Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Saitohin

Gene

STH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32837-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Saitohin
Gene namesi
Name:STH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18839. STH.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi246744.
OpenTargetsiENSG00000256762.
PharmGKBiPA162405011.

Polymorphism and mutation databases

BioMutaiSTH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722721 – 128SaitohinAdd BLAST128

Proteomic databases

PaxDbiQ8IWL8.
PRIDEiQ8IWL8.

PTM databases

iPTMnetiQ8IWL8.
PhosphoSitePlusiQ8IWL8.

Expressioni

Tissue specificityi

Highest expression in placenta, muscle, fetal brain, and adult brain, with lower expression in heart, kidney, stomach, testis, and adrenal gland. In the central nervous system, highest expression is in temporal lobe, hypothalamus, medulla and spinal cord, with lower expression in other brain regions.1 Publication

Gene expression databases

BgeeiENSG00000256762.
CleanExiHS_STH.
GenevisibleiQ8IWL8. HS.

Interactioni

Subunit structurei

Interacts with PRDX6.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000443168.

Structurei

3D structure databases

ProteinModelPortaliQ8IWL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG057845.
InParanoidiQ8IWL8.
OrthoDBiEOG091G0NNQ.
PhylomeDBiQ8IWL8.

Sequencei

Sequence statusi: Complete.

Q8IWL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGGGQVSC IFAAPTRLCR WPALIECGVN LTQPLCEWMI QVARDRTLSL
60 70 80 90 100
AWEVASLLTL SSSEVGLEGV GTIWPSSYSS EESSRNGAEQ GRQLSIEGPF
110 120
QGQNCPSHPA AALPLPMRGE SQATSCQV
Length:128
Mass (Da):13,652
Last modified:March 1, 2003 - v1
Checksum:i6D14C8BE6C540F0D
GO

Polymorphismi

The Arg-7 polymorphism may be associated with progressive supranuclear palsy.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0195487Q → R.3 PublicationsCorresponds to variant rs62063857dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179170 mRNA. Translation: AAO03577.1.
BC130319 mRNA. Translation: AAI30320.1.
BC130321 mRNA. Translation: AAI30322.1.
CCDSiCCDS54136.1.
RefSeqiNP_001007533.1. NM_001007532.2.
UniGeneiHs.661831.

Genome annotation databases

EnsembliENST00000537309; ENSP00000443168; ENSG00000256762.
GeneIDi246744.
KEGGihsa:246744.
UCSCiuc002ijy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179170 mRNA. Translation: AAO03577.1.
BC130319 mRNA. Translation: AAI30320.1.
BC130321 mRNA. Translation: AAI30322.1.
CCDSiCCDS54136.1.
RefSeqiNP_001007533.1. NM_001007532.2.
UniGeneiHs.661831.

3D structure databases

ProteinModelPortaliQ8IWL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000443168.

PTM databases

iPTMnetiQ8IWL8.
PhosphoSitePlusiQ8IWL8.

Polymorphism and mutation databases

BioMutaiSTH.

Proteomic databases

PaxDbiQ8IWL8.
PRIDEiQ8IWL8.

Protocols and materials databases

DNASUi246744.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537309; ENSP00000443168; ENSG00000256762.
GeneIDi246744.
KEGGihsa:246744.
UCSCiuc002ijy.2. human.

Organism-specific databases

CTDi246744.
DisGeNETi246744.
GeneCardsiSTH.
HGNCiHGNC:18839. STH.
MIMi607067. gene.
neXtProtiNX_Q8IWL8.
OpenTargetsiENSG00000256762.
PharmGKBiPA162405011.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG057845.
InParanoidiQ8IWL8.
OrthoDBiEOG091G0NNQ.
PhylomeDBiQ8IWL8.

Enzyme and pathway databases

BioCyciZFISH:G66-32837-MONOMER.

Miscellaneous databases

GeneWikiiSTH_(gene).
GenomeRNAii246744.
PROiQ8IWL8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000256762.
CleanExiHS_STH.
GenevisibleiQ8IWL8. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSTH_HUMAN
AccessioniPrimary (citable) accession number: Q8IWL8
Secondary accession number(s): A1L3X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Was called 'saitohin' in honor of the late Tsuanao Saitoh and his laboratory.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.