Q8IWQ7 (Q8IWQ7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CDC42-binding protein kinase beta EMBL AAN86031.1

Gene names

Name:

CDC42BPA HGNC 1737

Organism

Homo sapiens (Human) EMBL AAN86031.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1638 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. SAAS SAAS000095
Sequence similarities	Contains 1 AGC-kinase C-terminal domain. SAAS SAAS000961 Contains 1 PH domain. SAAS SAAS000961 Contains 1 protein kinase domain. SAAS SAAS000095

Ontologies

Keywords
Domain	Zinc-finger SAAS SAAS000961
Ligand	ATP-binding SAAS SAAS000095 RuleBase RU000304 Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS000095 Transferase
Gene Ontology (GO)
Biological_process	actin cytoskeleton reorganization Inferred from electronic annotation. Source: InterPro intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW small GTPase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IWQ7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 6AF8981F30E6C404	FASTA	1,638	186,038
	10 20 30 40 50 60 MSGEVRLRQL EQFILDGPAQ TNGQCFSVET LLDILICLYD ECNNSPLRRE KNILEYLEWA 70 80 90 100 110 120 KPFTSKVKQM RLHREDFEIL KVIGRGAFGE VAVVKLKNAD KVFAMKILNK WEMLKRAETA 130 140 150 160 170 180 CFREERDVLV NGDNKWITTL HYAFQDDNNL YLVMDYYVGG DLLTLLSKFE DRLPEDMARF 190 200 210 220 230 240 YLAEMVIAID SVHQLHYVHR DIKPDNILMD MNGHIRLADF GSCLKLMEDG TVQSSVAVGT 250 260 270 280 290 300 PDYISPEILQ AMEDGKGRYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER 310 320 330 340 350 360 FQFPAQVTDV SENAKDPIRR LICGREHRLG QSGIEDFKKH PFFSGIDWDN IRNCEAPYIP 370 380 390 400 410 420 EVSSPTDTSN FDVDDDCLKN SETMPPPTHT AFSGHHLPFV GFTYTSSCVL SDRSCLRVTA 430 440 450 460 470 480 GPTSLDLDVN VQRTLDNNLA TEAYERRIKR LEQEKLELSR KLQESTQTVQ ALQYSTVDGP 490 500 510 520 530 540 LTASKDLEIK NLKEVIEKLR KQVTESSHLE QQLEEANAVR QELDDAFRQI KAYEKQIKTL 550 560 570 580 590 600 QQEREDLNKL EVHTEALAAE ASKDRKLREQ SEHYSKQLEN ELEGLKQKQI SYSPGVCSIE 610 620 630 640 650 660 HQQEITKLKT DLEKKSIFYE EELSKREGIH ANEIKNLKKE LHDSEGQQLA LNKEIMILKD 670 680 690 700 710 720 KLEKTRRESQ SEREEFESEF KQQYEREKVL LTEENKKLTS ELDKLTTLYE NLSIHNQQLE 730 740 750 760 770 780 EEVKDLADKK ESVAHWEAQI TEIIQWVSDE KDARGYLQAL ASKMTEELEA LRNSSLGTRA 790 800 810 820 830 840 TDMPWKMRRF AKLDMSARLE LQSALDAEIR AKQAIQEELN KVKASNIITE CKLKDSEKKN 850 860 870 880 890 900 LELLSEIEQL IKDTEELRSE KGIEHQDSQH SFLAFLNTPT DALDQFETVD STPLSVHTPT 910 920 930 940 950 960 LRKKGCPGST GFPPKRKTHQ FFVKSFTTPT KCHQCTSLMV GLIRQGCSCE VCGFSCHITC 970 980 990 1000 1010 1020 VNKAPTTCPV PPEQTKGPLG IDPQKGIGTA YEGHVRIPKP AGVKKGWQRA LAIVCDFKLF 1030 1040 1050 1060 1070 1080 LYDIAEGKAS QPSVVISQVI DMRDEEFSVS SVLASDVIHA SRKDIPCIFR VTASQLSASN 1090 1100 1110 1120 1130 1140 NKCSILMLAD TENEKNKWVG VLSELHKILK KNKFRDRSVY VPKEAYDSTL PLIKTTQAAA 1150 1160 1170 1180 1190 1200 IIDHERIALG NEEGLFVVHV TKDEIIRVGD NKKIHQIELI PNDQLVAVIS GRNRHVRLFP 1210 1220 1230 1240 1250 1260 MSALDGRETD FYKLSETKGC QTVTSGKVRH GALTCLCVAM KRQVLCYELF QSKTRHRKFK 1270 1280 1290 1300 1310 1320 EIQVPYNVQW MAIFSEQLCV GFQSGFLRYP LNGEGNPYSM LHSNDHTLSF IAHQPMDAIC 1330 1340 1350 1360 1370 1380 AVEISSKEYL LCFNSIGIYT DCQGRRSRQQ ELMWPANPSS CCYNAPYLSV YSENAVDIFD 1390 1400 1410 1420 1430 1440 VNSMEWIQTL PLKKVRPLNN EGSLNLLGLE TIRLIYFKNK MAEGDELVVP ETSDNSRKQM 1450 1460 1470 1480 1490 1500 VRNINNKRRY SFRVPEEERM QQRREMLRDP EMRNKLISNP TNFNHIAHMG PGDGIQILKD 1510 1520 1530 1540 1550 1560 LPMNPRPQES RTVFSGSVSI PSITKSRPEP GRSMSASSGL SARSSAQNGS ALKREFSGGS 1570 1580 1590 1600 1610 1620 YSAKRQPMPS PSEGSLSSGG MDQGSDAPAR DFDGEDSDSP RHSTASNSSN LSSPPSPVSP 1630 RKTKSLSLES TDRGSWDP

References

[1]	"Plasmid tagging for efficient large-scale sequence completion of entire clone inserts." Fu G.K., Jackson A.A. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY166586 mRNA. Translation: AAN86031.1.
IPI	IPI00642165.
UniGene	Hs.35433.
3D structure databases
ProteinModelPortal	Q8IWQ7.
SMR	Q8IWQ7. Positions 11-409.
ModBase	Search...
Proteomic databases
PRIDE	Q8IWQ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000294133.
HOVERGEN	HBG055933.
Enzyme and pathway databases
SignaLink	Q8IWQ7.
Gene expression databases
ArrayExpress	Q8IWQ7.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR001180. Citron. IPR011009. Kinase-like_dom. IPR014930. Myotonic_dystrophy_kinase_coil. IPR000095. PAK_box_Rho-bd. IPR017892. Pkinase_C. IPR001849. Pleckstrin_homology. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR026611. Ser/Thr_kinase_MRCK. [Graphical view]
PANTHER	PTHR22988:SF2. PTHR22988:SF2. 1 hit.
Pfam	PF00130. C1_1. 1 hit. PF00780. CNH. 1 hit. PF08826. DMPK_coil. 1 hit. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
ProDom	PD011252. Myotonic_dystrophy_kinase_coil. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00109. C1. 1 hit. SM00036. CNH. 1 hit. SM00285. PBD. 1 hit. SM00233. PH. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS50219. CNH. 1 hit. PS50108. CRIB. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CDC42BPA. human.

Entry information

Entry name

Q8IWQ7_HUMAN

Accession

Primary (citable) accession number: Q8IWQ7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.