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Protein

Tripartite motif-containing protein 59

Gene

TRIM59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May serve as a multifunctional regulator for innate immune signaling pathways.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri10 – 6051RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 13443B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cilium assembly Source: GO_Central
  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 59
Alternative name(s):
RING finger protein 104
Tumor suppressor TSBF-1
Gene namesi
Name:TRIM59
Synonyms:RNF104, TRIM57, TSBF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30834. TRIM59.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899610.

Polymorphism and mutation databases

BioMutaiTRIM59.
DMDMi74714421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Tripartite motif-containing protein 59PRO_0000249679Add
BLAST

Proteomic databases

EPDiQ8IWR1.
MaxQBiQ8IWR1.
PaxDbiQ8IWR1.
PRIDEiQ8IWR1.

PTM databases

iPTMnetiQ8IWR1.
PhosphoSiteiQ8IWR1.

Expressioni

Gene expression databases

BgeeiQ8IWR1.
CleanExiHS_TRIM59.
ExpressionAtlasiQ8IWR1. baseline and differential.
GenevisibleiQ8IWR1. HS.

Organism-specific databases

HPAiHPA017750.

Interactioni

Subunit structurei

Interacts with ECSIT.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NRMQ8IXM63EBI-10262539,EBI-10262547
VTI1BQ9UEU03EBI-10262539,EBI-723716
ZDHHC22Q8N9663EBI-10262539,EBI-10268111

Protein-protein interaction databases

BioGridi130421. 8 interactions.
IntActiQ8IWR1. 3 interactions.
STRINGi9606.ENSP00000311219.

Structurei

3D structure databases

ProteinModelPortaliQ8IWR1.
SMRiQ8IWR1. Positions 4-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili163 – 24684Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri10 – 6051RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 13443B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG5. Eukaryota.
ENOG410YH9X. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000013095.
HOVERGENiHBG060002.
InParanoidiQ8IWR1.
KOiK12028.
OMAiKEFMWKI.
PhylomeDBiQ8IWR1.
TreeFamiTF331669.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHNFEEELTC PICYSIFEDP RVLPCSHTFC RNCLENILQA SGNFYIWRPL
60 70 80 90 100
RIPLKCPNCR SITEIAPTGI ESLPVNFALR AIIEKYQQED HPDIVTCPEH
110 120 130 140 150
YRQPLNVYCL LDKKLVCGHC LTIGQHHGHP IDDLQSAYLK EKDTPQKLLE
160 170 180 190 200
QLTDTHWTDL THLIEKLKEQ KSHSEKMIQG DKEAVLQYFK ELNDTLEQKK
210 220 230 240 250
KSFLTALCDV GNLINQEYTP QIERMKEIRE QQLELMALTI SLQEESPLKF
260 270 280 290 300
LEKVDDVRQH VQILKQRPLP EVQPVEIYPR VSKILKEEWS RTEIGQIKNV
310 320 330 340 350
LIPKMKISPK RMSCSWPGKD EKEVEFLKIL NIVVVTLISV ILMSILFFNQ
360 370 380 390 400
HIITFLSEIT LIWFSEASLS VYQSLSNSLH KVKNILCHIF YLLKEFVWKI

VSH
Length:403
Mass (Da):47,114
Last modified:March 1, 2003 - v1
Checksum:i5C32183E7633F45D
GO
Isoform IFT80-L (identifier: Q9P2H3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q9P2H3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a TRIM59-IFT80 fusion protein.
Length:1,080
Mass (Da):123,321
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY159379 mRNA. Translation: AAN86853.1.
AK291284 mRNA. Translation: BAF83973.1.
CH471052 Genomic DNA. Translation: EAW78635.1.
CH471052 Genomic DNA. Translation: EAW78636.1.
CH471052 Genomic DNA. Translation: EAW78637.1.
CH471052 Genomic DNA. Translation: EAW78638.1.
BC109259 mRNA. Translation: AAI09260.1.
BC109260 mRNA. Translation: AAI09261.1.
CCDSiCCDS3190.1. [Q8IWR1-1]
RefSeqiNP_775107.1. NM_173084.2. [Q8IWR1-1]
UniGeneiHs.212957.

Genome annotation databases

EnsembliENST00000309784; ENSP00000311219; ENSG00000213186. [Q8IWR1-1]
GeneIDi286827.
KEGGihsa:286827.
UCSCiuc003fdm.4. human. [Q8IWR1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY159379 mRNA. Translation: AAN86853.1.
AK291284 mRNA. Translation: BAF83973.1.
CH471052 Genomic DNA. Translation: EAW78635.1.
CH471052 Genomic DNA. Translation: EAW78636.1.
CH471052 Genomic DNA. Translation: EAW78637.1.
CH471052 Genomic DNA. Translation: EAW78638.1.
BC109259 mRNA. Translation: AAI09260.1.
BC109260 mRNA. Translation: AAI09261.1.
CCDSiCCDS3190.1. [Q8IWR1-1]
RefSeqiNP_775107.1. NM_173084.2. [Q8IWR1-1]
UniGeneiHs.212957.

3D structure databases

ProteinModelPortaliQ8IWR1.
SMRiQ8IWR1. Positions 4-65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130421. 8 interactions.
IntActiQ8IWR1. 3 interactions.
STRINGi9606.ENSP00000311219.

PTM databases

iPTMnetiQ8IWR1.
PhosphoSiteiQ8IWR1.

Polymorphism and mutation databases

BioMutaiTRIM59.
DMDMi74714421.

Proteomic databases

EPDiQ8IWR1.
MaxQBiQ8IWR1.
PaxDbiQ8IWR1.
PRIDEiQ8IWR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309784; ENSP00000311219; ENSG00000213186. [Q8IWR1-1]
GeneIDi286827.
KEGGihsa:286827.
UCSCiuc003fdm.4. human. [Q8IWR1-1]

Organism-specific databases

CTDi286827.
GeneCardsiTRIM59.
HGNCiHGNC:30834. TRIM59.
HPAiHPA017750.
MIMi616148. gene.
neXtProtiNX_Q8IWR1.
PharmGKBiPA134899610.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITG5. Eukaryota.
ENOG410YH9X. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000013095.
HOVERGENiHBG060002.
InParanoidiQ8IWR1.
KOiK12028.
OMAiKEFMWKI.
PhylomeDBiQ8IWR1.
TreeFamiTF331669.

Miscellaneous databases

GenomeRNAii286827.
PROiQ8IWR1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IWR1.
CleanExiHS_TRIM59.
ExpressionAtlasiQ8IWR1. baseline and differential.
GenevisibleiQ8IWR1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of TSBF-1, a novel gene encoding a tumor suppressor with ring finger domain."
    Gong L., Wu K.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification and characterization of a long isoform of human IFT80, IFT80-L."
    Huang W., Kane J.K., Li M.D.
    Biochem. Biophys. Res. Commun. 373:653-658(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ISOFORM IFT80-L, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTRI59_HUMAN
AccessioniPrimary (citable) accession number: Q8IWR1
Secondary accession number(s): A8K5G9, D3DNL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.