Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8IWT3

- CUL9_HUMAN

UniProt

Q8IWT3 - CUL9_HUMAN

Protein

Cullin-9

Gene

CUL9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1363 – 13708ATPSequence Analysis
    Zinc fingeri2070 – 212051RING-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri2140 – 220364IBR-typeAdd
    BLAST
    Zinc fingeri2236 – 226530RING-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. microtubule cytoskeleton organization Source: UniProtKB
    2. protein ubiquitination Source: UniProtKB
    3. regulation of mitosis Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cullin-9
    Short name:
    CUL-9
    Alternative name(s):
    UbcH7-associated protein 1
    p53-associated parkin-like cytoplasmic protein
    Gene namesi
    Name:CUL9
    Synonyms:H7AP1, KIAA0708, PARC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:15982. CUL9.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cullin-RING ubiquitin ligase complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164718328.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 25172517Cullin-9PRO_0000119815Add
    BLAST

    Post-translational modificationi

    In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.
    Neddylated.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ8IWT3.
    PaxDbiQ8IWT3.
    PRIDEiQ8IWT3.

    PTM databases

    PhosphoSiteiQ8IWT3.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ8IWT3.
    BgeeiQ8IWT3.
    GenevestigatoriQ8IWT3.

    Organism-specific databases

    HPAiHPA016434.

    Interactioni

    Subunit structurei

    Part of a Cul9-RING complex at least composed of CUL9 and RBX1. Interacts with CUL7: interaction with CUL7 component of the 3M complex leads to inhibition of CUL9 activity. The CUL7-CUL9 heterodimer seems to interact specifically with TP53. Forms a complex with p53/TP53 in the cytoplasm of unstressed cells. Interacts with UBCH7 and UBCH8.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TP53P046373EBI-311123,EBI-366083

    Protein-protein interaction databases

    BioGridi116736. 9 interactions.
    IntActiQ8IWT3. 8 interactions.
    MINTiMINT-6615845.
    STRINGi9606.ENSP00000252050.

    Structurei

    Secondary structure

    1
    2517
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi376 – 3827
    Beta strandi388 – 3936
    Beta strandi403 – 4086
    Beta strandi411 – 4133
    Beta strandi416 – 4205
    Turni421 – 4244
    Beta strandi425 – 4295
    Helixi431 – 4333

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JUFNMR-A366-466[»]
    ProteinModelPortaliQ8IWT3.
    SMRiQ8IWT3. Positions 375-438, 1997-2417.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8IWT3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1143 – 1322180DOCPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1649 – 169143Sequence AnalysisAdd
    BLAST
    Coiled coili2365 – 238521Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1661 – 168929Glu-richAdd
    BLAST

    Domaini

    The IBR domain is required for interaction with UBCH7 and UBCH8.

    Sequence similaritiesi

    Belongs to the cullin family.PROSITE-ProRule annotation
    Contains 1 DOC domain.PROSITE-ProRule annotation
    Contains 1 IBR-type zinc finger.Curated
    Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri2070 – 212051RING-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri2140 – 220364IBR-typeAdd
    BLAST
    Zinc fingeri2236 – 226530RING-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG48148.
    KOiK11970.
    OMAiTKHEWRP.
    OrthoDBiEOG70S74H.
    PhylomeDBiQ8IWT3.
    TreeFamiTF101154.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.25.10.10. 4 hits.
    2.30.30.30. 1 hit.
    2.60.120.260. 1 hit.
    InterProiIPR004939. APC_su10/DOC_dom.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR021097. CPH_domain.
    IPR016157. Cullin_CS.
    IPR016158. Cullin_homology.
    IPR001373. Cullin_N.
    IPR019559. Cullin_neddylation_domain.
    IPR008979. Galactose-bd-like.
    IPR014722. Rib_L2_dom2.
    IPR011991. WHTH_DNA-bd_dom.
    IPR002867. Znf_C6HC.
    IPR001841. Znf_RING.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF03256. APC10. 1 hit.
    PF11515. Cul7. 1 hit.
    PF00888. Cullin. 1 hit.
    PF01485. IBR. 2 hits.
    [Graphical view]
    SMARTiSM00884. Cullin_Nedd8. 1 hit.
    SM00647. IBR. 2 hits.
    SM00184. RING. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.
    SSF49785. SSF49785. 1 hit.
    SSF75632. SSF75632. 2 hits.
    PROSITEiPS01256. CULLIN_1. 1 hit.
    PS50069. CULLIN_2. 1 hit.
    PS51284. DOC. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWT3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVGERHAGDL MVPLGPRLQA YPEELIRQRP GHDGHPEYLI RWSVLKCGEV     50
    GKVGVEEGKA EHILMWLSAP EVYANCPGLL GERALSKGLQ HEPAGVSGSF 100
    PRDPGGLDEV AMGEMEADVQ ALVRRAARQL AESGTPSLTA AVLHTIHVLS 150
    AYASIGPLTG VFRETGALDL LMHMLCNPEP QIRRSAGKML QALAAHDAGS 200
    RAHVLLSLSQ QDGIEQHMDF DSRYTLLELF AETTSSEEHC MAFEGIHLPQ 250
    IPGKLLFSLV KRYLCVTSLL DQLNSSPELG AGDQSSPCAT REKSRGQREL 300
    EFSMAVGNLI SELVRSMGWA RNLSEQGMSP PRPTRSIFQP YISGPSLLLP 350
    TIVTTPRRQG WVFRQRSEFS SRSGYGEYVQ QTLQPGMRVR MLDDYEEISA 400
    GDEGEFRQSN NGIPPVQVFW QSTGRTYWVH WHMLEILGPE EATEDKASAA 450
    VEKGAGATVL GTAFPSWDWN PMDGLYPLPY LQPEPQKNER VGYLTQAEWW 500
    ELLFFIKKLD LCEQQPIFQN LWKNLDETLG EKALGEISVS VEMAESLLQV 550
    LSSRFEGSTL NDLLNSQIYT KYGLLSNEPS SSSTSRNHSC TPDPEEESKS 600
    EASFSEEETE SLKAKAEAPK TEAEPTKTRT ETPMAQSDSQ LFNQLLVTEG 650
    MTLPTEMKEA ASEMARALRG PGPRSSLDQH VAAVVATVQI SSLDTNLQLS 700
    GLSALSQAVE EVTERDHPLV RPDRSLREKL VKMLVELLTN QVGEKMVVVQ 750
    ALRLLYLLMT KHEWRPLFAR EGGIYAVLVC MQEYKTSVLV QQAGLAALKM 800
    LAVASSSEIP TFVTGRDSIH SLFDAQMTRE IFASIDSATR PGSESLLLTV 850
    PAAVILMLNT EGCSSAARNG LLLLNLLLCN HHTLGDQIIT QELRDTLFRH 900
    SGIAPRTEPM PTTRTILMML LNRYSEPPGS PERAALETPI IQGQDGSPEL 950
    LIRSLVGGPS AELLLDLERV LCREGSPGGA VRPLLKRLQQ ETQPFLLLLR 1000
    TLDAPGPNKT LLLSVLRVIT RLLDFPEAMV LPWHEVLEPC LNCLSGPSSD 1050
    SEIVQELTCF LHRLASMHKD YAVVLCCLGA KEILSKVLDK HSAQLLLGCE 1100
    LRDLVTECEK YAQLYSNLTS SILAGCIQMV LGQIEDHRRT HQPINIPFFD 1150
    VFLRHLCQGS SVEVKEDKCW EKVEVSSNPH RASKLTDHNP KTYWESNGST 1200
    GSHYITLHMH RGVLVRQLTL LVASEDSSYM PARVVVFGGD STSCIGTELN 1250
    TVNVMPSASR VILLENLNRF WPIIQIRIKR CQQGGIDTRV RGVEVLGPKP 1300
    TFWPLFREQL CRRTCLFYTI RAQAWSRDIA EDHRRLLQLC PRLNRVLRHE 1350
    QNFADRFLPD DEAAQALGKT CWEALVSPLV QNITSPDAEG VSALGWLLDQ 1400
    YLEQRETSRN PLSRAASFAS RVRRLCHLLV HVEPPPGPSP EPSTRPFSKN 1450
    SKGRDRSPAP SPVLPSSSLR NITQCWLSVV QEQVSRFLAA AWRAPDFVPR 1500
    YCKLYEHLQR AGSELFGPRA AFMLALRSGF SGALLQQSFL TAAHMSEQFA 1550
    RYIDQQIQGG LIGGAPGVEM LGQLQRHLEP IMVLSGLELA TTFEHFYQHY 1600
    MADRLLSFGS SWLEGAVLEQ IGLCFPNRLP QLMLQSLSTS EELQRQFHLF 1650
    QLQRLDKLFL EQEDEEEKRL EEEEEEEEEE EAEKELFIED PSPAISILVL 1700
    SPRCWPVSPL CYLYHPRKCL PTEFCDALDR FSSFYSQSQN HPVLDMGPHR 1750
    RLQWTWLGRA ELQFGKQILH VSTVQMWLLL KFNQTEEVSV ETLLKDSDLS 1800
    PELLLQALVP LTSGNGPLTL HEGQDFPHGG VLRLHEPGPQ RSGEALWLIP 1850
    PQAYLNVEKD EGRTLEQKRN LLSCLLVRIL KAHGEKGLHI DQLVCLVLEA 1900
    WQKGPNPPGT LGHTVAGGVA CTSTDVLSCI LHLLGQGYVK RRDDRPQILM 1950
    YAAPEPMGPC RGQADVPFCG SQSETSKPSP EAVATLASLQ LPAGRTMSPQ 2000
    EVEGLMKQTV RQVQETLNLE PDVAQHLLAH SHWGAEQLLQ SYSEDPEPLL 2050
    LAAGLCVHQA QAVPVRPDHC PVCVSPLGCD DDLPSLCCMH YCCKSCWNEY 2100
    LTTRIEQNLV LNCTCPIADC PAQPTGAFIR AIVSSPEVIS KYEKALLRGY 2150
    VESCSNLTWC TNPQGCDRIL CRQGLGCGTT CSKCGWASCF NCSFPEAHYP 2200
    ASCGHMSQWV DDGGYYDGMS VEAQSKHLAK LISKRCPSCQ APIEKNEGCL 2250
    HMTCAKCNHG FCWRCLKSWK PNHKDYYNCS AMVSKAARQE KRFQDYNERC 2300
    TFHHQAREFA VNLRNRVSAI HEVPPPRSFT FLNDACQGLE QARKVLAYAC 2350
    VYSFYSQDAE YMDVVEQQTE NLELHTNALQ ILLEETLLRC RDLASSLRLL 2400
    RADCLSTGME LLRRIQERLL AILQHSAQDF RVGLQSPSVE AWEAKGPNMP 2450
    GSQPQASSGP EAEEEEEDDE DDVPEWQQDE FDEELDNDSF SYDESENLDQ 2500
    ETFFFGDEEE DEDEAYD 2517
    Length:2,517
    Mass (Da):281,229
    Last modified:January 4, 2005 - v2
    Checksum:i42387A55DCC52EAF
    GO
    Isoform 2 (identifier: Q8IWT3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         418-527: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,407
    Mass (Da):268,362
    Checksum:iF41FAF09CC71656C
    GO

    Sequence cautioni

    The sequence BAC85207.1 differs from that shown. Reason: Intron retention.
    The sequence BAC86090.1 differs from that shown. Reason: Intron retention.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti527 – 5271E → G in CAH18696. (PubMed:17974005)Curated
    Sequence conflicti663 – 6631E → K in AAN61516. (PubMed:12526791)Curated
    Sequence conflicti1171 – 11711E → K in CAH18328. (PubMed:17974005)Curated
    Sequence conflicti1230 – 12301M → T in CAH18328. (PubMed:17974005)Curated
    Sequence conflicti1268 – 12681N → S in CAH18328. (PubMed:17974005)Curated
    Sequence conflicti1277 – 12771R → H in CAH18328. (PubMed:17974005)Curated
    Sequence conflicti1830 – 185728Missing in CAH18696. (PubMed:17974005)CuratedAdd
    BLAST
    Sequence conflicti2049 – 20491L → P in CAH18696. (PubMed:17974005)Curated
    Sequence conflicti2058 – 20592HQ → PL in CAH18696. (PubMed:17974005)Curated
    Sequence conflicti2345 – 23451V → VV in CAI20204. (PubMed:14574404)Curated
    Sequence conflicti2345 – 23451V → VV in EAX04163. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2058 – 20581H → P.
    Corresponds to variant rs2273709 [ dbSNP | Ensembl ].
    VAR_048844
    Natural varianti2180 – 21801T → I.
    Corresponds to variant rs11962520 [ dbSNP | Ensembl ].
    VAR_048845

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei418 – 527110Missing in isoform 2. 1 PublicationVSP_009573Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY145132 mRNA. Translation: AAN61516.1.
    AJ318215 mRNA. Translation: CAC85756.1.
    CR749511 mRNA. Translation: CAH18328.1.
    CR749841 mRNA. Translation: CAH18696.1.
    AL133375 Genomic DNA. Translation: CAI20204.1.
    CH471081 Genomic DNA. Translation: EAX04163.1.
    AK125228 mRNA. Translation: BAC86090.1. Sequence problems.
    AK129649 mRNA. Translation: BAC85207.1. Sequence problems.
    AB014608 mRNA. Translation: BAA31683.3.
    BC002879 mRNA. Translation: AAH02879.2.
    CCDSiCCDS4890.1. [Q8IWT3-1]
    PIRiT00350.
    RefSeqiNP_055904.1. NM_015089.3. [Q8IWT3-1]
    XP_006715094.1. XM_006715031.1. [Q8IWT3-3]
    UniGeneiHs.485434.

    Genome annotation databases

    EnsembliENST00000252050; ENSP00000252050; ENSG00000112659. [Q8IWT3-1]
    GeneIDi23113.
    KEGGihsa:23113.
    UCSCiuc003ouk.3. human. [Q8IWT3-1]

    Polymorphism databases

    DMDMi57015409.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY145132 mRNA. Translation: AAN61516.1 .
    AJ318215 mRNA. Translation: CAC85756.1 .
    CR749511 mRNA. Translation: CAH18328.1 .
    CR749841 mRNA. Translation: CAH18696.1 .
    AL133375 Genomic DNA. Translation: CAI20204.1 .
    CH471081 Genomic DNA. Translation: EAX04163.1 .
    AK125228 mRNA. Translation: BAC86090.1 . Sequence problems.
    AK129649 mRNA. Translation: BAC85207.1 . Sequence problems.
    AB014608 mRNA. Translation: BAA31683.3 .
    BC002879 mRNA. Translation: AAH02879.2 .
    CCDSi CCDS4890.1. [Q8IWT3-1 ]
    PIRi T00350.
    RefSeqi NP_055904.1. NM_015089.3. [Q8IWT3-1 ]
    XP_006715094.1. XM_006715031.1. [Q8IWT3-3 ]
    UniGenei Hs.485434.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JUF NMR - A 366-466 [» ]
    ProteinModelPortali Q8IWT3.
    SMRi Q8IWT3. Positions 375-438, 1997-2417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116736. 9 interactions.
    IntActi Q8IWT3. 8 interactions.
    MINTi MINT-6615845.
    STRINGi 9606.ENSP00000252050.

    PTM databases

    PhosphoSitei Q8IWT3.

    Polymorphism databases

    DMDMi 57015409.

    Proteomic databases

    MaxQBi Q8IWT3.
    PaxDbi Q8IWT3.
    PRIDEi Q8IWT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252050 ; ENSP00000252050 ; ENSG00000112659 . [Q8IWT3-1 ]
    GeneIDi 23113.
    KEGGi hsa:23113.
    UCSCi uc003ouk.3. human. [Q8IWT3-1 ]

    Organism-specific databases

    CTDi 23113.
    GeneCardsi GC06P043149.
    HGNCi HGNC:15982. CUL9.
    HPAi HPA016434.
    MIMi 607489. gene.
    neXtProti NX_Q8IWT3.
    PharmGKBi PA164718328.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG48148.
    KOi K11970.
    OMAi TKHEWRP.
    OrthoDBi EOG70S74H.
    PhylomeDBi Q8IWT3.
    TreeFami TF101154.

    Miscellaneous databases

    ChiTaRSi CUL9. human.
    EvolutionaryTracei Q8IWT3.
    GeneWikii PARC_(gene).
    GenomeRNAii 23113.
    NextBioi 44317.
    PROi Q8IWT3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IWT3.
    Bgeei Q8IWT3.
    Genevestigatori Q8IWT3.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.25.10.10. 4 hits.
    2.30.30.30. 1 hit.
    2.60.120.260. 1 hit.
    InterProi IPR004939. APC_su10/DOC_dom.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR021097. CPH_domain.
    IPR016157. Cullin_CS.
    IPR016158. Cullin_homology.
    IPR001373. Cullin_N.
    IPR019559. Cullin_neddylation_domain.
    IPR008979. Galactose-bd-like.
    IPR014722. Rib_L2_dom2.
    IPR011991. WHTH_DNA-bd_dom.
    IPR002867. Znf_C6HC.
    IPR001841. Znf_RING.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF03256. APC10. 1 hit.
    PF11515. Cul7. 1 hit.
    PF00888. Cullin. 1 hit.
    PF01485. IBR. 2 hits.
    [Graphical view ]
    SMARTi SM00884. Cullin_Nedd8. 1 hit.
    SM00647. IBR. 2 hits.
    SM00184. RING. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    SSF49785. SSF49785. 1 hit.
    SSF75632. SSF75632. 2 hits.
    PROSITEi PS01256. CULLIN_1. 1 hit.
    PS50069. CULLIN_2. 1 hit.
    PS51284. DOC. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 786-791; 2419-2431 AND 2432-2445, INTERACTION WITH TP53, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
      Tissue: Cervix carcinoma.
    2. "UbcH7 associated protein, H7AP1. A new member of the Parkin/Ariadne E3 ubiquitin Ligase (PAUL) family."
      Rose S.A., Ardley H.C., Tan N.G., Scott G.B., Markham A.F., Robinson P.A.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala and Testis.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-662 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-662 (ISOFORMS 1/2).
      Tissue: Chondrocyte and Thymus.
    7. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 765-2517 (ISOFORM 1).
      Tissue: Brain.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1554-2517 (ISOFORM 1).
      Tissue: Lung.
    9. "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1."
      Moynihan T.P., Ardley H.C., Nuber U., Rose S.A., Jones P.F., Markham A.F., Scheffner M., Robinson P.A.
      J. Biol. Chem. 274:30963-30968(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBCH7 AND UBCH8.
    10. "Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development."
      Skaar J.R., Arai T., DeCaprio J.A.
      Mol. Cell. Biol. 25:5579-5589(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CUL7.
    11. Cited for: FUNCTION, INTERACTION WITH CUL7; RBX1 AND TP53, NEDDYLATION.
    12. "CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity."
      Li Z., Pei X.H., Yan J., Yan F., Cappell K.M., Whitehurst A.W., Xiong Y.
      Mol. Cell 54:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CUL7 AND RBX1.

    Entry informationi

    Entry nameiCUL9_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWT3
    Secondary accession number(s): O75188
    , Q5TCY3, Q68CP2, Q68D92, Q8N3W9, Q9BU56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3