SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IWL2

- SFTA1_HUMAN

UniProt

Q8IWL2 - SFTA1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pulmonary surfactant-associated protein A1
Gene
SFTPA1, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. lipid transporter activity Source: ProtInc

GO - Biological processi

  1. lipid transport Source: GOC
  2. respiratory gaseous exchange Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

ReactomeiREACT_23916. Signal regulatory protein (SIRP) family interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A1
Short name:
PSP-A
Short name:
PSPA
Short name:
SP-A
Short name:
SP-A1
Alternative name(s):
35 kDa pulmonary surfactant-associated protein
Alveolar proteinosis protein
Collectin-4
Gene namesi
Name:SFTPA1
Synonyms:COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:10798. SFTPA1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB-SubCell
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

Pathology & Biotechi

Involvement in diseasei

Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB.1 Publication

Organism-specific databases

MIMi178500. phenotype.
267450. phenotype.
Orphaneti2032. Idiopathic pulmonary fibrosis.
PharmGKBiPA35710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020
Add
BLAST
Chaini21 – 248228Pulmonary surfactant-associated protein A1
PRO_0000017457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211N-acetylglutamate; partial1 Publication
Disulfide bondi26 – 26Interchain Inferred
Modified residuei30 – 3014-hydroxyproline By similarity
Modified residuei33 – 3314-hydroxyproline By similarity
Modified residuei36 – 3614-hydroxyproline By similarity
Modified residuei42 – 4214-hydroxyproline By similarity
Modified residuei54 – 5414-hydroxyproline By similarity
Modified residuei57 – 5714-hydroxyproline By similarity
Modified residuei63 – 6314-hydroxyproline By similarity
Modified residuei67 – 6714-hydroxyproline By similarity
Modified residuei70 – 7014-hydroxyproline By similarity
Disulfide bondi155 ↔ 2461 Publication
Glycosylationi207 – 2071N-linked (GlcNAc...) Inferred
Disulfide bondi224 ↔ 2381 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ8IWL2.
PRIDEiQ8IWL2.

PTM databases

PhosphoSiteiQ8IWL2.

Expressioni

Gene expression databases

BgeeiQ8IWL2.
CleanExiHS_PSAP.
HS_SFTPA1B.
GenevestigatoriQ8IWL2.

Organism-specific databases

HPAiCAB016793.

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.

Protein-protein interaction databases

BioGridi575839. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8IWL2.
SMRiQ8IWL2. Positions 104-248.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10073Collagen-like
Add
BLAST
Domaini132 – 248117C-type lectin
Add
BLAST

Sequence similaritiesi

Belongs to the SFTPA family.

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG315755.
HOVERGENiHBG108270.
InParanoidiQ8IWL2.
KOiK10067.
OMAiEMYTDGK.
OrthoDBiEOG7HXCVB.
PhylomeDBiQ8IWL2.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWL2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWLCPLALNL ILMAASGAVC EVKDVCVGSP GIPGTPGSHG LPGRDGRDGL    50
KGDPGPPGPM GPPGEMPCPP GNDGLPGAPG IPGECGEKGE PGERGPPGLP 100
AHLDEELQAT LHDFRHQILQ TRGALSLQGS IMTVGEKVFS SNGQSITFDA 150
IQEACARAGG RIAVPRNPEE NEAIASFVKK YNTYAYVGLT EGPSPGDFRY 200
SDGTPVNYTN WYRGEPAGRG KEQCVEMYTD GQWNDRNCLY SRLTICEF 248
Length:248
Mass (Da):26,242
Last modified:March 1, 2005 - v2
Checksum:iAFFFCF38B87BE081
GO
Isoform 2 (identifier: Q8IWL2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPCQVPGAATGPRAM

Show »
Length:263
Mass (Da):27,736
Checksum:i39F4A2E09F3F0AC3
GO

Sequence cautioni

The sequence CAI16065.1 differs from that shown. Reason: Erroneous gene model prediction.

Polymorphismi

At least 5 allelic variants of SFTPA1 are known: 6A, 6A2, 6A3, 6A4 and 6A5. The sequence shown is that of allele 6A3.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51P → L.1 Publication
VAR_063517
Natural varianti9 – 91N → T.2 Publications
Corresponds to variant rs1059046 [ dbSNP | Ensembl ].
VAR_004184
Natural varianti19 – 191V → A in allele 6A and allele 6A(5). 4 Publications
Corresponds to variant rs1059047 [ dbSNP | Ensembl ].
VAR_021292
Natural varianti50 – 501L → V in allele 6A(2). 3 Publications
Corresponds to variant rs1136450 [ dbSNP | Ensembl ].
VAR_012231
Natural varianti219 – 2191R → W Associated with susceptibility to idiopathic pulmonary fibrosis in smokers; allele 6A(4) and allele 6A(5). 4 Publications
Corresponds to variant rs4253527 [ dbSNP | Ensembl ].
VAR_012232
Natural varianti223 – 2231Q → K.
Corresponds to variant rs1965708 [ dbSNP | Ensembl ].
VAR_012233

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRPCQVPGAATGPRAM in isoform 2.
VSP_046802

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451D → H in AAA36510. 1 Publication
Sequence conflicti54 – 541P → L in AAA36510. 1 Publication
Sequence conflicti100 – 1001P → R in AAA36510. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30838 Genomic DNA. Translation: AAA36510.1.
M13686 mRNA. Translation: AAA60211.1.
HQ021433 mRNA. Translation: ADO27676.1.
HQ021434 mRNA. Translation: ADO27677.1.
HQ021435 mRNA. Translation: ADO27678.1.
HQ021436 mRNA. Translation: ADO27679.1.
HQ021437 mRNA. Translation: ADO27680.1.
HQ021438 mRNA. Translation: ADO27681.1.
HQ021439 mRNA. Translation: ADO27682.1.
HQ021440 mRNA. Translation: ADO27683.1.
HQ021441 mRNA. Translation: ADO27684.1.
HQ021442 mRNA. Translation: ADO27685.1.
AK290703 mRNA. Translation: BAF83392.1.
AY198391 Genomic DNA. Translation: AAO13486.1.
BX248123 Genomic DNA. Translation: CAI16065.1. Sequence problems.
BX248123 Genomic DNA. Translation: CAI16066.1.
BX248123 Genomic DNA. Translation: CAI16067.1.
CH471083 Genomic DNA. Translation: EAW54657.1.
CH471083 Genomic DNA. Translation: EAW54651.1.
CH471083 Genomic DNA. Translation: EAW54658.1.
BC029913 mRNA. Translation: AAH29913.1.
BC111570 mRNA. Translation: AAI11571.1.
BC171875 mRNA. Translation: AAI71875.1.
CCDSiCCDS44444.2. [Q8IWL2-2]
CCDS44445.1. [Q8IWL2-1]
PIRiA24622. LNHUPS.
A25720. LNHUP6.
RefSeqiNP_001087239.2. NM_001093770.2. [Q8IWL2-2]
NP_001158116.1. NM_001164644.1. [Q8IWL2-1]
NP_001158119.1. NM_001164647.1. [Q8IWL2-1]
NP_005402.3. NM_005411.4. [Q8IWL2-1]
XP_005270119.1. XM_005270062.2. [Q8IWL2-1]
XP_006718016.1. XM_006717953.1. [Q8IWL2-2]
UniGeneiHs.535295.
Hs.745476.

Genome annotation databases

EnsembliENST00000398636; ENSP00000381633; ENSG00000122852. [Q8IWL2-1]
ENST00000419470; ENSP00000397082; ENSG00000122852. [Q8IWL2-2]
ENST00000428376; ENSP00000411102; ENSG00000122852. [Q8IWL2-1]
ENST00000429958; ENSP00000395527; ENSG00000122852.
ENST00000439264; ENSP00000401649; ENSG00000122852.
GeneIDi653509.
KEGGihsa:653509.
UCSCiuc001kap.3. human. [Q8IWL2-1]
uc009xry.3. human.

Polymorphism databases

DMDMi60416440.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-A1

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30838 Genomic DNA. Translation: AAA36510.1 .
M13686 mRNA. Translation: AAA60211.1 .
HQ021433 mRNA. Translation: ADO27676.1 .
HQ021434 mRNA. Translation: ADO27677.1 .
HQ021435 mRNA. Translation: ADO27678.1 .
HQ021436 mRNA. Translation: ADO27679.1 .
HQ021437 mRNA. Translation: ADO27680.1 .
HQ021438 mRNA. Translation: ADO27681.1 .
HQ021439 mRNA. Translation: ADO27682.1 .
HQ021440 mRNA. Translation: ADO27683.1 .
HQ021441 mRNA. Translation: ADO27684.1 .
HQ021442 mRNA. Translation: ADO27685.1 .
AK290703 mRNA. Translation: BAF83392.1 .
AY198391 Genomic DNA. Translation: AAO13486.1 .
BX248123 Genomic DNA. Translation: CAI16065.1 . Sequence problems.
BX248123 Genomic DNA. Translation: CAI16066.1 .
BX248123 Genomic DNA. Translation: CAI16067.1 .
CH471083 Genomic DNA. Translation: EAW54657.1 .
CH471083 Genomic DNA. Translation: EAW54651.1 .
CH471083 Genomic DNA. Translation: EAW54658.1 .
BC029913 mRNA. Translation: AAH29913.1 .
BC111570 mRNA. Translation: AAI11571.1 .
BC171875 mRNA. Translation: AAI71875.1 .
CCDSi CCDS44444.2. [Q8IWL2-2 ]
CCDS44445.1. [Q8IWL2-1 ]
PIRi A24622. LNHUPS.
A25720. LNHUP6.
RefSeqi NP_001087239.2. NM_001093770.2. [Q8IWL2-2 ]
NP_001158116.1. NM_001164644.1. [Q8IWL2-1 ]
NP_001158119.1. NM_001164647.1. [Q8IWL2-1 ]
NP_005402.3. NM_005411.4. [Q8IWL2-1 ]
XP_005270119.1. XM_005270062.2. [Q8IWL2-1 ]
XP_006718016.1. XM_006717953.1. [Q8IWL2-2 ]
UniGenei Hs.535295.
Hs.745476.

3D structure databases

ProteinModelPortali Q8IWL2.
SMRi Q8IWL2. Positions 104-248.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 575839. 2 interactions.

PTM databases

PhosphoSitei Q8IWL2.

Polymorphism databases

DMDMi 60416440.

Proteomic databases

PaxDbi Q8IWL2.
PRIDEi Q8IWL2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398636 ; ENSP00000381633 ; ENSG00000122852 . [Q8IWL2-1 ]
ENST00000419470 ; ENSP00000397082 ; ENSG00000122852 . [Q8IWL2-2 ]
ENST00000428376 ; ENSP00000411102 ; ENSG00000122852 . [Q8IWL2-1 ]
ENST00000429958 ; ENSP00000395527 ; ENSG00000122852 .
ENST00000439264 ; ENSP00000401649 ; ENSG00000122852 .
GeneIDi 653509.
KEGGi hsa:653509.
UCSCi uc001kap.3. human. [Q8IWL2-1 ]
uc009xry.3. human.

Organism-specific databases

CTDi 653509.
GeneCardsi GC10P081384.
HGNCi HGNC:10798. SFTPA1.
HPAi CAB016793.
MIMi 178500. phenotype.
178630. gene.
267450. phenotype.
neXtProti NX_Q8IWL2.
Orphaneti 2032. Idiopathic pulmonary fibrosis.
PharmGKBi PA35710.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315755.
HOVERGENi HBG108270.
InParanoidi Q8IWL2.
KOi K10067.
OMAi EMYTDGK.
OrthoDBi EOG7HXCVB.
PhylomeDBi Q8IWL2.
TreeFami TF330481.

Enzyme and pathway databases

Reactomei REACT_23916. Signal regulatory protein (SIRP) family interactions.

Miscellaneous databases

GeneWikii Pulmonary_surfactant-associated_protein_A1.
GenomeRNAii 653509.
NextBioi 123347.
PROi Q8IWL2.
SOURCEi Search...

Gene expression databases

Bgeei Q8IWL2.
CleanExi HS_PSAP.
HS_SFTPA1B.
Genevestigatori Q8IWL2.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view ]
Pfami PF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the human pulmonary surfactant apoprotein gene."
    White R.T., Damm D., Miller J., Spratt K., Schilling J., Hawgood S., Benson B., Cordell B.
    Nature 317:361-363(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein."
    Floros J., Steinbrink R., Jacobs K., Phelps D., Kriz R., Recny M., Sultzman L., Jones S., Taeusch H.W., Frank H.A., Fritsch E.F.
    J. Biol. Chem. 261:9029-9033(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-19, ACETYLATION AT GLU-21.
  3. "Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene."
    Silveyra P., Wang G., Floros J.
    Am. J. Physiol. 299:L523-L534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-19; VAL-50 AND TRP-219.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. SeattleSNPs variation discovery resource
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-9; ALA-19; VAL-50 AND TRP-219.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Studies of the structure of lung surfactant protein SP-A."
    Haagsman H.P., White R.T., Schilling J., Lau K., Benson B.J., Golden J., Hawgood S., Clements J.A.
    Am. J. Physiol. 257:L421-L429(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  10. "Genetics of the hydrophilic surfactant proteins A and D."
    Floros J., Hoover R.R.
    Biochim. Biophys. Acta 1408:312-322(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEFINITION OF SFTPA1 ALLELES.
  11. "Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population."
    Raemet M., Haataja R., Marttila R., Floros J., Hallman M.
    Am. J. Hum. Genet. 66:1569-1579(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RDS.
  12. "Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis."
    Selman M., Lin H.-M., Montano M., Jenkins A.L., Estrada A., Lin Z., Wang G., DiAngelo S.L., Guo X., Umstead T.M., Lang C.M., Pardo A., Phelps D.S., Floros J.
    Hum. Genet. 113:542-550(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TRP-219, ASSOCIATION WITH IDIOPATHIC PULMONARY FIBROSIS.
  13. "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."
    Wang Y., Kuan P.J., Xing C., Cronkhite J.T., Torres F., Rosenblatt R.L., DiMaio J.M., Kinch L.N., Grishin N.V., Garcia C.K.
    Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LEU-5; THR-9; ALA-19; VAL-50 AND TRP-219.

Entry informationi

Entry nameiSFTA1_HUMAN
AccessioniPrimary (citable) accession number: Q8IWL2
Secondary accession number(s): A8K3T8
, B7ZW50, E3VLD8, E3VLD9, E3VLE0, E3VLE1, G5E9J3, P07714, Q14DV4, Q5RIR5, Q5RIR7, Q6PIT0, Q8TC19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi