Q8IWK6 (GP125_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 125

Gene names

Name:	GPR125
ORF Names:	UNQ556/PRO1113

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan receptor.
Subunit structure	Interacts with DLG1. Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein.
Domain	Binds to DLG1 through its PDZ-binding motif By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 5 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.
Sequence caution	The sequence AAH35645.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Traceable author statement PubMed 15203201. Source: GDB
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWK6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWK6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     604-616: NTIVEASIQLPPS → VCYILQSFKTIYS
     617-1321: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8IWK6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: MEPPGRRRGR...FWGLSSLKRL → MMRVMPCQV
     603-620: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8IWK6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MEPPGRRRGR → MPLKRNNSKY
     11-236: Missing.
     604-607: NTIV → GKFR
     608-1321: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 1321	1288	Probable G-protein coupled receptor 125		PRO_0000012900
Regions
	Topological domain	34 – 761	728	Extracellular Potential
	Transmembrane	762 – 782	21	Helical; Name=1; Potential
	Topological domain	783 – 796	14	Cytoplasmic Potential
	Transmembrane	797 – 817	21	Helical; Name=2; Potential
	Topological domain	818 – 826	9	Extracellular Potential
	Transmembrane	827 – 847	21	Helical; Name=3; Potential
	Topological domain	848 – 876	29	Cytoplasmic Potential
	Transmembrane	877 – 897	21	Helical; Name=4; Potential
	Topological domain	898 – 919	22	Extracellular Potential
	Transmembrane	920 – 940	21	Helical; Name=5; Potential
	Topological domain	941 – 996	56	Cytoplasmic Potential
	Transmembrane	997 – 1017	21	Helical; Name=6; Potential
	Topological domain	1018 – 1024	7	Extracellular Potential
	Transmembrane	1025 – 1045	21	Helical; Name=7; Potential
	Topological domain	1046 – 1321	276	Cytoplasmic Potential
	Repeat	82 – 103	22	LRR 1
	Repeat	106 – 127	22	LRR 2
	Repeat	130 – 151	22	LRR 3
	Repeat	154 – 175	22	LRR 4
	Domain	187 – 237	51	LRRCT
	Domain	242 – 340	99	Ig-like
	Repeat	594 – 620	27	LRR 5
	Domain	698 – 749	52	GPS
	Motif	1319 – 1321	3	PDZ-binding Potential
Amino acid modifications
	Glycosylation	81	1	N-linked (GlcNAc...) Potential
	Glycosylation	98	1	N-linked (GlcNAc...) Potential
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Glycosylation	206	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	332	1	N-linked (GlcNAc...) Potential
	Glycosylation	433	1	N-linked (GlcNAc...) Potential
	Glycosylation	453	1	N-linked (GlcNAc...) Potential
	Glycosylation	592	1	N-linked (GlcNAc...) Potential
	Glycosylation	652	1	N-linked (GlcNAc...) Potential
	Glycosylation	687	1	N-linked (GlcNAc...) Potential
	Glycosylation	728	1	N-linked (GlcNAc...) Potential
	Glycosylation	821	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 134	134	MEPPG…SLKRL → MMRVMPCQV in isoform 3.		VSP_010738
	Alternative sequence	1 – 10	10	MEPPGRRRGR → MPLKRNNSKY in isoform 4.		VSP_010743
	Alternative sequence	11 – 236	226	Missing in isoform 4.		VSP_010744
	Alternative sequence	603 – 620	18	Missing in isoform 3.		VSP_010740
	Alternative sequence	604 – 616	13	NTIVE…QLPPS → VCYILQSFKTIYS in isoform 2.		VSP_010741
	Alternative sequence	604 – 607	4	NTIV → GKFR in isoform 4.		VSP_010745
	Alternative sequence	608 – 1321	714	Missing in isoform 4.		VSP_010746
	Alternative sequence	617 – 1321	705	Missing in isoform 2.		VSP_010742
	Natural variant	1043	1	V → M. Corresponds to variant rs9002 [ dbSNP | Ensembl ].		VAR_033971
	Natural variant	1166	1	V → G. Corresponds to variant rs3814416 [ dbSNP | Ensembl ].		VAR_033972
Experimental info
	Sequence conflict	537	1	S → P in BC026009. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 25EBC1620E1895EA	FASTA	1,321	146,151
	10 20 30 40 50 60 MEPPGRRRGR AQPPLLLPLS LLALLALLGG GGGGGAAALP AGCKHDGRPR GAGRAAGAAE 70 80 90 100 110 120 GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS FSGLSLLERL DLRNNLISSI 130 140 150 160 170 180 DPGAFWGLSS LKRLDLTNNR IGCLNADIFR GLTNLVRLNL SGNLFSSLSQ GTFDYLASLR 190 200 210 220 230 240 SLEFQTEYLL CDCNILWMHR WVKEKNITVR DTRCVYPKSL QAQPVTGVKQ ELLTCDPPLE 250 260 270 280 290 300 LPSFYMTPSH RQVVFEGDSL PFQCMASYID QDMQVLWYQD GRIVETDESQ GIFVEKNMIH 310 320 330 340 350 360 NCSLIASALT ISNIQAGSTG NWGCHVQTKR GNNTRTVDIV VLESSAQYCP PERVVNNKGD 370 380 390 400 410 420 FRWPRTLAGI TAYLQCTRNT HGSGIYPGNP QDERKAWRRC DRGGFWADDD YSRCQYANDV 430 440 450 460 470 480 TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE AANFSDKMDV IFVAEMIEKF GRFTKEEKSK 490 500 510 520 530 540 ELGDVMVDIA SNIMLADERV LWLAQREAKA CSRIVQCLQR IATYRLAGGA HVYSTYSPNI 550 560 570 580 590 600 ALEAYVIKST GFTGMTCTVF QKVAASDRTG LSDYGRRDPE GNLDKQLSFK CNVSNTFSSL 610 620 630 640 650 660 ALKNTIVEAS IQLPPSLFSP KQKRELRPTD DSLYKLQLIA FRNGKLFPAT GNSTNLADDG 670 680 690 700 710 720 KRRTVVTPVI LTKIDGVNVD THHIPVNVTL RRIAHGADAV AARWDFDLLN GQGGWKSDGC 730 740 750 760 770 780 HILYSDENIT TIQCYSLSNY AVLMDLTGSE LYTQAASLLH PVVYTTAIIL LLCLLAVIVS 790 800 810 820 830 840 YIYHHSLIRI SLKSWHMLVN LCFHIFLTCV VFVGGITQTR NASICQAVGI ILHYSTLATV 850 860 870 880 890 900 LWVGVTARNI YKQVTKKAKR CQDPDEPPPP PRPMLRFYLI GGGIPIIVCG ITAAANIKNY 910 920 930 940 950 960 GSRPNAPYCW MAWEPSLGAF YGPASFITFV NCMYFLSIFI QLKRHPERKY ELKEPTEEQQ 970 980 990 1000 1010 1020 RLAANENGEI NHQDSMSLSL ISTSALENEH TFHSQLLGAS LTLLLYVALW MFGALAVSLY 1030 1040 1050 1060 1070 1080 YPLDLVFSFV FGATSLSFSA FFVVHHCVNR EDVRLAWIMT CCPGRSSYSV QVNVQPPNSN 1090 1100 1110 1120 1130 1140 GTNGEAPKCP NSSAESSCTN KSASSFKNSS QGCKLTNLQA AAAQCHANSL PLNSTPQLDN 1150 1160 1170 1180 1190 1200 SLTEHSMDND IKMHVAPLEV QFRTNVHSSR HHKNRSKGHR ASRLTVLREY AYDVPTSVEG 1210 1220 1230 1240 1250 1260 SVQNGLPKSR LGNNEGHSRS RRAYLAYRER QYNPPQQDSS DACSTLPKSS RNFEKPVSTT 1270 1280 1290 1300 1310 1320 SKKDALRKPA VVELENQQKS YGLNLAIQNG PIKSNGQEGP LLGTDSTGNV RTGLWKHETT V
	Isoform 2 [UniParc]. Checksum: 00CEB483C5714F80	FASTA	616	68,243
	10 20 30 40 50 60 MEPPGRRRGR AQPPLLLPLS LLALLALLGG GGGGGAAALP AGCKHDGRPR GAGRAAGAAE 70 80 90 100 110 120 GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS FSGLSLLERL DLRNNLISSI 130 140 150 160 170 180 DPGAFWGLSS LKRLDLTNNR IGCLNADIFR GLTNLVRLNL SGNLFSSLSQ GTFDYLASLR 190 200 210 220 230 240 SLEFQTEYLL CDCNILWMHR WVKEKNITVR DTRCVYPKSL QAQPVTGVKQ ELLTCDPPLE 250 260 270 280 290 300 LPSFYMTPSH RQVVFEGDSL PFQCMASYID QDMQVLWYQD GRIVETDESQ GIFVEKNMIH 310 320 330 340 350 360 NCSLIASALT ISNIQAGSTG NWGCHVQTKR GNNTRTVDIV VLESSAQYCP PERVVNNKGD 370 380 390 400 410 420 FRWPRTLAGI TAYLQCTRNT HGSGIYPGNP QDERKAWRRC DRGGFWADDD YSRCQYANDV 430 440 450 460 470 480 TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE AANFSDKMDV IFVAEMIEKF GRFTKEEKSK 490 500 510 520 530 540 ELGDVMVDIA SNIMLADERV LWLAQREAKA CSRIVQCLQR IATYRLAGGA HVYSTYSPNI 550 560 570 580 590 600 ALEAYVIKST GFTGMTCTVF QKVAASDRTG LSDYGRRDPE GNLDKQLSFK CNVSNTFSSL 610 ALKVCYILQS FKTIYS
	Isoform 3 [UniParc]. Checksum: 8C46F040B84B26E9	FASTA	1,178	131,543
	10 20 30 40 50 60 MMRVMPCQVD LTNNRIGCLN ADIFRGLTNL VRLNLSGNLF SSLSQGTFDY LASLRSLEFQ 70 80 90 100 110 120 TEYLLCDCNI LWMHRWVKEK NITVRDTRCV YPKSLQAQPV TGVKQELLTC DPPLELPSFY 130 140 150 160 170 180 MTPSHRQVVF EGDSLPFQCM ASYIDQDMQV LWYQDGRIVE TDESQGIFVE KNMIHNCSLI 190 200 210 220 230 240 ASALTISNIQ AGSTGNWGCH VQTKRGNNTR TVDIVVLESS AQYCPPERVV NNKGDFRWPR 250 260 270 280 290 300 TLAGITAYLQ CTRNTHGSGI YPGNPQDERK AWRRCDRGGF WADDDYSRCQ YANDVTRVLY 310 320 330 340 350 360 MFNQMPLNLT NAVATARQLL AYTVEAANFS DKMDVIFVAE MIEKFGRFTK EEKSKELGDV 370 380 390 400 410 420 MVDIASNIML ADERVLWLAQ REAKACSRIV QCLQRIATYR LAGGAHVYST YSPNIALEAY 430 440 450 460 470 480 VIKSTGFTGM TCTVFQKVAA SDRTGLSDYG RRDPEGNLDK QLSFKCNVSN TFSSLALKQK 490 500 510 520 530 540 RELRPTDDSL YKLQLIAFRN GKLFPATGNS TNLADDGKRR TVVTPVILTK IDGVNVDTHH 550 560 570 580 590 600 IPVNVTLRRI AHGADAVAAR WDFDLLNGQG GWKSDGCHIL YSDENITTIQ CYSLSNYAVL 610 620 630 640 650 660 MDLTGSELYT QAASLLHPVV YTTAIILLLC LLAVIVSYIY HHSLIRISLK SWHMLVNLCF 670 680 690 700 710 720 HIFLTCVVFV GGITQTRNAS ICQAVGIILH YSTLATVLWV GVTARNIYKQ VTKKAKRCQD 730 740 750 760 770 780 PDEPPPPPRP MLRFYLIGGG IPIIVCGITA AANIKNYGSR PNAPYCWMAW EPSLGAFYGP 790 800 810 820 830 840 ASFITFVNCM YFLSIFIQLK RHPERKYELK EPTEEQQRLA ANENGEINHQ DSMSLSLIST 850 860 870 880 890 900 SALENEHTFH SQLLGASLTL LLYVALWMFG ALAVSLYYPL DLVFSFVFGA TSLSFSAFFV 910 920 930 940 950 960 VHHCVNREDV RLAWIMTCCP GRSSYSVQVN VQPPNSNGTN GEAPKCPNSS AESSCTNKSA 970 980 990 1000 1010 1020 SSFKNSSQGC KLTNLQAAAA QCHANSLPLN STPQLDNSLT EHSMDNDIKM HVAPLEVQFR 1030 1040 1050 1060 1070 1080 TNVHSSRHHK NRSKGHRASR LTVLREYAYD VPTSVEGSVQ NGLPKSRLGN NEGHSRSRRA 1090 1100 1110 1120 1130 1140 YLAYRERQYN PPQQDSSDAC STLPKSSRNF EKPVSTTSKK DALRKPAVVE LENQQKSYGL 1150 1160 1170 NLAIQNGPIK SNGQEGPLLG TDSTGNVRTG LWKHETTV
	Isoform 4 [UniParc]. Checksum: 56F63AE58F94AFEC	FASTA	381	42,973
	10 20 30 40 50 60 MPLKRNNSKY PPLELPSFYM TPSHRQVVFE GDSLPFQCMA SYIDQDMQVL WYQDGRIVET 70 80 90 100 110 120 DESQGIFVEK NMIHNCSLIA SALTISNIQA GSTGNWGCHV QTKRGNNTRT VDIVVLESSA 130 140 150 160 170 180 QYCPPERVVN NKGDFRWPRT LAGITAYLQC TRNTHGSGIY PGNPQDERKA WRRCDRGGFW 190 200 210 220 230 240 ADDDYSRCQY ANDVTRVLYM FNQMPLNLTN AVATARQLLA YTVEAANFSD KMDVIFVAEM 250 260 270 280 290 300 IEKFGRFTKE EKSKELGDVM VDIASNIMLA DERVLWLAQR EAKACSRIVQ CLQRIATYRL 310 320 330 340 350 360 AGGAHVYSTY SPNIALEAYV IKSTGFTGMT CTVFQKVAAS DRTGLSDYGR RDPEGNLDKQ 370 380 LSFKCNVSNT FSSLALKGKF R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini." Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B. Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Eye and Liver.
[5]	"Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein." Yamamoto Y., Irie K., Asada M., Mino A., Mandai K., Takai Y. Oncogene 23:3889-3897(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DLG1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY181243 mRNA. Translation: AAO27355.1. AY358306 mRNA. Translation: AAQ88673.1. AC093735 Genomic DNA. No translation available. AC093814 Genomic DNA. No translation available. BC026009 mRNA. No translation available. BC035645 mRNA. Translation: AAH35645.1. Sequence problems.
IPI	IPI00452590. IPI00452591. IPI00452592. IPI00452593.
RefSeq	NP_660333.2. NM_145290.3.
UniGene	Hs.99195.
3D structure databases
ProteinModelPortal	Q8IWK6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000334952.
Protein family/group databases
MEROPS	S63.021.
GPCRDB	Search...
PTM databases
PhosphoSite	Q8IWK6.
Polymorphism databases
DMDM	50400542.
Proteomic databases
PaxDb	Q8IWK6.
PRIDE	Q8IWK6.
Protocols and materials databases
DNASU	166647.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334304; ENSP00000334952; ENSG00000152990. ENST00000502482; ENSP00000421006; ENSG00000152990. ENST00000508133; ENSP00000422606; ENSG00000152990.
GeneID	166647.
KEGG	hsa:166647.
UCSC	uc003gqm.1. human. uc003gqn.1. human. uc003gqo.3. human. uc010ieo.1. human.
Organism-specific databases
CTD	166647.
GeneCards	GC04M022346.
HGNC	HGNC:13839. GPR125.
HPA	HPA008904.
MIM	612303. gene.
neXtProt	NX_Q8IWK6.
PharmGKB	PA134919579.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307919.
HOGENOM	HOG000112767.
HOVERGEN	HBG051777.
InParanoid	Q8IWK6.
KO	K08462.
OMA	HHIPVNV.
OrthoDB	EOG42820R.
Gene expression databases
ArrayExpress	Q8IWK6.
Bgee	Q8IWK6.
CleanEx	HS_GPR125.
Genevestigator	Q8IWK6.
GermOnline	ENSG00000152990. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR000203. GPS_dom. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. PF02793. HRM. 1 hit. PF07679. I-set. 1 hit. [Graphical view]
SMART	SM00303. GPS. 1 hit. SM00409. IG. 1 hit. SM00369. LRR_TYP. 3 hits. SM00082. LRRCT. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS50835. IG_LIKE. 1 hit. PS51450. LRR. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPR125. human.
GenomeRNAi	166647.
NextBio	88603.
SOURCE	Search...

Entry information

Entry name

GP125_HUMAN

Accession

Primary (citable) accession number: Q8IWK6
Secondary accession number(s): Q6UXK9, Q86SQ5, Q8TC55

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.