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Protein

Tripartite motif-containing protein 59

Gene

TRIM59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as a multifunctional regulator for innate immune signaling pathways.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 60RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri92 – 134B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 59
Alternative name(s):
RING finger protein 104
Tumor suppressor TSBF-1
Gene namesi
Name:TRIM59
Synonyms:RNF104, TRIM57, TSBF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000213186.7
HGNCiHGNC:30834 TRIM59
MIMi616148 gene
neXtProtiNX_Q8IWR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi286827
OpenTargetsiENSG00000213186
PharmGKBiPA134899610

Polymorphism and mutation databases

BioMutaiTRIM59
DMDMi74714421

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002496791 – 403Tripartite motif-containing protein 59Add BLAST403

Proteomic databases

PaxDbiQ8IWR1
PeptideAtlasiQ8IWR1
PRIDEiQ8IWR1

PTM databases

iPTMnetiQ8IWR1
PhosphoSitePlusiQ8IWR1

Expressioni

Gene expression databases

BgeeiENSG00000213186
CleanExiHS_TRIM59
ExpressionAtlasiQ8IWR1 baseline and differential
GenevisibleiQ8IWR1 HS

Organism-specific databases

HPAiHPA017750

Interactioni

Subunit structurei

Interacts with ECSIT.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130421, 11 interactors
IntActiQ8IWR1, 12 interactors
STRINGi9606.ENSP00000311219

Structurei

3D structure databases

ProteinModelPortaliQ8IWR1
SMRiQ8IWR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili163 – 246Sequence analysisAdd BLAST84

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 60RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri92 – 134B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG5 Eukaryota
ENOG410YH9X LUCA
GeneTreeiENSGT00910000144153
HOGENOMiHOG000013095
HOVERGENiHBG060002
InParanoidiQ8IWR1
KOiK12028
OMAiKEFMWKI
OrthoDBiEOG091G06VP
PhylomeDBiQ8IWR1
TreeFamiTF331669

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHNFEEELTC PICYSIFEDP RVLPCSHTFC RNCLENILQA SGNFYIWRPL
60 70 80 90 100
RIPLKCPNCR SITEIAPTGI ESLPVNFALR AIIEKYQQED HPDIVTCPEH
110 120 130 140 150
YRQPLNVYCL LDKKLVCGHC LTIGQHHGHP IDDLQSAYLK EKDTPQKLLE
160 170 180 190 200
QLTDTHWTDL THLIEKLKEQ KSHSEKMIQG DKEAVLQYFK ELNDTLEQKK
210 220 230 240 250
KSFLTALCDV GNLINQEYTP QIERMKEIRE QQLELMALTI SLQEESPLKF
260 270 280 290 300
LEKVDDVRQH VQILKQRPLP EVQPVEIYPR VSKILKEEWS RTEIGQIKNV
310 320 330 340 350
LIPKMKISPK RMSCSWPGKD EKEVEFLKIL NIVVVTLISV ILMSILFFNQ
360 370 380 390 400
HIITFLSEIT LIWFSEASLS VYQSLSNSLH KVKNILCHIF YLLKEFVWKI

VSH
Length:403
Mass (Da):47,114
Last modified:March 1, 2003 - v1
Checksum:i5C32183E7633F45D
GO
Isoform IFT80-L (identifier: Q9P2H3-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9P2H3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a TRIM59-IFT80 fusion protein.
Length:1,080
Mass (Da):123,321
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY159379 mRNA Translation: AAN86853.1
AK291284 mRNA Translation: BAF83973.1
CH471052 Genomic DNA Translation: EAW78635.1
CH471052 Genomic DNA Translation: EAW78636.1
CH471052 Genomic DNA Translation: EAW78637.1
CH471052 Genomic DNA Translation: EAW78638.1
BC109259 mRNA Translation: AAI09260.1
BC109260 mRNA Translation: AAI09261.1
CCDSiCCDS3190.1 [Q8IWR1-1]
RefSeqiNP_775107.1, NM_173084.2 [Q8IWR1-1]
UniGeneiHs.212957

Genome annotation databases

EnsembliENST00000309784; ENSP00000311219; ENSG00000213186 [Q8IWR1-1]
GeneIDi286827
KEGGihsa:286827
UCSCiuc003fdm.4 human [Q8IWR1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRI59_HUMAN
AccessioniPrimary (citable) accession number: Q8IWR1
Secondary accession number(s): A8K5G9, D3DNL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health