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Q8IWU9

- TPH2_HUMAN

UniProt

Q8IWU9 - TPH2_HUMAN

Protein

Tryptophan 5-hydroxylase 2

Gene

TPH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

    Cofactori

    Fe2+ ion.By similarity

    Kineticsi

    1. KM=41.3 µM for L-tryptophan1 Publication

    Vmax=833 nmol/min/mg enzyme1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi318 – 3181IronBy similarity
    Metal bindingi323 – 3231IronBy similarity
    Metal bindingi363 – 3631IronBy similarity

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. tryptophan 5-monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic amino acid family metabolic process Source: InterPro
    2. cellular nitrogen compound metabolic process Source: Reactome
    3. cellular response to lithium ion Source: Ensembl
    4. circadian rhythm Source: Ensembl
    5. indolalkylamine biosynthetic process Source: Reactome
    6. response to activity Source: Ensembl
    7. response to calcium ion Source: Ensembl
    8. response to estrogen Source: Ensembl
    9. response to glucocorticoid Source: Ensembl
    10. response to nutrient levels Source: Ensembl
    11. serotonin biosynthetic process Source: UniProtKB-UniPathway
    12. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Serotonin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS06603-MONOMER.
    ReactomeiREACT_15439. Serotonin and melatonin biosynthesis.
    SABIO-RKQ8IWU9.
    UniPathwayiUPA00846; UER00799.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan 5-hydroxylase 2 (EC:1.14.16.4)
    Alternative name(s):
    Neuronal tryptophan hydroxylase
    Tryptophan 5-monooxygenase 2
    Gene namesi
    Name:TPH2
    Synonyms:NTPH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:20692. TPH2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. neuron projection Source: Ensembl

    Pathology & Biotechi

    Involvement in diseasei

    Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Attention deficit-hyperactivity disorder 7 (ADHD7) [MIM:613003]: A neurobehavioral developmental disorder primarily characterized by the coexistence of attentional problems and hyperactivity, with each behavior occurring infrequently alone.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti303 – 3031R → W in ADHD7; has severely reduced solubility and is completely inactive; loss of function may lead to a reduced serotonin synthesis which in turn makes the mutation carriers susceptible to ADHD and possibly other psychiatric disorders. 1 Publication
    VAR_058942

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi608516. phenotype.
    613003. phenotype.
    PharmGKBiPA128747823.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Tryptophan 5-hydroxylase 2PRO_0000205574Add
    BLAST

    Proteomic databases

    PaxDbiQ8IWU9.
    PRIDEiQ8IWU9.

    PTM databases

    PhosphoSiteiQ8IWU9.

    Expressioni

    Tissue specificityi

    Brain specific.

    Gene expression databases

    ArrayExpressiQ8IWU9.
    BgeeiQ8IWU9.
    CleanExiHS_TPH2.
    GenevestigatoriQ8IWU9.

    Organism-specific databases

    HPAiHPA046274.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8IWU9. 1 interaction.
    MINTiMINT-7997360.
    STRINGi9606.ENSP00000329093.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWU9.
    SMRiQ8IWU9. Positions 48-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 14076ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3186.
    HOGENOMiHOG000233373.
    HOVERGENiHBG006841.
    KOiK00502.
    OMAiEDVSMFL.
    OrthoDBiEOG7KM5T1.
    PhylomeDBiQ8IWU9.
    TreeFamiTF313327.

    Family and domain databases

    Gene3Di1.10.800.10. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005963. Trp_5_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    [Graphical view]
    PANTHERiPTHR11473. PTHR11473. 1 hit.
    PfamiPF01842. ACT. 1 hit.
    PF00351. Biopterin_H. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000336. TH. 1 hit.
    PRINTSiPR00372. FYWHYDRXLASE.
    SUPFAMiSSF56534. SSF56534. 1 hit.
    TIGRFAMsiTIGR01270. Trp_5_monoox. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q8IWU9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGSSTLNKPN SGKNDDKGNK    50
    GSSKREAATE SGKTAVVFSL KNEVGGLVKA LRLFQEKRVN MVHIESRKSR 100
    RRSSEVEIFV DCECGKTEFN ELIQLLKFQT TIVTLNPPEN IWTEEEELED 150
    VPWFPRKISE LDKCSHRVLM YGSELDADHP GFKDNVYRQR RKYFVDVAMG 200
    YKYGQPIPRV EYTEEETKTW GVVFRELSKL YPTHACREYL KNFPLLTKYC 250
    GYREDNVPQL EDVSMFLKER SGFTVRPVAG YLSPRDFLAG LAYRVFHCTQ 300
    YIRHGSDPLY TPEPDTCHEL LGHVPLLADP KFAQFSQEIG LASLGASDED 350
    VQKLATCYFF TIEFGLCKQE GQLRAYGAGL LSSIGELKHA LSDKACVKAF 400
    DPKTTCLQEC LITTFQEAYF VSESFEEAKE KMRDFAKSIT RPFSVYFNPY 450
    TQSIEILKDT RSIENVVQDL RSDLNTVCDA LNKMNQYLGI 490
    Length:490
    Mass (Da):56,057
    Last modified:March 1, 2003 - v1
    Checksum:i753645E6E0CE430B
    GO
    Isoform b (identifier: Q8IWU9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         147-147: E → GKE

    Show »
    Length:492
    Mass (Da):56,242
    Checksum:i5B90CB629F9F6DD6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531S → N in AAI14500. (PubMed:15489334)Curated

    RNA editingi

    Modulates the kinetic properties of both isoforms.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361L → P The property of the variant is indistinguishable from the wild-type.
    VAR_058938
    Natural varianti36 – 361L → V The property of the variant is indistinguishable from the wild-type.
    Corresponds to variant rs34115267 [ dbSNP | Ensembl ].
    VAR_058939
    Natural varianti41 – 411S → Y The property of the variant is indistinguishable from the wild-type.
    Corresponds to variant rs78162420 [ dbSNP | Ensembl ].
    VAR_058940
    Natural varianti55 – 551R → C The property of the variant is indistinguishable from the wild-type.
    Corresponds to variant rs75558144 [ dbSNP | Ensembl ].
    VAR_058941
    Natural varianti206 – 2061P → S May be associated with susceptibility to bipolar affective disorder; decreases solubility; decreases thermal stability; catalytic activity as the wild type; moderate loss-of-function observed manifested via stability and solubility effect. 1 Publication
    Corresponds to variant rs17110563 [ dbSNP | Ensembl ].
    VAR_046136
    Natural varianti303 – 3031R → W in ADHD7; has severely reduced solubility and is completely inactive; loss of function may lead to a reduced serotonin synthesis which in turn makes the mutation carriers susceptible to ADHD and possibly other psychiatric disorders. 1 Publication
    VAR_058942
    Natural varianti328 – 3281A → V Moderate loss-of-function observed manifested via stability and solubility effect.
    Corresponds to variant rs2887147 [ dbSNP | Ensembl ].
    VAR_058943
    Natural varianti433 – 4331R → G in RNA edited version.
    VAR_065019
    Natural varianti441 – 4411R → H May be due to a rare RNA editing event; functional polymorphism linked with susceptibility to major depressive disorder; 80% loss of function; decreases solubility; decreases thermal stability; reduces catalytic activity. 1 Publication
    VAR_026749
    Natural varianti468 – 4681Q → R in RNA edited version.
    VAR_065020
    Natural varianti479 – 4791D → E Moderate loss-of-function observed manifested via stability and solubility effect.
    Corresponds to variant rs7488262 [ dbSNP | Ensembl ].
    VAR_058944

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei147 – 1471E → GKE in isoform b. CuratedVSP_040971

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY098914 mRNA. Translation: AAM28946.1.
    AC090109 Genomic DNA. No translation available.
    BC114499 mRNA. Translation: AAI14500.1.
    CCDSiCCDS31859.1. [Q8IWU9-1]
    RefSeqiNP_775489.2. NM_173353.3. [Q8IWU9-1]
    UniGeneiHs.736576.

    Genome annotation databases

    EnsembliENST00000333850; ENSP00000329093; ENSG00000139287. [Q8IWU9-1]
    GeneIDi121278.
    KEGGihsa:121278.
    UCSCiuc001swy.2. human. [Q8IWU9-1]

    Polymorphism databases

    DMDMi30580625.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism, RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY098914 mRNA. Translation: AAM28946.1 .
    AC090109 Genomic DNA. No translation available.
    BC114499 mRNA. Translation: AAI14500.1 .
    CCDSi CCDS31859.1. [Q8IWU9-1 ]
    RefSeqi NP_775489.2. NM_173353.3. [Q8IWU9-1 ]
    UniGenei Hs.736576.

    3D structure databases

    ProteinModelPortali Q8IWU9.
    SMRi Q8IWU9. Positions 48-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8IWU9. 1 interaction.
    MINTi MINT-7997360.
    STRINGi 9606.ENSP00000329093.

    Chemistry

    BindingDBi Q8IWU9.
    ChEMBLi CHEMBL5433.
    DrugBanki DB00150. L-Tryptophan.
    GuidetoPHARMACOLOGYi 1242.

    PTM databases

    PhosphoSitei Q8IWU9.

    Polymorphism databases

    DMDMi 30580625.

    Proteomic databases

    PaxDbi Q8IWU9.
    PRIDEi Q8IWU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333850 ; ENSP00000329093 ; ENSG00000139287 . [Q8IWU9-1 ]
    GeneIDi 121278.
    KEGGi hsa:121278.
    UCSCi uc001swy.2. human. [Q8IWU9-1 ]

    Organism-specific databases

    CTDi 121278.
    GeneCardsi GC12P072284.
    HGNCi HGNC:20692. TPH2.
    HPAi HPA046274.
    MIMi 607478. gene.
    608516. phenotype.
    613003. phenotype.
    neXtProti NX_Q8IWU9.
    PharmGKBi PA128747823.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3186.
    HOGENOMi HOG000233373.
    HOVERGENi HBG006841.
    KOi K00502.
    OMAi EDVSMFL.
    OrthoDBi EOG7KM5T1.
    PhylomeDBi Q8IWU9.
    TreeFami TF313327.

    Enzyme and pathway databases

    UniPathwayi UPA00846 ; UER00799 .
    BioCyci MetaCyc:HS06603-MONOMER.
    Reactomei REACT_15439. Serotonin and melatonin biosynthesis.
    SABIO-RK Q8IWU9.

    Miscellaneous databases

    GeneWikii TPH2.
    GenomeRNAii 121278.
    NextBioi 80710.
    PROi Q8IWU9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IWU9.
    Bgeei Q8IWU9.
    CleanExi HS_TPH2.
    Genevestigatori Q8IWU9.

    Family and domain databases

    Gene3Di 1.10.800.10. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005963. Trp_5_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    [Graphical view ]
    PANTHERi PTHR11473. PTHR11473. 1 hit.
    Pfami PF01842. ACT. 1 hit.
    PF00351. Biopterin_H. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000336. TH. 1 hit.
    PRINTSi PR00372. FYWHYDRXLASE.
    SUPFAMi SSF56534. SSF56534. 1 hit.
    TIGRFAMsi TIGR01270. Trp_5_monoox. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Synthesis of serotonin by a second tryptophan hydroxylase isoform."
      Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.
      Science 299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    4. "Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder."
      Cichon S., Winge I., Mattheisen M., Georgi A., Karpushova A., Freudenberg J., Freudenberg-Hua Y., Babadjanova G., Van Den Bogaert A., Abramova L.I., Kapiletti S., Knappskog P.M., McKinney J., Maier W., Jamra R.A., Schulze T.G., Schumacher J., Propping P.
      , Rietschel M., Haavik J., Noethen M.M.
      Hum. Mol. Genet. 17:87-97(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: BIOPHYSICOCHEMICAL PROPERTIES, VARIANT SER-206, CHARACTERIZATION OF VARIANTS SER-206 AND HIS-441.
    5. Cited for: ALTERNATIVE SPLICING (ISOFORMS A AND B), RNA EDITING OF POSITIONS 433; 441 AND 468.
      Tissue: Brain.
    6. "Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression."
      Zhang X., Gainetdinov R.R., Beaulieu J.-M., Sotnikova T.D., Burch L.H., Williams R.B., Schwartz D.A., Krishnan K.R.R., Caron M.G.
      Neuron 45:11-16(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HIS-441, CHARACTERIZATION OF VARIANT HIS-441.
    7. "A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder."
      McKinney J., Johansson S., Halmoy A., Dramsdahl M., Winge I., Knappskog P.M., Haavik J.
      Mol. Psychiatry 13:365-367(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ADHD7 TRP-303.
    8. "Functional properties of missense variants of human tryptophan hydroxylase 2."
      McKinney J.A., Turel B., Winge I., Knappskog P.M., Haavik J.
      Hum. Mutat. 30:787-794(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANTS VAL-36; PRO-36; TYR-41; CYS-55; SER-206; TRP-303; VAL-328; HIS-441 AND GLU-479.

    Entry informationi

    Entry nameiTPH2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWU9
    Secondary accession number(s): A6NGA4, Q14CB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3