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Q8IWU2 (LMTK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase LMTK2

EC=2.7.11.1
Alternative name(s):
Apoptosis-associated tyrosine kinase 2
Brain-enriched kinase
Short name=hBREK
CDK5/p35-regulated kinase
Short name=CPRK
Kinase/phosphatase/inhibitor 2
Lemur tyrosine kinase 2
Serine/threonine-protein kinase KPI-2
Gene names
Name:LMTK2
Synonyms:AATYK2, BREK, KIAA1079, KPI2, LMR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1503 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphorylates PPP1C, phosphorylase b and CFTR.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with PPP1C and inhibitor-2. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein Ref.9.

Tissue specificity

Mainly expressed in skeletal muscle, and weakly in brain and pancreas. Ref.1

Post-translational modification

Autophosphorylated. Phosphorylated By similarity. Ref.7

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAA83031.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processearly endosome to late endosome transport

Inferred from mutant phenotype PubMed 18429820. Source: UniProtKB

endocytic recycling

Inferred from mutant phenotype PubMed 18029400. Source: UniProtKB

negative regulation of catalytic activity

Inferred from direct assay Ref.1. Source: GOC

peptidyl-serine phosphorylation

Inferred from direct assay Ref.7. Source: UniProtKB

peptidyl-threonine phosphorylation

Inferred from direct assay Ref.7. Source: UniProtKB

protein autophosphorylation

Inferred from direct assay Ref.1. Source: UniProtKB

protein phosphorylation

Inferred from direct assay Ref.1. Source: UniProtKB

receptor recycling

Inferred from mutant phenotype PubMed 18029400PubMed 18429820. Source: UniProtKB

transferrin transport

Inferred from mutant phenotype PubMed 18029400PubMed 18429820. Source: UniProtKB

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 12832520. Source: UniProtKB

early endosome

Inferred from direct assay PubMed 18029400PubMed 18429820. Source: UniProtKB

integral component of membrane

Inferred from direct assay Ref.1. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from direct assay PubMed 12832520PubMed 18429820. Source: UniProtKB

recycling endosome

Inferred from direct assay PubMed 18029400PubMed 18429820. Source: UniProtKB

   Molecular_functionATP binding

Non-traceable author statement Ref.1. Source: UniProtKB

myosin VI binding

Inferred from physical interaction PubMed 18029400PubMed 18429820. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.1PubMed 12832520. Source: UniProtKB

protein phosphatase inhibitor activity

Inferred from direct assay Ref.1. Source: UniProtKB

protein serine/threonine kinase activity

Inferred from direct assay Ref.1Ref.7. Source: UniProtKB

protein tyrosine kinase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PPP1R2P412363EBI-2008933,EBI-1056517

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15031503Serine/threonine-protein kinase LMTK2
PRO_0000259458

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 4211Lumenal Potential
Transmembrane43 – 6321Helical; Potential
Topological domain64 – 15031440Cytoplasmic Potential
Domain137 – 407271Protein kinase
Nucleotide binding143 – 1519ATP By similarity
Compositional bias1451 – 14544Poly-Pro

Sites

Active site2651Proton acceptor By similarity
Binding site1681ATP By similarity

Amino acid modifications

Modified residue8051Phosphothreonine By similarity

Natural variations

Natural variant301P → A.
Corresponds to variant rs3735252 [ dbSNP | Ensembl ].
VAR_028940
Natural variant4841D → H in a lung large cell carcinoma sample; somatic mutation. Ref.10
VAR_041727
Natural variant5951V → I. Ref.10
Corresponds to variant rs34461195 [ dbSNP | Ensembl ].
VAR_041728
Natural variant6241V → M. Ref.10
Corresponds to variant rs34628253 [ dbSNP | Ensembl ].
VAR_041729
Natural variant6931I → T. Ref.10
Corresponds to variant rs56204700 [ dbSNP | Ensembl ].
VAR_041730
Natural variant7801L → M. Ref.2 Ref.10
Corresponds to variant rs11765552 [ dbSNP | Ensembl ].
VAR_028941
Natural variant8491V → F. Ref.10
Corresponds to variant rs56196840 [ dbSNP | Ensembl ].
VAR_041731
Natural variant8621A → T. Ref.10
Corresponds to variant rs34005293 [ dbSNP | Ensembl ].
VAR_041732
Natural variant9161S → R. Ref.10
Corresponds to variant rs55867257 [ dbSNP | Ensembl ].
VAR_041733
Natural variant10611D → N. Ref.10
Corresponds to variant rs3801295 [ dbSNP | Ensembl ].
VAR_028942
Natural variant12201D → N. Ref.10
Corresponds to variant rs35912712 [ dbSNP | Ensembl ].
VAR_041734
Natural variant13411A → G. Ref.10
Corresponds to variant rs56343792 [ dbSNP | Ensembl ].
VAR_041735
Natural variant14011S → N. Ref.10
Corresponds to variant rs45488394 [ dbSNP | Ensembl ].
VAR_041736

Experimental info

Sequence conflict9101S → I in AAN08717. Ref.1
Sequence conflict1444 – 145411QTSKYFSPPPP → PSTLPAFPSHT in BAA83031. Ref.2
Sequence conflict1455 – 150349Missing in BAA83031. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8IWU2 [UniParc].

Last modified April 17, 2007. Version 2.
Checksum: 52665B054F04D17A

FASTA1,503164,900
        10         20         30         40         50         60 
MPGPPALRRR LLLLLLVLLI AGSAGAAPLP QTGAGEAPPA AEVSSSFVIL CVCSLIILIV 

        70         80         90        100        110        120 
LIANCVSCCK DPEIDFKEFE DNFDDEIDFT PPAEDTPSVQ SPAEVFTLSV PNISLPAPSQ 

       130        140        150        160        170        180 
FQPSVEGLKS QVARHSLNYI QEIGNGWFGK VLLGEIYTGT SVARVIVKEL KASANPKEQD 

       190        200        210        220        230        240 
TFLKNGEPYY ILQHPNILQC VGQCVEAIPY LLVFEFCDLG DLKAYLRSEQ EHMRGDSQTM 

       250        260        270        280        290        300 
LLQRMACEVA AGLAAMHKLH FLHSDLALRN CFLTSDLNVK VGDYGIGFSR YKEDYIETDD 

       310        320        330        340        350        360 
KKVFPLRWTA PELVTSFQDR LLTADQTKYS NIWSLGVTLW ELFDNAAQPY SNLSNLDVLN 

       370        380        390        400        410        420 
QVIRERDTKL PKPQLEQPYS DRWYEVLQFC WLSPEKRPAA EDVHRLLTYL RLQSQRDSEV 

       430        440        450        460        470        480 
DFEQQWNALK PNTNSRDSSN NAAFPILDHF ARDRLGREME EVLTVTETSQ GLSFEYVWEA 

       490        500        510        520        530        540 
AKHDHFDERS RGHLDEGLSY TSIFYPVEVF ESSLSDPGPG KQDDSGQDVP LRVPGVVPVF 

       550        560        570        580        590        600 
DAHNLSVGSD YYIQLEEKSG SNLELDYPPA LLTTDMDNPE RTGPELSQLT ALRSVELEES 

       610        620        630        640        650        660 
STDEDFFQSS TDPKDSSLPG DLHVTSGPES PFNNIFNDVD KSEDLPSHQK IFDLMELNGV 

       670        680        690        700        710        720 
QADFKPATLS SSLDNPKESV ITGHFEKEKP RKIFDSEPLC LSDNLMHQDN FDPLNVQELS 

       730        740        750        760        770        780 
ENFLFLQEKN LLKGSLSSKE HINDLQTELK NAGFTEAMLE TSCRNSLDTE LQFAENKPGL 

       790        800        810        820        830        840 
SLLQENVSTK GDDTDVMLTG DTLSTSLQSS PEVQVPPTSF ETEETPRRVP PDSLPTQGET 

       850        860        870        880        890        900 
QPTCLDVIVP EDCLHQDISP DAVTVPVEIL STDARTHSLD NRSQDSPGES EETLRLTESD 

       910        920        930        940        950        960 
SVLADDILAS RVSVGSSLPE LGQELHNKPF SEDHHSHRRL EKNLEAVETL NQLNSKDAAK 

       970        980        990       1000       1010       1020 
EAGLVSALSS DSTSQDSLLE DSLSAPFPAS EPSLETPDSL ESVDVHEALL DSLGSHTPQK 

      1030       1040       1050       1060       1070       1080 
LVPPDKPADS GYETENLESP EWTLHPAPEG TADSEPATTG DGGHSGLPPN PVIVISDAGD 

      1090       1100       1110       1120       1130       1140 
GHRGTEVTPE TFTAGSQGSY RDSAYFSDND SEPEKRSEEV PGTSPSALVL VQEQPLPEPV 

      1150       1160       1170       1180       1190       1200 
LPEQSPAAQD SCLEARKSQP DESCLSALHN SSDLELRATP EPAQTGVPQQ VHPTEDEASS 

      1210       1220       1230       1240       1250       1260 
PWSVLNAELS SGDDFETQDD RPCTLASTGT NTNELLAYTN SALDKSLSSH SEGPKLKEPD 

      1270       1280       1290       1300       1310       1320 
IEGKYLGKLG VSGMLDLSED GMDADEEDEN SDDSDEDLRA FNLHSLSSES EDETEHPVPI 

      1330       1340       1350       1360       1370       1380 
ILSNEDGRHL RSLLKPTAAN APDPLPEDWK KEKKAVTFFD DVTVYLFDQE TPTKELGPCG 

      1390       1400       1410       1420       1430       1440 
GEACGPDLSG PAPASGSPYL SRCINSESST DEEGGGFEWD DDFSPDPFMS KTTSNLLSSK 

      1450       1460       1470       1480       1490       1500 
PSLQTSKYFS PPPPARSTEQ SWPHSAPYSR FSISPANIAS FSLTHLTDSD IEQGGSSEDG 


EKD 

« Hide

References

« Hide 'large scale' references
[1]"A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2."
Wang H., Brautigan D.L.
J. Biol. Chem. 277:49605-49612(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PPP1C AND INH2.
Tissue: Cervix carcinoma.
[2]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-780.
Tissue: Brain.
[3]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling."
Kawa S., Fujimoto J., Tezuka T., Nakazawa T., Yamamoto T.
Genes Cells 9:219-232(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase."
Wang H., Brautigan D.L.
Mol. Cell. Proteomics 5:2124-2130(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION.
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[9]"Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection."
Nixon A., Jia Y., White C., Bradbury N.A.
Am. J. Physiol. 304:C164-169(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY, SUBCELLULAR LOCATION.
[10]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-484; ILE-595; MET-624; THR-693; MET-780; PHE-849; THR-862; ARG-916; ASN-1061; ASN-1220; GLY-1341 AND ASN-1401.
+Additional computationally mapped references.

Web resources

Wikipedia

LMTK2 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY130988 mRNA. Translation: AAN08717.1.
AB029002 mRNA. Translation: BAA83031.2. Different initiation.
AC073101 Genomic DNA. Translation: AAS07515.1.
CH471091 Genomic DNA. Translation: EAW76721.1.
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23894.1.
CCDSCCDS5654.1.
RefSeqNP_055731.2. NM_014916.3.
UniGeneHs.444179.

3D structure databases

ProteinModelPortalQ8IWU2.
SMRQ8IWU2. Positions 111-470.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116524. 7 interactions.
IntActQ8IWU2. 3 interactions.
STRING9606.ENSP00000297293.

PTM databases

PhosphoSiteQ8IWU2.

Proteomic databases

MaxQBQ8IWU2.
PaxDbQ8IWU2.
PRIDEQ8IWU2.

Protocols and materials databases

DNASU22853.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297293; ENSP00000297293; ENSG00000164715.
GeneID22853.
KEGGhsa:22853.
UCSCuc003upd.2. human.

Organism-specific databases

CTD22853.
GeneCardsGC07P097736.
H-InvDBHIX0006877.
HIX0167839.
HGNCHGNC:17880. LMTK2.
HPAHPA010657.
MIM610989. gene.
neXtProtNX_Q8IWU2.
PharmGKBPA134884391.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000252999.
HOVERGENHBG081920.
InParanoidQ8IWU2.
KOK08898.
OMANLESPEW.
OrthoDBEOG7HTHG4.
PhylomeDBQ8IWU2.
TreeFamTF332280.

Enzyme and pathway databases

SignaLinkQ8IWU2.

Gene expression databases

BgeeQ8IWU2.
CleanExHS_LMTK2.
GenevestigatorQ8IWU2.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLMTK2. human.
GeneWikiLMTK2.
GenomeRNAi22853.
NextBio43333.
PROQ8IWU2.
SOURCESearch...

Entry information

Entry nameLMTK2_HUMAN
AccessionPrimary (citable) accession number: Q8IWU2
Secondary accession number(s): A4D272, Q75MG7, Q9UPS3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 17, 2007
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM