSTKITNLK 550 560 570 580 590 600 GSVLYHLAVK AYNSAGTGPS SATVNVTTRK PPPSQPPGNI IWNSSDSKII LNWDQVKALD 610 620 630 640 650 660 NESEVKGYKV LYRWNRQSST SVIETNKTSV ELSLPFDEDY IIEIKPFSDG GDGSSSEQIR 670 680 690 IPKISNAYAR GSGASTSNAC TLSAISTIMI SLTARSSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel splice variant of the cell adhesion molecule contactin 4 (CNTN4) is mainly expressed in human brain." Zeng L., Zhang C., Xu J., Ye X., Wu Q., Dai J., Ji C., Gu S., Xie Y., Mao Y. J. Hum. Genet. 47:497-499(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2)." Hansford L.M., Smith S.A., Haber M., Norris M.D., Cheung B., Marshall G.M. Cytogenet. Genome Res. 101:17-23(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Testis.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Testis.
[7]	"Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members." Kamei Y., Takeda Y., Teramoto K., Tsutsumi O., Taketani Y., Watanabe K. Genomics 69:113-119(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome." Fernandez T., Morgan T., Davis N., Klin A., Morris A., Farhi A., Lifton R.P., State M.W. Am. J. Hum. Genet. 74:1286-1293(2004) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION, INVOLVEMENT IN 3PDS.
[9]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65, MASS SPECTROMETRY. Tissue: Plasma.
[10]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-176 AND ASN-420.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF464063 mRNA. Translation: AAN86141.1. AY090737 mRNA. Translation: AAM00025.1. AF549455 mRNA. Translation: AAP05786.1. AK314396 mRNA. Translation: BAG37020.1. AC018842 Genomic DNA. No translation available. AC022002 Genomic DNA. No translation available. AC022008 Genomic DNA. No translation available. AC024057 Genomic DNA. No translation available. AC026882 Genomic DNA. No translation available. AC066608 Genomic DNA. No translation available. AC087094 Genomic DNA. No translation available. AC087427 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW63874.1. BC026119 mRNA. Translation: AAH26119.1.
IPI	IPI00178854. IPI00479016. IPI00744041.
RefSeq	NP_001193884.1. NM_001206955.1. NP_001193885.1. NM_001206956.1. NP_783200.1. NM_175607.2. NP_783302.1. NM_175613.2.
UniGene	Hs.298705. Hs.626418.
3D structure databases
ProteinModelPortal	Q8IWV2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IWV2. 3 interactions.
STRING	9606.ENSP00000380602.
PTM databases
PhosphoSite	Q8IWV2.
Polymorphism databases
DMDM	55976529.
Proteomic databases
PaxDb	Q8IWV2.
PRIDE	Q8IWV2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397459; ENSP00000380600; ENSG00000144619. ENST00000397461; ENSP00000380602; ENSG00000144619. ENST00000418658; ENSP00000396010; ENSG00000144619. ENST00000427331; ENSP00000413642; ENSG00000144619. ENST00000448906; ENSP00000392077; ENSG00000144619.
GeneID	152330.
KEGG	hsa:152330.
UCSC	uc003bpb.1. human. uc003bpc.3. human. uc003bpg.3. human.
Organism-specific databases
CTD	152330.
GeneCards	GC03P002117.
HGNC	HGNC:2174. CNTN4.
HPA	HPA021068.
MIM	607280. gene.
neXtProt	NX_Q8IWV2.
Orphanet	1620. Distal monosomy 3p.
PharmGKB	PA26688.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293951.
HOGENOM	HOG000059617.
HOVERGEN	HBG051047.
InParanoid	Q8IWV2.
KO	K06762.
OMA	IEQGTLN.
OrthoDB	EOG48GW2G.
Gene expression databases
ArrayExpress	Q8IWV2.
Bgee	Q8IWV2.
CleanEx	HS_CNTN4.
Genevestigator	Q8IWV2.
GermOnline	ENSG00000144619. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 10 hits.
InterPro	IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Pfam	PF00041. fn3. 2 hits. PF07679. I-set. 5 hits. [Graphical view]
SMART	SM00060. FN3. 4 hits. SM00409. IG. 2 hits. SM00408. IGc2. 4 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 4 hits.
PROSITE	PS50853. FN3. 4 hits. PS50835. IG_LIKE. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CNTN4. human.
GenomeRNAi	152330.
NextBio	86944.
SOURCE	Search...

Entry information

Entry name

CNTN4_HUMAN

Accession

Primary (citable) accession number: Q8IWV2
Secondary accession number(s): B2RAX3, Q8IX14, Q8TC35

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.