SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IWU2

- LMTK2_HUMAN

UniProt

Q8IWU2 - LMTK2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Serine/threonine-protein kinase LMTK2
Gene
LMTK2, AATYK2, BREK, KIAA1079, KPI2, LMR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphorylates PPP1C, phosphorylase b and CFTR.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei168 – 1681ATP By similarity
Active sitei265 – 2651Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 1519ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. myosin VI binding Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. protein phosphatase inhibitor activity Source: UniProtKB
  5. protein serine/threonine kinase activity Source: UniProtKB
  6. protein tyrosine kinase activity Source: InterPro

GO - Biological processi

  1. early endosome to late endosome transport Source: UniProtKB
  2. endocytic recycling Source: UniProtKB
  3. negative regulation of catalytic activity Source: GOC
  4. peptidyl-serine phosphorylation Source: UniProtKB
  5. peptidyl-threonine phosphorylation Source: UniProtKB
  6. protein autophosphorylation Source: UniProtKB
  7. protein phosphorylation Source: UniProtKB
  8. receptor recycling Source: UniProtKB
  9. transferrin transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IWU2.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK2 (EC:2.7.11.1)
Alternative name(s):
Apoptosis-associated tyrosine kinase 2
Brain-enriched kinase
Short name:
hBREK
CDK5/p35-regulated kinase
Short name:
CPRK
Kinase/phosphatase/inhibitor 2
Lemur tyrosine kinase 2
Serine/threonine-protein kinase KPI-2
Gene namesi
Name:LMTK2
Synonyms:AATYK2, BREK, KIAA1079, KPI2, LMR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:17880. LMTK2.

Subcellular locationi

Membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Reviewed prediction
Add
BLAST
Topological domaini32 – 4211Lumenal Reviewed prediction
Add
BLAST
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Topological domaini64 – 15031440Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
  5. recycling endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15031503Serine/threonine-protein kinase LMTK2
PRO_0000259458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei805 – 8051Phosphothreonine By similarity

Post-translational modificationi

Autophosphorylated. Phosphorylated By similarity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IWU2.
PaxDbiQ8IWU2.
PRIDEiQ8IWU2.

PTM databases

PhosphoSiteiQ8IWU2.

Expressioni

Tissue specificityi

Mainly expressed in skeletal muscle, and weakly in brain and pancreas.1 Publication

Gene expression databases

BgeeiQ8IWU2.
CleanExiHS_LMTK2.
GenevestigatoriQ8IWU2.

Organism-specific databases

HPAiHPA010657.

Interactioni

Subunit structurei

Interacts with PPP1C and inhibitor-2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1R2P412363EBI-2008933,EBI-1056517

Protein-protein interaction databases

BioGridi116524. 7 interactions.
IntActiQ8IWU2. 3 interactions.
STRINGi9606.ENSP00000297293.

Structurei

3D structure databases

ProteinModelPortaliQ8IWU2.
SMRiQ8IWU2. Positions 111-470.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 407271Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1451 – 14544Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000252999.
HOVERGENiHBG081920.
InParanoidiQ8IWU2.
KOiK08898.
OMAiNLESPEW.
OrthoDBiEOG7HTHG4.
PhylomeDBiQ8IWU2.
TreeFamiTF332280.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWU2-1 [UniParc]FASTAAdd to Basket

« Hide

MPGPPALRRR LLLLLLVLLI AGSAGAAPLP QTGAGEAPPA AEVSSSFVIL     50
CVCSLIILIV LIANCVSCCK DPEIDFKEFE DNFDDEIDFT PPAEDTPSVQ 100
SPAEVFTLSV PNISLPAPSQ FQPSVEGLKS QVARHSLNYI QEIGNGWFGK 150
VLLGEIYTGT SVARVIVKEL KASANPKEQD TFLKNGEPYY ILQHPNILQC 200
VGQCVEAIPY LLVFEFCDLG DLKAYLRSEQ EHMRGDSQTM LLQRMACEVA 250
AGLAAMHKLH FLHSDLALRN CFLTSDLNVK VGDYGIGFSR YKEDYIETDD 300
KKVFPLRWTA PELVTSFQDR LLTADQTKYS NIWSLGVTLW ELFDNAAQPY 350
SNLSNLDVLN QVIRERDTKL PKPQLEQPYS DRWYEVLQFC WLSPEKRPAA 400
EDVHRLLTYL RLQSQRDSEV DFEQQWNALK PNTNSRDSSN NAAFPILDHF 450
ARDRLGREME EVLTVTETSQ GLSFEYVWEA AKHDHFDERS RGHLDEGLSY 500
TSIFYPVEVF ESSLSDPGPG KQDDSGQDVP LRVPGVVPVF DAHNLSVGSD 550
YYIQLEEKSG SNLELDYPPA LLTTDMDNPE RTGPELSQLT ALRSVELEES 600
STDEDFFQSS TDPKDSSLPG DLHVTSGPES PFNNIFNDVD KSEDLPSHQK 650
IFDLMELNGV QADFKPATLS SSLDNPKESV ITGHFEKEKP RKIFDSEPLC 700
LSDNLMHQDN FDPLNVQELS ENFLFLQEKN LLKGSLSSKE HINDLQTELK 750
NAGFTEAMLE TSCRNSLDTE LQFAENKPGL SLLQENVSTK GDDTDVMLTG 800
DTLSTSLQSS PEVQVPPTSF ETEETPRRVP PDSLPTQGET QPTCLDVIVP 850
EDCLHQDISP DAVTVPVEIL STDARTHSLD NRSQDSPGES EETLRLTESD 900
SVLADDILAS RVSVGSSLPE LGQELHNKPF SEDHHSHRRL EKNLEAVETL 950
NQLNSKDAAK EAGLVSALSS DSTSQDSLLE DSLSAPFPAS EPSLETPDSL 1000
ESVDVHEALL DSLGSHTPQK LVPPDKPADS GYETENLESP EWTLHPAPEG 1050
TADSEPATTG DGGHSGLPPN PVIVISDAGD GHRGTEVTPE TFTAGSQGSY 1100
RDSAYFSDND SEPEKRSEEV PGTSPSALVL VQEQPLPEPV LPEQSPAAQD 1150
SCLEARKSQP DESCLSALHN SSDLELRATP EPAQTGVPQQ VHPTEDEASS 1200
PWSVLNAELS SGDDFETQDD RPCTLASTGT NTNELLAYTN SALDKSLSSH 1250
SEGPKLKEPD IEGKYLGKLG VSGMLDLSED GMDADEEDEN SDDSDEDLRA 1300
FNLHSLSSES EDETEHPVPI ILSNEDGRHL RSLLKPTAAN APDPLPEDWK 1350
KEKKAVTFFD DVTVYLFDQE TPTKELGPCG GEACGPDLSG PAPASGSPYL 1400
SRCINSESST DEEGGGFEWD DDFSPDPFMS KTTSNLLSSK PSLQTSKYFS 1450
PPPPARSTEQ SWPHSAPYSR FSISPANIAS FSLTHLTDSD IEQGGSSEDG 1500
EKD 1503
Length:1,503
Mass (Da):164,900
Last modified:April 17, 2007 - v2
Checksum:i52665B054F04D17A
GO

Sequence cautioni

The sequence BAA83031.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301P → A.
Corresponds to variant rs3735252 [ dbSNP | Ensembl ].
VAR_028940
Natural varianti484 – 4841D → H in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_041727
Natural varianti595 – 5951V → I.1 Publication
Corresponds to variant rs34461195 [ dbSNP | Ensembl ].
VAR_041728
Natural varianti624 – 6241V → M.1 Publication
Corresponds to variant rs34628253 [ dbSNP | Ensembl ].
VAR_041729
Natural varianti693 – 6931I → T.1 Publication
Corresponds to variant rs56204700 [ dbSNP | Ensembl ].
VAR_041730
Natural varianti780 – 7801L → M.2 Publications
Corresponds to variant rs11765552 [ dbSNP | Ensembl ].
VAR_028941
Natural varianti849 – 8491V → F.1 Publication
Corresponds to variant rs56196840 [ dbSNP | Ensembl ].
VAR_041731
Natural varianti862 – 8621A → T.1 Publication
Corresponds to variant rs34005293 [ dbSNP | Ensembl ].
VAR_041732
Natural varianti916 – 9161S → R.1 Publication
Corresponds to variant rs55867257 [ dbSNP | Ensembl ].
VAR_041733
Natural varianti1061 – 10611D → N.1 Publication
Corresponds to variant rs3801295 [ dbSNP | Ensembl ].
VAR_028942
Natural varianti1220 – 12201D → N.1 Publication
Corresponds to variant rs35912712 [ dbSNP | Ensembl ].
VAR_041734
Natural varianti1341 – 13411A → G.1 Publication
Corresponds to variant rs56343792 [ dbSNP | Ensembl ].
VAR_041735
Natural varianti1401 – 14011S → N.1 Publication
Corresponds to variant rs45488394 [ dbSNP | Ensembl ].
VAR_041736

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti910 – 9101S → I in AAN08717. 1 Publication
Sequence conflicti1444 – 145411QTSKYFSPPPP → PSTLPAFPSHT in BAA83031. 1 Publication
Add
BLAST
Sequence conflicti1455 – 150349Missing in BAA83031. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY130988 mRNA. Translation: AAN08717.1.
AB029002 mRNA. Translation: BAA83031.2. Different initiation.
AC073101 Genomic DNA. Translation: AAS07515.1.
CH471091 Genomic DNA. Translation: EAW76721.1.
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23894.1.
CCDSiCCDS5654.1.
RefSeqiNP_055731.2. NM_014916.3.
UniGeneiHs.444179.

Genome annotation databases

EnsembliENST00000297293; ENSP00000297293; ENSG00000164715.
GeneIDi22853.
KEGGihsa:22853.
UCSCiuc003upd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

LMTK2 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY130988 mRNA. Translation: AAN08717.1 .
AB029002 mRNA. Translation: BAA83031.2 . Different initiation.
AC073101 Genomic DNA. Translation: AAS07515.1 .
CH471091 Genomic DNA. Translation: EAW76721.1 .
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23894.1 .
CCDSi CCDS5654.1.
RefSeqi NP_055731.2. NM_014916.3.
UniGenei Hs.444179.

3D structure databases

ProteinModelPortali Q8IWU2.
SMRi Q8IWU2. Positions 111-470.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116524. 7 interactions.
IntActi Q8IWU2. 3 interactions.
STRINGi 9606.ENSP00000297293.

PTM databases

PhosphoSitei Q8IWU2.

Proteomic databases

MaxQBi Q8IWU2.
PaxDbi Q8IWU2.
PRIDEi Q8IWU2.

Protocols and materials databases

DNASUi 22853.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297293 ; ENSP00000297293 ; ENSG00000164715 .
GeneIDi 22853.
KEGGi hsa:22853.
UCSCi uc003upd.2. human.

Organism-specific databases

CTDi 22853.
GeneCardsi GC07P097736.
H-InvDB HIX0006877.
HIX0167839.
HGNCi HGNC:17880. LMTK2.
HPAi HPA010657.
MIMi 610989. gene.
neXtProti NX_Q8IWU2.
PharmGKBi PA134884391.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000252999.
HOVERGENi HBG081920.
InParanoidi Q8IWU2.
KOi K08898.
OMAi NLESPEW.
OrthoDBi EOG7HTHG4.
PhylomeDBi Q8IWU2.
TreeFami TF332280.

Enzyme and pathway databases

SignaLinki Q8IWU2.

Miscellaneous databases

ChiTaRSi LMTK2. human.
GeneWikii LMTK2.
GenomeRNAii 22853.
NextBioi 43333.
PROi Q8IWU2.
SOURCEi Search...

Gene expression databases

Bgeei Q8IWU2.
CleanExi HS_LMTK2.
Genevestigatori Q8IWU2.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2."
    Wang H., Brautigan D.L.
    J. Biol. Chem. 277:49605-49612(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PPP1C AND INH2.
    Tissue: Cervix carcinoma.
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-780.
    Tissue: Brain.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling."
    Kawa S., Fujimoto J., Tezuka T., Nakazawa T., Yamamoto T.
    Genes Cells 9:219-232(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase."
    Wang H., Brautigan D.L.
    Mol. Cell. Proteomics 5:2124-2130(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection."
    Nixon A., Jia Y., White C., Bradbury N.A.
    Am. J. Physiol. 304:C164-169(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY, SUBCELLULAR LOCATION.
  10. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-484; ILE-595; MET-624; THR-693; MET-780; PHE-849; THR-862; ARG-916; ASN-1061; ASN-1220; GLY-1341 AND ASN-1401.

Entry informationi

Entry nameiLMTK2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWU2
Secondary accession number(s): A4D272, Q75MG7, Q9UPS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 17, 2007
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi