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Q8IWL2

- SFTA1_HUMAN

UniProt

Q8IWL2 - SFTA1_HUMAN

Protein

Pulmonary surfactant-associated protein A1

Gene

SFTPA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. lipid transporter activity Source: ProtInc

    GO - Biological processi

    1. lipid transport Source: GOC
    2. respiratory gaseous exchange Source: UniProtKB-KW

    Keywords - Biological processi

    Gaseous exchange

    Keywords - Ligandi

    Calcium, Lectin

    Enzyme and pathway databases

    ReactomeiREACT_23916. Signal regulatory protein (SIRP) family interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pulmonary surfactant-associated protein A1
    Short name:
    PSP-A
    Short name:
    PSPA
    Short name:
    SP-A
    Short name:
    SP-A1
    Alternative name(s):
    35 kDa pulmonary surfactant-associated protein
    Alveolar proteinosis protein
    Collectin-4
    Gene namesi
    Name:SFTPA1
    Synonyms:COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:10798. SFTPA1.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProtKB-SubCell
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted, Surface film

    Pathology & Biotechi

    Involvement in diseasei

    Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB.

    Organism-specific databases

    MIMi178500. phenotype.
    267450. phenotype.
    Orphaneti2032. Idiopathic pulmonary fibrosis.
    PharmGKBiPA35710.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 248228Pulmonary surfactant-associated protein A1PRO_0000017457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211N-acetylglutamate; partial1 Publication
    Disulfide bondi26 – 26Interchain1 Publication
    Modified residuei30 – 3014-hydroxyprolineBy similarity
    Modified residuei33 – 3314-hydroxyprolineBy similarity
    Modified residuei36 – 3614-hydroxyprolineBy similarity
    Modified residuei42 – 4214-hydroxyprolineBy similarity
    Modified residuei54 – 5414-hydroxyprolineBy similarity
    Modified residuei57 – 5714-hydroxyprolineBy similarity
    Modified residuei63 – 6314-hydroxyprolineBy similarity
    Modified residuei67 – 6714-hydroxyprolineBy similarity
    Modified residuei70 – 7014-hydroxyprolineBy similarity
    Disulfide bondi155 ↔ 2461 PublicationPROSITE-ProRule annotation
    Glycosylationi207 – 2071N-linked (GlcNAc...)Curated
    Disulfide bondi224 ↔ 2381 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    PaxDbiQ8IWL2.
    PRIDEiQ8IWL2.

    PTM databases

    PhosphoSiteiQ8IWL2.

    Expressioni

    Gene expression databases

    BgeeiQ8IWL2.
    CleanExiHS_PSAP.
    HS_SFTPA1B.
    GenevestigatoriQ8IWL2.

    Organism-specific databases

    HPAiCAB016793.

    Interactioni

    Subunit structurei

    Oligomeric complex of 6 set of homotrimers.

    Protein-protein interaction databases

    BioGridi575839. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWL2.
    SMRiQ8IWL2. Positions 104-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 10073Collagen-likeAdd
    BLAST
    Domaini132 – 248117C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SFTPA family.Curated
    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Signal

    Phylogenomic databases

    eggNOGiNOG315755.
    HOVERGENiHBG108270.
    InParanoidiQ8IWL2.
    KOiK10067.
    OMAiEMYTDGK.
    OrthoDBiEOG7HXCVB.
    PhylomeDBiQ8IWL2.
    TreeFamiTF330481.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    [Graphical view]
    PfamiPF01391. Collagen. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWL2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWLCPLALNL ILMAASGAVC EVKDVCVGSP GIPGTPGSHG LPGRDGRDGL    50
    KGDPGPPGPM GPPGEMPCPP GNDGLPGAPG IPGECGEKGE PGERGPPGLP 100
    AHLDEELQAT LHDFRHQILQ TRGALSLQGS IMTVGEKVFS SNGQSITFDA 150
    IQEACARAGG RIAVPRNPEE NEAIASFVKK YNTYAYVGLT EGPSPGDFRY 200
    SDGTPVNYTN WYRGEPAGRG KEQCVEMYTD GQWNDRNCLY SRLTICEF 248
    Length:248
    Mass (Da):26,242
    Last modified:March 1, 2005 - v2
    Checksum:iAFFFCF38B87BE081
    GO
    Isoform 2 (identifier: Q8IWL2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRPCQVPGAATGPRAM

    Show »
    Length:263
    Mass (Da):27,736
    Checksum:i39F4A2E09F3F0AC3
    GO

    Sequence cautioni

    The sequence CAI16065.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451D → H in AAA36510. (PubMed:2995821)Curated
    Sequence conflicti54 – 541P → L in AAA36510. (PubMed:2995821)Curated
    Sequence conflicti100 – 1001P → R in AAA36510. (PubMed:2995821)Curated

    Polymorphismi

    At least 5 allelic variants of SFTPA1 are known: 6A, 6A2, 6A3, 6A4 and 6A5. The sequence shown is that of allele 6A3.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51P → L.1 Publication
    VAR_063517
    Natural varianti9 – 91N → T.2 Publications
    Corresponds to variant rs1059046 [ dbSNP | Ensembl ].
    VAR_004184
    Natural varianti19 – 191V → A in allele 6A and allele 6A(5). 4 Publications
    Corresponds to variant rs1059047 [ dbSNP | Ensembl ].
    VAR_021292
    Natural varianti50 – 501L → V in allele 6A(2). 3 Publications
    Corresponds to variant rs1136450 [ dbSNP | Ensembl ].
    VAR_012231
    Natural varianti219 – 2191R → W Associated with susceptibility to idiopathic pulmonary fibrosis in smokers; allele 6A(4) and allele 6A(5). 4 Publications
    Corresponds to variant rs4253527 [ dbSNP | Ensembl ].
    VAR_012232
    Natural varianti223 – 2231Q → K.
    Corresponds to variant rs1965708 [ dbSNP | Ensembl ].
    VAR_012233

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MRPCQVPGAATGPRAM in isoform 2. CuratedVSP_046802

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30838 Genomic DNA. Translation: AAA36510.1.
    M13686 mRNA. Translation: AAA60211.1.
    HQ021433 mRNA. Translation: ADO27676.1.
    HQ021434 mRNA. Translation: ADO27677.1.
    HQ021435 mRNA. Translation: ADO27678.1.
    HQ021436 mRNA. Translation: ADO27679.1.
    HQ021437 mRNA. Translation: ADO27680.1.
    HQ021438 mRNA. Translation: ADO27681.1.
    HQ021439 mRNA. Translation: ADO27682.1.
    HQ021440 mRNA. Translation: ADO27683.1.
    HQ021441 mRNA. Translation: ADO27684.1.
    HQ021442 mRNA. Translation: ADO27685.1.
    AK290703 mRNA. Translation: BAF83392.1.
    AY198391 Genomic DNA. Translation: AAO13486.1.
    BX248123 Genomic DNA. Translation: CAI16065.1. Sequence problems.
    BX248123 Genomic DNA. Translation: CAI16066.1.
    BX248123 Genomic DNA. Translation: CAI16067.1.
    CH471083 Genomic DNA. Translation: EAW54657.1.
    CH471083 Genomic DNA. Translation: EAW54651.1.
    CH471083 Genomic DNA. Translation: EAW54658.1.
    BC029913 mRNA. Translation: AAH29913.1.
    BC111570 mRNA. Translation: AAI11571.1.
    BC171875 mRNA. Translation: AAI71875.1.
    CCDSiCCDS44444.2. [Q8IWL2-2]
    CCDS44445.1. [Q8IWL2-1]
    PIRiA24622. LNHUPS.
    A25720. LNHUP6.
    RefSeqiNP_001087239.2. NM_001093770.2. [Q8IWL2-2]
    NP_001158116.1. NM_001164644.1. [Q8IWL2-1]
    NP_001158119.1. NM_001164647.1. [Q8IWL2-1]
    NP_005402.3. NM_005411.4. [Q8IWL2-1]
    XP_005270119.1. XM_005270062.2. [Q8IWL2-1]
    XP_006718016.1. XM_006717953.1. [Q8IWL2-2]
    UniGeneiHs.535295.
    Hs.745476.

    Genome annotation databases

    EnsembliENST00000398636; ENSP00000381633; ENSG00000122852. [Q8IWL2-1]
    ENST00000419470; ENSP00000397082; ENSG00000122852. [Q8IWL2-2]
    ENST00000428376; ENSP00000411102; ENSG00000122852. [Q8IWL2-1]
    ENST00000429958; ENSP00000395527; ENSG00000122852.
    ENST00000439264; ENSP00000401649; ENSG00000122852.
    GeneIDi653509.
    KEGGihsa:653509.
    UCSCiuc001kap.3. human. [Q8IWL2-1]
    uc009xry.3. human.

    Polymorphism databases

    DMDMi60416440.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs
    Functional Glycomics Gateway - Glycan Binding

    Pulmonary surfactant protein SP-A1

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30838 Genomic DNA. Translation: AAA36510.1 .
    M13686 mRNA. Translation: AAA60211.1 .
    HQ021433 mRNA. Translation: ADO27676.1 .
    HQ021434 mRNA. Translation: ADO27677.1 .
    HQ021435 mRNA. Translation: ADO27678.1 .
    HQ021436 mRNA. Translation: ADO27679.1 .
    HQ021437 mRNA. Translation: ADO27680.1 .
    HQ021438 mRNA. Translation: ADO27681.1 .
    HQ021439 mRNA. Translation: ADO27682.1 .
    HQ021440 mRNA. Translation: ADO27683.1 .
    HQ021441 mRNA. Translation: ADO27684.1 .
    HQ021442 mRNA. Translation: ADO27685.1 .
    AK290703 mRNA. Translation: BAF83392.1 .
    AY198391 Genomic DNA. Translation: AAO13486.1 .
    BX248123 Genomic DNA. Translation: CAI16065.1 . Sequence problems.
    BX248123 Genomic DNA. Translation: CAI16066.1 .
    BX248123 Genomic DNA. Translation: CAI16067.1 .
    CH471083 Genomic DNA. Translation: EAW54657.1 .
    CH471083 Genomic DNA. Translation: EAW54651.1 .
    CH471083 Genomic DNA. Translation: EAW54658.1 .
    BC029913 mRNA. Translation: AAH29913.1 .
    BC111570 mRNA. Translation: AAI11571.1 .
    BC171875 mRNA. Translation: AAI71875.1 .
    CCDSi CCDS44444.2. [Q8IWL2-2 ]
    CCDS44445.1. [Q8IWL2-1 ]
    PIRi A24622. LNHUPS.
    A25720. LNHUP6.
    RefSeqi NP_001087239.2. NM_001093770.2. [Q8IWL2-2 ]
    NP_001158116.1. NM_001164644.1. [Q8IWL2-1 ]
    NP_001158119.1. NM_001164647.1. [Q8IWL2-1 ]
    NP_005402.3. NM_005411.4. [Q8IWL2-1 ]
    XP_005270119.1. XM_005270062.2. [Q8IWL2-1 ]
    XP_006718016.1. XM_006717953.1. [Q8IWL2-2 ]
    UniGenei Hs.535295.
    Hs.745476.

    3D structure databases

    ProteinModelPortali Q8IWL2.
    SMRi Q8IWL2. Positions 104-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 575839. 2 interactions.

    PTM databases

    PhosphoSitei Q8IWL2.

    Polymorphism databases

    DMDMi 60416440.

    Proteomic databases

    PaxDbi Q8IWL2.
    PRIDEi Q8IWL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398636 ; ENSP00000381633 ; ENSG00000122852 . [Q8IWL2-1 ]
    ENST00000419470 ; ENSP00000397082 ; ENSG00000122852 . [Q8IWL2-2 ]
    ENST00000428376 ; ENSP00000411102 ; ENSG00000122852 . [Q8IWL2-1 ]
    ENST00000429958 ; ENSP00000395527 ; ENSG00000122852 .
    ENST00000439264 ; ENSP00000401649 ; ENSG00000122852 .
    GeneIDi 653509.
    KEGGi hsa:653509.
    UCSCi uc001kap.3. human. [Q8IWL2-1 ]
    uc009xry.3. human.

    Organism-specific databases

    CTDi 653509.
    GeneCardsi GC10P081384.
    HGNCi HGNC:10798. SFTPA1.
    HPAi CAB016793.
    MIMi 178500. phenotype.
    178630. gene.
    267450. phenotype.
    neXtProti NX_Q8IWL2.
    Orphaneti 2032. Idiopathic pulmonary fibrosis.
    PharmGKBi PA35710.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315755.
    HOVERGENi HBG108270.
    InParanoidi Q8IWL2.
    KOi K10067.
    OMAi EMYTDGK.
    OrthoDBi EOG7HXCVB.
    PhylomeDBi Q8IWL2.
    TreeFami TF330481.

    Enzyme and pathway databases

    Reactomei REACT_23916. Signal regulatory protein (SIRP) family interactions.

    Miscellaneous databases

    GeneWikii Pulmonary_surfactant-associated_protein_A1.
    GenomeRNAii 653509.
    NextBioi 123347.
    PROi Q8IWL2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IWL2.
    CleanExi HS_PSAP.
    HS_SFTPA1B.
    Genevestigatori Q8IWL2.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    [Graphical view ]
    Pfami PF01391. Collagen. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the human pulmonary surfactant apoprotein gene."
      White R.T., Damm D., Miller J., Spratt K., Schilling J., Hawgood S., Benson B., Cordell B.
      Nature 317:361-363(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein."
      Floros J., Steinbrink R., Jacobs K., Phelps D., Kriz R., Recny M., Sultzman L., Jones S., Taeusch H.W., Frank H.A., Fritsch E.F.
      J. Biol. Chem. 261:9029-9033(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-19, ACETYLATION AT GLU-21.
    3. "Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene."
      Silveyra P., Wang G., Floros J.
      Am. J. Physiol. 299:L523-L534(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-19; VAL-50 AND TRP-219.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. SeattleSNPs variation discovery resource
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-9; ALA-19; VAL-50 AND TRP-219.
    6. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "Studies of the structure of lung surfactant protein SP-A."
      Haagsman H.P., White R.T., Schilling J., Lau K., Benson B.J., Golden J., Hawgood S., Clements J.A.
      Am. J. Physiol. 257:L421-L429(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    10. "Genetics of the hydrophilic surfactant proteins A and D."
      Floros J., Hoover R.R.
      Biochim. Biophys. Acta 1408:312-322(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEFINITION OF SFTPA1 ALLELES.
    11. "Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population."
      Raemet M., Haataja R., Marttila R., Floros J., Hallman M.
      Am. J. Hum. Genet. 66:1569-1579(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN RDS.
    12. "Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis."
      Selman M., Lin H.-M., Montano M., Jenkins A.L., Estrada A., Lin Z., Wang G., DiAngelo S.L., Guo X., Umstead T.M., Lang C.M., Pardo A., Phelps D.S., Floros J.
      Hum. Genet. 113:542-550(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT TRP-219, ASSOCIATION WITH IDIOPATHIC PULMONARY FIBROSIS.
    13. "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."
      Wang Y., Kuan P.J., Xing C., Cronkhite J.T., Torres F., Rosenblatt R.L., DiMaio J.M., Kinch L.N., Grishin N.V., Garcia C.K.
      Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LEU-5; THR-9; ALA-19; VAL-50 AND TRP-219.

    Entry informationi

    Entry nameiSFTA1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWL2
    Secondary accession number(s): A8K3T8
    , B7ZW50, E3VLD8, E3VLD9, E3VLE0, E3VLE1, G5E9J3, P07714, Q14DV4, Q5RIR5, Q5RIR7, Q6PIT0, Q8TC19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3