Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pulmonary surfactant-associated protein A1

Gene

SFTPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. lipid transporter activity Source: ProtInc

GO - Biological processi

  1. lipid transport Source: GOC
  2. respiratory gaseous exchange Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

ReactomeiREACT_23916. Signal regulatory protein (SIRP) family interactions.
REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
REACT_8005. Toll Like Receptor TLR1:TLR2 Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A1
Short name:
PSP-A
Short name:
PSPA
Short name:
SP-A
Short name:
SP-A1
Alternative name(s):
35 kDa pulmonary surfactant-associated protein
Alveolar proteinosis protein
Collectin-4
Gene namesi
Name:SFTPA1
Synonyms:COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:10798. SFTPA1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB-SubCell
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

Pathology & Biotechi

Involvement in diseasei

Pulmonary fibrosis, idiopathic

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.

See also OMIM:178500
Respiratory distress syndrome in premature infants1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB.

Disease descriptionA lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.

See also OMIM:267450

Organism-specific databases

MIMi178500. phenotype.
267450. phenotype.
Orphaneti2032. Idiopathic pulmonary fibrosis.
PharmGKBiPA35710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 248228Pulmonary surfactant-associated protein A1PRO_0000017457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211N-acetylglutamate; partial1 Publication
Disulfide bondi26 – 26Interchain1 Publication
Modified residuei30 – 3014-hydroxyprolineBy similarity
Modified residuei33 – 3314-hydroxyprolineBy similarity
Modified residuei36 – 3614-hydroxyprolineBy similarity
Modified residuei42 – 4214-hydroxyprolineBy similarity
Modified residuei54 – 5414-hydroxyprolineBy similarity
Modified residuei57 – 5714-hydroxyprolineBy similarity
Modified residuei63 – 6314-hydroxyprolineBy similarity
Modified residuei67 – 6714-hydroxyprolineBy similarity
Modified residuei70 – 7014-hydroxyprolineBy similarity
Disulfide bondi155 ↔ 2461 PublicationPROSITE-ProRule annotation
Glycosylationi207 – 2071N-linked (GlcNAc...)Curated
Disulfide bondi224 ↔ 2381 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ8IWL2.
PRIDEiQ8IWL2.

PTM databases

PhosphoSiteiQ8IWL2.

Expressioni

Gene expression databases

BgeeiQ8IWL2.
CleanExiHS_PSAP.
HS_SFTPA1B.
ExpressionAtlasiQ8IWL2. baseline.
GenevestigatoriQ8IWL2.

Organism-specific databases

HPAiCAB016793.

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.

Protein-protein interaction databases

BioGridi575839. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8IWL2.
SMRiQ8IWL2. Positions 53-80, 104-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10073Collagen-likeAdd
BLAST
Domaini132 – 248117C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SFTPA family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG315755.
GeneTreeiENSGT00700000104102.
HOVERGENiHBG108270.
InParanoidiQ8IWL2.
KOiK10067.
OMAiSLQGSML.
OrthoDBiEOG7HXCVB.
PhylomeDBiQ8IWL2.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWL2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLCPLALNL ILMAASGAVC EVKDVCVGSP GIPGTPGSHG LPGRDGRDGL
60 70 80 90 100
KGDPGPPGPM GPPGEMPCPP GNDGLPGAPG IPGECGEKGE PGERGPPGLP
110 120 130 140 150
AHLDEELQAT LHDFRHQILQ TRGALSLQGS IMTVGEKVFS SNGQSITFDA
160 170 180 190 200
IQEACARAGG RIAVPRNPEE NEAIASFVKK YNTYAYVGLT EGPSPGDFRY
210 220 230 240
SDGTPVNYTN WYRGEPAGRG KEQCVEMYTD GQWNDRNCLY SRLTICEF
Length:248
Mass (Da):26,242
Last modified:March 1, 2005 - v2
Checksum:iAFFFCF38B87BE081
GO
Isoform 2 (identifier: Q8IWL2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPCQVPGAATGPRAM

Show »
Length:263
Mass (Da):27,736
Checksum:i39F4A2E09F3F0AC3
GO

Sequence cautioni

The sequence CAI16065.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451D → H in AAA36510. (PubMed:2995821)Curated
Sequence conflicti54 – 541P → L in AAA36510. (PubMed:2995821)Curated
Sequence conflicti100 – 1001P → R in AAA36510. (PubMed:2995821)Curated

Polymorphismi

At least 5 allelic variants of SFTPA1 are known: 6A, 6A2, 6A3, 6A4 and 6A5. The sequence shown is that of allele 6A3.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51P → L.1 Publication
VAR_063517
Natural varianti9 – 91N → T.2 Publications
Corresponds to variant rs1059046 [ dbSNP | Ensembl ].
VAR_004184
Natural varianti19 – 191V → A in allele 6A and allele 6A(5). 4 Publications
Corresponds to variant rs1059047 [ dbSNP | Ensembl ].
VAR_021292
Natural varianti50 – 501L → V in allele 6A(2). 3 Publications
Corresponds to variant rs1136450 [ dbSNP | Ensembl ].
VAR_012231
Natural varianti219 – 2191R → W Associated with susceptibility to idiopathic pulmonary fibrosis in smokers; allele 6A(4) and allele 6A(5). 4 Publications
Corresponds to variant rs4253527 [ dbSNP | Ensembl ].
VAR_012232
Natural varianti223 – 2231Q → K.
Corresponds to variant rs1965708 [ dbSNP | Ensembl ].
VAR_012233

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRPCQVPGAATGPRAM in isoform 2. CuratedVSP_046802

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30838 Genomic DNA. Translation: AAA36510.1.
M13686 mRNA. Translation: AAA60211.1.
HQ021433 mRNA. Translation: ADO27676.1.
HQ021434 mRNA. Translation: ADO27677.1.
HQ021435 mRNA. Translation: ADO27678.1.
HQ021436 mRNA. Translation: ADO27679.1.
HQ021437 mRNA. Translation: ADO27680.1.
HQ021438 mRNA. Translation: ADO27681.1.
HQ021439 mRNA. Translation: ADO27682.1.
HQ021440 mRNA. Translation: ADO27683.1.
HQ021441 mRNA. Translation: ADO27684.1.
HQ021442 mRNA. Translation: ADO27685.1.
AK290703 mRNA. Translation: BAF83392.1.
AY198391 Genomic DNA. Translation: AAO13486.1.
BX248123 Genomic DNA. Translation: CAI16065.1. Sequence problems.
BX248123 Genomic DNA. Translation: CAI16066.1.
BX248123 Genomic DNA. Translation: CAI16067.1.
CH471083 Genomic DNA. Translation: EAW54657.1.
CH471083 Genomic DNA. Translation: EAW54651.1.
CH471083 Genomic DNA. Translation: EAW54658.1.
BC029913 mRNA. Translation: AAH29913.1.
BC111570 mRNA. Translation: AAI11571.1.
BC171875 mRNA. Translation: AAI71875.1.
CCDSiCCDS44444.2. [Q8IWL2-2]
CCDS44445.1. [Q8IWL2-1]
PIRiA24622. LNHUPS.
A25720. LNHUP6.
RefSeqiNP_001087239.2. NM_001093770.2. [Q8IWL2-2]
NP_001158116.1. NM_001164644.1. [Q8IWL2-1]
NP_001158119.1. NM_001164647.1. [Q8IWL2-1]
NP_005402.3. NM_005411.4. [Q8IWL2-1]
XP_005270119.1. XM_005270062.2. [Q8IWL2-1]
XP_006718016.1. XM_006717953.1. [Q8IWL2-2]
UniGeneiHs.535295.
Hs.745476.

Genome annotation databases

EnsembliENST00000398636; ENSP00000381633; ENSG00000122852. [Q8IWL2-1]
ENST00000419470; ENSP00000397082; ENSG00000122852. [Q8IWL2-2]
ENST00000428376; ENSP00000411102; ENSG00000122852. [Q8IWL2-1]
ENST00000429958; ENSP00000395527; ENSG00000122852.
ENST00000439264; ENSP00000401649; ENSG00000122852.
GeneIDi653509.
KEGGihsa:653509.
UCSCiuc001kap.3. human. [Q8IWL2-1]
uc009xry.3. human.

Polymorphism databases

DMDMi60416440.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-A1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30838 Genomic DNA. Translation: AAA36510.1.
M13686 mRNA. Translation: AAA60211.1.
HQ021433 mRNA. Translation: ADO27676.1.
HQ021434 mRNA. Translation: ADO27677.1.
HQ021435 mRNA. Translation: ADO27678.1.
HQ021436 mRNA. Translation: ADO27679.1.
HQ021437 mRNA. Translation: ADO27680.1.
HQ021438 mRNA. Translation: ADO27681.1.
HQ021439 mRNA. Translation: ADO27682.1.
HQ021440 mRNA. Translation: ADO27683.1.
HQ021441 mRNA. Translation: ADO27684.1.
HQ021442 mRNA. Translation: ADO27685.1.
AK290703 mRNA. Translation: BAF83392.1.
AY198391 Genomic DNA. Translation: AAO13486.1.
BX248123 Genomic DNA. Translation: CAI16065.1. Sequence problems.
BX248123 Genomic DNA. Translation: CAI16066.1.
BX248123 Genomic DNA. Translation: CAI16067.1.
CH471083 Genomic DNA. Translation: EAW54657.1.
CH471083 Genomic DNA. Translation: EAW54651.1.
CH471083 Genomic DNA. Translation: EAW54658.1.
BC029913 mRNA. Translation: AAH29913.1.
BC111570 mRNA. Translation: AAI11571.1.
BC171875 mRNA. Translation: AAI71875.1.
CCDSiCCDS44444.2. [Q8IWL2-2]
CCDS44445.1. [Q8IWL2-1]
PIRiA24622. LNHUPS.
A25720. LNHUP6.
RefSeqiNP_001087239.2. NM_001093770.2. [Q8IWL2-2]
NP_001158116.1. NM_001164644.1. [Q8IWL2-1]
NP_001158119.1. NM_001164647.1. [Q8IWL2-1]
NP_005402.3. NM_005411.4. [Q8IWL2-1]
XP_005270119.1. XM_005270062.2. [Q8IWL2-1]
XP_006718016.1. XM_006717953.1. [Q8IWL2-2]
UniGeneiHs.535295.
Hs.745476.

3D structure databases

ProteinModelPortaliQ8IWL2.
SMRiQ8IWL2. Positions 53-80, 104-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575839. 2 interactions.

PTM databases

PhosphoSiteiQ8IWL2.

Polymorphism databases

DMDMi60416440.

Proteomic databases

PaxDbiQ8IWL2.
PRIDEiQ8IWL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398636; ENSP00000381633; ENSG00000122852. [Q8IWL2-1]
ENST00000419470; ENSP00000397082; ENSG00000122852. [Q8IWL2-2]
ENST00000428376; ENSP00000411102; ENSG00000122852. [Q8IWL2-1]
ENST00000429958; ENSP00000395527; ENSG00000122852.
ENST00000439264; ENSP00000401649; ENSG00000122852.
GeneIDi653509.
KEGGihsa:653509.
UCSCiuc001kap.3. human. [Q8IWL2-1]
uc009xry.3. human.

Organism-specific databases

CTDi653509.
GeneCardsiGC10P081509.
HGNCiHGNC:10798. SFTPA1.
HPAiCAB016793.
MIMi178500. phenotype.
178630. gene.
267450. phenotype.
neXtProtiNX_Q8IWL2.
Orphaneti2032. Idiopathic pulmonary fibrosis.
PharmGKBiPA35710.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG315755.
GeneTreeiENSGT00700000104102.
HOVERGENiHBG108270.
InParanoidiQ8IWL2.
KOiK10067.
OMAiSLQGSML.
OrthoDBiEOG7HXCVB.
PhylomeDBiQ8IWL2.
TreeFamiTF330481.

Enzyme and pathway databases

ReactomeiREACT_23916. Signal regulatory protein (SIRP) family interactions.
REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
REACT_8005. Toll Like Receptor TLR1:TLR2 Cascade.

Miscellaneous databases

GeneWikiiPulmonary_surfactant-associated_protein_A1.
GenomeRNAii653509.
NextBioi123347.
PROiQ8IWL2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IWL2.
CleanExiHS_PSAP.
HS_SFTPA1B.
ExpressionAtlasiQ8IWL2. baseline.
GenevestigatoriQ8IWL2.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the human pulmonary surfactant apoprotein gene."
    White R.T., Damm D., Miller J., Spratt K., Schilling J., Hawgood S., Benson B., Cordell B.
    Nature 317:361-363(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein."
    Floros J., Steinbrink R., Jacobs K., Phelps D., Kriz R., Recny M., Sultzman L., Jones S., Taeusch H.W., Frank H.A., Fritsch E.F.
    J. Biol. Chem. 261:9029-9033(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-19, ACETYLATION AT GLU-21.
  3. "Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene."
    Silveyra P., Wang G., Floros J.
    Am. J. Physiol. 299:L523-L534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-19; VAL-50 AND TRP-219.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. SeattleSNPs variation discovery resource
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-9; ALA-19; VAL-50 AND TRP-219.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Studies of the structure of lung surfactant protein SP-A."
    Haagsman H.P., White R.T., Schilling J., Lau K., Benson B.J., Golden J., Hawgood S., Clements J.A.
    Am. J. Physiol. 257:L421-L429(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  10. "Genetics of the hydrophilic surfactant proteins A and D."
    Floros J., Hoover R.R.
    Biochim. Biophys. Acta 1408:312-322(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEFINITION OF SFTPA1 ALLELES.
  11. "Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population."
    Raemet M., Haataja R., Marttila R., Floros J., Hallman M.
    Am. J. Hum. Genet. 66:1569-1579(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RDS.
  12. "Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis."
    Selman M., Lin H.-M., Montano M., Jenkins A.L., Estrada A., Lin Z., Wang G., DiAngelo S.L., Guo X., Umstead T.M., Lang C.M., Pardo A., Phelps D.S., Floros J.
    Hum. Genet. 113:542-550(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TRP-219, ASSOCIATION WITH IDIOPATHIC PULMONARY FIBROSIS.
  13. "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."
    Wang Y., Kuan P.J., Xing C., Cronkhite J.T., Torres F., Rosenblatt R.L., DiMaio J.M., Kinch L.N., Grishin N.V., Garcia C.K.
    Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LEU-5; THR-9; ALA-19; VAL-50 AND TRP-219.

Entry informationi

Entry nameiSFTA1_HUMAN
AccessioniPrimary (citable) accession number: Q8IWL2
Secondary accession number(s): A8K3T8
, B7ZW50, E3VLD8, E3VLD9, E3VLE0, E3VLE1, G5E9J3, P07714, Q14DV4, Q5RIR5, Q5RIR7, Q6PIT0, Q8TC19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: March 1, 2005
Last modified: January 7, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.