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Protein

Saitohin

Gene

STH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Was called 'saitohin' in honor of the late Tsuanao Saitoh and his laboratory.

GO - Biological processi

  • positive regulation of mRNA splicing, via spliceosome Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Saitohin
Gene namesi
Name:STH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000256762.1
HGNCiHGNC:18839 STH
MIMi607067 gene
neXtProtiNX_Q8IWL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi246744
OpenTargetsiENSG00000256762
PharmGKBiPA162405011

Polymorphism and mutation databases

BioMutaiSTH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722721 – 128SaitohinAdd BLAST128

Proteomic databases

PaxDbiQ8IWL8
PRIDEiQ8IWL8

PTM databases

iPTMnetiQ8IWL8
PhosphoSitePlusiQ8IWL8

Expressioni

Tissue specificityi

Highest expression in placenta, muscle, fetal brain, and adult brain, with lower expression in heart, kidney, stomach, testis, and adrenal gland. In the central nervous system, highest expression is in temporal lobe, hypothalamus, medulla and spinal cord, with lower expression in other brain regions.1 Publication

Gene expression databases

BgeeiENSG00000256762
CleanExiHS_STH
GenevisibleiQ8IWL8 HS

Interactioni

Subunit structurei

Interacts with PRDX6.1 Publication

Protein-protein interaction databases

BioGridi128918, 1 interactor
IntActiQ8IWL8, 14 interactors
STRINGi9606.ENSP00000443168

Structurei

3D structure databases

ProteinModelPortaliQ8IWL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00910000148294
HOVERGENiHBG057845
InParanoidiQ8IWL8
OrthoDBiEOG091G0NNQ
PhylomeDBiQ8IWL8

Sequencei

Sequence statusi: Complete.

Q8IWL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGGGQVSC IFAAPTRLCR WPALIECGVN LTQPLCEWMI QVARDRTLSL
60 70 80 90 100
AWEVASLLTL SSSEVGLEGV GTIWPSSYSS EESSRNGAEQ GRQLSIEGPF
110 120
QGQNCPSHPA AALPLPMRGE SQATSCQV
Length:128
Mass (Da):13,652
Last modified:March 1, 2003 - v1
Checksum:i6D14C8BE6C540F0D
GO

Polymorphismi

The Arg-7 polymorphism may be associated with progressive supranuclear palsy.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0195487Q → R3 PublicationsCorresponds to variant dbSNP:rs62063857Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179170 mRNA Translation: AAO03577.1
BC130319 mRNA Translation: AAI30320.1
BC130321 mRNA Translation: AAI30322.1
CCDSiCCDS54136.1
RefSeqiNP_001007533.1, NM_001007532.2
UniGeneiHs.661831

Genome annotation databases

EnsembliENST00000537309; ENSP00000443168; ENSG00000256762
GeneIDi246744
KEGGihsa:246744
UCSCiuc002ijy.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTH_HUMAN
AccessioniPrimary (citable) accession number: Q8IWL8
Secondary accession number(s): A1L3X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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