##gff-version 3 Q8IWT1 UniProtKB Signal peptide 1 30 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IWT1 UniProtKB Chain 31 228 . . . ID=PRO_0000014937;Note=Sodium channel subunit beta-4 Q8IWT1 UniProtKB Topological domain 31 162 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IWT1 UniProtKB Transmembrane 163 183 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IWT1 UniProtKB Topological domain 184 228 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IWT1 UniProtKB Domain 31 148 . . . Note=Ig-like C2-type Q8IWT1 UniProtKB Region 200 228 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IWT1 UniProtKB Glycosylation 45 45 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IWT1 UniProtKB Glycosylation 71 71 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IWT1 UniProtKB Glycosylation 113 113 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IWT1 UniProtKB Disulfide bond 53 131 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:24297919;Dbxref=PMID:24297919 Q8IWT1 UniProtKB Disulfide bond 58 58 . . . Note=Interchain%3B with alpha subunit;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:24297919;Dbxref=PMID:24297919 Q8IWT1 UniProtKB Alternative sequence 1 110 . . . ID=VSP_053913;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWT1 UniProtKB Alternative sequence 21 155 . . . ID=VSP_046971;Note=In isoform 3. GLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRL->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWT1 UniProtKB Natural variant 162 162 . . . ID=VAR_071317;Note=In ATFB17. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23604097;Dbxref=dbSNP:rs587777559,PMID:23604097 Q8IWT1 UniProtKB Natural variant 166 166 . . . ID=VAR_071318;Note=In ATFB17. I->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23604097;Dbxref=dbSNP:rs587777560,PMID:23604097 Q8IWT1 UniProtKB Natural variant 179 179 . . . ID=VAR_043488;Note=In LQT10%3B increase in late sodium current. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17592081;Dbxref=dbSNP:rs121434386,PMID:17592081 Q8IWT1 UniProtKB Mutagenesis 58 58 . . . Note=Abolishes regulation of channel activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24297919;Dbxref=PMID:24297919 Q8IWT1 UniProtKB Mutagenesis 131 131 . . . Note=Decreases protein stability. Causes conformation changes that impair interaction with the alpha subunit. C->A%2CW;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24297919;Dbxref=PMID:24297919 Q8IWT1 UniProtKB Sequence conflict 40 40 . . . Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IWT1 UniProtKB Beta strand 32 34 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5XAW Q8IWT1 UniProtKB Beta strand 39 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Beta strand 49 51 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Turn 58 60 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4MZ3 Q8IWT1 UniProtKB Beta strand 62 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Beta strand 76 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Beta strand 92 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Beta strand 101 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Beta strand 116 118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Helix 123 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Beta strand 127 135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Helix 136 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Beta strand 140 143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV Q8IWT1 UniProtKB Beta strand 147 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6VSV