Q8IWR0 (Z3H7A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger CCCH domain-containing protein 7A

Gene names

Name:	ZC3H7A
Synonyms:	ZC3H7, ZC3HDC7
ORF Names:	HSPC055

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	971 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 C2H2-type zinc finger. Contains 3 C3H1-type zinc fingers. Contains 3 TPR repeats.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat TPR repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWR0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWR0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-804: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 971

971

Zinc finger CCCH domain-containing protein 7A

PRO_0000106321

Regions

Repeat

43 – 76

34

TPR 1

Repeat

89 – 122

34

TPR 2

Repeat

124 – 156

33

TPR 3

Zinc finger

634 – 656

23

C3H1-type 1

Zinc finger

769 – 797

29

C3H1-type 2

Zinc finger

857 – 881

25

C2H2-type

Zinc finger

906 – 928

23

C3H1-type 3

Coiled coil

924 – 952

29

Potential

Amino acid modifications

Modified residue

750

1

Phosphoserine Ref.6

Natural variations

Alternative sequence

1 – 804

804

Missing in isoform 2.

VSP_014383

Natural variant

3

1

N → S.
Corresponds to variant rs1429077 [ dbSNP | Ensembl ].

VAR_052632

Natural variant

57

1

H → R.
Corresponds to variant rs16958654 [ dbSNP | Ensembl ].

VAR_052633

Secondary structure

1

.

.

.

.

.

.

.

971

Helix Strand Turn

Details...

Helix

908 – 912

5

Beta strand

922 – 926

5

Helix

927 – 940

14

Turn

941 – 943

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A62D4EF6BC639181	FASTA	971	110,538
	10 20 30 40 50 60 MSNVSEERRK RQQNIKEGLQ FIQSPLSYPG TQEQYAVYLR ALVRNLFNEG NDVYREHDWN 70 80 90 100 110 120 NSISQYTEAL NIADYAKSEE ILIPKEIIEK LYINRIACYS NMGFHDKVLE DCNIVLSLNA 130 140 150 160 170 180 SNCKALYRKS KALSDLGRYK KAYDAVAKCS LAVPQDEHVI KLTQELAQKL GFKIRKAYVR 190 200 210 220 230 240 AELSLKSVPG DGATKALNHS VEDIEPDLLT PRQEAVPVVS LPAPSFSHEV GSELASVPVM 250 260 270 280 290 300 PLTSILPLQV EESALPSAVL ANGGKMPFTM PEAFLDDGDM VLGDELDDLL DSAPETNETV 310 320 330 340 350 360 MPSALVRGPL QTASVSPSMP FSASLLGTLP IGARYAPPPS FSEFYPPLTS SLEDFCSSLN 370 380 390 400 410 420 SFSMSESKRD LSTSTSREGT PLNNSNSSLL LMNGPGSLFA SENFLGISSQ PRNDFGNFFG 430 440 450 460 470 480 SAVTKPSSSV TPRHPLEGTH ELRQACQICF VKSGPKLMDF TYHANIDHKC KKDILIGRIK 490 500 510 520 530 540 NVEDKSWKKI RPRPTKTNYE GPYYICKDVA AEEECRYSGH CTFAYCQEEI DVWTLERKGA 550 560 570 580 590 600 FSREAFFGGN GKINLTVFKL LQEHLGEFIF LCEKCFDHKP RMISKRNKDN STACSHPVTK 610 620 630 640 650 660 HEFEDNKCLV HILRETTVKY SKIRSFHGQC QLDLCRHEVR YGCLREDECF YAHSLVELKV 670 680 690 700 710 720 WIMQNETGIS HDAIAQESKR YWQNLEANVP GAQVLGNQIM PGFLNMKIKF VCAQCLRNGQ 730 740 750 760 770 780 VIEPDKNRKY CSAKARHSWT KDRRAMRVMS IERKKWMNIR PLPTKKQMPL QFDLCNHIAS 790 800 810 820 830 840 GKKCQYVGNC SFAHSPEERE VWTYMKENGI QDMEQFYELW LKSQKNEKSE DIASQSNKEN 850 860 870 880 890 900 GKQIHMPTDY AEVTVDFHCW MCGKNCNSEK QWQGHISSEK HKEKVFHTED DQYCWQHRFP 910 920 930 940 950 960 TGYFSICDRY MNGTCPEGNS CKFAHGNAEL HEWEERRDAL KMKLNKARKD HLIGPNDNDF 970 GKYSFLFKDL N
	Isoform 2 [UniParc]. Checksum: 5A672347194A2897	FASTA	167	19,811
	10 20 30 40 50 60 MKENGIQDME QFYELWLKSQ KNEKSEDIAS QSNKENGKQI HMPTDYAEVT VDFHCWMCGK 70 80 90 100 110 120 NCNSEKQWQG HISSEKHKEK VFHTEDDQYC WQHRFPTGYF SICDRYMNGT CPEGNSCKFA 130 140 150 160 HGNAELHEWE ERRDALKMKL NKARKDHLIG PNDNDFGKYS FLFKDLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Chen L., Guo J.H. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Umbilical cord blood.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Skeletal muscle and Skin.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-750, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"Solution structure of CCCH type zinc-finger domain 3 in zinc finger CCCH-type domain containing 7a." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 892-947.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY163807 mRNA. Translation: AAO06906.1.
AF161540 mRNA. Translation: AAF29027.1.
AK000889 mRNA. Translation: BAA91408.1.
AK001869 mRNA. Translation: BAA91952.1.
CH471112 Genomic DNA. Translation: EAW85138.1.
CH471112 Genomic DNA. Translation: EAW85139.1.
BC012575 mRNA. Translation: AAH12575.1.
BC046363 mRNA. Translation: AAH46363.1.

IPI

IPI00217355.
IPI00607547.

RefSeq

NP_054872.2. NM_014153.3.

UniGene

Hs.371856.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2D9M	NMR	-	A	892-947	[»]

ProteinModelPortal

Q8IWR0.

SMR

Q8IWR0. Positions 32-178, 484-541, 773-798, 892-947.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IWR0. 3 interactions.

MINT

MINT-1390905.

STRING

Q8IWR0.

PTM databases

PhosphoSite

Q8IWR0.

Polymorphism databases

DMDM

68566208.

Proteomic databases

PRIDE

Q8IWR0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000355758; ENSP00000347999; ENSG00000122299.
ENST00000396516; ENSP00000379773; ENSG00000122299.

GeneID

29066.

KEGG

hsa:29066.

UCSC

uc002dbi.1. human.
uc002dbk.1. human.

Organism-specific databases

CTD

29066.

GeneCards

GC16M011752.

H-InvDB

HIX0202245.

HGNC

HGNC:30959. ZC3H7A.

HPA

HPA040808.

neXtProt

NX_Q8IWR0.

PharmGKB

PA128394652.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG443825.

HOVERGEN

HBG058699.

InParanoid

Q8IWR0.

OMA

HDAIAQE.

OrthoDB

EOG4QZ7K6.

PhylomeDB

Q8IWR0.

Gene expression databases

ArrayExpress

Q8IWR0.

Bgee

Q8IWR0.

CleanEx

HS_ZC3H7A.

Genevestigator

Q8IWR0.

GermOnline

ENSG00000122299. Homo sapiens.

Family and domain databases

InterPro

IPR011990. TPR-like_helical.
IPR015880. Znf_C2H2-like.
IPR000571. Znf_CCCH.
[Graphical view]

Gene3D

G3DSA:1.25.40.10. TPR-like_helical. 1 hit.

Pfam

PF00642. zf-CCCH. 1 hit.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 2 hits.
SM00356. ZnF_C3H1. 3 hits.
[Graphical view]

PROSITE

PS50005. TPR. False negative.
PS50293. TPR_REGION. False negative.
PS50103. ZF_C3H1. 3 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. False negative.
[Graphical view]

ProtoNet

Search...

Other

NextBio

52013.

Entry information

Entry name

Z3H7A_HUMAN

Accession

Primary (citable) accession number: Q8IWR0
Secondary accession number(s): D3DUG5, Q9NPE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.