SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IWT3

- CUL9_HUMAN

UniProt

Q8IWT3 - CUL9_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cullin-9

Gene
CUL9, H7AP1, KIAA0708, PARC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (1 Publication). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (1 Publication, 1 Publication).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1363 – 13708ATP Reviewed prediction
Zinc fingeri2070 – 212051RING-type 1Add
BLAST
Zinc fingeri2140 – 220364IBR-typeAdd
BLAST
Zinc fingeri2236 – 226530RING-type 2Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cullin-9
Short name:
CUL-9
Alternative name(s):
UbcH7-associated protein 1
p53-associated parkin-like cytoplasmic protein
Gene namesi
Name:CUL9
Synonyms:H7AP1, KIAA0708, PARC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:15982. CUL9.

Subcellular locationi

GO - Cellular componenti

  1. cullin-RING ubiquitin ligase complex Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25172517Cullin-9PRO_0000119815Add
BLAST

Post-translational modificationi

In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.
Neddylated.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8IWT3.
PaxDbiQ8IWT3.
PRIDEiQ8IWT3.

PTM databases

PhosphoSiteiQ8IWT3.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.

Gene expression databases

ArrayExpressiQ8IWT3.
BgeeiQ8IWT3.
GenevestigatoriQ8IWT3.

Organism-specific databases

HPAiHPA016434.

Interactioni

Subunit structurei

Part of a Cul9-RING complex at least composed of CUL9 and RBX1. Interacts with CUL7: interaction with CUL7 component of the 3M complex leads to inhibition of CUL9 activity. The CUL7-CUL9 heterodimer seems to interact specifically with TP53. Forms a complex with p53/TP53 in the cytoplasm of unstressed cells. Interacts with UBCH7 and UBCH8.

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046373EBI-311123,EBI-366083

Protein-protein interaction databases

BioGridi116736. 9 interactions.
IntActiQ8IWT3. 8 interactions.
MINTiMINT-6615845.
STRINGi9606.ENSP00000252050.

Structurei

Secondary structure

1
2517
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi376 – 3827
Beta strandi388 – 3936
Beta strandi403 – 4086
Beta strandi411 – 4133
Beta strandi416 – 4205
Turni421 – 4244
Beta strandi425 – 4295
Helixi431 – 4333

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JUFNMR-A366-466[»]
ProteinModelPortaliQ8IWT3.
SMRiQ8IWT3. Positions 375-438, 1997-2417.

Miscellaneous databases

EvolutionaryTraceiQ8IWT3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1143 – 1322180DOCAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1649 – 169143 Reviewed predictionAdd
BLAST
Coiled coili2365 – 238521 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1661 – 168929Glu-richAdd
BLAST

Domaini

The IBR domain is required for interaction with UBCH7 and UBCH8.

Sequence similaritiesi

Belongs to the cullin family.
Contains 1 DOC domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2070 – 212051RING-type 1Add
BLAST
Zinc fingeri2140 – 220364IBR-typeAdd
BLAST
Zinc fingeri2236 – 226530RING-type 2Add
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG48148.
KOiK11970.
OMAiTKHEWRP.
OrthoDBiEOG70S74H.
PhylomeDBiQ8IWT3.
TreeFamiTF101154.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.10.10. 4 hits.
2.30.30.30. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021097. CPH_domain.
IPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR008979. Galactose-bd-like.
IPR014722. Rib_L2_dom2.
IPR011991. WHTH_DNA-bd_dom.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF03256. APC10. 1 hit.
PF11515. Cul7. 1 hit.
PF00888. Cullin. 1 hit.
PF01485. IBR. 2 hits.
[Graphical view]
SMARTiSM00884. Cullin_Nedd8. 1 hit.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
SSF49785. SSF49785. 1 hit.
SSF75632. SSF75632. 2 hits.
PROSITEiPS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
PS51284. DOC. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWT3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVGERHAGDL MVPLGPRLQA YPEELIRQRP GHDGHPEYLI RWSVLKCGEV     50
GKVGVEEGKA EHILMWLSAP EVYANCPGLL GERALSKGLQ HEPAGVSGSF 100
PRDPGGLDEV AMGEMEADVQ ALVRRAARQL AESGTPSLTA AVLHTIHVLS 150
AYASIGPLTG VFRETGALDL LMHMLCNPEP QIRRSAGKML QALAAHDAGS 200
RAHVLLSLSQ QDGIEQHMDF DSRYTLLELF AETTSSEEHC MAFEGIHLPQ 250
IPGKLLFSLV KRYLCVTSLL DQLNSSPELG AGDQSSPCAT REKSRGQREL 300
EFSMAVGNLI SELVRSMGWA RNLSEQGMSP PRPTRSIFQP YISGPSLLLP 350
TIVTTPRRQG WVFRQRSEFS SRSGYGEYVQ QTLQPGMRVR MLDDYEEISA 400
GDEGEFRQSN NGIPPVQVFW QSTGRTYWVH WHMLEILGPE EATEDKASAA 450
VEKGAGATVL GTAFPSWDWN PMDGLYPLPY LQPEPQKNER VGYLTQAEWW 500
ELLFFIKKLD LCEQQPIFQN LWKNLDETLG EKALGEISVS VEMAESLLQV 550
LSSRFEGSTL NDLLNSQIYT KYGLLSNEPS SSSTSRNHSC TPDPEEESKS 600
EASFSEEETE SLKAKAEAPK TEAEPTKTRT ETPMAQSDSQ LFNQLLVTEG 650
MTLPTEMKEA ASEMARALRG PGPRSSLDQH VAAVVATVQI SSLDTNLQLS 700
GLSALSQAVE EVTERDHPLV RPDRSLREKL VKMLVELLTN QVGEKMVVVQ 750
ALRLLYLLMT KHEWRPLFAR EGGIYAVLVC MQEYKTSVLV QQAGLAALKM 800
LAVASSSEIP TFVTGRDSIH SLFDAQMTRE IFASIDSATR PGSESLLLTV 850
PAAVILMLNT EGCSSAARNG LLLLNLLLCN HHTLGDQIIT QELRDTLFRH 900
SGIAPRTEPM PTTRTILMML LNRYSEPPGS PERAALETPI IQGQDGSPEL 950
LIRSLVGGPS AELLLDLERV LCREGSPGGA VRPLLKRLQQ ETQPFLLLLR 1000
TLDAPGPNKT LLLSVLRVIT RLLDFPEAMV LPWHEVLEPC LNCLSGPSSD 1050
SEIVQELTCF LHRLASMHKD YAVVLCCLGA KEILSKVLDK HSAQLLLGCE 1100
LRDLVTECEK YAQLYSNLTS SILAGCIQMV LGQIEDHRRT HQPINIPFFD 1150
VFLRHLCQGS SVEVKEDKCW EKVEVSSNPH RASKLTDHNP KTYWESNGST 1200
GSHYITLHMH RGVLVRQLTL LVASEDSSYM PARVVVFGGD STSCIGTELN 1250
TVNVMPSASR VILLENLNRF WPIIQIRIKR CQQGGIDTRV RGVEVLGPKP 1300
TFWPLFREQL CRRTCLFYTI RAQAWSRDIA EDHRRLLQLC PRLNRVLRHE 1350
QNFADRFLPD DEAAQALGKT CWEALVSPLV QNITSPDAEG VSALGWLLDQ 1400
YLEQRETSRN PLSRAASFAS RVRRLCHLLV HVEPPPGPSP EPSTRPFSKN 1450
SKGRDRSPAP SPVLPSSSLR NITQCWLSVV QEQVSRFLAA AWRAPDFVPR 1500
YCKLYEHLQR AGSELFGPRA AFMLALRSGF SGALLQQSFL TAAHMSEQFA 1550
RYIDQQIQGG LIGGAPGVEM LGQLQRHLEP IMVLSGLELA TTFEHFYQHY 1600
MADRLLSFGS SWLEGAVLEQ IGLCFPNRLP QLMLQSLSTS EELQRQFHLF 1650
QLQRLDKLFL EQEDEEEKRL EEEEEEEEEE EAEKELFIED PSPAISILVL 1700
SPRCWPVSPL CYLYHPRKCL PTEFCDALDR FSSFYSQSQN HPVLDMGPHR 1750
RLQWTWLGRA ELQFGKQILH VSTVQMWLLL KFNQTEEVSV ETLLKDSDLS 1800
PELLLQALVP LTSGNGPLTL HEGQDFPHGG VLRLHEPGPQ RSGEALWLIP 1850
PQAYLNVEKD EGRTLEQKRN LLSCLLVRIL KAHGEKGLHI DQLVCLVLEA 1900
WQKGPNPPGT LGHTVAGGVA CTSTDVLSCI LHLLGQGYVK RRDDRPQILM 1950
YAAPEPMGPC RGQADVPFCG SQSETSKPSP EAVATLASLQ LPAGRTMSPQ 2000
EVEGLMKQTV RQVQETLNLE PDVAQHLLAH SHWGAEQLLQ SYSEDPEPLL 2050
LAAGLCVHQA QAVPVRPDHC PVCVSPLGCD DDLPSLCCMH YCCKSCWNEY 2100
LTTRIEQNLV LNCTCPIADC PAQPTGAFIR AIVSSPEVIS KYEKALLRGY 2150
VESCSNLTWC TNPQGCDRIL CRQGLGCGTT CSKCGWASCF NCSFPEAHYP 2200
ASCGHMSQWV DDGGYYDGMS VEAQSKHLAK LISKRCPSCQ APIEKNEGCL 2250
HMTCAKCNHG FCWRCLKSWK PNHKDYYNCS AMVSKAARQE KRFQDYNERC 2300
TFHHQAREFA VNLRNRVSAI HEVPPPRSFT FLNDACQGLE QARKVLAYAC 2350
VYSFYSQDAE YMDVVEQQTE NLELHTNALQ ILLEETLLRC RDLASSLRLL 2400
RADCLSTGME LLRRIQERLL AILQHSAQDF RVGLQSPSVE AWEAKGPNMP 2450
GSQPQASSGP EAEEEEEDDE DDVPEWQQDE FDEELDNDSF SYDESENLDQ 2500
ETFFFGDEEE DEDEAYD 2517
Length:2,517
Mass (Da):281,229
Last modified:January 4, 2005 - v2
Checksum:i42387A55DCC52EAF
GO
Isoform 2 (identifier: Q8IWT3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-527: Missing.

Note: No experimental confirmation available.

Show »
Length:2,407
Mass (Da):268,362
Checksum:iF41FAF09CC71656C
GO

Sequence cautioni

The sequence BAC85207.1 differs from that shown. Reason: Intron retention.
The sequence BAC86090.1 differs from that shown. Reason: Intron retention.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2058 – 20581H → P.
Corresponds to variant rs2273709 [ dbSNP | Ensembl ].
VAR_048844
Natural varianti2180 – 21801T → I.
Corresponds to variant rs11962520 [ dbSNP | Ensembl ].
VAR_048845

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei418 – 527110Missing in isoform 2. VSP_009573Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti527 – 5271E → G in CAH18696. 1 Publication
Sequence conflicti663 – 6631E → K in AAN61516. 1 Publication
Sequence conflicti1171 – 11711E → K in CAH18328. 1 Publication
Sequence conflicti1230 – 12301M → T in CAH18328. 1 Publication
Sequence conflicti1268 – 12681N → S in CAH18328. 1 Publication
Sequence conflicti1277 – 12771R → H in CAH18328. 1 Publication
Sequence conflicti1830 – 185728Missing in CAH18696. 1 PublicationAdd
BLAST
Sequence conflicti2049 – 20491L → P in CAH18696. 1 Publication
Sequence conflicti2058 – 20592HQ → PL in CAH18696. 1 Publication
Sequence conflicti2345 – 23451V → VV in CAI20204. 1 Publication
Sequence conflicti2345 – 23451V → VV in EAX04163. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY145132 mRNA. Translation: AAN61516.1.
AJ318215 mRNA. Translation: CAC85756.1.
CR749511 mRNA. Translation: CAH18328.1.
CR749841 mRNA. Translation: CAH18696.1.
AL133375 Genomic DNA. Translation: CAI20204.1.
CH471081 Genomic DNA. Translation: EAX04163.1.
AK125228 mRNA. Translation: BAC86090.1. Sequence problems.
AK129649 mRNA. Translation: BAC85207.1. Sequence problems.
AB014608 mRNA. Translation: BAA31683.3.
BC002879 mRNA. Translation: AAH02879.2.
CCDSiCCDS4890.1. [Q8IWT3-1]
PIRiT00350.
RefSeqiNP_055904.1. NM_015089.3. [Q8IWT3-1]
XP_006715094.1. XM_006715031.1. [Q8IWT3-3]
UniGeneiHs.485434.

Genome annotation databases

EnsembliENST00000252050; ENSP00000252050; ENSG00000112659. [Q8IWT3-1]
ENST00000354495; ENSP00000346490; ENSG00000112659. [Q8IWT3-3]
GeneIDi23113.
KEGGihsa:23113.
UCSCiuc003ouk.3. human. [Q8IWT3-1]

Polymorphism databases

DMDMi57015409.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY145132 mRNA. Translation: AAN61516.1 .
AJ318215 mRNA. Translation: CAC85756.1 .
CR749511 mRNA. Translation: CAH18328.1 .
CR749841 mRNA. Translation: CAH18696.1 .
AL133375 Genomic DNA. Translation: CAI20204.1 .
CH471081 Genomic DNA. Translation: EAX04163.1 .
AK125228 mRNA. Translation: BAC86090.1 . Sequence problems.
AK129649 mRNA. Translation: BAC85207.1 . Sequence problems.
AB014608 mRNA. Translation: BAA31683.3 .
BC002879 mRNA. Translation: AAH02879.2 .
CCDSi CCDS4890.1. [Q8IWT3-1 ]
PIRi T00350.
RefSeqi NP_055904.1. NM_015089.3. [Q8IWT3-1 ]
XP_006715094.1. XM_006715031.1. [Q8IWT3-3 ]
UniGenei Hs.485434.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JUF NMR - A 366-466 [» ]
ProteinModelPortali Q8IWT3.
SMRi Q8IWT3. Positions 375-438, 1997-2417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116736. 9 interactions.
IntActi Q8IWT3. 8 interactions.
MINTi MINT-6615845.
STRINGi 9606.ENSP00000252050.

PTM databases

PhosphoSitei Q8IWT3.

Polymorphism databases

DMDMi 57015409.

Proteomic databases

MaxQBi Q8IWT3.
PaxDbi Q8IWT3.
PRIDEi Q8IWT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252050 ; ENSP00000252050 ; ENSG00000112659 . [Q8IWT3-1 ]
ENST00000354495 ; ENSP00000346490 ; ENSG00000112659 . [Q8IWT3-3 ]
GeneIDi 23113.
KEGGi hsa:23113.
UCSCi uc003ouk.3. human. [Q8IWT3-1 ]

Organism-specific databases

CTDi 23113.
GeneCardsi GC06P043149.
HGNCi HGNC:15982. CUL9.
HPAi HPA016434.
MIMi 607489. gene.
neXtProti NX_Q8IWT3.
PharmGKBi PA164718328.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG48148.
KOi K11970.
OMAi TKHEWRP.
OrthoDBi EOG70S74H.
PhylomeDBi Q8IWT3.
TreeFami TF101154.

Miscellaneous databases

ChiTaRSi CUL9. human.
EvolutionaryTracei Q8IWT3.
GeneWikii PARC_(gene).
GenomeRNAii 23113.
NextBioi 44317.
PROi Q8IWT3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IWT3.
Bgeei Q8IWT3.
Genevestigatori Q8IWT3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.25.10.10. 4 hits.
2.30.30.30. 1 hit.
2.60.120.260. 1 hit.
InterProi IPR004939. APC_su10/DOC_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021097. CPH_domain.
IPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR008979. Galactose-bd-like.
IPR014722. Rib_L2_dom2.
IPR011991. WHTH_DNA-bd_dom.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF03256. APC10. 1 hit.
PF11515. Cul7. 1 hit.
PF00888. Cullin. 1 hit.
PF01485. IBR. 2 hits.
[Graphical view ]
SMARTi SM00884. Cullin_Nedd8. 1 hit.
SM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
SSF49785. SSF49785. 1 hit.
SSF75632. SSF75632. 2 hits.
PROSITEi PS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
PS51284. DOC. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 786-791; 2419-2431 AND 2432-2445, INTERACTION WITH TP53, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
    Tissue: Cervix carcinoma.
  2. "UbcH7 associated protein, H7AP1. A new member of the Parkin/Ariadne E3 ubiquitin Ligase (PAUL) family."
    Rose S.A., Ardley H.C., Tan N.G., Scott G.B., Markham A.F., Robinson P.A.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala and Testis.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-662 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-662 (ISOFORMS 1/2).
    Tissue: Chondrocyte and Thymus.
  7. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 765-2517 (ISOFORM 1).
    Tissue: Brain.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1554-2517 (ISOFORM 1).
    Tissue: Lung.
  9. "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1."
    Moynihan T.P., Ardley H.C., Nuber U., Rose S.A., Jones P.F., Markham A.F., Scheffner M., Robinson P.A.
    J. Biol. Chem. 274:30963-30968(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBCH7 AND UBCH8.
  10. "Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development."
    Skaar J.R., Arai T., DeCaprio J.A.
    Mol. Cell. Biol. 25:5579-5589(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CUL7.
  11. Cited for: FUNCTION, INTERACTION WITH CUL7; RBX1 AND TP53, NEDDYLATION.
  12. "CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity."
    Li Z., Pei X.H., Yan J., Yan F., Cappell K.M., Whitehurst A.W., Xiong Y.
    Mol. Cell 54:0-0(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CUL7 AND RBX1.

Entry informationi

Entry nameiCUL9_HUMAN
AccessioniPrimary (citable) accession number: Q8IWT3
Secondary accession number(s): O75188
, Q5TCY3, Q68CP2, Q68D92, Q8N3W9, Q9BU56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi