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Q8IWT6

- LRC8A_HUMAN

UniProt

Q8IWT6 - LRC8A_HUMAN

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Protein

Volume-regulated anion channel subunit LRRC8A

Gene
LRRC8A, KIAA1437, LRRC8, SWELL1, UNQ221/PRO247
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.3 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. anion transport Source: UniProtKB
  2. cell volume homeostasis Source: UniProtKB
  3. pre-B cell differentiation Source: UniProtKB
  4. response to osmotic stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Differentiation, Ion transport, Transport

Protein family/group databases

TCDBi1.A.25.3.1. the gap junction-forming innexin (innexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Volume-regulated anion channel subunit LRRC8A
Alternative name(s):
Leucine-rich repeat-containing protein 8A
Swelling protein 1
Gene namesi
Name:LRRC8A
Synonyms:KIAA1437, LRRC8, SWELL1
ORF Names:UNQ221/PRO247
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:19027. LRRC8A.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei26 – 4520Helical; Reviewed predictionAdd
BLAST
Topological domaini46 – 12378Extracellular Reviewed predictionAdd
BLAST
Transmembranei124 – 14623Helical; Reviewed predictionAdd
BLAST
Topological domaini147 – 262116Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei263 – 28523Helical; Reviewed predictionAdd
BLAST
Topological domaini286 – 31934Extracellular Reviewed predictionAdd
BLAST
Transmembranei320 – 34223Helical; Reviewed predictionAdd
BLAST
Topological domaini343 – 810468Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. ion channel complex Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Agammaglobulinemia 5, autosomal dominant (AGM5) [MIM:613506]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Note: The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving LRRC8 has been found in a patient with congenital agammaglobulinemia. Translocation t(9;20)(q33.2;q12). The translocation truncates the LRRC8 gene, resulting in deletion of the eighth, ninth, and half of the seventh LRR domains.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi44 – 441T → A or C: Altered anion selectivity. 1 Publication
Mutagenesisi66 – 661N → A: Abolishes N-glycosylation; when associated with A-83. 1 Publication
Mutagenesisi83 – 831N → A: Abolishes N-glycosylation; when associated with A-66. 1 Publication

Organism-specific databases

MIMi613506. phenotype.
Orphaneti33110. Autosomal agammaglobulinemia.
PharmGKBiPA134909315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Volume-regulated anion channel subunit LRRC8APRO_0000084499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Modified residuei217 – 2171Phosphoserine2 Publications

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IWT6.
PaxDbiQ8IWT6.
PeptideAtlasiQ8IWT6.
PRIDEiQ8IWT6.

PTM databases

PhosphoSiteiQ8IWT6.

Expressioni

Tissue specificityi

Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as on B-lineage cells.2 Publications

Gene expression databases

ArrayExpressiQ8IWT6.
BgeeiQ8IWT6.
CleanExiHS_LRRC8A.
GenevestigatoriQ8IWT6.

Organism-specific databases

HPAiHPA016811.

Interactioni

Subunit structurei

Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8B, LRRC8C, LRRC8D and/or LRRC8E), possibly to form a heterohexamer.1 Publication

Protein-protein interaction databases

BioGridi121126. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8IWT6.
SMRiQ8IWT6. Positions 331-802.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati373 – 40129LRR 1Add
BLAST
Repeati402 – 42423LRR 2Add
BLAST
Repeati425 – 44723LRR 3Add
BLAST
Repeati448 – 47023LRR 4Add
BLAST
Repeati471 – 49424LRR 5Add
BLAST
Repeati495 – 51824LRR 6Add
BLAST
Repeati519 – 54527LRR 7Add
BLAST
Repeati546 – 56823LRR 8Add
BLAST
Repeati569 – 59224LRR 9Add
BLAST
Repeati593 – 61523LRR 10Add
BLAST
Repeati616 – 64025LRR 11Add
BLAST
Repeati641 – 66323LRR 12Add
BLAST
Repeati664 – 68623LRR 13Add
BLAST
Repeati687 – 70620LRR 14Add
BLAST
Repeati707 – 73226LRR 15Add
BLAST
Repeati733 – 75523LRR 16Add
BLAST
Repeati756 – 77722LRR 17Add
BLAST

Sequence similaritiesi

Belongs to the LRRC8 family.

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000231806.
HOVERGENiHBG052360.
InParanoidiQ8IWT6.
OMAiHIAYIPM.
OrthoDBiEOG7Z3F3T.
PhylomeDBiQ8IWT6.
TreeFamiTF331443.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR021040. LRR_protein-8_N.
[Graphical view]
PfamiPF12534. DUF3733. 2 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
[Graphical view]
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWT6-1 [UniParc]FASTAAdd to Basket

« Hide

MIPVTELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMIAV FGGTLQVTQD    50
KMICLPCKWV TKDSCNDSFR GWAAPGPEPT YPNSTILPTP DTGPTGIKYD 100
LDRHQYNYVD AVCYENRLHW FAKYFPYLVL LHTLIFLACS NFWFKFPRTS 150
SKLEHFVSIL LKCFDSPWTT RALSETVVEE SDPKPAFSKM NGSMDKKSST 200
VSEDVEATVP MLQRTKSRIE QGIVDRSETG VLDKKEGEQA KALFEKVKKF 250
RTHVEEGDIV YRLYMRQTII KVIKFILIIC YTVYYVHNIK FDVDCTVDIE 300
SLTGYRTYRC AHPLATLFKI LASFYISLVI FYGLICMYTL WWMLRRSLKK 350
YSFESIREES SYSDIPDVKN DFAFMLHLID QYDPLYSKRF AVFLSEVSEN 400
KLRQLNLNNE WTLDKLRQRL TKNAQDKLEL HLFMLSGIPD TVFDLVELEV 450
LKLELIPDVT IPPSIAQLTG LKELWLYHTA AKIEAPALAF LRENLRALHI 500
KFTDIKEIPL WIYSLKTLEE LHLTGNLSAE NNRYIVIDGL RELKRLKVLR 550
LKSNLSKLPQ VVTDVGVHLQ KLSINNEGTK LIVLNSLKKM ANLTELELIR 600
CDLERIPHSI FSLHNLQEID LKDNNLKTIE EIISFQHLHR LTCLKLWYNH 650
IAYIPIQIGN LTNLERLYLN RNKIEKIPTQ LFYCRKLRYL DLSHNNLTFL 700
PADIGLLQNL QNLAITANRI ETLPPELFQC RKLRALHLGN NVLQSLPSRV 750
GELTNLTQIE LRGNRLECLP VELGECPLLK RSGLVVEEDL FNTLPPEVKE 800
RLWRADKEQA 810
Length:810
Mass (Da):94,199
Last modified:March 1, 2003 - v1
Checksum:iE0C5E6EBEE8275E8
GO

Sequence cautioni

The sequence AAQ88653.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA92675.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC11161.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti323 – 3231S → P in BAC11161. 1 Publication
Sequence conflicti744 – 7441Q → R in BAC11161. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY143166 mRNA. Translation: AAN18279.1.
AB037858 mRNA. Translation: BAA92675.1. Different initiation.
AL672142 Genomic DNA. Translation: CAI10839.1.
BC051322 mRNA. Translation: AAH51322.1.
AY358286 mRNA. Translation: AAQ88653.1. Different initiation.
AK074723 mRNA. Translation: BAC11161.1. Different initiation.
CCDSiCCDS35155.1.
RefSeqiNP_001120716.1. NM_001127244.1.
NP_001120717.1. NM_001127245.1.
NP_062540.2. NM_019594.3.
XP_005252152.1. XM_005252095.1.
XP_005252153.1. XM_005252096.1.
XP_006717249.1. XM_006717186.1.
UniGeneiHs.643600.

Genome annotation databases

EnsembliENST00000259324; ENSP00000259324; ENSG00000136802.
ENST00000372599; ENSP00000361680; ENSG00000136802.
ENST00000372600; ENSP00000361682; ENSG00000136802.
GeneIDi56262.
KEGGihsa:56262.
UCSCiuc004bwl.4. human.

Polymorphism databases

DMDMi37537912.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

LRRC8Abase

LRRC8A mutation db

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY143166 mRNA. Translation: AAN18279.1 .
AB037858 mRNA. Translation: BAA92675.1 . Different initiation.
AL672142 Genomic DNA. Translation: CAI10839.1 .
BC051322 mRNA. Translation: AAH51322.1 .
AY358286 mRNA. Translation: AAQ88653.1 . Different initiation.
AK074723 mRNA. Translation: BAC11161.1 . Different initiation.
CCDSi CCDS35155.1.
RefSeqi NP_001120716.1. NM_001127244.1.
NP_001120717.1. NM_001127245.1.
NP_062540.2. NM_019594.3.
XP_005252152.1. XM_005252095.1.
XP_005252153.1. XM_005252096.1.
XP_006717249.1. XM_006717186.1.
UniGenei Hs.643600.

3D structure databases

ProteinModelPortali Q8IWT6.
SMRi Q8IWT6. Positions 331-802.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121126. 3 interactions.

Protein family/group databases

TCDBi 1.A.25.3.1. the gap junction-forming innexin (innexin) family.

PTM databases

PhosphoSitei Q8IWT6.

Polymorphism databases

DMDMi 37537912.

Proteomic databases

MaxQBi Q8IWT6.
PaxDbi Q8IWT6.
PeptideAtlasi Q8IWT6.
PRIDEi Q8IWT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259324 ; ENSP00000259324 ; ENSG00000136802 .
ENST00000372599 ; ENSP00000361680 ; ENSG00000136802 .
ENST00000372600 ; ENSP00000361682 ; ENSG00000136802 .
GeneIDi 56262.
KEGGi hsa:56262.
UCSCi uc004bwl.4. human.

Organism-specific databases

CTDi 56262.
GeneCardsi GC09P131644.
HGNCi HGNC:19027. LRRC8A.
HPAi HPA016811.
MIMi 608360. gene.
613506. phenotype.
neXtProti NX_Q8IWT6.
Orphaneti 33110. Autosomal agammaglobulinemia.
PharmGKBi PA134909315.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000231806.
HOVERGENi HBG052360.
InParanoidi Q8IWT6.
OMAi HIAYIPM.
OrthoDBi EOG7Z3F3T.
PhylomeDBi Q8IWT6.
TreeFami TF331443.

Miscellaneous databases

ChiTaRSi LRRC8A. human.
GeneWikii LRRC8A.
GenomeRNAii 56262.
NextBioi 61921.
PROi Q8IWT6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IWT6.
Bgeei Q8IWT6.
CleanExi HS_LRRC8A.
Genevestigatori Q8IWT6.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR021040. LRR_protein-8_N.
[Graphical view ]
Pfami PF12534. DUF3733. 2 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
[Graphical view ]
PROSITEi PS51450. LRR. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION, INVOLVEMENT IN AGM5.
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  5. Bienvenut W.V., Pchelintsev N., Adams P.D.
    Submitted (OCT-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-8; 483-492; 534-541 AND 735-749, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Lung fibroblast.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 239-810.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-810.
  8. "LRRC8 extracellular domain is composed of 17 leucine-rich repeats."
    Smits G., Kajava A.V.
    Mol. Immunol. 41:561-562(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAINS LEUCINE-RICH REPEATS.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication."
    Abascal F., Zardoya R.
    Bioessays 34:551-560(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel."
    Qiu Z., Dubin A.E., Mathur J., Tu B., Reddy K., Miraglia L.J., Reinhardt J., Orth A.P., Patapoutian A.
    Cell 157:447-458(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-44.
  14. "The protein synthesis inhibitor blasticidin S enters mammalian cells via leucine-rich repeat-containing protein 8D."
    Lee C.C., Freinkman E., Sabatini D.M., Ploegh H.L.
    J. Biol. Chem. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
  15. "Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC."
    Voss F.K., Ullrich F., Muench J., Lazarow K., Lutter D., Mah N., Andrade-Navarro M.A., von Kries J.P., Stauber T., Jentsch T.J.
    Science 344:634-638(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, TOPOLOGY, GLYCOSYLATION, MUTAGENESIS OF ASN-66 AND ASN-83.

Entry informationi

Entry nameiLRC8A_HUMAN
AccessioniPrimary (citable) accession number: Q8IWT6
Secondary accession number(s): Q6UXM2, Q8NCI0, Q9P2B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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