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Protein

Adhesion G protein-coupled receptor A3

Gene

ADGRA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor that may have a role in planar cell polarity pathway.By similarity

Miscellaneous

Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: GDB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.018

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor A31 Publication
Alternative name(s):
G-protein coupled receptor 125
Gene namesi
Name:ADGRA3Imported
Synonyms:GPR125
ORF Names:UNQ556/PRO1113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000152990.13
HGNCiHGNC:13839 ADGRA3
MIMi612303 gene
neXtProtiNX_Q8IWK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 761ExtracellularCuratedAdd BLAST728
Transmembranei762 – 782Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini783 – 796CytoplasmicCuratedAdd BLAST14
Transmembranei797 – 817Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini818 – 826ExtracellularCurated9
Transmembranei827 – 847Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini848 – 876CytoplasmicCuratedAdd BLAST29
Transmembranei877 – 897Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini898 – 919ExtracellularCuratedAdd BLAST22
Transmembranei920 – 940Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini941 – 996CytoplasmicCuratedAdd BLAST56
Transmembranei997 – 1017Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1018 – 1024ExtracellularCurated7
Transmembranei1025 – 1045Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1046 – 1321CytoplasmicCuratedAdd BLAST276

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi166647
OpenTargetsiENSG00000152990
PharmGKBiPA134919579

Polymorphism and mutation databases

DMDMi50400542

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001290034 – 1321Adhesion G protein-coupled receptor A3Add BLAST1288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi264 ↔ 324PROSITE-ProRule annotation
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi592N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi652N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi728N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi821N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8IWK6
PaxDbiQ8IWK6
PeptideAtlasiQ8IWK6
PRIDEiQ8IWK6

PTM databases

iPTMnetiQ8IWK6
PhosphoSitePlusiQ8IWK6

Expressioni

Gene expression databases

BgeeiENSG00000152990
CleanExiHS_GPR125
ExpressionAtlasiQ8IWK6 baseline and differential
GenevisibleiQ8IWK6 HS

Organism-specific databases

HPAiHPA008904

Interactioni

Subunit structurei

Interacts (via PDZ-binding motif) with DLG1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DLG1Q12959-22EBI-10949249,EBI-357500

Protein-protein interaction databases

BioGridi127930, 2 interactors
IntActiQ8IWK6, 1 interactor
MINTiQ8IWK6
STRINGi9606.ENSP00000334952

Structurei

3D structure databases

ProteinModelPortaliQ8IWK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati82 – 103LRR 1Add BLAST22
Repeati106 – 127LRR 2Add BLAST22
Repeati130 – 151LRR 3Add BLAST22
Repeati154 – 175LRR 4Add BLAST22
Domaini187 – 237LRRCTAdd BLAST51
Domaini242 – 340Ig-likeAdd BLAST99
Repeati594 – 620LRR 5Add BLAST27
Domaini698 – 749GPSPROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1319 – 1321PDZ-bindingSequence analysis3

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00860000133701
HOGENOMiHOG000112767
HOVERGENiHBG051777
InParanoidiQ8IWK6
KOiK08462
OMAiANFSDKM
OrthoDBiEOG091G03GB
PhylomeDBiQ8IWK6
TreeFamiTF331206

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00409 IG, 1 hit
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPPGRRRGR AQPPLLLPLS LLALLALLGG GGGGGAAALP AGCKHDGRPR
60 70 80 90 100
GAGRAAGAAE GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS
110 120 130 140 150
FSGLSLLERL DLRNNLISSI DPGAFWGLSS LKRLDLTNNR IGCLNADIFR
160 170 180 190 200
GLTNLVRLNL SGNLFSSLSQ GTFDYLASLR SLEFQTEYLL CDCNILWMHR
210 220 230 240 250
WVKEKNITVR DTRCVYPKSL QAQPVTGVKQ ELLTCDPPLE LPSFYMTPSH
260 270 280 290 300
RQVVFEGDSL PFQCMASYID QDMQVLWYQD GRIVETDESQ GIFVEKNMIH
310 320 330 340 350
NCSLIASALT ISNIQAGSTG NWGCHVQTKR GNNTRTVDIV VLESSAQYCP
360 370 380 390 400
PERVVNNKGD FRWPRTLAGI TAYLQCTRNT HGSGIYPGNP QDERKAWRRC
410 420 430 440 450
DRGGFWADDD YSRCQYANDV TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE
460 470 480 490 500
AANFSDKMDV IFVAEMIEKF GRFTKEEKSK ELGDVMVDIA SNIMLADERV
510 520 530 540 550
LWLAQREAKA CSRIVQCLQR IATYRLAGGA HVYSTYSPNI ALEAYVIKST
560 570 580 590 600
GFTGMTCTVF QKVAASDRTG LSDYGRRDPE GNLDKQLSFK CNVSNTFSSL
610 620 630 640 650
ALKNTIVEAS IQLPPSLFSP KQKRELRPTD DSLYKLQLIA FRNGKLFPAT
660 670 680 690 700
GNSTNLADDG KRRTVVTPVI LTKIDGVNVD THHIPVNVTL RRIAHGADAV
710 720 730 740 750
AARWDFDLLN GQGGWKSDGC HILYSDENIT TIQCYSLSNY AVLMDLTGSE
760 770 780 790 800
LYTQAASLLH PVVYTTAIIL LLCLLAVIVS YIYHHSLIRI SLKSWHMLVN
810 820 830 840 850
LCFHIFLTCV VFVGGITQTR NASICQAVGI ILHYSTLATV LWVGVTARNI
860 870 880 890 900
YKQVTKKAKR CQDPDEPPPP PRPMLRFYLI GGGIPIIVCG ITAAANIKNY
910 920 930 940 950
GSRPNAPYCW MAWEPSLGAF YGPASFITFV NCMYFLSIFI QLKRHPERKY
960 970 980 990 1000
ELKEPTEEQQ RLAANENGEI NHQDSMSLSL ISTSALENEH TFHSQLLGAS
1010 1020 1030 1040 1050
LTLLLYVALW MFGALAVSLY YPLDLVFSFV FGATSLSFSA FFVVHHCVNR
1060 1070 1080 1090 1100
EDVRLAWIMT CCPGRSSYSV QVNVQPPNSN GTNGEAPKCP NSSAESSCTN
1110 1120 1130 1140 1150
KSASSFKNSS QGCKLTNLQA AAAQCHANSL PLNSTPQLDN SLTEHSMDND
1160 1170 1180 1190 1200
IKMHVAPLEV QFRTNVHSSR HHKNRSKGHR ASRLTVLREY AYDVPTSVEG
1210 1220 1230 1240 1250
SVQNGLPKSR LGNNEGHSRS RRAYLAYRER QYNPPQQDSS DACSTLPKSS
1260 1270 1280 1290 1300
RNFEKPVSTT SKKDALRKPA VVELENQQKS YGLNLAIQNG PIKSNGQEGP
1310 1320
LLGTDSTGNV RTGLWKHETT V
Length:1,321
Mass (Da):146,151
Last modified:July 19, 2004 - v2
Checksum:i25EBC1620E1895EA
GO
Isoform 2 (identifier: Q8IWK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     604-616: NTIVEASIQLPPS → VCYILQSFKTIYS
     617-1321: Missing.

Note: No experimental confirmation available.
Show »
Length:616
Mass (Da):68,243
Checksum:i00CEB483C5714F80
GO
Isoform 3 (identifier: Q8IWK6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: MEPPGRRRGR...FWGLSSLKRL → MMRVMPCQV
     603-620: Missing.

Note: No experimental confirmation available.
Show »
Length:1,178
Mass (Da):131,543
Checksum:i8C46F040B84B26E9
GO
Isoform 4 (identifier: Q8IWK6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MEPPGRRRGR → MPLKRNNSKY
     11-236: Missing.
     604-607: NTIV → GKFR
     608-1321: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):42,973
Checksum:i56F63AE58F94AFEC
GO

Sequence cautioni

The sequence AAH35645 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti537S → P in BC026009 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0339711043V → M. Corresponds to variant dbSNP:rs9002Ensembl.1
Natural variantiVAR_0339721166V → G. Corresponds to variant dbSNP:rs3814416Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107381 – 134MEPPG…SLKRL → MMRVMPCQV in isoform 3. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_0107431 – 10MEPPGRRRGR → MPLKRNNSKY in isoform 4. 1 Publication10
Alternative sequenceiVSP_01074411 – 236Missing in isoform 4. 1 PublicationAdd BLAST226
Alternative sequenceiVSP_010740603 – 620Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_010741604 – 616NTIVE…QLPPS → VCYILQSFKTIYS in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_010745604 – 607NTIV → GKFR in isoform 4. 1 Publication4
Alternative sequenceiVSP_010746608 – 1321Missing in isoform 4. 1 PublicationAdd BLAST714
Alternative sequenceiVSP_010742617 – 1321Missing in isoform 2. 1 PublicationAdd BLAST705

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181243 mRNA Translation: AAO27355.1
AY358306 mRNA Translation: AAQ88673.1
AC093735 Genomic DNA No translation available.
AC093814 Genomic DNA No translation available.
BC026009 mRNA No translation available.
BC035645 mRNA Translation: AAH35645.1 Sequence problems.
CCDSiCCDS33964.1 [Q8IWK6-1]
RefSeqiNP_660333.2, NM_145290.3 [Q8IWK6-1]
UniGeneiHs.684429
Hs.99195

Genome annotation databases

EnsembliENST00000334304; ENSP00000334952; ENSG00000152990 [Q8IWK6-1]
ENST00000502482; ENSP00000421006; ENSG00000152990 [Q8IWK6-2]
ENST00000508133; ENSP00000422606; ENSG00000152990 [Q8IWK6-4]
GeneIDi166647
KEGGihsa:166647
UCSCiuc003gqm.3 human [Q8IWK6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAGRA3_HUMAN
AccessioniPrimary (citable) accession number: Q8IWK6
Secondary accession number(s): Q6UXK9, Q86SQ5, Q8TC55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 25, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health