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Protein

Serine/threonine-protein kinase LMTK2

Gene

LMTK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates PPP1C, phosphorylase b and CFTR.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168ATPPROSITE-ProRule annotation1
Active sitei265Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi143 – 151ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • myosin VI binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • early endosome to late endosome transport Source: UniProtKB
  • endocytic recycling Source: UniProtKB
  • peptidyl-serine phosphorylation Source: UniProtKB
  • peptidyl-threonine phosphorylation Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • receptor recycling Source: UniProtKB
  • transferrin transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS09123-MONOMER.
SignaLinkiQ8IWU2.
SIGNORiQ8IWU2.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK2 (EC:2.7.11.1)
Alternative name(s):
Apoptosis-associated tyrosine kinase 2
Brain-enriched kinase
Short name:
hBREK
CDK5/p35-regulated kinase
Short name:
CPRK
Kinase/phosphatase/inhibitor 2
Lemur tyrosine kinase 2
Serine/threonine-protein kinase KPI-2
Gene namesi
Name:LMTK2
Synonyms:AATYK2, BREK, KIAA1079, KPI2, LMR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17880. LMTK2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 42LumenalSequence analysisAdd BLAST11
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 1503CytoplasmicSequence analysisAdd BLAST1440

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • recycling endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22853.
OpenTargetsiENSG00000164715.
PharmGKBiPA134884391.

Polymorphism and mutation databases

BioMutaiLMTK2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002594581 – 1503Serine/threonine-protein kinase LMTK2Add BLAST1503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei805PhosphothreonineBy similarity1
Modified residuei806PhosphoserineBy similarity1
Modified residuei886PhosphoserineCombined sources1
Modified residuei1107PhosphoserineCombined sources1
Modified residuei1305PhosphoserineBy similarity1
Modified residuei1307PhosphoserineBy similarity1
Modified residuei1308PhosphoserineBy similarity1
Modified residuei1310PhosphoserineBy similarity1
Modified residuei1450PhosphoserineCombined sources1
Modified residuei1496PhosphoserineBy similarity1
Modified residuei1497PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated. Phosphorylated (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IWU2.
MaxQBiQ8IWU2.
PaxDbiQ8IWU2.
PeptideAtlasiQ8IWU2.
PRIDEiQ8IWU2.

PTM databases

iPTMnetiQ8IWU2.
PhosphoSitePlusiQ8IWU2.
SwissPalmiQ8IWU2.

Expressioni

Tissue specificityi

Mainly expressed in skeletal muscle, and weakly in brain and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000164715.
CleanExiHS_LMTK2.
GenevisibleiQ8IWU2. HS.

Organism-specific databases

HPAiHPA010657.
HPA041836.

Interactioni

Subunit structurei

Interacts with PPP1C and inhibitor-2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1R2P412363EBI-2008933,EBI-1056517

GO - Molecular functioni

  • myosin VI binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116524. 11 interactors.
IntActiQ8IWU2. 6 interactors.
STRINGi9606.ENSP00000297293.

Structurei

3D structure databases

ProteinModelPortaliQ8IWU2.
SMRiQ8IWU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 407Protein kinasePROSITE-ProRule annotationAdd BLAST271

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1451 – 1454Poly-Pro4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQE. Eukaryota.
ENOG410XQFM. LUCA.
GeneTreeiENSGT00640000091449.
HOGENOMiHOG000252999.
HOVERGENiHBG081920.
InParanoidiQ8IWU2.
KOiK08898.
OMAiGPGKQDD.
OrthoDBiEOG091G0NTB.
PhylomeDBiQ8IWU2.
TreeFamiTF332280.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPPALRRR LLLLLLVLLI AGSAGAAPLP QTGAGEAPPA AEVSSSFVIL
60 70 80 90 100
CVCSLIILIV LIANCVSCCK DPEIDFKEFE DNFDDEIDFT PPAEDTPSVQ
110 120 130 140 150
SPAEVFTLSV PNISLPAPSQ FQPSVEGLKS QVARHSLNYI QEIGNGWFGK
160 170 180 190 200
VLLGEIYTGT SVARVIVKEL KASANPKEQD TFLKNGEPYY ILQHPNILQC
210 220 230 240 250
VGQCVEAIPY LLVFEFCDLG DLKAYLRSEQ EHMRGDSQTM LLQRMACEVA
260 270 280 290 300
AGLAAMHKLH FLHSDLALRN CFLTSDLNVK VGDYGIGFSR YKEDYIETDD
310 320 330 340 350
KKVFPLRWTA PELVTSFQDR LLTADQTKYS NIWSLGVTLW ELFDNAAQPY
360 370 380 390 400
SNLSNLDVLN QVIRERDTKL PKPQLEQPYS DRWYEVLQFC WLSPEKRPAA
410 420 430 440 450
EDVHRLLTYL RLQSQRDSEV DFEQQWNALK PNTNSRDSSN NAAFPILDHF
460 470 480 490 500
ARDRLGREME EVLTVTETSQ GLSFEYVWEA AKHDHFDERS RGHLDEGLSY
510 520 530 540 550
TSIFYPVEVF ESSLSDPGPG KQDDSGQDVP LRVPGVVPVF DAHNLSVGSD
560 570 580 590 600
YYIQLEEKSG SNLELDYPPA LLTTDMDNPE RTGPELSQLT ALRSVELEES
610 620 630 640 650
STDEDFFQSS TDPKDSSLPG DLHVTSGPES PFNNIFNDVD KSEDLPSHQK
660 670 680 690 700
IFDLMELNGV QADFKPATLS SSLDNPKESV ITGHFEKEKP RKIFDSEPLC
710 720 730 740 750
LSDNLMHQDN FDPLNVQELS ENFLFLQEKN LLKGSLSSKE HINDLQTELK
760 770 780 790 800
NAGFTEAMLE TSCRNSLDTE LQFAENKPGL SLLQENVSTK GDDTDVMLTG
810 820 830 840 850
DTLSTSLQSS PEVQVPPTSF ETEETPRRVP PDSLPTQGET QPTCLDVIVP
860 870 880 890 900
EDCLHQDISP DAVTVPVEIL STDARTHSLD NRSQDSPGES EETLRLTESD
910 920 930 940 950
SVLADDILAS RVSVGSSLPE LGQELHNKPF SEDHHSHRRL EKNLEAVETL
960 970 980 990 1000
NQLNSKDAAK EAGLVSALSS DSTSQDSLLE DSLSAPFPAS EPSLETPDSL
1010 1020 1030 1040 1050
ESVDVHEALL DSLGSHTPQK LVPPDKPADS GYETENLESP EWTLHPAPEG
1060 1070 1080 1090 1100
TADSEPATTG DGGHSGLPPN PVIVISDAGD GHRGTEVTPE TFTAGSQGSY
1110 1120 1130 1140 1150
RDSAYFSDND SEPEKRSEEV PGTSPSALVL VQEQPLPEPV LPEQSPAAQD
1160 1170 1180 1190 1200
SCLEARKSQP DESCLSALHN SSDLELRATP EPAQTGVPQQ VHPTEDEASS
1210 1220 1230 1240 1250
PWSVLNAELS SGDDFETQDD RPCTLASTGT NTNELLAYTN SALDKSLSSH
1260 1270 1280 1290 1300
SEGPKLKEPD IEGKYLGKLG VSGMLDLSED GMDADEEDEN SDDSDEDLRA
1310 1320 1330 1340 1350
FNLHSLSSES EDETEHPVPI ILSNEDGRHL RSLLKPTAAN APDPLPEDWK
1360 1370 1380 1390 1400
KEKKAVTFFD DVTVYLFDQE TPTKELGPCG GEACGPDLSG PAPASGSPYL
1410 1420 1430 1440 1450
SRCINSESST DEEGGGFEWD DDFSPDPFMS KTTSNLLSSK PSLQTSKYFS
1460 1470 1480 1490 1500
PPPPARSTEQ SWPHSAPYSR FSISPANIAS FSLTHLTDSD IEQGGSSEDG

EKD
Length:1,503
Mass (Da):164,900
Last modified:April 17, 2007 - v2
Checksum:i52665B054F04D17A
GO

Sequence cautioni

The sequence BAA83031 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti910S → I in AAN08717 (PubMed:12393858).Curated1
Sequence conflicti1444 – 1454QTSKYFSPPPP → PSTLPAFPSHT in BAA83031 (PubMed:10470851).CuratedAdd BLAST11
Sequence conflicti1455 – 1503Missing in BAA83031 (PubMed:10470851).CuratedAdd BLAST49

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02894030P → A.Corresponds to variant rs3735252dbSNPEnsembl.1
Natural variantiVAR_041727484D → H in a lung large cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs147940573dbSNPEnsembl.1
Natural variantiVAR_041728595V → I.1 PublicationCorresponds to variant rs34461195dbSNPEnsembl.1
Natural variantiVAR_041729624V → M.1 PublicationCorresponds to variant rs34628253dbSNPEnsembl.1
Natural variantiVAR_041730693I → T.1 PublicationCorresponds to variant rs56204700dbSNPEnsembl.1
Natural variantiVAR_028941780L → M.2 PublicationsCorresponds to variant rs11765552dbSNPEnsembl.1
Natural variantiVAR_041731849V → F.1 PublicationCorresponds to variant rs56196840dbSNPEnsembl.1
Natural variantiVAR_041732862A → T.1 PublicationCorresponds to variant rs34005293dbSNPEnsembl.1
Natural variantiVAR_041733916S → R.1 PublicationCorresponds to variant rs55867257dbSNPEnsembl.1
Natural variantiVAR_0289421061D → N.1 PublicationCorresponds to variant rs3801295dbSNPEnsembl.1
Natural variantiVAR_0417341220D → N.1 PublicationCorresponds to variant rs35912712dbSNPEnsembl.1
Natural variantiVAR_0417351341A → G.1 PublicationCorresponds to variant rs56343792dbSNPEnsembl.1
Natural variantiVAR_0417361401S → N.1 PublicationCorresponds to variant rs45488394dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130988 mRNA. Translation: AAN08717.1.
AB029002 mRNA. Translation: BAA83031.2. Different initiation.
AC073101 Genomic DNA. Translation: AAS07515.1.
CH471091 Genomic DNA. Translation: EAW76721.1.
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23894.1.
CCDSiCCDS5654.1.
RefSeqiNP_055731.2. NM_014916.3.
UniGeneiHs.444179.

Genome annotation databases

EnsembliENST00000297293; ENSP00000297293; ENSG00000164715.
GeneIDi22853.
KEGGihsa:22853.
UCSCiuc003upd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

LMTK2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130988 mRNA. Translation: AAN08717.1.
AB029002 mRNA. Translation: BAA83031.2. Different initiation.
AC073101 Genomic DNA. Translation: AAS07515.1.
CH471091 Genomic DNA. Translation: EAW76721.1.
AC091654 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23894.1.
CCDSiCCDS5654.1.
RefSeqiNP_055731.2. NM_014916.3.
UniGeneiHs.444179.

3D structure databases

ProteinModelPortaliQ8IWU2.
SMRiQ8IWU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116524. 11 interactors.
IntActiQ8IWU2. 6 interactors.
STRINGi9606.ENSP00000297293.

PTM databases

iPTMnetiQ8IWU2.
PhosphoSitePlusiQ8IWU2.
SwissPalmiQ8IWU2.

Polymorphism and mutation databases

BioMutaiLMTK2.

Proteomic databases

EPDiQ8IWU2.
MaxQBiQ8IWU2.
PaxDbiQ8IWU2.
PeptideAtlasiQ8IWU2.
PRIDEiQ8IWU2.

Protocols and materials databases

DNASUi22853.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297293; ENSP00000297293; ENSG00000164715.
GeneIDi22853.
KEGGihsa:22853.
UCSCiuc003upd.3. human.

Organism-specific databases

CTDi22853.
DisGeNETi22853.
GeneCardsiLMTK2.
H-InvDBHIX0006877.
HIX0167839.
HGNCiHGNC:17880. LMTK2.
HPAiHPA010657.
HPA041836.
MIMi610989. gene.
neXtProtiNX_Q8IWU2.
OpenTargetsiENSG00000164715.
PharmGKBiPA134884391.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQE. Eukaryota.
ENOG410XQFM. LUCA.
GeneTreeiENSGT00640000091449.
HOGENOMiHOG000252999.
HOVERGENiHBG081920.
InParanoidiQ8IWU2.
KOiK08898.
OMAiGPGKQDD.
OrthoDBiEOG091G0NTB.
PhylomeDBiQ8IWU2.
TreeFamiTF332280.

Enzyme and pathway databases

BioCyciZFISH:HS09123-MONOMER.
SignaLinkiQ8IWU2.
SIGNORiQ8IWU2.

Miscellaneous databases

ChiTaRSiLMTK2. human.
GeneWikiiLMTK2.
GenomeRNAii22853.
PROiQ8IWU2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164715.
CleanExiHS_LMTK2.
GenevisibleiQ8IWU2. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMTK2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWU2
Secondary accession number(s): A4D272, Q75MG7, Q9UPS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.