Q8IWT0 (ARCH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein archease

Alternative name(s):
Protein ZBTB8OS
Zinc finger and BTB domain-containing opposite strand protein 8

Gene names

Name:	ZBTB8OS
Synonyms:	ARCH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the archease family.
Sequence caution	The sequence AAM34477.1 differs from that shown. Reason: Erroneous initiation. The sequence AAN75223.1 differs from that shown. Reason: Erroneous initiation. The sequence AAN75224.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI20020.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI20021.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWT0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWT0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     110-167: EVKVLSIDQR...NPEVFVIIDI → VGRRIFIVQAPSGNRSQSNNIFSNAGL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 167	166	Protein archease		PRO_0000285950
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.5
Natural variations
	Alternative sequence	110 – 167	58	EVKVL…VIIDI → VGRRIFIVQAPSGNRSQSNN IFSNAGL in isoform 2.		VSP_024926
Experimental info
	Sequence conflict	51	1	E → V in AAM34478. Ref.1
	Sequence conflict	76	1	V → A in AAM34478. Ref.1
	Sequence conflict	93	1	L → S in AAM34478. Ref.1
	Sequence conflict	119	1	R → G in AAM34478. Ref.1
	Sequence conflict	137	1	H → R in AAM34478. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 26EC7F03CA7B42F1	FASTA	167	19,491
	10 20 30 40 50 60 MAQEEEDVRD YNLTEEQKAI KAKYPPVNRK YEYLDHTADV QLHAWGDTLE EAFEQCAMAM 70 80 90 100 110 120 FGYMTDTGTV EPLQTVEVET QGDDLQSLLF HFLDEWLYKF SADEFFIPRE VKVLSIDQRN 130 140 150 160 FKLRSIGWGE EFSLSKHPQG TEVKAITYSA MQVYNEENPE VFVIIDI
	Isoform 2 [UniParc]. Checksum: 6B166BC23296478F	FASTA	136	15,709
	10 20 30 40 50 60 MAQEEEDVRD YNLTEEQKAI KAKYPPVNRK YEYLDHTADV QLHAWGDTLE EAFEQCAMAM 70 80 90 100 110 120 FGYMTDTGTV EPLQTVEVET QGDDLQSLLF HFLDEWLYKF SADEFFIPRV GRRIFIVQAP 130 SGNRSQSNNI FSNAGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, expression and sequence comparison of human and murine archease." Alliel P.M., Goudou D., Bitoun M., Langlois C., Rieger F., Seddiqi N., Perin J.P. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Predicted role for the archease protein family based on structural and sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics efforts." Canaves J.M. Proteins 56:19-27(2004) [PubMed: 15162483] [Abstract] Cited for: IDENTIFICATION.
[5]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY099493 mRNA. Translation: AAM34477.1. Different initiation. AY099494 mRNA. Translation: AAM34478.1. AY151084 mRNA. Translation: AAN75223.1. Different initiation. AY151085 mRNA. Translation: AAN75224.1. Different initiation. AL033529, AC114489 Genomic DNA. Translation: CAI20020.1. Different initiation. AL033529, AC114489 Genomic DNA. Translation: CAI20021.1. Different initiation. BC058843 mRNA. Translation: AAH58843.1.
IPI	IPI00217375. IPI00640902.
RefSeq	NP_848642.1. NM_178547.2.
UniGene	Hs.655921.
3D structure databases
HSSP	HSSP built from PDB template 1JW3 based on UniProtKB O27635.
ProteinModelPortal	Q8IWT0.
SMR	Q8IWT0. Positions 28-167.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IWT0. 2 interactions.
STRING	Q8IWT0.
Polymorphism databases
DMDM	146286037.
Proteomic databases
PRIDE	Q8IWT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000468695; ENSP00000417677; ENSG00000176261.
GeneID	339487.
KEGG	hsa:339487.
NMPDR	fig|9606.3.peg.774.
UCSC	uc001bvp.1. human. uc001bvq.1. human.
Organism-specific databases
CTD	339487.
GeneCards	GC01M033065.
H-InvDB	HIX0028669.
HGNC	HGNC:24094. ZBTB8OS.
neXtProt	NX_Q8IWT0.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000003245.
HOVERGEN	HBG104905.
InParanoid	Q8IWT0.
OrthoDB	EOG4PVP0R.
Gene expression databases
ArrayExpress	Q8IWT0.
Bgee	Q8IWT0.
CleanEx	HS_ZBTB8OS.
Genevestigator	Q8IWT0.
Family and domain databases
InterPro	IPR002804. Archease. IPR023572. Archease_dom. [Graphical view]
Gene3D	G3DSA:3.55.10.10. DUF101. 1 hit.
PANTHER	PTHR12682. DUF101. 1 hit.
Pfam	PF01951. Archease. 1 hit. [Graphical view]
ProDom	PD012969. PD012969. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF69819. DUF101. 1 hit.
ProtoNet	Search...
Other
NextBio	97428.

Entry information

Entry name

ARCH_HUMAN

Accession

Primary (citable) accession number: Q8IWT0
Secondary accession number(s): Q5TGK5 , Q6PDA1, Q8IWS9, Q8NEV6, Q8NEV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	January 25, 2012
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.