Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IWK6

- GP125_HUMAN

UniProt

Q8IWK6 - GP125_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable G-protein coupled receptor 125

Gene

GPR125

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 125
Gene namesi
Name:GPR125
ORF Names:UNQ556/PRO1113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:13839. GPR125.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 761728ExtracellularSequence AnalysisAdd
BLAST
Transmembranei762 – 78221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini783 – 79614CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei797 – 81721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini818 – 8269ExtracellularSequence Analysis
Transmembranei827 – 84721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini848 – 87629CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei877 – 89721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini898 – 91922ExtracellularSequence AnalysisAdd
BLAST
Transmembranei920 – 94021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini941 – 99656CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei997 – 101721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini1018 – 10247ExtracellularSequence Analysis
Transmembranei1025 – 104521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini1046 – 1321276CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of membrane Source: GDB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 13211288Probable G-protein coupled receptor 125PRO_0000012900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi592 – 5921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi687 – 6871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi728 – 7281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi821 – 8211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IWK6.
PRIDEiQ8IWK6.

PTM databases

PhosphoSiteiQ8IWK6.

Expressioni

Gene expression databases

BgeeiQ8IWK6.
CleanExiHS_GPR125.
ExpressionAtlasiQ8IWK6. baseline and differential.
GenevestigatoriQ8IWK6.

Organism-specific databases

HPAiHPA008904.

Interactioni

Subunit structurei

Interacts with DLG1.1 Publication

Protein-protein interaction databases

BioGridi127930. 1 interaction.
STRINGi9606.ENSP00000334952.

Structurei

3D structure databases

ProteinModelPortaliQ8IWK6.
SMRiQ8IWK6. Positions 49-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati82 – 10322LRR 1Add
BLAST
Repeati106 – 12722LRR 2Add
BLAST
Repeati130 – 15122LRR 3Add
BLAST
Repeati154 – 17522LRR 4Add
BLAST
Domaini187 – 23751LRRCTAdd
BLAST
Domaini242 – 34099Ig-likeAdd
BLAST
Repeati594 – 62027LRR 5Add
BLAST
Domaini698 – 74952GPSPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1319 – 13213PDZ-bindingSequence Analysis

Domaini

Binds to DLG1 through its PDZ-binding motif.By similarity

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307919.
GeneTreeiENSGT00390000016104.
HOGENOMiHOG000112767.
HOVERGENiHBG051777.
InParanoidiQ8IWK6.
KOiK08462.
OMAiHHIPVNV.
OrthoDBiEOG7RV9F8.
PhylomeDBiQ8IWK6.
TreeFamiTF331206.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
PROSITEiPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWK6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPPGRRRGR AQPPLLLPLS LLALLALLGG GGGGGAAALP AGCKHDGRPR
60 70 80 90 100
GAGRAAGAAE GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS
110 120 130 140 150
FSGLSLLERL DLRNNLISSI DPGAFWGLSS LKRLDLTNNR IGCLNADIFR
160 170 180 190 200
GLTNLVRLNL SGNLFSSLSQ GTFDYLASLR SLEFQTEYLL CDCNILWMHR
210 220 230 240 250
WVKEKNITVR DTRCVYPKSL QAQPVTGVKQ ELLTCDPPLE LPSFYMTPSH
260 270 280 290 300
RQVVFEGDSL PFQCMASYID QDMQVLWYQD GRIVETDESQ GIFVEKNMIH
310 320 330 340 350
NCSLIASALT ISNIQAGSTG NWGCHVQTKR GNNTRTVDIV VLESSAQYCP
360 370 380 390 400
PERVVNNKGD FRWPRTLAGI TAYLQCTRNT HGSGIYPGNP QDERKAWRRC
410 420 430 440 450
DRGGFWADDD YSRCQYANDV TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE
460 470 480 490 500
AANFSDKMDV IFVAEMIEKF GRFTKEEKSK ELGDVMVDIA SNIMLADERV
510 520 530 540 550
LWLAQREAKA CSRIVQCLQR IATYRLAGGA HVYSTYSPNI ALEAYVIKST
560 570 580 590 600
GFTGMTCTVF QKVAASDRTG LSDYGRRDPE GNLDKQLSFK CNVSNTFSSL
610 620 630 640 650
ALKNTIVEAS IQLPPSLFSP KQKRELRPTD DSLYKLQLIA FRNGKLFPAT
660 670 680 690 700
GNSTNLADDG KRRTVVTPVI LTKIDGVNVD THHIPVNVTL RRIAHGADAV
710 720 730 740 750
AARWDFDLLN GQGGWKSDGC HILYSDENIT TIQCYSLSNY AVLMDLTGSE
760 770 780 790 800
LYTQAASLLH PVVYTTAIIL LLCLLAVIVS YIYHHSLIRI SLKSWHMLVN
810 820 830 840 850
LCFHIFLTCV VFVGGITQTR NASICQAVGI ILHYSTLATV LWVGVTARNI
860 870 880 890 900
YKQVTKKAKR CQDPDEPPPP PRPMLRFYLI GGGIPIIVCG ITAAANIKNY
910 920 930 940 950
GSRPNAPYCW MAWEPSLGAF YGPASFITFV NCMYFLSIFI QLKRHPERKY
960 970 980 990 1000
ELKEPTEEQQ RLAANENGEI NHQDSMSLSL ISTSALENEH TFHSQLLGAS
1010 1020 1030 1040 1050
LTLLLYVALW MFGALAVSLY YPLDLVFSFV FGATSLSFSA FFVVHHCVNR
1060 1070 1080 1090 1100
EDVRLAWIMT CCPGRSSYSV QVNVQPPNSN GTNGEAPKCP NSSAESSCTN
1110 1120 1130 1140 1150
KSASSFKNSS QGCKLTNLQA AAAQCHANSL PLNSTPQLDN SLTEHSMDND
1160 1170 1180 1190 1200
IKMHVAPLEV QFRTNVHSSR HHKNRSKGHR ASRLTVLREY AYDVPTSVEG
1210 1220 1230 1240 1250
SVQNGLPKSR LGNNEGHSRS RRAYLAYRER QYNPPQQDSS DACSTLPKSS
1260 1270 1280 1290 1300
RNFEKPVSTT SKKDALRKPA VVELENQQKS YGLNLAIQNG PIKSNGQEGP
1310 1320
LLGTDSTGNV RTGLWKHETT V
Length:1,321
Mass (Da):146,151
Last modified:July 19, 2004 - v2
Checksum:i25EBC1620E1895EA
GO
Isoform 2 (identifier: Q8IWK6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     604-616: NTIVEASIQLPPS → VCYILQSFKTIYS
     617-1321: Missing.

Note: No experimental confirmation available.

Show »
Length:616
Mass (Da):68,243
Checksum:i00CEB483C5714F80
GO
Isoform 3 (identifier: Q8IWK6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: MEPPGRRRGR...FWGLSSLKRL → MMRVMPCQV
     603-620: Missing.

Note: No experimental confirmation available.

Show »
Length:1,178
Mass (Da):131,543
Checksum:i8C46F040B84B26E9
GO
Isoform 4 (identifier: Q8IWK6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MEPPGRRRGR → MPLKRNNSKY
     11-236: Missing.
     604-607: NTIV → GKFR
     608-1321: Missing.

Note: No experimental confirmation available.

Show »
Length:381
Mass (Da):42,973
Checksum:i56F63AE58F94AFEC
GO

Sequence cautioni

The sequence AAH35645.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti537 – 5371S → P in BC026009. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1043 – 10431V → M.
Corresponds to variant rs9002 [ dbSNP | Ensembl ].
VAR_033971
Natural varianti1166 – 11661V → G.
Corresponds to variant rs3814416 [ dbSNP | Ensembl ].
VAR_033972

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 134134MEPPG…SLKRL → MMRVMPCQV in isoform 3. 1 PublicationVSP_010738Add
BLAST
Alternative sequencei1 – 1010MEPPGRRRGR → MPLKRNNSKY in isoform 4. 1 PublicationVSP_010743
Alternative sequencei11 – 236226Missing in isoform 4. 1 PublicationVSP_010744Add
BLAST
Alternative sequencei603 – 62018Missing in isoform 3. 1 PublicationVSP_010740Add
BLAST
Alternative sequencei604 – 61613NTIVE…QLPPS → VCYILQSFKTIYS in isoform 2. 1 PublicationVSP_010741Add
BLAST
Alternative sequencei604 – 6074NTIV → GKFR in isoform 4. 1 PublicationVSP_010745
Alternative sequencei608 – 1321714Missing in isoform 4. 1 PublicationVSP_010746Add
BLAST
Alternative sequencei617 – 1321705Missing in isoform 2. 1 PublicationVSP_010742Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181243 mRNA. Translation: AAO27355.1.
AY358306 mRNA. Translation: AAQ88673.1.
AC093735 Genomic DNA. No translation available.
AC093814 Genomic DNA. No translation available.
BC026009 mRNA. No translation available.
BC035645 mRNA. Translation: AAH35645.1. Sequence problems.
CCDSiCCDS33964.1. [Q8IWK6-1]
RefSeqiNP_660333.2. NM_145290.3. [Q8IWK6-1]
UniGeneiHs.99195.

Genome annotation databases

EnsembliENST00000334304; ENSP00000334952; ENSG00000152990. [Q8IWK6-1]
ENST00000502482; ENSP00000421006; ENSG00000152990. [Q8IWK6-2]
ENST00000508133; ENSP00000422606; ENSG00000152990. [Q8IWK6-4]
GeneIDi166647.
KEGGihsa:166647.
UCSCiuc003gqm.2. human. [Q8IWK6-1]
uc003gqn.1. human. [Q8IWK6-4]
uc003gqo.4. human. [Q8IWK6-2]
uc010ieo.2. human. [Q8IWK6-3]

Polymorphism databases

DMDMi50400542.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181243 mRNA. Translation: AAO27355.1 .
AY358306 mRNA. Translation: AAQ88673.1 .
AC093735 Genomic DNA. No translation available.
AC093814 Genomic DNA. No translation available.
BC026009 mRNA. No translation available.
BC035645 mRNA. Translation: AAH35645.1 . Sequence problems.
CCDSi CCDS33964.1. [Q8IWK6-1 ]
RefSeqi NP_660333.2. NM_145290.3. [Q8IWK6-1 ]
UniGenei Hs.99195.

3D structure databases

ProteinModelPortali Q8IWK6.
SMRi Q8IWK6. Positions 49-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127930. 1 interaction.
STRINGi 9606.ENSP00000334952.

Protein family/group databases

MEROPSi S63.021.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8IWK6.

Polymorphism databases

DMDMi 50400542.

Proteomic databases

PaxDbi Q8IWK6.
PRIDEi Q8IWK6.

Protocols and materials databases

DNASUi 166647.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334304 ; ENSP00000334952 ; ENSG00000152990 . [Q8IWK6-1 ]
ENST00000502482 ; ENSP00000421006 ; ENSG00000152990 . [Q8IWK6-2 ]
ENST00000508133 ; ENSP00000422606 ; ENSG00000152990 . [Q8IWK6-4 ]
GeneIDi 166647.
KEGGi hsa:166647.
UCSCi uc003gqm.2. human. [Q8IWK6-1 ]
uc003gqn.1. human. [Q8IWK6-4 ]
uc003gqo.4. human. [Q8IWK6-2 ]
uc010ieo.2. human. [Q8IWK6-3 ]

Organism-specific databases

CTDi 166647.
GeneCardsi GC04M022346.
HGNCi HGNC:13839. GPR125.
HPAi HPA008904.
MIMi 612303. gene.
neXtProti NX_Q8IWK6.
PharmGKBi PA134919579.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307919.
GeneTreei ENSGT00390000016104.
HOGENOMi HOG000112767.
HOVERGENi HBG051777.
InParanoidi Q8IWK6.
KOi K08462.
OMAi HHIPVNV.
OrthoDBi EOG7RV9F8.
PhylomeDBi Q8IWK6.
TreeFami TF331206.

Miscellaneous databases

ChiTaRSi GPR125. human.
GeneWikii GPR125.
GenomeRNAii 166647.
NextBioi 88603.
PROi Q8IWK6.
SOURCEi Search...

Gene expression databases

Bgeei Q8IWK6.
CleanExi HS_GPR125.
ExpressionAtlasi Q8IWK6. baseline and differential.
Genevestigatori Q8IWK6.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view ]
PROSITEi PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
    Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
    Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Eye and Liver.
  5. "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein."
    Yamamoto Y., Irie K., Asada M., Mino A., Mandai K., Takai Y.
    Oncogene 23:3889-3897(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DLG1.

Entry informationi

Entry nameiGP125_HUMAN
AccessioniPrimary (citable) accession number: Q8IWK6
Secondary accession number(s): Q6UXK9, Q86SQ5, Q8TC55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3