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Q8IWU2

- LMTK2_HUMAN

UniProt

Q8IWU2 - LMTK2_HUMAN

Protein

Serine/threonine-protein kinase LMTK2

Gene

LMTK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Phosphorylates PPP1C, phosphorylase b and CFTR.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei168 – 1681ATPPROSITE-ProRule annotation
    Active sitei265 – 2651Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi143 – 1519ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. myosin VI binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein phosphatase inhibitor activity Source: UniProtKB
    5. protein serine/threonine kinase activity Source: UniProtKB
    6. protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. early endosome to late endosome transport Source: UniProtKB
    2. endocytic recycling Source: UniProtKB
    3. negative regulation of catalytic activity Source: GOC
    4. peptidyl-serine phosphorylation Source: UniProtKB
    5. peptidyl-threonine phosphorylation Source: UniProtKB
    6. protein autophosphorylation Source: UniProtKB
    7. protein phosphorylation Source: UniProtKB
    8. receptor recycling Source: UniProtKB
    9. transferrin transport Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8IWU2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase LMTK2 (EC:2.7.11.1)
    Alternative name(s):
    Apoptosis-associated tyrosine kinase 2
    Brain-enriched kinase
    Short name:
    hBREK
    CDK5/p35-regulated kinase
    Short name:
    CPRK
    Kinase/phosphatase/inhibitor 2
    Lemur tyrosine kinase 2
    Serine/threonine-protein kinase KPI-2
    Gene namesi
    Name:LMTK2
    Synonyms:AATYK2, BREK, KIAA1079, KPI2, LMR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:17880. LMTK2.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB
    3. integral component of membrane Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB
    5. recycling endosome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134884391.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15031503Serine/threonine-protein kinase LMTK2PRO_0000259458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei805 – 8051PhosphothreonineBy similarity

    Post-translational modificationi

    Autophosphorylated. Phosphorylated By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IWU2.
    PaxDbiQ8IWU2.
    PRIDEiQ8IWU2.

    PTM databases

    PhosphoSiteiQ8IWU2.

    Expressioni

    Tissue specificityi

    Mainly expressed in skeletal muscle, and weakly in brain and pancreas.1 Publication

    Gene expression databases

    BgeeiQ8IWU2.
    CleanExiHS_LMTK2.
    GenevestigatoriQ8IWU2.

    Organism-specific databases

    HPAiHPA010657.

    Interactioni

    Subunit structurei

    Interacts with PPP1C and inhibitor-2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP1R2P412363EBI-2008933,EBI-1056517

    Protein-protein interaction databases

    BioGridi116524. 7 interactions.
    IntActiQ8IWU2. 3 interactions.
    STRINGi9606.ENSP00000297293.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWU2.
    SMRiQ8IWU2. Positions 111-470.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 4211LumenalSequence AnalysisAdd
    BLAST
    Topological domaini64 – 15031440CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini137 – 407271Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1451 – 14544Poly-Pro

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000252999.
    HOVERGENiHBG081920.
    InParanoidiQ8IWU2.
    KOiK08898.
    OMAiNLESPEW.
    OrthoDBiEOG7HTHG4.
    PhylomeDBiQ8IWU2.
    TreeFamiTF332280.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IWU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGPPALRRR LLLLLLVLLI AGSAGAAPLP QTGAGEAPPA AEVSSSFVIL     50
    CVCSLIILIV LIANCVSCCK DPEIDFKEFE DNFDDEIDFT PPAEDTPSVQ 100
    SPAEVFTLSV PNISLPAPSQ FQPSVEGLKS QVARHSLNYI QEIGNGWFGK 150
    VLLGEIYTGT SVARVIVKEL KASANPKEQD TFLKNGEPYY ILQHPNILQC 200
    VGQCVEAIPY LLVFEFCDLG DLKAYLRSEQ EHMRGDSQTM LLQRMACEVA 250
    AGLAAMHKLH FLHSDLALRN CFLTSDLNVK VGDYGIGFSR YKEDYIETDD 300
    KKVFPLRWTA PELVTSFQDR LLTADQTKYS NIWSLGVTLW ELFDNAAQPY 350
    SNLSNLDVLN QVIRERDTKL PKPQLEQPYS DRWYEVLQFC WLSPEKRPAA 400
    EDVHRLLTYL RLQSQRDSEV DFEQQWNALK PNTNSRDSSN NAAFPILDHF 450
    ARDRLGREME EVLTVTETSQ GLSFEYVWEA AKHDHFDERS RGHLDEGLSY 500
    TSIFYPVEVF ESSLSDPGPG KQDDSGQDVP LRVPGVVPVF DAHNLSVGSD 550
    YYIQLEEKSG SNLELDYPPA LLTTDMDNPE RTGPELSQLT ALRSVELEES 600
    STDEDFFQSS TDPKDSSLPG DLHVTSGPES PFNNIFNDVD KSEDLPSHQK 650
    IFDLMELNGV QADFKPATLS SSLDNPKESV ITGHFEKEKP RKIFDSEPLC 700
    LSDNLMHQDN FDPLNVQELS ENFLFLQEKN LLKGSLSSKE HINDLQTELK 750
    NAGFTEAMLE TSCRNSLDTE LQFAENKPGL SLLQENVSTK GDDTDVMLTG 800
    DTLSTSLQSS PEVQVPPTSF ETEETPRRVP PDSLPTQGET QPTCLDVIVP 850
    EDCLHQDISP DAVTVPVEIL STDARTHSLD NRSQDSPGES EETLRLTESD 900
    SVLADDILAS RVSVGSSLPE LGQELHNKPF SEDHHSHRRL EKNLEAVETL 950
    NQLNSKDAAK EAGLVSALSS DSTSQDSLLE DSLSAPFPAS EPSLETPDSL 1000
    ESVDVHEALL DSLGSHTPQK LVPPDKPADS GYETENLESP EWTLHPAPEG 1050
    TADSEPATTG DGGHSGLPPN PVIVISDAGD GHRGTEVTPE TFTAGSQGSY 1100
    RDSAYFSDND SEPEKRSEEV PGTSPSALVL VQEQPLPEPV LPEQSPAAQD 1150
    SCLEARKSQP DESCLSALHN SSDLELRATP EPAQTGVPQQ VHPTEDEASS 1200
    PWSVLNAELS SGDDFETQDD RPCTLASTGT NTNELLAYTN SALDKSLSSH 1250
    SEGPKLKEPD IEGKYLGKLG VSGMLDLSED GMDADEEDEN SDDSDEDLRA 1300
    FNLHSLSSES EDETEHPVPI ILSNEDGRHL RSLLKPTAAN APDPLPEDWK 1350
    KEKKAVTFFD DVTVYLFDQE TPTKELGPCG GEACGPDLSG PAPASGSPYL 1400
    SRCINSESST DEEGGGFEWD DDFSPDPFMS KTTSNLLSSK PSLQTSKYFS 1450
    PPPPARSTEQ SWPHSAPYSR FSISPANIAS FSLTHLTDSD IEQGGSSEDG 1500
    EKD 1503
    Length:1,503
    Mass (Da):164,900
    Last modified:April 17, 2007 - v2
    Checksum:i52665B054F04D17A
    GO

    Sequence cautioni

    The sequence BAA83031.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti910 – 9101S → I in AAN08717. (PubMed:12393858)Curated
    Sequence conflicti1444 – 145411QTSKYFSPPPP → PSTLPAFPSHT in BAA83031. (PubMed:10470851)CuratedAdd
    BLAST
    Sequence conflicti1455 – 150349Missing in BAA83031. (PubMed:10470851)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301P → A.
    Corresponds to variant rs3735252 [ dbSNP | Ensembl ].
    VAR_028940
    Natural varianti484 – 4841D → H in a lung large cell carcinoma sample; somatic mutation. 1 Publication
    VAR_041727
    Natural varianti595 – 5951V → I.1 Publication
    Corresponds to variant rs34461195 [ dbSNP | Ensembl ].
    VAR_041728
    Natural varianti624 – 6241V → M.1 Publication
    Corresponds to variant rs34628253 [ dbSNP | Ensembl ].
    VAR_041729
    Natural varianti693 – 6931I → T.1 Publication
    Corresponds to variant rs56204700 [ dbSNP | Ensembl ].
    VAR_041730
    Natural varianti780 – 7801L → M.2 Publications
    Corresponds to variant rs11765552 [ dbSNP | Ensembl ].
    VAR_028941
    Natural varianti849 – 8491V → F.1 Publication
    Corresponds to variant rs56196840 [ dbSNP | Ensembl ].
    VAR_041731
    Natural varianti862 – 8621A → T.1 Publication
    Corresponds to variant rs34005293 [ dbSNP | Ensembl ].
    VAR_041732
    Natural varianti916 – 9161S → R.1 Publication
    Corresponds to variant rs55867257 [ dbSNP | Ensembl ].
    VAR_041733
    Natural varianti1061 – 10611D → N.1 Publication
    Corresponds to variant rs3801295 [ dbSNP | Ensembl ].
    VAR_028942
    Natural varianti1220 – 12201D → N.1 Publication
    Corresponds to variant rs35912712 [ dbSNP | Ensembl ].
    VAR_041734
    Natural varianti1341 – 13411A → G.1 Publication
    Corresponds to variant rs56343792 [ dbSNP | Ensembl ].
    VAR_041735
    Natural varianti1401 – 14011S → N.1 Publication
    Corresponds to variant rs45488394 [ dbSNP | Ensembl ].
    VAR_041736

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY130988 mRNA. Translation: AAN08717.1.
    AB029002 mRNA. Translation: BAA83031.2. Different initiation.
    AC073101 Genomic DNA. Translation: AAS07515.1.
    CH471091 Genomic DNA. Translation: EAW76721.1.
    AC091654 Genomic DNA. No translation available.
    CH236956 Genomic DNA. Translation: EAL23894.1.
    CCDSiCCDS5654.1.
    RefSeqiNP_055731.2. NM_014916.3.
    UniGeneiHs.444179.

    Genome annotation databases

    EnsembliENST00000297293; ENSP00000297293; ENSG00000164715.
    GeneIDi22853.
    KEGGihsa:22853.
    UCSCiuc003upd.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    LMTK2 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY130988 mRNA. Translation: AAN08717.1 .
    AB029002 mRNA. Translation: BAA83031.2 . Different initiation.
    AC073101 Genomic DNA. Translation: AAS07515.1 .
    CH471091 Genomic DNA. Translation: EAW76721.1 .
    AC091654 Genomic DNA. No translation available.
    CH236956 Genomic DNA. Translation: EAL23894.1 .
    CCDSi CCDS5654.1.
    RefSeqi NP_055731.2. NM_014916.3.
    UniGenei Hs.444179.

    3D structure databases

    ProteinModelPortali Q8IWU2.
    SMRi Q8IWU2. Positions 111-470.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116524. 7 interactions.
    IntActi Q8IWU2. 3 interactions.
    STRINGi 9606.ENSP00000297293.

    PTM databases

    PhosphoSitei Q8IWU2.

    Proteomic databases

    MaxQBi Q8IWU2.
    PaxDbi Q8IWU2.
    PRIDEi Q8IWU2.

    Protocols and materials databases

    DNASUi 22853.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297293 ; ENSP00000297293 ; ENSG00000164715 .
    GeneIDi 22853.
    KEGGi hsa:22853.
    UCSCi uc003upd.2. human.

    Organism-specific databases

    CTDi 22853.
    GeneCardsi GC07P097736.
    H-InvDB HIX0006877.
    HIX0167839.
    HGNCi HGNC:17880. LMTK2.
    HPAi HPA010657.
    MIMi 610989. gene.
    neXtProti NX_Q8IWU2.
    PharmGKBi PA134884391.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000252999.
    HOVERGENi HBG081920.
    InParanoidi Q8IWU2.
    KOi K08898.
    OMAi NLESPEW.
    OrthoDBi EOG7HTHG4.
    PhylomeDBi Q8IWU2.
    TreeFami TF332280.

    Enzyme and pathway databases

    SignaLinki Q8IWU2.

    Miscellaneous databases

    ChiTaRSi LMTK2. human.
    GeneWikii LMTK2.
    GenomeRNAii 22853.
    NextBioi 43333.
    PROi Q8IWU2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IWU2.
    CleanExi HS_LMTK2.
    Genevestigatori Q8IWU2.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2."
      Wang H., Brautigan D.L.
      J. Biol. Chem. 277:49605-49612(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PPP1C AND INH2.
      Tissue: Cervix carcinoma.
    2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-780.
      Tissue: Brain.
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling."
      Kawa S., Fujimoto J., Tezuka T., Nakazawa T., Yamamoto T.
      Genes Cells 9:219-232(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    7. "Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase."
      Wang H., Brautigan D.L.
      Mol. Cell. Proteomics 5:2124-2130(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection."
      Nixon A., Jia Y., White C., Bradbury N.A.
      Am. J. Physiol. 304:C164-169(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY, SUBCELLULAR LOCATION.
    10. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-484; ILE-595; MET-624; THR-693; MET-780; PHE-849; THR-862; ARG-916; ASN-1061; ASN-1220; GLY-1341 AND ASN-1401.

    Entry informationi

    Entry nameiLMTK2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWU2
    Secondary accession number(s): A4D272, Q75MG7, Q9UPS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3