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Q8IWV2

- CNTN4_HUMAN

UniProt

Q8IWV2 - CNTN4_HUMAN

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Protein

Contactin-4

Gene

CNTN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.

GO - Biological processi

  1. axonal fasciculation Source: UniProtKB
  2. axon guidance Source: UniProtKB
  3. axonogenesis Source: UniProtKB
  4. brain development Source: UniProtKB
  5. negative regulation of neuron differentiation Source: UniProtKB
  6. nervous system development Source: UniProtKB
  7. neuron cell-cell adhesion Source: UniProtKB
  8. neuron projection development Source: UniProtKB
  9. regulation of synaptic plasticity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-4
Alternative name(s):
Brain-derived immunoglobulin superfamily protein 2
Short name:
BIG-2
Gene namesi
Name:CNTN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:2174. CNTN4.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. axon Source: UniProtKB
  3. extracellular region Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.

Organism-specific databases

Orphaneti1620. Distal monosomy 3p.
PharmGKBiPA26688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 1000982Contactin-4PRO_0000014711Add
BLAST
Propeptidei1001 – 102626Removed in mature formSequence AnalysisPRO_0000014712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65 – 651N-linked (GlcNAc...)1 Publication
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi144 ↔ 194PROSITE-ProRule annotation
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi247 ↔ 295PROSITE-ProRule annotation
Disulfide bondi337 ↔ 384PROSITE-ProRule annotation
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi429 ↔ 477PROSITE-ProRule annotation
Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi519 ↔ 576PROSITE-ProRule annotation
Glycosylationi705 – 7051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi764 – 7641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi858 – 8581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi893 – 8931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi954 – 9541N-linked (GlcNAc...)Sequence Analysis
Lipidationi1000 – 10001GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8IWV2.
PRIDEiQ8IWV2.

PTM databases

PhosphoSiteiQ8IWV2.

Expressioni

Tissue specificityi

Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.2 Publications

Inductioni

By retinoic acid, suggesting that it may act in response to differentiating agents.1 Publication

Gene expression databases

BgeeiQ8IWV2.
CleanExiHS_CNTN4.
ExpressionAtlasiQ8IWV2. baseline and differential.
GenevestigatoriQ8IWV2.

Organism-specific databases

HPAiHPA021068.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

BioGridi127444. 4 interactions.
IntActiQ8IWV2. 3 interactions.
STRINGi9606.ENSP00000380602.

Structurei

3D structure databases

ProteinModelPortaliQ8IWV2.
SMRiQ8IWV2. Positions 25-995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 11786Ig-like C2-type 1Add
BLAST
Domaini122 – 20786Ig-like C2-type 2Add
BLAST
Domaini225 – 31187Ig-like C2-type 3Add
BLAST
Domaini316 – 40085Ig-like C2-type 4Add
BLAST
Domaini406 – 49388Ig-like C2-type 5Add
BLAST
Domaini497 – 58690Ig-like C2-type 6Add
BLAST
Domaini599 – 69799Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini702 – 79998Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini804 – 89996Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini900 – 99596Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG293951.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ8IWV2.
KOiK06762.
OMAiFMLCLAD.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ8IWV2.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWV2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLPWELLVL QSFILCLADD STLHGPIFIQ EPSPVMFPLD SEEKKVKLNC
60 70 80 90 100
EVKGNPKPHI RWKLNGTDVD TGMDFRYSVV EGSLLINNPN KTQDAGTYQC
110 120 130 140 150
TATNSFGTIV SREAKLQFAY LDNFKTRTRS TVSVRRGQGM VLLCGPPPHS
160 170 180 190 200
GELSYAWIFN EYPSYQDNRR FVSQETGNLY IAKVEKSDVG NYTCVVTNTV
210 220 230 240 250
TNHKVLGPPT PLILRNDGVM GEYEPKIEVQ FPETVPTAKG ATVKLECFAL
260 270 280 290 300
GNPVPTIIWR RADGKPIARK ARRHKSNGIL EIPNFQQEDA GLYECVAENS
310 320 330 340 350
RGKNVARGQL TFYAQPNWIQ KINDIHVAME ENVFWECKAN GRPKPTYKWL
360 370 380 390 400
KNGEPLLTRD RIQIEQGTLN ITIVNLSDAG MYQCLAENKH GVIFSNAELS
410 420 430 440 450
VIAVGPDFSR TLLKRVTLVK VGGEVVIECK PKASPKPVYT WKKGRDILKE
460 470 480 490 500
NERITISEDG NLRIINVTKS DAGSYTCIAT NHFGTASSTG NLVVKDPTRV
510 520 530 540 550
MVPPSSMDVT VGESIVLPCQ VTHDHSLDIV FTWSFNGHLI DFDRDGDHFE
560 570 580 590 600
RVGGQDSAGD LMIRNIQLKH AGKYVCMVQT SVDRLSAAAD LIVRGPPGPP
610 620 630 640 650
EAVTIDEITD TTAQLSWRPG PDNHSPITMY VIQARTPFSV GWQAVSTVPE
660 670 680 690 700
LIDGKTFTAT VVGLNPWVEY EFRTVAANVI GIGEPSRPSE KRRTEEALPE
710 720 730 740 750
VTPANVSGGG GSKSELVITW ETVPEELQNG RGFGYVVAFR PYGKMIWMLT
760 770 780 790 800
VLASADASRY VFRNESVHPF SPFEVKVGVF NNKGEGPFSP TTVVYSAEEE
810 820 830 840 850
PTKPPASIFA RSLSATDIEV FWASPLEKNR GRIQGYEVKY WRHEDKEENA
860 870 880 890 900
RKIRTVGNQT STKITNLKGS VLYHLAVKAY NSAGTGPSSA TVNVTTRKPP
910 920 930 940 950
PSQPPGNIIW NSSDSKIILN WDQVKALDNE SEVKGYKVLY RWNRQSSTSV
960 970 980 990 1000
IETNKTSVEL SLPFDEDYII EIKPFSDGGD GSSSEQIRIP KISNAYARGS
1010 1020
GASTSNACTL SAISTIMISL TARSSL
Length:1,026
Mass (Da):113,454
Last modified:March 1, 2003 - v1
Checksum:i2B53D15665B4287B
GO
Isoform 2 (identifier: Q8IWV2-2) [UniParc]FASTAAdd to Basket

Also known as: CNTN4A

The sequence of this isoform differs from the canonical sequence as follows:
     1-744: Missing.

Show »
Length:282
Mass (Da):31,066
Checksum:iFC0BD80B86F9E048
GO
Isoform 3 (identifier: Q8IWV2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-328: Missing.
     555-555: Missing.

Note: No experimental confirmation available.

Show »
Length:697
Mass (Da):76,527
Checksum:i9984789B5E5334F9
GO
Isoform 4 (identifier: Q8IWV2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-328: Missing.

Show »
Length:698
Mass (Da):76,655
Checksum:iBA1E4A8521B5D6FF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti176 – 1761T → P in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035507
Natural varianti420 – 4201K → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035508

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 744744Missing in isoform 2. 1 PublicationVSP_011961Add
BLAST
Alternative sequencei1 – 328328Missing in isoform 3 and isoform 4. 2 PublicationsVSP_044270Add
BLAST
Alternative sequencei555 – 5551Missing in isoform 3. CuratedVSP_011962

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF464063 mRNA. Translation: AAN86141.1.
AY090737 mRNA. Translation: AAM00025.1.
AF549455 mRNA. Translation: AAP05786.1.
AK314396 mRNA. Translation: BAG37020.1.
AC018842 Genomic DNA. No translation available.
AC022002 Genomic DNA. No translation available.
AC022008 Genomic DNA. No translation available.
AC024057 Genomic DNA. No translation available.
AC026882 Genomic DNA. No translation available.
AC066608 Genomic DNA. No translation available.
AC087094 Genomic DNA. No translation available.
AC087427 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63874.1.
BC026119 mRNA. Translation: AAH26119.1.
CCDSiCCDS2558.1. [Q8IWV2-4]
CCDS43041.1. [Q8IWV2-1]
RefSeqiNP_001193884.1. NM_001206955.1. [Q8IWV2-1]
NP_001193885.1. NM_001206956.1. [Q8IWV2-3]
NP_783200.1. NM_175607.2. [Q8IWV2-1]
NP_783302.1. NM_175613.2. [Q8IWV2-4]
UniGeneiHs.298705.
Hs.626418.

Genome annotation databases

EnsembliENST00000397459; ENSP00000380600; ENSG00000144619. [Q8IWV2-4]
ENST00000397461; ENSP00000380602; ENSG00000144619. [Q8IWV2-1]
ENST00000418658; ENSP00000396010; ENSG00000144619. [Q8IWV2-1]
ENST00000427331; ENSP00000413642; ENSG00000144619. [Q8IWV2-1]
GeneIDi152330.
KEGGihsa:152330.
UCSCiuc003bpb.1. human. [Q8IWV2-3]
uc003bpc.3. human. [Q8IWV2-1]
uc003bpg.3. human. [Q8IWV2-2]

Polymorphism databases

DMDMi55976529.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF464063 mRNA. Translation: AAN86141.1 .
AY090737 mRNA. Translation: AAM00025.1 .
AF549455 mRNA. Translation: AAP05786.1 .
AK314396 mRNA. Translation: BAG37020.1 .
AC018842 Genomic DNA. No translation available.
AC022002 Genomic DNA. No translation available.
AC022008 Genomic DNA. No translation available.
AC024057 Genomic DNA. No translation available.
AC026882 Genomic DNA. No translation available.
AC066608 Genomic DNA. No translation available.
AC087094 Genomic DNA. No translation available.
AC087427 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63874.1 .
BC026119 mRNA. Translation: AAH26119.1 .
CCDSi CCDS2558.1. [Q8IWV2-4 ]
CCDS43041.1. [Q8IWV2-1 ]
RefSeqi NP_001193884.1. NM_001206955.1. [Q8IWV2-1 ]
NP_001193885.1. NM_001206956.1. [Q8IWV2-3 ]
NP_783200.1. NM_175607.2. [Q8IWV2-1 ]
NP_783302.1. NM_175613.2. [Q8IWV2-4 ]
UniGenei Hs.298705.
Hs.626418.

3D structure databases

ProteinModelPortali Q8IWV2.
SMRi Q8IWV2. Positions 25-995.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127444. 4 interactions.
IntActi Q8IWV2. 3 interactions.
STRINGi 9606.ENSP00000380602.

PTM databases

PhosphoSitei Q8IWV2.

Polymorphism databases

DMDMi 55976529.

Proteomic databases

PaxDbi Q8IWV2.
PRIDEi Q8IWV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397459 ; ENSP00000380600 ; ENSG00000144619 . [Q8IWV2-4 ]
ENST00000397461 ; ENSP00000380602 ; ENSG00000144619 . [Q8IWV2-1 ]
ENST00000418658 ; ENSP00000396010 ; ENSG00000144619 . [Q8IWV2-1 ]
ENST00000427331 ; ENSP00000413642 ; ENSG00000144619 . [Q8IWV2-1 ]
GeneIDi 152330.
KEGGi hsa:152330.
UCSCi uc003bpb.1. human. [Q8IWV2-3 ]
uc003bpc.3. human. [Q8IWV2-1 ]
uc003bpg.3. human. [Q8IWV2-2 ]

Organism-specific databases

CTDi 152330.
GeneCardsi GC03P002117.
HGNCi HGNC:2174. CNTN4.
HPAi HPA021068.
MIMi 607280. gene.
neXtProti NX_Q8IWV2.
Orphaneti 1620. Distal monosomy 3p.
PharmGKBi PA26688.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293951.
GeneTreei ENSGT00760000118840.
HOGENOMi HOG000059617.
HOVERGENi HBG051047.
InParanoidi Q8IWV2.
KOi K06762.
OMAi FMLCLAD.
OrthoDBi EOG7J17Z5.
PhylomeDBi Q8IWV2.
TreeFami TF351103.

Miscellaneous databases

ChiTaRSi CNTN4. human.
GeneWikii CNTN4.
GenomeRNAii 152330.
NextBioi 86944.
PROi Q8IWV2.
SOURCEi Search...

Gene expression databases

Bgeei Q8IWV2.
CleanExi HS_CNTN4.
ExpressionAtlasi Q8IWV2. baseline and differential.
Genevestigatori Q8IWV2.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel splice variant of the cell adhesion molecule contactin 4 (CNTN4) is mainly expressed in human brain."
    Zeng L., Zhang C., Xu J., Ye X., Wu Q., Dai J., Ji C., Gu S., Xie Y., Mao Y.
    J. Hum. Genet. 47:497-499(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2)."
    Hansford L.M., Smith S.A., Haber M., Norris M.D., Cheung B., Marshall G.M.
    Cytogenet. Genome Res. 101:17-23(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  7. "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members."
    Kamei Y., Takeda Y., Teramoto K., Tsutsumi O., Taketani Y., Watanabe K.
    Genomics 69:113-119(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome."
    Fernandez T., Morgan T., Davis N., Klin A., Morris A., Farhi A., Lifton R.P., State M.W.
    Am. J. Hum. Genet. 74:1286-1293(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION, INVOLVEMENT IN 3PDS.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65.
    Tissue: Plasma.
  10. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
    Bouyain S., Watkins D.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPRG.
  11. Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-176 AND ASN-420.

Entry informationi

Entry nameiCNTN4_HUMAN
AccessioniPrimary (citable) accession number: Q8IWV2
Secondary accession number(s): B2RAX3, Q8IX14, Q8TC35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3