Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8IWT3 (CUL9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cullin-9

Short name=CUL-9
Alternative name(s):
UbcH7-associated protein 1
p53-associated parkin-like cytoplasmic protein
Gene names
Name:CUL9
Synonyms:H7AP1, KIAA0708, PARC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2517 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytoplasmic anchor protein in p53-associated protein complex. Regulates the subcellular localization of p53 and subsequent function. Seems to be part of an atypical cullin-RING-based E3 ubiquitin-protein ligase complex. In vitro, complexes of CUL9/PARC with either CUL7 or TP53 contain E3 ubiquitin-protein ligase activity. Ref.10

Subunit structure

Forms a complex with p53/TP53 in the cytoplasm of unstressed cells. Interacts with UBCH7 and UBCH8. Interacts with CUL7 and RBX1. The CUL7-CUL9 heterodimer seems to interact specifically with TP53. Ref.1 Ref.9 Ref.10

Subcellular location

Cytoplasm.

Tissue specificity

Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.

Domain

The IBR domain is required for interaction with UBCH7 and UBCH8.

Post-translational modification

In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.

Neddylated.

Sequence similarities

Belongs to the cullin family.

Contains 1 DOC domain.

Contains 1 IBR-type zinc finger.

Contains 2 RING-type zinc fingers.

Sequence caution

The sequence BAC85207.1 differs from that shown. Reason: Intron retention.

The sequence BAC86090.1 differs from that shown. Reason: Intron retention.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TP53P046373EBI-311123,EBI-366083

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IWT3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IWT3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     418-527: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 25172517Cullin-9
PRO_0000119815

Regions

Domain1143 – 1322180DOC
Nucleotide binding1363 – 13708ATP Potential
Zinc finger2070 – 212051RING-type 1
Zinc finger2140 – 220364IBR-type
Zinc finger2236 – 226530RING-type 2
Coiled coil1649 – 169143 Potential
Coiled coil2365 – 238521 Potential
Compositional bias1661 – 168929Glu-rich

Natural variations

Alternative sequence418 – 527110Missing in isoform 2.
VSP_009573
Natural variant20581H → P.
Corresponds to variant rs2273709 [ dbSNP | Ensembl ].
VAR_048844
Natural variant21801T → I.
Corresponds to variant rs11962520 [ dbSNP | Ensembl ].
VAR_048845

Experimental info

Sequence conflict5271E → G in CAH18696. Ref.3
Sequence conflict6631E → K in AAN61516. Ref.1
Sequence conflict11711E → K in CAH18328. Ref.3
Sequence conflict12301M → T in CAH18328. Ref.3
Sequence conflict12681N → S in CAH18328. Ref.3
Sequence conflict12771R → H in CAH18328. Ref.3
Sequence conflict1830 – 185728Missing in CAH18696. Ref.3
Sequence conflict20491L → P in CAH18696. Ref.3
Sequence conflict2058 – 20592HQ → PL in CAH18696. Ref.3
Sequence conflict23451V → VV in CAI20204. Ref.4
Sequence conflict23451V → VV in EAX04163. Ref.5

Secondary structure

............... 2517
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: 42387A55DCC52EAF

FASTA2,517281,229
        10         20         30         40         50         60 
MVGERHAGDL MVPLGPRLQA YPEELIRQRP GHDGHPEYLI RWSVLKCGEV GKVGVEEGKA 

        70         80         90        100        110        120 
EHILMWLSAP EVYANCPGLL GERALSKGLQ HEPAGVSGSF PRDPGGLDEV AMGEMEADVQ 

       130        140        150        160        170        180 
ALVRRAARQL AESGTPSLTA AVLHTIHVLS AYASIGPLTG VFRETGALDL LMHMLCNPEP 

       190        200        210        220        230        240 
QIRRSAGKML QALAAHDAGS RAHVLLSLSQ QDGIEQHMDF DSRYTLLELF AETTSSEEHC 

       250        260        270        280        290        300 
MAFEGIHLPQ IPGKLLFSLV KRYLCVTSLL DQLNSSPELG AGDQSSPCAT REKSRGQREL 

       310        320        330        340        350        360 
EFSMAVGNLI SELVRSMGWA RNLSEQGMSP PRPTRSIFQP YISGPSLLLP TIVTTPRRQG 

       370        380        390        400        410        420 
WVFRQRSEFS SRSGYGEYVQ QTLQPGMRVR MLDDYEEISA GDEGEFRQSN NGIPPVQVFW 

       430        440        450        460        470        480 
QSTGRTYWVH WHMLEILGPE EATEDKASAA VEKGAGATVL GTAFPSWDWN PMDGLYPLPY 

       490        500        510        520        530        540 
LQPEPQKNER VGYLTQAEWW ELLFFIKKLD LCEQQPIFQN LWKNLDETLG EKALGEISVS 

       550        560        570        580        590        600 
VEMAESLLQV LSSRFEGSTL NDLLNSQIYT KYGLLSNEPS SSSTSRNHSC TPDPEEESKS 

       610        620        630        640        650        660 
EASFSEEETE SLKAKAEAPK TEAEPTKTRT ETPMAQSDSQ LFNQLLVTEG MTLPTEMKEA 

       670        680        690        700        710        720 
ASEMARALRG PGPRSSLDQH VAAVVATVQI SSLDTNLQLS GLSALSQAVE EVTERDHPLV 

       730        740        750        760        770        780 
RPDRSLREKL VKMLVELLTN QVGEKMVVVQ ALRLLYLLMT KHEWRPLFAR EGGIYAVLVC 

       790        800        810        820        830        840 
MQEYKTSVLV QQAGLAALKM LAVASSSEIP TFVTGRDSIH SLFDAQMTRE IFASIDSATR 

       850        860        870        880        890        900 
PGSESLLLTV PAAVILMLNT EGCSSAARNG LLLLNLLLCN HHTLGDQIIT QELRDTLFRH 

       910        920        930        940        950        960 
SGIAPRTEPM PTTRTILMML LNRYSEPPGS PERAALETPI IQGQDGSPEL LIRSLVGGPS 

       970        980        990       1000       1010       1020 
AELLLDLERV LCREGSPGGA VRPLLKRLQQ ETQPFLLLLR TLDAPGPNKT LLLSVLRVIT 

      1030       1040       1050       1060       1070       1080 
RLLDFPEAMV LPWHEVLEPC LNCLSGPSSD SEIVQELTCF LHRLASMHKD YAVVLCCLGA 

      1090       1100       1110       1120       1130       1140 
KEILSKVLDK HSAQLLLGCE LRDLVTECEK YAQLYSNLTS SILAGCIQMV LGQIEDHRRT 

      1150       1160       1170       1180       1190       1200 
HQPINIPFFD VFLRHLCQGS SVEVKEDKCW EKVEVSSNPH RASKLTDHNP KTYWESNGST 

      1210       1220       1230       1240       1250       1260 
GSHYITLHMH RGVLVRQLTL LVASEDSSYM PARVVVFGGD STSCIGTELN TVNVMPSASR 

      1270       1280       1290       1300       1310       1320 
VILLENLNRF WPIIQIRIKR CQQGGIDTRV RGVEVLGPKP TFWPLFREQL CRRTCLFYTI 

      1330       1340       1350       1360       1370       1380 
RAQAWSRDIA EDHRRLLQLC PRLNRVLRHE QNFADRFLPD DEAAQALGKT CWEALVSPLV 

      1390       1400       1410       1420       1430       1440 
QNITSPDAEG VSALGWLLDQ YLEQRETSRN PLSRAASFAS RVRRLCHLLV HVEPPPGPSP 

      1450       1460       1470       1480       1490       1500 
EPSTRPFSKN SKGRDRSPAP SPVLPSSSLR NITQCWLSVV QEQVSRFLAA AWRAPDFVPR 

      1510       1520       1530       1540       1550       1560 
YCKLYEHLQR AGSELFGPRA AFMLALRSGF SGALLQQSFL TAAHMSEQFA RYIDQQIQGG 

      1570       1580       1590       1600       1610       1620 
LIGGAPGVEM LGQLQRHLEP IMVLSGLELA TTFEHFYQHY MADRLLSFGS SWLEGAVLEQ 

      1630       1640       1650       1660       1670       1680 
IGLCFPNRLP QLMLQSLSTS EELQRQFHLF QLQRLDKLFL EQEDEEEKRL EEEEEEEEEE 

      1690       1700       1710       1720       1730       1740 
EAEKELFIED PSPAISILVL SPRCWPVSPL CYLYHPRKCL PTEFCDALDR FSSFYSQSQN 

      1750       1760       1770       1780       1790       1800 
HPVLDMGPHR RLQWTWLGRA ELQFGKQILH VSTVQMWLLL KFNQTEEVSV ETLLKDSDLS 

      1810       1820       1830       1840       1850       1860 
PELLLQALVP LTSGNGPLTL HEGQDFPHGG VLRLHEPGPQ RSGEALWLIP PQAYLNVEKD 

      1870       1880       1890       1900       1910       1920 
EGRTLEQKRN LLSCLLVRIL KAHGEKGLHI DQLVCLVLEA WQKGPNPPGT LGHTVAGGVA 

      1930       1940       1950       1960       1970       1980 
CTSTDVLSCI LHLLGQGYVK RRDDRPQILM YAAPEPMGPC RGQADVPFCG SQSETSKPSP 

      1990       2000       2010       2020       2030       2040 
EAVATLASLQ LPAGRTMSPQ EVEGLMKQTV RQVQETLNLE PDVAQHLLAH SHWGAEQLLQ 

      2050       2060       2070       2080       2090       2100 
SYSEDPEPLL LAAGLCVHQA QAVPVRPDHC PVCVSPLGCD DDLPSLCCMH YCCKSCWNEY 

      2110       2120       2130       2140       2150       2160 
LTTRIEQNLV LNCTCPIADC PAQPTGAFIR AIVSSPEVIS KYEKALLRGY VESCSNLTWC 

      2170       2180       2190       2200       2210       2220 
TNPQGCDRIL CRQGLGCGTT CSKCGWASCF NCSFPEAHYP ASCGHMSQWV DDGGYYDGMS 

      2230       2240       2250       2260       2270       2280 
VEAQSKHLAK LISKRCPSCQ APIEKNEGCL HMTCAKCNHG FCWRCLKSWK PNHKDYYNCS 

      2290       2300       2310       2320       2330       2340 
AMVSKAARQE KRFQDYNERC TFHHQAREFA VNLRNRVSAI HEVPPPRSFT FLNDACQGLE 

      2350       2360       2370       2380       2390       2400 
QARKVLAYAC VYSFYSQDAE YMDVVEQQTE NLELHTNALQ ILLEETLLRC RDLASSLRLL 

      2410       2420       2430       2440       2450       2460 
RADCLSTGME LLRRIQERLL AILQHSAQDF RVGLQSPSVE AWEAKGPNMP GSQPQASSGP 

      2470       2480       2490       2500       2510 
EAEEEEEDDE DDVPEWQQDE FDEELDNDSF SYDESENLDQ ETFFFGDEEE DEDEAYD 

« Hide

Isoform 2 [UniParc].

Checksum: F41FAF09CC71656C
Show »

FASTA2,407268,362

References

« Hide 'large scale' references
[1]"Parc: a cytoplasmic anchor for p53."
Nikolaev A.Y., Li M., Puskas N., Qin J., Gu W.
Cell 112:29-40(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 786-791; 2419-2431 AND 2432-2445, INTERACTION WITH TP53.
Tissue: Cervix carcinoma.
[2]"UbcH7 associated protein, H7AP1. A new member of the Parkin/Ariadne E3 ubiquitin Ligase (PAUL) family."
Rose S.A., Ardley H.C., Tan N.G., Scott G.B., Markham A.F., Robinson P.A.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala and Testis.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-662 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-662 (ISOFORMS 1/2).
Tissue: Chondrocyte and Thymus.
[7]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 765-2517 (ISOFORM 1).
Tissue: Brain.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1554-2517 (ISOFORM 1).
Tissue: Lung.
[9]"The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1."
Moynihan T.P., Ardley H.C., Nuber U., Rose S.A., Jones P.F., Markham A.F., Scheffner M., Robinson P.A.
J. Biol. Chem. 274:30963-30968(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UBCH7 AND UBCH8.
[10]"PARC and CUL7 form atypical cullin RING ligase complexes."
Skaar J.R., Florens L., Tsutsumi T., Arai T., Tron A., Swanson S.K., Washburn M.P., DeCaprio J.A.
Cancer Res. 67:2006-2014(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CUL7; RBX1 AND TP53, NEDDYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY145132 mRNA. Translation: AAN61516.1.
AJ318215 mRNA. Translation: CAC85756.1.
CR749511 mRNA. Translation: CAH18328.1.
CR749841 mRNA. Translation: CAH18696.1.
AL133375 Genomic DNA. Translation: CAI20204.1.
CH471081 Genomic DNA. Translation: EAX04163.1.
AK125228 mRNA. Translation: BAC86090.1. Sequence problems.
AK129649 mRNA. Translation: BAC85207.1. Sequence problems.
AB014608 mRNA. Translation: BAA31683.3.
BC002879 mRNA. Translation: AAH02879.2.
CCDSCCDS4890.1. [Q8IWT3-1]
PIRT00350.
RefSeqNP_055904.1. NM_015089.3. [Q8IWT3-1]
XP_006715094.1. XM_006715031.1. [Q8IWT3-3]
UniGeneHs.485434.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JUFNMR-A366-466[»]
ProteinModelPortalQ8IWT3.
SMRQ8IWT3. Positions 375-438, 1997-2417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116736. 9 interactions.
IntActQ8IWT3. 8 interactions.
MINTMINT-6615845.
STRING9606.ENSP00000252050.

PTM databases

PhosphoSiteQ8IWT3.

Polymorphism databases

DMDM57015409.

Proteomic databases

MaxQBQ8IWT3.
PaxDbQ8IWT3.
PRIDEQ8IWT3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252050; ENSP00000252050; ENSG00000112659. [Q8IWT3-1]
ENST00000354495; ENSP00000346490; ENSG00000112659. [Q8IWT3-3]
GeneID23113.
KEGGhsa:23113.
UCSCuc003ouk.3. human. [Q8IWT3-1]

Organism-specific databases

CTD23113.
GeneCardsGC06P043149.
HGNCHGNC:15982. CUL9.
HPAHPA016434.
MIM607489. gene.
neXtProtNX_Q8IWT3.
PharmGKBPA164718328.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG48148.
KOK11970.
OMATKHEWRP.
OrthoDBEOG70S74H.
PhylomeDBQ8IWT3.
TreeFamTF101154.

Gene expression databases

ArrayExpressQ8IWT3.
BgeeQ8IWT3.
GenevestigatorQ8IWT3.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.25.10.10. 4 hits.
2.30.30.30. 1 hit.
2.60.120.260. 1 hit.
InterProIPR004939. APC_su10/DOC_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021097. CPH_domain.
IPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR008979. Galactose-bd-like.
IPR014722. Rib_L2_dom2.
IPR011991. WHTH_DNA-bd_dom.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF03256. APC10. 1 hit.
PF11515. Cul7. 1 hit.
PF00888. Cullin. 1 hit.
PF01485. IBR. 2 hits.
[Graphical view]
SMARTSM00884. Cullin_Nedd8. 1 hit.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 4 hits.
SSF49785. SSF49785. 1 hit.
SSF75632. SSF75632. 2 hits.
PROSITEPS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
PS51284. DOC. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCUL9. human.
EvolutionaryTraceQ8IWT3.
GeneWikiPARC_(gene).
GenomeRNAi23113.
NextBio44317.
PROQ8IWT3.
SOURCESearch...

Entry information

Entry nameCUL9_HUMAN
AccessionPrimary (citable) accession number: Q8IWT3
Secondary accession number(s): O75188 expand/collapse secondary AC list , Q5TCY3, Q68CP2, Q68D92, Q8N3W9, Q9BU56
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM