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Q8IWK6

- GP125_HUMAN

UniProt

Q8IWK6 - GP125_HUMAN

Protein

Probable G-protein coupled receptor 125

Gene

GPR125

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.021.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 125
    Gene namesi
    Name:GPR125
    ORF Names:UNQ556/PRO1113
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:13839. GPR125.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of membrane Source: GDB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134919579.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 13211288Probable G-protein coupled receptor 125PRO_0000012900Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi592 – 5921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi687 – 6871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi728 – 7281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi821 – 8211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8IWK6.
    PRIDEiQ8IWK6.

    PTM databases

    PhosphoSiteiQ8IWK6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IWK6.
    BgeeiQ8IWK6.
    CleanExiHS_GPR125.
    GenevestigatoriQ8IWK6.

    Organism-specific databases

    HPAiHPA008904.

    Interactioni

    Subunit structurei

    Interacts with DLG1.1 Publication

    Protein-protein interaction databases

    BioGridi127930. 1 interaction.
    STRINGi9606.ENSP00000334952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWK6.
    SMRiQ8IWK6. Positions 36-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 761728ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini783 – 79614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini818 – 8269ExtracellularSequence Analysis
    Topological domaini848 – 87629CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini898 – 91922ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini941 – 99656CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1018 – 10247ExtracellularSequence Analysis
    Topological domaini1046 – 1321276CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei762 – 78221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei797 – 81721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei827 – 84721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei877 – 89721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei920 – 94021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei997 – 101721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1025 – 104521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati82 – 10322LRR 1Add
    BLAST
    Repeati106 – 12722LRR 2Add
    BLAST
    Repeati130 – 15122LRR 3Add
    BLAST
    Repeati154 – 17522LRR 4Add
    BLAST
    Domaini187 – 23751LRRCTAdd
    BLAST
    Domaini242 – 34099Ig-likeAdd
    BLAST
    Repeati594 – 62027LRR 5Add
    BLAST
    Domaini698 – 74952GPSPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1319 – 13213PDZ-bindingSequence Analysis

    Domaini

    Binds to DLG1 through its PDZ-binding motif.By similarity

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 5 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307919.
    HOGENOMiHOG000112767.
    HOVERGENiHBG051777.
    InParanoidiQ8IWK6.
    KOiK08462.
    OMAiHHIPVNV.
    OrthoDBiEOG7RV9F8.
    PhylomeDBiQ8IWK6.
    TreeFamiTF331206.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF07679. I-set. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view]
    SMARTiSM00303. GPS. 1 hit.
    SM00409. IG. 1 hit.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    [Graphical view]
    PROSITEiPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS51450. LRR. 4 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWK6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPPGRRRGR AQPPLLLPLS LLALLALLGG GGGGGAAALP AGCKHDGRPR     50
    GAGRAAGAAE GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS 100
    FSGLSLLERL DLRNNLISSI DPGAFWGLSS LKRLDLTNNR IGCLNADIFR 150
    GLTNLVRLNL SGNLFSSLSQ GTFDYLASLR SLEFQTEYLL CDCNILWMHR 200
    WVKEKNITVR DTRCVYPKSL QAQPVTGVKQ ELLTCDPPLE LPSFYMTPSH 250
    RQVVFEGDSL PFQCMASYID QDMQVLWYQD GRIVETDESQ GIFVEKNMIH 300
    NCSLIASALT ISNIQAGSTG NWGCHVQTKR GNNTRTVDIV VLESSAQYCP 350
    PERVVNNKGD FRWPRTLAGI TAYLQCTRNT HGSGIYPGNP QDERKAWRRC 400
    DRGGFWADDD YSRCQYANDV TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE 450
    AANFSDKMDV IFVAEMIEKF GRFTKEEKSK ELGDVMVDIA SNIMLADERV 500
    LWLAQREAKA CSRIVQCLQR IATYRLAGGA HVYSTYSPNI ALEAYVIKST 550
    GFTGMTCTVF QKVAASDRTG LSDYGRRDPE GNLDKQLSFK CNVSNTFSSL 600
    ALKNTIVEAS IQLPPSLFSP KQKRELRPTD DSLYKLQLIA FRNGKLFPAT 650
    GNSTNLADDG KRRTVVTPVI LTKIDGVNVD THHIPVNVTL RRIAHGADAV 700
    AARWDFDLLN GQGGWKSDGC HILYSDENIT TIQCYSLSNY AVLMDLTGSE 750
    LYTQAASLLH PVVYTTAIIL LLCLLAVIVS YIYHHSLIRI SLKSWHMLVN 800
    LCFHIFLTCV VFVGGITQTR NASICQAVGI ILHYSTLATV LWVGVTARNI 850
    YKQVTKKAKR CQDPDEPPPP PRPMLRFYLI GGGIPIIVCG ITAAANIKNY 900
    GSRPNAPYCW MAWEPSLGAF YGPASFITFV NCMYFLSIFI QLKRHPERKY 950
    ELKEPTEEQQ RLAANENGEI NHQDSMSLSL ISTSALENEH TFHSQLLGAS 1000
    LTLLLYVALW MFGALAVSLY YPLDLVFSFV FGATSLSFSA FFVVHHCVNR 1050
    EDVRLAWIMT CCPGRSSYSV QVNVQPPNSN GTNGEAPKCP NSSAESSCTN 1100
    KSASSFKNSS QGCKLTNLQA AAAQCHANSL PLNSTPQLDN SLTEHSMDND 1150
    IKMHVAPLEV QFRTNVHSSR HHKNRSKGHR ASRLTVLREY AYDVPTSVEG 1200
    SVQNGLPKSR LGNNEGHSRS RRAYLAYRER QYNPPQQDSS DACSTLPKSS 1250
    RNFEKPVSTT SKKDALRKPA VVELENQQKS YGLNLAIQNG PIKSNGQEGP 1300
    LLGTDSTGNV RTGLWKHETT V 1321
    Length:1,321
    Mass (Da):146,151
    Last modified:July 19, 2004 - v2
    Checksum:i25EBC1620E1895EA
    GO
    Isoform 2 (identifier: Q8IWK6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         604-616: NTIVEASIQLPPS → VCYILQSFKTIYS
         617-1321: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:616
    Mass (Da):68,243
    Checksum:i00CEB483C5714F80
    GO
    Isoform 3 (identifier: Q8IWK6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-134: MEPPGRRRGR...FWGLSSLKRL → MMRVMPCQV
         603-620: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,178
    Mass (Da):131,543
    Checksum:i8C46F040B84B26E9
    GO
    Isoform 4 (identifier: Q8IWK6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MEPPGRRRGR → MPLKRNNSKY
         11-236: Missing.
         604-607: NTIV → GKFR
         608-1321: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:381
    Mass (Da):42,973
    Checksum:i56F63AE58F94AFEC
    GO

    Sequence cautioni

    The sequence AAH35645.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti537 – 5371S → P in BC026009. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1043 – 10431V → M.
    Corresponds to variant rs9002 [ dbSNP | Ensembl ].
    VAR_033971
    Natural varianti1166 – 11661V → G.
    Corresponds to variant rs3814416 [ dbSNP | Ensembl ].
    VAR_033972

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 134134MEPPG…SLKRL → MMRVMPCQV in isoform 3. 1 PublicationVSP_010738Add
    BLAST
    Alternative sequencei1 – 1010MEPPGRRRGR → MPLKRNNSKY in isoform 4. 1 PublicationVSP_010743
    Alternative sequencei11 – 236226Missing in isoform 4. 1 PublicationVSP_010744Add
    BLAST
    Alternative sequencei603 – 62018Missing in isoform 3. 1 PublicationVSP_010740Add
    BLAST
    Alternative sequencei604 – 61613NTIVE…QLPPS → VCYILQSFKTIYS in isoform 2. 1 PublicationVSP_010741Add
    BLAST
    Alternative sequencei604 – 6074NTIV → GKFR in isoform 4. 1 PublicationVSP_010745
    Alternative sequencei608 – 1321714Missing in isoform 4. 1 PublicationVSP_010746Add
    BLAST
    Alternative sequencei617 – 1321705Missing in isoform 2. 1 PublicationVSP_010742Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY181243 mRNA. Translation: AAO27355.1.
    AY358306 mRNA. Translation: AAQ88673.1.
    AC093735 Genomic DNA. No translation available.
    AC093814 Genomic DNA. No translation available.
    BC026009 mRNA. No translation available.
    BC035645 mRNA. Translation: AAH35645.1. Sequence problems.
    CCDSiCCDS33964.1. [Q8IWK6-1]
    RefSeqiNP_660333.2. NM_145290.3. [Q8IWK6-1]
    UniGeneiHs.99195.

    Genome annotation databases

    EnsembliENST00000334304; ENSP00000334952; ENSG00000152990. [Q8IWK6-1]
    ENST00000502482; ENSP00000421006; ENSG00000152990. [Q8IWK6-2]
    ENST00000508133; ENSP00000422606; ENSG00000152990. [Q8IWK6-4]
    GeneIDi166647.
    KEGGihsa:166647.
    UCSCiuc003gqm.2. human. [Q8IWK6-1]
    uc003gqn.1. human. [Q8IWK6-4]
    uc003gqo.4. human. [Q8IWK6-2]
    uc010ieo.2. human. [Q8IWK6-3]

    Polymorphism databases

    DMDMi50400542.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY181243 mRNA. Translation: AAO27355.1 .
    AY358306 mRNA. Translation: AAQ88673.1 .
    AC093735 Genomic DNA. No translation available.
    AC093814 Genomic DNA. No translation available.
    BC026009 mRNA. No translation available.
    BC035645 mRNA. Translation: AAH35645.1 . Sequence problems.
    CCDSi CCDS33964.1. [Q8IWK6-1 ]
    RefSeqi NP_660333.2. NM_145290.3. [Q8IWK6-1 ]
    UniGenei Hs.99195.

    3D structure databases

    ProteinModelPortali Q8IWK6.
    SMRi Q8IWK6. Positions 36-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127930. 1 interaction.
    STRINGi 9606.ENSP00000334952.

    Protein family/group databases

    MEROPSi S63.021.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8IWK6.

    Polymorphism databases

    DMDMi 50400542.

    Proteomic databases

    PaxDbi Q8IWK6.
    PRIDEi Q8IWK6.

    Protocols and materials databases

    DNASUi 166647.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334304 ; ENSP00000334952 ; ENSG00000152990 . [Q8IWK6-1 ]
    ENST00000502482 ; ENSP00000421006 ; ENSG00000152990 . [Q8IWK6-2 ]
    ENST00000508133 ; ENSP00000422606 ; ENSG00000152990 . [Q8IWK6-4 ]
    GeneIDi 166647.
    KEGGi hsa:166647.
    UCSCi uc003gqm.2. human. [Q8IWK6-1 ]
    uc003gqn.1. human. [Q8IWK6-4 ]
    uc003gqo.4. human. [Q8IWK6-2 ]
    uc010ieo.2. human. [Q8IWK6-3 ]

    Organism-specific databases

    CTDi 166647.
    GeneCardsi GC04M022346.
    HGNCi HGNC:13839. GPR125.
    HPAi HPA008904.
    MIMi 612303. gene.
    neXtProti NX_Q8IWK6.
    PharmGKBi PA134919579.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307919.
    HOGENOMi HOG000112767.
    HOVERGENi HBG051777.
    InParanoidi Q8IWK6.
    KOi K08462.
    OMAi HHIPVNV.
    OrthoDBi EOG7RV9F8.
    PhylomeDBi Q8IWK6.
    TreeFami TF331206.

    Miscellaneous databases

    ChiTaRSi GPR125. human.
    GeneWikii GPR125.
    GenomeRNAii 166647.
    NextBioi 88603.
    PROi Q8IWK6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IWK6.
    Bgeei Q8IWK6.
    CleanExi HS_GPR125.
    Genevestigatori Q8IWK6.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF07679. I-set. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00303. GPS. 1 hit.
    SM00409. IG. 1 hit.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    [Graphical view ]
    PROSITEi PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS51450. LRR. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
      Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
      Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Eye and Liver.
    5. "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein."
      Yamamoto Y., Irie K., Asada M., Mino A., Mandai K., Takai Y.
      Oncogene 23:3889-3897(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DLG1.

    Entry informationi

    Entry nameiGP125_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWK6
    Secondary accession number(s): Q6UXK9, Q86SQ5, Q8TC55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3