Reviewed,
UniProtKB/Swiss-Prot Q8IWL3 (HSC20_HUMAN)
Last modified
June 16, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Co-chaperone protein HscB, mitochondrial Alternative name(s): DnaJ homolog subfamily C member 20 Short name=Hsc20 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 235 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May act as a co-chaperone in iron-sulfur cluster assembly in mitochondria. |
| Subcellular location | Mitochondrion Potential. |
| Tissue specificity | Liver, muscle and heart. Ref.1 |
| Sequence similarities | Belongs to the hscB family. Contains 1 J domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Coding sequence diversity | Polymorphism |
| Domain | Transit peptide |
| Molecular function | Chaperone |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrion Ref.1 Inferred from expression pattern. Source: HGNC |
| Molecular function | chaperone binding Inferred from electronic annotation. Source: InterPro heat shock protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 71 | 71 | Mitochondrion Potential | |||||||||||||||||||||||||||||
| Chain | 72 – 235 | 164 | Co-chaperone protein HscB, mitochondrial | PRO_0000007262 | ||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||
| Domain | 72 – 144 | 73 | J | |||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||
| Natural variant | 73 | 1 | Y → C: dbSNP rs17886090. | VAR_048916 | ||||||||||||||||||||||||||||
| Natural variant | 163 | 1 | I → M: dbSNP rs17884212. | VAR_048917 | ||||||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||||||
| Sequence conflict | 43 | 1 | N → S Ref.1 | |||||||||||||||||||||||||||||
| Sequence conflict | 43 | 1 | N → S Ref.3 | |||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||
| Beta strand | 42 – 44 | 3 | ||||||||||||||||||||||||||||||
| Turn | 59 – 61 | 3 | ||||||||||||||||||||||||||||||
| Helix | 73 – 76 | 4 | ||||||||||||||||||||||||||||||
| Helix | 87 – 101 | 15 | ||||||||||||||||||||||||||||||
| Helix | 103 – 106 | 4 | ||||||||||||||||||||||||||||||
| Helix | 111 – 132 | 22 | ||||||||||||||||||||||||||||||
| Helix | 134 – 144 | 11 | ||||||||||||||||||||||||||||||
| Beta strand | 154 – 157 | 4 | ||||||||||||||||||||||||||||||
| Helix | 159 – 174 | 16 | ||||||||||||||||||||||||||||||
| Helix | 178 – 204 | 27 | ||||||||||||||||||||||||||||||
| Helix | 208 – 231 | 24 | ||||||||||||||||||||||||||||||
| Turn | 232 – 234 | 3 | ||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a novel candidate gene in the iron-sulfur pathway implicated in ataxia-susceptibility: human gene encoding HscB, a J-type co-chaperone." Sun G., Gargus J.J., Ta D.T., Vickery L.E. J. Hum. Genet. 48:415-419(2003) [PubMed: 12938016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. Wright H.Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Placenta. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AY191719 mRNA. Translation: AAN85282.1. CR456462 mRNA. Translation: CAG30348.1. AL023494, AL117330 Genomic DNA. Translation: CAI20339.1. AL117330, AL023494 Genomic DNA. Translation: CAH73876.1. BC000004 mRNA. Translation: AAH00004.2. BC065569 mRNA. Translation: AAH65569.1. | |||||||||||||
| IPI | IPI00217313. | ||||||||||||
| RefSeq | NP_741999.3. | ||||||||||||
| UniGene | Hs.291363 Hs.632780 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q8IWL3. 3 interactions. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q8IWL3. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000100209. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 150274. | ||||||||||||
| KEGG | hsa:150274. | ||||||||||||
| NMPDR | fig|9606.3.peg.21472. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC22P027468. | ||||||||||||
| HGNC | HGNC:28913. HSCB. | ||||||||||||
| MIM | 608142. gene. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | Q8IWL3. | ||||||||||||
| HOVERGEN | Q8IWL3. | ||||||||||||
| OMA | Q8IWL3. LMRRMQF. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q8IWL3. | ||||||||||||
| Bgee | Q8IWL3. | ||||||||||||
| CleanEx | HS_HSCB. | ||||||||||||
| GermOnline | ENSG00000100209. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR001623. DnaJ_N. IPR009073. Heat_shock_cognate_B_oligo_C. IPR018253. Heat_shock_DnaJ_CS. IPR004640. HscB. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.10.287.110. DnaJ_N. 1 hit. G3DSA:1.20.1280.20. Heat_shock_cognate_B_oligo_C. 1 hit. | ||||||||||||
| Pfam | PF00226. DnaJ. 1 hit. PF07743. HSCB_C. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00271. DnaJ. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00714. hscB. 1 hit. | ||||||||||||
| PROSITE | PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. False negative. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 86381. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | HSC20_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8IWL3 Secondary accession number(s): Q9BWS7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


